Robust Deep Sensing Through Transfer Learning in Cognitive Radio

We propose a robust spectrum sensing framework based on deep learning. The received signals at the secondary user's receiver are filtered, sampled and then directly fed into a convolutional neural network. Although this deep sensing is effective when operating in the same scenario as the collected training data, the sensing performance is degraded when it is applied in a different scenario with different wireless signals and propagation. We incorporate transfer learning into the framework to improve the robustness. Results validate the effectiveness as well as the robustness of the proposed deep spectrum sensing framework

Options for Producing a Warm-Water Fish in the UK: limits to "Green-Growth"?

This paper explores the development of a sustainable production system for tilapia and the research implications involved with ensuring commercial viability of such a system for UK farmers. The tilapia is a warm water fish with firm texture, white flesh and mild taste quite similar to a cod or haddock. Whilst tropical in origin it is thought to be highly suitable for low cost aquaculture in temperate zones with the potential to be a more sustainable source of food with fewer environmental impacts than other substitutes. Drawing on a literature review and findings from technical trials the paper will review and compare two production systems - novel Activated Suspension Technology (AST) and conventional Recirculating Aquaculture Systems (RAS) - considering their feasibility in terms of potential and financial viability for scaling up to commercial production of tilapia and their environmental and sustainability benefits. The review concludes that AST based only on microbial floc is currently uncompetitive with RAS in a UK context although the approach has benefits that might be incorporated in a new generation of mixed systems. Refinement of such systems needs to occur with potential adopters and could be part of diversification of mixed farms. Such development might further enhance the ethical values of fish produced in small-scale, modular RAS

Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help

Background: Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis of human CD4+ T cell help is largely lacking. Our goal was to elucidate the mechanisms of human CD4+ T cell help of CD8+ T cell proliferation using a novel in vitro model. Methods/Principal Findings: We developed a genetically engineered novel human cell-based artificial APC, aAPC/mOKT3, which expresses a membranous form of the anti-CD3 monoclonal antibody OKT3 as well as other immune accessory molecules. Without requiring the addition of allogeneic feeder cells, aAPC/mOKT3 enabled the expansion of both peripheral and tumor-infiltrating T cells, regardless of HLA-restriction. Stimulation with aAPC/mOKT3 did not expand Foxp3+ regulatory T cells, and expanded tumor infiltrating lymphocytes predominantly secreted Th1-type cytokines, interferon-γ and IL-2. In this aAPC-based system, the presence of autologous CD4+ T cells was associated with significantly improved CD8+ T cell expansion in vitro. The CD4+ T cell derived cytokines IL-2 and IL-21 were necessary but not sufficient for this effect. However, CD4+ T cell help of CD8+ T cell proliferation was partially recapitulated by both adding IL-2/IL-21 and by upregulation of IL-21 receptor on CD8+ T cells. Conclusions: We have developed an in vitro model that advances our understanding of the immunobiology of human CD4+ T cell help of CD8+ T cells. Our data suggests that human CD4+ T cell help can be leveraged to expand CD8+ T cells in vitro

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

The drug-induced liver injury network (DILIN) is conducting a prospective study of patients with DILI in the United States. We present characteristics and subgroup analyses from the first 1257 patients enrolled in the study

The Gondi family : strategy and survival in late sixteenth-century France

This thesis details the rise to power of one of the great families of late sixteenth-century France, the Gondi. Antoine de Gondi, the last of fifteen children, left his native Florence to settle permanently in France in the first decade of the sixteenth century. Like many other Italian immigrants of his time, he established himself in Lyon as a merchant and banker. He later bought the Seigneurie du Perron, and married a woman of Piedmontese origin, Marie-Catherine de Pierrevive. Catherine de’ Medici met the couple and soon after invited them to court, giving them positions in the royal households. Antoine’s children, most notably Albert and Pierre, distinguished themselves at court, and not long afterwards were awarded the highest offices of state and church. Albert became Marshal of France in 1573, and Pierre became Bishop of Paris in 1570. At the same time, they proved themselves indispensable servants to the monarchy, and served the crown diplomatically, politically and financially, both in France and on foreign missions. Both brothers had large Parisian real estate holdings, both inside and outside the city centre. The essential role of the Gondi women in family strategy is also analysed. Albert and Pierre’s sister, Jeanne, became Prioress at the royal Priory of Saint-Louis de Poissy. The cousins of Albert and Pierre, Jean-Baptiste and Jérôme Gondi, stayed closely connected to the world of international banking and, together with other bankers, facilitated loans to the increasingly insolvent crown. The Gondi were often targets of anti-Italian hostility from various segments of French society, and contemporary perceptions of the Gondi family are examined. This study shows the family’s deployment of and reliance on close kin to expand their web of influence throughout France and abroad. This dissertation details the many mechanisms employed by the Gondi family to consolidate and expand their influence during the tumultuous French wars of religion.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Letting a Good Crisis Go to Waste.

The widespread implementation of electronic health records (EHRs) was predicated on hopes that they would rapidly improve care, but initial experiences have been disappointing and thought to be a key part of physician dissatisfaction and burnout. The crisis created by EHR implementation is only in part due to EHRs themselves, and might also be viewed as a crisis that has served to surface longstanding problems in healthcare-ones that if grappled with, will lead to more rapidly effective digital transformation

Letting a Good Crisis Go to Waste.

The widespread implementation of electronic health records (EHRs) was predicated on hopes that they would rapidly improve care, but initial experiences have been disappointing and thought to be a key part of physician dissatisfaction and burnout. The crisis created by EHR implementation is only in part due to EHRs themselves, and might also be viewed as a crisis that has served to surface longstanding problems in healthcare-ones that if grappled with, will lead to more rapidly effective digital transformation