565 research outputs found

    Quasi two-dimensional antiferromagnet on a triangular lattice RbFe(MoO4)2

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    RbFe(MoO4)2 is a rare example of a nearly two-dimensional Heisenberg antiferromagnet on a triangular lattice. Magnetic resonance spectra and magnetization curves reveal that the system has a layered spin structure with six magnetic sublattices. The sublattices within a layer are arranged in a triangular manner with the magnetization vectors 120 degree apart. The H-T phase diagram, containing at least five different magnetic phases is constructed. In zero field, RbFe(MoO4)2 undergoes a phase transition at T_N=3.8 K into a non-collinear triangular spin structure with all the spins confined in the basal plane. The application of an in-plane magnetic field induces a collinear spin state between the fields H_c1=47 kOe and H_c2=71 kOe and produces a magnetization plateau at one-third of the saturation moment. Both the ESR and the magnetization measurements also clearly indicate an additional first-order phase transition in a field of 35 kOe. The exact nature of this phase transition is uncertain.Comment: 9 pages incl 11 figure

    Forbush decrease observed by SEVAN particle detector network on November 4, 2021

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    On November 3-4 2021, an interplanetary coronal mass injection (ICME) hits the magnetosphere, sparking a strong G3-class geomagnetic storm and auroras as far south as California and New Mexico. All detectors of the SEVAN network registered a Forbush decrease (FD) of 5-10 percentdeep in 1 minute time series of count rates. We present the results of a comparison of Fd registered on mountain altitudes on Aragats (Armenia), Lomnicky Stit (Slovakia), Musala (Bulgaria), and at sea level DESY (Hamburg, Germany), and in Mileshovka, Czechia. We present as well purity and barometric coefficients of different coincidences of SEVAN detector layers on Aragats. We demonstrate disturbances of the near-surface electric (NSEF) and geomagnetic fields at the arrival of the ICME on Earth

    Synthesis of structurally diverse major groove DNA interstrand crosslinks using three different aldehyde precursors

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    DNA interstrand crosslinks (ICLs) are extremely cytotoxic lesions that block essential cellular processes, such as replication and transcription. Crosslinking agents are widely used in cancer chemotherapy and form an array of structurally diverse ICLs. Despite the clinical success of these agents, resistance of tumors to crosslinking agents, for example, through repair of these lesions by the cellular machinery remains a problem. We have previously reported the synthesis of site-specific ICLs mimicking those formed by nitrogen mustards to facilitate the studies of cellular responses to ICL formation. Here we extend these efforts and report the synthesis of structurally diverse major groove ICLs that induce severe, little or no distortion in the DNA. Our approach employs the incorporation of aldehyde precursors of different lengths into complementary strands and ICL formation using a double reductive amination with a variety of amines. Our studies provide insight into the structure and reactivity parameters of ICL formation by double reductive amination and yield a set of diverse ICLs that will be invaluable for exploring structure-activity relationships in ICL repairope

    Component-Based Real-Time Operating System for Embedded Applications

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    Acceptance rate: 37%, Rank (CORE): AInternational audienceAs embedded systems must constantly integrate new functionalities, their developement cycles must be based on high-level abstractions, making the software design more flexible. CBSE provides an approach to these new requirements. However, low-level services provided by operating systems are an integral part of embedded applications, furthermore deployed on resource-limited devices. Therefore, the expected benefits of CBSE must not impact on the constraints imposed by the targetted domain, such as memory footprint, energy consumption, and execution time. In this paper, we present the componentization of a legacy industry-established Real-Time Operating System, and how component-based applications are built on top of it. We use the Think framework that allows to produce flexible systems while paying for flexibility only where desired. Performed experimentions show that the induced overhead is negligeable

    Properties of the Volume Operator in Loop Quantum Gravity II: Detailed Presentation

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    The properties of the Volume operator in Loop Quantum Gravity, as constructed by Ashtekar and Lewandowski, are analyzed for the first time at generic vertices of valence greater than four. The present analysis benefits from the general simplified formula for matrix elements of the Volume operator derived in gr-qc/0405060, making it feasible to implement it on a computer as a matrix which is then diagonalized numerically. The resulting eigenvalues serve as a database to investigate the spectral properties of the volume operator. Analytical results on the spectrum at 4-valent vertices are included. This is a companion paper to arXiv:0706.0469, providing details of the analysis presented there.Comment: Companion to arXiv:0706.0469. Version as published in CQG in 2008. More compact presentation. Sign factor combinatorics now much better understood in context of oriented matroids, see arXiv:1003.2348, where also important remarks given regarding sigma configurations. Subsequent computations revealed some minor errors, which do not change qualitative results but modify some numbers presented her

    γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.

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    The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ-catenin in the initiation and maintenance of BCR-ABL1 &lt;sup&gt;+&lt;/sup&gt; B-ALL but not CML. The selectivity was explained by a partial γ-catenin dependence of MYC expression together with the susceptibility of B-ALL, but not CML, to reduced MYC levels. MYC and γ-catenin enabled B-ALL maintenance by augmenting BIRC5 and enforced BIRC5 expression overcame γ-catenin loss. Since γ-catenin was dispensable for normal hematopoiesis, these lineage- and disease-specific features of canonical Wnt signaling identified a potential therapeutic target for the treatment of BCR-ABL1 &lt;sup&gt;+&lt;/sup&gt; B-ALL
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