Effect Of Aerobic Exercise Training On Regional Blood Flow And Vascular Resistance In Diabetic Rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evaluate coronary and renal blood flows and vascular resistances after ET in diabetic rats. Methods: Thirty-two rats were divided into four groups (n = 8): sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD). Diabetes was induced by an injection of streptozotocin (STZ, 50 mg/kg). The ET was performed on a treadmill for 10 weeks. The blood flows were measured using colored microspheres. Results: The diabetic groups presented hyperglycemia (blood glucose >350 mg/dL) and ET did not change this parameter. The SD group showed reduced renal blood flow when compared to SC group, and ET was able to normalize this parameter in TD rats (SC: 4.3 +/- 0.5; TC: 2.9 +/- 0.3; SD: 1.9 +/- 0.4; TD: 3.2 +/- 0.4 mL/min/g). TD group presented increased coronary blood flow in relation to SD group (SC: 2.3 +/- 0.23; TC: 2.8 +/- 0.5; SD: 1.2 +/- 0.4; TD: 3.0 +/- 0.4 mL/min/g). The heart and kidneys vascular resistance were increased in SD group when compared to SC group, and ET was able to reverse these changes. Conclusions: Given the relevance of cardiomyopathy and nephropathy in mortality of diabetics, our results demonstrated that ET is effective in improving coronary and renal blood flows and vascular resistances in STZ-diabetic rats, reinforcing the positive role of this approach in preventing hyperglycemia-induced long-term organ damage.7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CAPES [88881.062178/2014-01]FAPESP [2012/20141-5, 2007/52419-4]CNPq [563961/2010-4, 457200/2014-6

Critical patient’s family needs in terminality of life : integrative review

Objetivo:identificar na literatura científica as principais necessidades da família do paciente crítico terminal. Método:revisão integrativa realizada de acordo com as seis etapas propostas. As buscas foram realizadas nas bases de dados SciELO, LILACS e PubMed, sendo incluídos artigos publicados entre 2010 e março de 2021. Resultados:do total da amostra analisada (n=6), destacaram-se os ensaios clínicos (50%) e pesquisas qualitativas (33%). Foram evidenciadas diferentes necessidades dos familiares de pacientes críticos na terminalidade, com destaque para as necessidades de comunicação e as necessidades emocionais, espirituais, psicológicas e sociais. Considerações finais:a literatura científica aponta que a família do paciente em terminalidade de vida no âmbito da terapia intensiva apresenta uma diversidade de necessidades, e que o investimento na melhor comunicação com a equipe clínica durante o período de hospitalização na Unidade de Terapia Intensiva é uma premência. Percebe-se a importância da integração da equipe de saúde no contexto de terminalidade para auxiliar a família nesse momento delicado, corroborando para uma resposta adequada de um plano terapêutico. O trabalho interdisciplinar é uma alternativa, visto que as necessidades são de ordens diversas e não se limitam à alta densidade tecnológica comum a terapia intensiva.Objective: to identify in the scientific literature the main needs of the terminally critical patient's family. Method:integrative review carried out according to the six proposed steps. Searches were performed in the SciELO, LILACS and PubMed databases, including articles published between 2010 and March 2021. Results:from the total sample analyzed (n=6), clinical trials (50%) and research stood out qualitative (33%). Different needs of families of critically ill patients in terminality were highlighted, with emphasis on communication needs and emotional, spiritual, psychological and social needs. Final considerations:the scientific literature indicates that the family of the terminally ill patient in the intensive care setting has a variety of needs, and that investing in better communication with the clinical team during the period of hospitalization in the Intensive Care Unit is a urgency. The importance of integrating the health team in the context of terminality to help the family in this delicate moment is perceived, supporting an adequate response to a therapeutic plan. Interdisciplinary work is an alternative, as the needs are of different orders and are not limited to the high technological density common to intensive care

THE INTERNATIONAL CLASSIFICATION OF PUBLIC HEALTH NURSING PRACTICES - CIPESC (R): A PEDAGOGICAL TOOL FOR EPIDEMIOLOGICAL STUDIES

The CIPESC (R) is a tool that informs the work of nurses in Public Health and assists in prioritizing their care in practice, management and research. It is also a powerful pedagogical instrument for the qualification of nurses within the Brazilian healthcare system. In the teaching of infectious diseases, using the CIPESC (R) assists in analyzing the interventions by encouraging clinical and epidemiological thinking regarding the health-illness process. With the purpose in mind of developing resources for teaching undergraduate nursing students and encouraging reflection regarding the process of nursing work, this article presents an experimental application of CIPESC (R), using meningococcal meningitis as an example

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways