56 research outputs found
Quantitative trait loci for sensitivity to ethanol intoxication in a C57BL/6J × 129S1/SvImJ inbred mouse cross
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and is a predictor of alcohol abuse. Previous studies have shown that the C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mouse strains differ in responses on certain measures of acute EtOH intoxication. To gain insight into genetic factors contributing to these differences, we performed quantitative trait locus (QTL) analysis of measures of EtOH-induced ataxia (accelerating rotarod), hypothermia, and loss of righting reflex (LORR) duration in a B6 × S1 F2 population. We confirmed that S1 showed greater EtOH-induced hypothermia (specifically at a high dose) and longer LORR compared to B6. QTL analysis revealed several additive and interacting loci for various phenotypes, as well as examples of genotype interactions with sex. QTLs for different EtOH phenotypes were largely non-overlapping, suggesting separable genetic influences on these behaviors. The most compelling main-effect QTLs were for hypothermia on chromosome 16 and for LORR on chromosomes 4 and 6. Several QTLs overlapped with loci repeatedly linked to EtOH drinking in previous mouse studies. The architecture of the traits we examined was complex but clearly amenable to dissection in future studies. Using integrative genomics strategies, plausible functional and positional candidates may be found. Uncovering candidate genes associated with variation in these phenotypes in this population could ultimately shed light on genetic factors underlying sensitivity to EtOH intoxication and risk for alcoholism in humans
Critical realism and economic anthropology
This paper discusses basic critical realism within the context of economic anthropology and develops an approach to studying material relations between people. A diachronic form of analysis, following the work of Bhaskar and Archer, is described as a practical means of analysing property rights. This new approach emphasises epistemic relativism and ontological realism in order to compare disparate forms of human interaction across cultures. The aim of doing this is to develop a philosophical framework that allows for the comparison of economic practices without resorting to judgemental relativism. The implications are significant for institutional economics and anthropology alike, particularly for researchers examining multiple overlapping practices such as market and gift exchange
Social Bonding and Nurture Kinship: Compatibility between Cultural and Biological Approaches
Fig 3 from: Selman RG, Cherrill AJ (2018) The lesser mottled grasshopper, Stenobothrus stigmaticus: lessons from habitat management at its only site in the British Isles. Journal of Orthoptera Research 27: 83-89. https://doi.org/10.3897/jor.27.15123
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