A stochastic intra-ring synchronous optimal network design problem

We develop a stochastic programming approach to solving an intra-ring Synchronous Optical Network (SONET) design problem. This research differs from pioneering SONET design studies in two fundamental ways. First, while traditional approaches to solving this problem assume that all data are deterministic, we observe that for practical planning situations, network demand levels are stochastic. Second, while most models disallow demand shortages and focus only on the minimization of capital Add-Drop Multiplexer (ADM) equipment expenditure, our model minimizes a mix of ADM installations and expected penalties arising from the failure to satisfy some or all of the actual telecommunication demand. We propose an L-shaped algorithm to solve this design problem, and demonstrate how a nonlinear reformulation of the problem may improve the strength of the generated optimality cuts. We next enhance the ba-sic algorithm by implementing powerful lower and upper bounding techniques via an assortment of modeling, valid inequality, and heuristic strategies. Our computational results conclusively demonstrate the efficacy of our proposed algorithm as opposed to standard L-shaped and extensive form approaches to solving the problem

Myosin II Activity Facilitates Microtubule Bundling in the Neuronal Growth Cone Neck

SummaryThe cell biological processes underlying axon growth and guidance are still not well understood. An outstanding question is how a new segment of the axon shaft is formed in the wake of neuronal growth cone advance. For this to occur, the highly dynamic, splayed-out microtubule (MT) arrays characteristic of the growth cone must be consolidated (bundled together) to form the core of the axon shaft. MT-associated proteins stabilize bundled MTs, but how individual MTs are brought together for initial bundling is unknown. Here, we show that laterally moving actin arcs, which are myosin II-driven contractile structures, interact with growing MTs and transport them from the sides of the growth cone into the central domain. Upon Myosin II inhibition, the movement of actin filaments and MTs immediately stopped and MTs unbundled. Thus, Myosin II-dependent compressive force is necessary for normal MT bundling in the growth cone neck

Charge Neutrality of the Color-Flavor Locked Phase from the Low Energy Effective Theory

We investigate the issue of charge neutrality of the CFL$K^0$ phase of dense quark matter using the low energy effective theory of high density QCD. We show that the local electric and color charge neutrality of the ground state in a homogeneous color superconducting medium follows from its dynamics. We also consider the situation of a spatially inhomogeneous medium, such as may be found in a neutron star core. We find that spatial inhomogeneity results in the generation of electric fields, and positrons/electrons may be present in the ground state. We estimate the concentration of charged leptons in the ground state to be $n_{e}\sim{10^2}{cm}^{-3}$ and consider their influence on the opacity of the medium with respect to the modified photons.Comment: typos corrected, this version to appear in PR

Interannual prediction of the Paraná River

Interannual‐to‐decadal predictability of the Paraná river in South America is investigated by extracting near‐cyclic components in summer‐season streamflows at Corrientes over the period 1904–1997. It is found that oscillatory components with periods of about 2–5, 8 and 17 years are accompanied by statistically significant changes in monthly streamflow. Autoregressive predictive models are constructed for each component. Cross‐validated categorical hindcasts based on the 8‐yr predicted component are found to yield some skill up to four years in advance for below‐average flows. A prediction based upon the 8‐ and 17‐yr components including data up to 1999 suggests increased probability of below‐average flows until 2006

Pentamethylcyclopentadienyl Aminoborollide Derivatives of Zirconium and Hafnium: A New Class of Amphoteric Molecule Having Both Lewis Acidic and Lewis Basic Sites

[no abstract

Pentamethylcyclopentadienyl Aminoborollide Derivatives of Zirconium and Hafnium: A New Class of Amphoteric Molecule Having Both Lewis Acidic and Lewis Basic Sites

[no abstract

Interferometric diameters of five evolved intermediate-mass planet-hosting stars measured with PAVO at the CHARA Array

Debate over the planet occurrence rates around intermediate-mass stars has hinged on the accurate determination of masses of evolved stars, and has been exacerbated by a paucity of reliable, directly measured fundamental properties for these stars. We present long-baseline optical interferometry of five evolved intermediate-mass (∼ 1.5 M⊙) planet-hosting stars using the PAVO beam combiner at the CHARA Array, which we combine with bolometric flux measurements and parallaxes to determine their radii and effective temperatures. We measured the radii and effective temperatures of 6 Lyncis (5.12 ± 0.16 R⊙, 4949 ± 58 K), 24 Sextantis (5.49 ± 0.18 R⊙, 4908 ± 65 K), κ Coronae Borealis (4.77 ± 0.07 R⊙, 4870 ± 47 K), HR 6817 (4.45 ± 0.08 R⊙, 5013 ± 59 K), and HR 8461 (4.91 ± 0.12 R⊙, 4950 ± 68 K). We find disagreements of typically 15  per cent in angular diameter and ∼200 K in temperature compared to interferometric measurements in the literature, yet good agreement with spectroscopic and photometric temperatures, concluding that the previous interferometric measurements may have been affected by systematic errors exceeding their formal uncertainties. Modelling based on BaSTI isochrones using various sets of asteroseismic, spectroscopic, and interferometric constraints tends to favour slightly (∼15  per cent) lower masses than generally reported in the literature.Funding for the Stellar Astrophysics Centre is provided by The Danish National Research Foundation. The research was supported by the ASTERISK project (ASTERoseismic Investigations with SONG and Kepler) funded by the European Research Council (Grant agreement no.: 267864). TRW and VSA acknowledge the support of the Villum Foundation (research grant 10118). DH acknowledges support by the Australian Research Council’s Discovery Projects funding scheme (project number DE140101364) and support by the NASA Grant NNX14AB92G issued through the Kepler Participating Scientist Program. LC is supported by the Australian Research Council Future Fellowship FT160100402. MJI was supported by the Australian Research Council Future Fellowship FT130100235. Parts of this research were conducted by the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE170100013

Epilepsy in adults with mitochondrial disease: A cohort study.

OBJECTIVE: The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. METHODS: We prospectively recruited a cohort of 182 consecutive adult patients attending a specialized mitochondrial disease clinic in Newcastle upon Tyne between January 1, 2005 and January 1, 2008. We then followed this cohort over a 7-year period, recording primary outcome measures of occurrence of first seizure, status epilepticus, stroke-like episode, and death. RESULTS: Overall prevalence of epilepsy in the cohort was 23.1%. Mean age of epilepsy onset was 29.4 years. Prevalence varied widely between genotypes, with several genotypes having no cases of epilepsy, a prevalence of 34.9% in the most common genotype (m.3243A>G mutation), and 92.3% in the m.8344A>G mutation. Among the cohort as a whole, focal seizures, with or without progression to bilateral convulsive seizures, was the most common seizure type. Conversely, all of the patients with the m.8344A>G mutation and epilepsy experienced myoclonic seizures. Patients with the m.3243A>G mutation remain at high risk of developing stroke-like episodes (1.16% per year). However, although the standardized mortality ratio for the entire cohort was high (2.86), this ratio did not differ significantly between patients with epilepsy (2.96) and those without (2.83). INTERPRETATION: Epilepsy is a common manifestation of mitochondrial disease. It develops early in the disease and, in the case of the m.3243A>G mutation, often presents in the context of a stroke-like episode or status epilepticus. However, epilepsy does not itself appear to contribute to the increased mortality in mitochondrial disease