19 research outputs found
New therapeutic options in SAPHO syndrome: anti - TNF - α
El síndrome SAPHO se caracteriza por la presencia de manifestaciones ostoarticulares junto con lesiones
cutáneas diversas como acné, psoriasis pustulosa y pustulosis palmoplantar. Se han empleado diversos
fármacos para el control de la enfermedad con resultados variados, recientemente se han introducido los
anti-TNF-á, con buena respuesta de las manifestaciones cutáneas y osteoarticulares. Se discute la utilidad
de estos nuevos fármacos para el tratamiento de esta patología.SAPHO syndrome is characterised by the presence of osteoarticular symptoms along with a variety of
cutaneous lesions such as acne, pustular psoriasis and palmoplantar pustulosis. Several agents have been
used in order to control this disorder, with different levels of success. Recently, TNF-á blocking agents have
been introduced in the treatment of SAPHO syndrome, usually with good response of both skin and
osteoarticular manifestations. The usefulness of these new drugs is discussed in the present manuscript
Poly[ADP-Ribose] Polymerase-1 Expression Is Related To Cold Ischemia, Acute Tubular Necrosis, and Delayed Renal Function In Kidney Transplantation
Cold ischemia time especially impacts on outcomes of expanded-criteria donor (ECD) transplantation. Ischemia-reperfusion (IR) injury produces excessive poly[ADP-Ribose] Polymerase-1 (PARP-1) activation. The present study explored the hypothesis that increased tubular expression of PARP-1 contributes to delayed renal function in suboptimal ECD kidney allografts and in non-ECD allografts that develop posttransplant acute tubular necrosis (ATN)
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Annular erythematous papules in the neckline.
A 45-year-old woman with personal history of hypertension presented with an erythematous lesion in the neckline for a year and with a progressive growth. A physical examination revealed an annular lesion with erythematous papules in the edge. Histological exam showed phagocytosis of elastic fibers by multinucleated cells compatible with annular elastolytic giant-cell granuloma. The patient did not present any other associated systemic manifestation. Treatment with tacrolimus 0.1 percent ointment was prescribed with a very good response after two months.YesUna mujer de 45 años de edad con antecedentes personales de hipertensión presenta una lesión eritematosa en el cuello durante un año y con un crecimiento progresivo. El examen físico reveló una anular lesión con pápulas eritematosas en el borde. Examen histológico reveló la fagocitosis de las fibras elásticas de las células multinucleadas compatible con anular elastolíticas granuloma de células gigantes. El paciente no presentó ninguna otra manifestación sistémica asociada. El tratamiento con pomada de tacrolimus 0,1 por ciento fue recetado con una muy buena respuesta después de dos meses
Expression of smoothelin and smooth muscle actin in the skin
Introduction: Smoothelin is a cytoskeletal
protein of differentiated smooth muscle cells with
contractile capacity, distinguishing it from other smooth
muscle proteins, such as smooth muscle actin (SMA).
Objective: To evaluate the expression of smoothelin
and SMA in the skin in order to establish specific
localizations of smoothelin in smooth muscle cells with
high contractile capacity and in the epithelial component
of cutaneous adnexal structures. Methods:
Immunohistochemical analysis (smoothelin and SMA)
was performed in 18 patients with normal skin.
Results: SMA was expressed by the vascular
structures of superficial, deep, intermediate and
adventitial plexuses, whereas smoothelin was
specifically expressed in the cytoplasm of smooth
muscle cells of the deepest vascular plexus and in no
other plexus of the dermis. The hair erector muscle
showed intense expression of smoothelin and SMA.
Cells with nuclear expression of smoothelin and
cytoplasmic expression of SMA were observed in the
outer root sheath of the inferior portion of the hair
follicles and intense cytoplasmic expression in cells of
the dermal sheath to SMA.
Conclusions: We report the first study of smoothelin
expression in normal skin, which differentiates the
superficial vascular plexus from the deep. The deep
plexus comprises vessels with high contractile capacity,
which is important for understanding dermal
hemodynamics in normal skin and pathological
processes. We suggest that the function of smoothelin in
the outer root sheath may be to enhance the function of
SMA, which has been related to mechanical stress
New therapeutic options in SAPHO syndrome: anti - TNF - α
El síndrome SAPHO se caracteriza por la presencia de manifestaciones ostoarticulares junto con lesiones
cutáneas diversas como acné, psoriasis pustulosa y pustulosis palmoplantar. Se han empleado diversos
fármacos para el control de la enfermedad con resultados variados, recientemente se han introducido los
anti-TNF-á, con buena respuesta de las manifestaciones cutáneas y osteoarticulares. Se discute la utilidad
de estos nuevos fármacos para el tratamiento de esta patología.SAPHO syndrome is characterised by the presence of osteoarticular symptoms along with a variety of
cutaneous lesions such as acne, pustular psoriasis and palmoplantar pustulosis. Several agents have been
used in order to control this disorder, with different levels of success. Recently, TNF-á blocking agents have
been introduced in the treatment of SAPHO syndrome, usually with good response of both skin and
osteoarticular manifestations. The usefulness of these new drugs is discussed in the present manuscript
Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.
The structure of the human skin is directly dependent on its location and the mechanical forces to which it is subjected. In the present work, we have performed a comprehensive analysis of the human ridged and non-ridged skin to identify the differences and similarities between both skin types. For this purpose, human skin samples were obtained from dorsal hand skin (DHS), palmar hand skin (PHS), dorsal foot skin (DFS) and plantar foot skin (PFS) from the same cadaveric donors. Histological, histochemical and semiquantitative and quantitative immunohistochemical analyses were carried out to evaluate the epidermis, dermis and basement membrane. Results show that the epithelial layer of ridged skin had larger cell number and size than non-ridged skin for most strata. Melanocytes and Langerhans cells were more abundant in non-ridged skin, whereas Merkel cells were preferentially found in ridged skin. The expression pattern of CK5/6 was slightly differed between non-ridged and ridged skin. Involucrin expression was slightly more intense in non-ridged skin than in ridged skin. Collagen was more abundant in foot skin dermis than in hand skin, and in ridged skin as compared to non-ridged skin. Elastic fibers were more abundant in DHS. Biglycan was more abundant in foot skin than in hand skin. No differences were found for blood and lymphatic vessels. The basement membrane laminin was preferentially found in foot skin. These results revealed important differences at the epithelial, dermal and basement membrane levels that could contribute to a better knowledge of the human skin histology