1,655 research outputs found
A radio census of the massive stellar cluster Westerlund 1
CONTEXT: Massive stars and their stellar winds are important for a number of feedback processes. The mass lost in the stellar wind can help determine the end-point of the star as a neutron star (NS) or a black hole (BH). However, the impact of mass loss on the post-main sequence evolutionary stage of massive stars is not well understood. Westerlund 1 is an ideal astrophysical laboratory in which to study massive stars and their winds in great detail over a large range of different evolutionary phases. AIMS: We aim to study the radio emission from Westerlund 1, in order to measure radio fluxes from the population of massive stars, and determine mass-loss rates and spectral indices where possible. METHODS: Observations were carried out in 2015 and 2016 with the Australia Telescope Compact Array (ATCA) at 5.5 and 9 GHz using multiple configurations, with maximum baselines ranging from 750 m to 6 km. RESULTS: Thirty stars are detected in the radio from the fully concatenated dataset, ten of which are Wolf-Rayet stars (WRs) (predominantly late type WN stars), five yellow hypergiants (YHGs), four red supergiants (RSGs), one luminous blue variable (LBV), the sgB[e] star W9, and several OB supergiants. New source detections in the radio are found for five WR stars, and five OB supergiants. These detections lead to evidence for three new OB supergiant binary candidates, which is inferred from derived spectral index limits. CONCLUSIONS: Spectral indices and index limits were determined for massive stars in Westerlund 1. For cluster members found to have partially optically thick emission, mass-loss rates were calculated. Under the approximation of a thermally emitting stellar wind and a steady mass-loss rate, clumping ratios were then estimated for eight WRs. Diffuse radio emission was detected throughout the cluster. Detections of knots of radio emission with no known stellar counterparts indicate the highly clumped structure of this intra-cluster medium, likely shaped by a dense cluster wind
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Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets
The activation of human platelets by α-thrombin is mediated at least in part by cleavage of protease-activated G-protein-coupled receptors, PAR-1 and PAR-4. Platelet glycoprotein Ibα also has a high affinity binding site for α-thrombin, and this interaction contributes to platelet activation through a still unknown mechanism. In the present study the hypothesis that GpIbα may contribute to platelet activation by modulating the hydrolysis of PAR-1 on the platelet membrane was investigated. Gel-filtered platelets from normal individuals were stimulated by α-thrombin, and the kinetics of PAR-1 hydrolysis by enzyme was followed with flow cytometry using an anti-PAR-1 monoclonal antibody (SPAN 12) that recognizes only intact PAR-1 molecules. This strategy allowed measurement of the apparentk cat/K m value for thrombin hydrolysis of PAR-1 on intact platelets, which was equal to 1.5 ± 0.1 × 107 m −1sec−1. The hydrolysis rate of PAR-1 by thrombin was measured under conditions in which thrombin binding to GpIb was inhibited by different strategies, with the following results. 1) Elimination of GpIbα on platelet membranes by mocarhagin treatment reduced the k cat/K m value by about 6-fold. 2) A monoclonal anti-GpIb antibody reduced the apparent k cat/K m value by about 5-fold. 3) An oligonucleotide DNA aptamer, HD22, which binds to the thrombin heparin-binding site (HBS) and inhibits thrombin interaction with GpIbα, reduced the apparentk cat/K m value by about 5-fold. 4) Displacement of α-thrombin from the binding site on GpIb using PPACK-thrombin reduced the apparentk cat/K m value by about 5-fold, and 5) mutation at the HBS of thrombin (R98A) caused a 5-fold reduction of the apparentk cat/K m value of PAR-1 hydrolysis. Altogether these results show that thrombin interaction with GpIb enhances the specificity of thrombin cleavage of PAR-1 on intact platelets, suggesting that GpIb may function as a “cofactor” for PAR-1 activation by thrombin
P11-12. A novel vaginal ring device for the sustained delivery of recombinant C-clade HIV-1 CN54gp140
P11-11. Stable lyophilised gel vehicles for vaginal administration of recombinant C-clade HIV-1 trimeric CN54gp140
Factors influencing the implementation of cognitive and behavioural screening in motor neurone disease
Super-A-polynomials for Twist Knots
We conjecture formulae of the colored superpolynomials for a class of twist
knots where p denotes the number of full twists. The validity of the
formulae is checked by applying differentials and taking special limits. Using
the formulae, we compute both the classical and quantum super-A-polynomial for
the twist knots with small values of p. The results support the categorified
versions of the generalized volume conjecture and the quantum volume
conjecture. Furthermore, we obtain the evidence that the Q-deformed
A-polynomials can be identified with the augmentation polynomials of knot
contact homology in the case of the twist knots.Comment: 22+16 pages, 16 tables and 5 figures; with a Maple program by Xinyu
Sun and a Mathematica notebook in the ancillary files linked on the right; v2
change in appendix B, typos corrected and references added; v3 change in
section 3.3; v4 corrections in Ooguri-Vafa polynomials and quantum
super-A-polynomials for 7_2 and 8_1 are adde
Longer fixation duration while viewing face images
The spatio-temporal properties of saccadic eye movements can be influenced by the cognitive demand and the characteristics of the observed scene. Probably due to its crucial role in social communication, it is argued that face perception may involve different cognitive processes compared with non-face object or scene perception. In this study, we investigated whether and how face and natural scene images can influence the patterns of visuomotor activity. We recorded monkeys’ saccadic eye movements as they freely viewed monkey face and natural scene images. The face and natural scene images attracted similar number of fixations, but viewing of faces was accompanied by longer fixations compared with natural scenes. These longer fixations were dependent on the context of facial features. The duration of fixations directed at facial contours decreased when the face images were scrambled, and increased at the later stage of normal face viewing. The results suggest that face and natural scene images can generate different patterns of visuomotor activity. The extra fixation duration on faces may be correlated with the detailed analysis of facial features
Why Can't Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study
The vomiting (emetic) reflex is documented in numerous mammalian species, including primates and carnivores, yet laboratory rats and mice appear to lack this response. It is unclear whether these rodents do not vomit because of anatomical constraints (e.g., a relatively long abdominal esophagus) or lack of key neural circuits. Moreover, it is unknown whether laboratory rodents are representative of Rodentia with regards to this reflex. Here we conducted behavioral testing of members of all three major groups of Rodentia; mouse-related (rat, mouse, vole, beaver), Ctenohystrica (guinea pig, nutria), and squirrel-related (mountain beaver) species. Prototypical emetic agents, apomorphine (sc), veratrine (sc), and copper sulfate (ig), failed to produce either retching or vomiting in these species (although other behavioral effects, e.g., locomotion, were noted). These rodents also had anatomical constraints, which could limit the efficiency of vomiting should it be attempted, including reduced muscularity of the diaphragm and stomach geometry that is not well structured for moving contents towards the esophagus compared to species that can vomit (cat, ferret, and musk shrew). Lastly, an in situ brainstem preparation was used to make sensitive measures of mouth, esophagus, and shoulder muscular movements, and phrenic nerve activity-key features of emetic episodes. Laboratory mice and rats failed to display any of the common coordinated actions of these indices after typical emetic stimulation (resiniferatoxin and vagal afferent stimulation) compared to musk shrews. Overall the results suggest that the inability to vomit is a general property of Rodentia and that an absent brainstem neurological component is the most likely cause. The implications of these findings for the utility of rodents as models in the area of emesis research are discussed. © 2013 Horn et al
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