Como tratar linfoma hepatoesplênico de células T no SUS

O linfoma hepatoesplênico de células T (LHCT) é uma neoplasia rara e agressiva e não existe consenso no tratamento de primeira linha. O Sistema Único de Saúde (SUS), por se tratar se sistema público de saúde, nem sempre tem acesso aos tratamentos e métodos diagnósticos mais recentes. O presente artigo irá realizar revisão de literatura e trazer as alternativas disponíveis no SUS para manejo do LHCT

Batailles entre chrétiens et Ottomans dans la Méditerranée du XVIe siècle (Les)

Mémoire du Master 1 Cultures de l\u27écrit et de l\u27image portant sur la production, la diffusion et les contenus des représentations des batailles entre chrétiens et Ottomans dans la Méditerranée du XVIe siècle

Trilobite (<i>vangl2</i>) mutants are highly sensitive to canonical signaling.

<p>Injection of a low dose (5pg) of <i>wnt8a</i> into embryos from a tri+/- X tri+/- parental cross results in extremely dorsalized embryos and significant lethality (A–D, I). Different classes of phenotypes are shown in (A–D) with an uninjected wild-type sibling shown at the top in (A), and an uninjected tri mutant shown at the top in (B) for comparison. Addition of Nkd1 is capable of fully suppressing the <i>wnt8a</i> overexpression lethality and dorsalization (I). n values are for all genotypes. In contrast to the extreme phenotypes seen at 1 dpf, there is no effect of Wnt8a on the early organizer (E–H) shown by expression of <i>gsc</i> (E, F) and <i>bozozok</i> (<i>boz</i>) (G, H) an early and direct transcription target of maternal Wnt signaling. (J–M) Injection of <i>vangl2</i> MO does not alter the expression of <i>gsc</i> (K), nor does the low level of <i>wnt8a</i> (M). However, co-injection of <i>vangl2</i> MO and <i>wnt8a</i> results in ectopic <i>gsc</i> expression about 2-5% of the time (red arrowheads, n= 21).</p

<i>Trilobite</i> (<i>vangl2</i>) mutants are sensitive to Nkd1.

<p>Knockdown of Nkd1 with morpholinos (D, E) or overexpression of Nkd1 (I, J) does not have an obvious effect during early somitogenesis. However, at 1 dpf, knockdown or overexpression of Nkd1 in <i>tri</i> mutants results in an increase in cyclopia (K, L, O). Before the onset of gastrulation, at 50% epiboly, embryos generated from a tri+/- X tri+/- parental cross are sensitive to Nkd1 overexpression, demonstrated by a reduction or absence of <i>gsc</i> expression (M; n=32, N; 56% of embryos with reduced expression, n=25). (O) The cyclopic index was calculated using criteria established in Marlow et al., 1998 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074666#B43" target="_blank">43</a>]. n values reflect the number of tri-/- embryos. Error bars represent standard error.</p

Increase of the Number of Detectable Gravitational Waves Signals Due to Gravitational Lensing

International audienceThis article deals with the gravitational lensing (GL) of gravitational waves (GW). We compute the increase in the number of detected GW events due to GL. First, we check that geometrical optics is valid for the GW frequency range on which Earth-based detectors are sensitive, and that this is also partially true for what concerns the future space-based interferometer LISA. To infer this result, both the diffraction parameter and a cut-off frequency are computed. Then, the variation in the number of GW signals is estimated in the general case, and applied to some lens models: point mass lens and singular isothermal sphere (SIS profile). An estimation of the magnification factor has also been done for the softened isothermal sphere and for the King profile. The results appear to be strongly model-dependent, but in all cases the increase in the number of detected GW signals is negligible. The use of time delays among images is also investigated

Paris Observatory Lunar Analysis Center: from LLR predictions to tests of fundamental Physics

International audiencePOLAC (Paris Observatory Lunar Analysis Center) is an ILRS analysis center founded by J. Chapront, M. Chapront-Touz&eacute; and G. Francou in 1996. They developed in the 80's a semi-analytical solution of the lunar motion named ELP (Eph&eacute;m&eacute;rides lunaires Parisienne). Thus, the original purpose of POLAC was the adjustment of ELP to the lunar laser ranging observations (LLR) for improving the determination of fundamental astronomical parameters, such as the free modes of lunar physical librations, the tidal secular acceleration of the lunar longitude, or the transformation between celestial reference systems. Since the beginning, POLAC worked in close collaboration with the laser ranging station of Grasse (M&eacute;O) by providing a posteriori validation of their LLR normal points in order to avoid calibration and format issues. &lt;P /&gt;Since 2010 POLAC has evolved. Firstly, it additionally provides predictions for laser ranging observations - mainly for the Moon tracking but also, in an experimental mode, for two ways LRO (Lunar Reconnaissance Orbiter) tracking . The POLAC LLR predictions, originally dedicated and optimized for M&eacute;O station, are now the official ILRS prediction for LLR. Secondly, with the elaboration of a new lunar ephemeris called ELPN (Eph&eacute;m&eacute;ride lunaire Parisienne Num&eacute;rique), POLAC also takes part to the long legacy of testing fundamental Physics with laser ranges to the Moon. Indeed, even if ELPN was built originally in the General Relativity (GR) framework, it allows for GR alternative theories of gravity as well. One of particular interest is the Standard Model Extension (SME) which parametrizes Lorentz symmetry violations, notably in the pure gravity sector and in the matter sector of the formalism. By fitting ELPN in the SME framework to the 50 years of collected data, we have been able to provide stringent and realistic estimates on possible Lorentz symmetry violations arising at the level of the weak and the strong Einstein equivalence principles

Paris Observatory Lunar Analysis Center: from LLR predictions to tests of fundamental Physics

International audiencePOLAC (Paris Observatory Lunar Analysis Center) is an ILRS analysis center founded by J. Chapront, M. Chapront-Touz&eacute; and G. Francou in 1996. They developed in the 80's a semi-analytical solution of the lunar motion named ELP (Eph&eacute;m&eacute;rides lunaires Parisienne). Thus, the original purpose of POLAC was the adjustment of ELP to the lunar laser ranging observations (LLR) for improving the determination of fundamental astronomical parameters, such as the free modes of lunar physical librations, the tidal secular acceleration of the lunar longitude, or the transformation between celestial reference systems. Since the beginning, POLAC worked in close collaboration with the laser ranging station of Grasse (M&eacute;O) by providing a posteriori validation of their LLR normal points in order to avoid calibration and format issues. &lt;P /&gt;Since 2010 POLAC has evolved. Firstly, it additionally provides predictions for laser ranging observations - mainly for the Moon tracking but also, in an experimental mode, for two ways LRO (Lunar Reconnaissance Orbiter) tracking . The POLAC LLR predictions, originally dedicated and optimized for M&eacute;O station, are now the official ILRS prediction for LLR. Secondly, with the elaboration of a new lunar ephemeris called ELPN (Eph&eacute;m&eacute;ride lunaire Parisienne Num&eacute;rique), POLAC also takes part to the long legacy of testing fundamental Physics with laser ranges to the Moon. Indeed, even if ELPN was built originally in the General Relativity (GR) framework, it allows for GR alternative theories of gravity as well. One of particular interest is the Standard Model Extension (SME) which parametrizes Lorentz symmetry violations, notably in the pure gravity sector and in the matter sector of the formalism. By fitting ELPN in the SME framework to the 50 years of collected data, we have been able to provide stringent and realistic estimates on possible Lorentz symmetry violations arising at the level of the weak and the strong Einstein equivalence principles