151 research outputs found
Effects of consecutive domestic and international tournaments on heart rate variability in an elite rugby sevens team
Objectives: The purpose of this study was to evaluate heart rate variability and athlete self-report measures of recovery status (ASRM) in response to consecutive domestic and international tournaments among an elite rugby sevens team. Design: Retrospective. Methods: Olympic-level rugby sevens players (n = 10) recorded post-waking natural logarithm of the root mean square of successive differences (LnRMSSD) and ASRM (sleep quality, energy, soreness, recovery and mood) throughout a 1-week baseline period and daily thereafter throughout a domestic and subsequent international tournament, separated by five days. Linear mixed models and Hedge's effect sizes ± 95% confidence interval (ES ± 95% CI) were used to evaluate variation in LnRMSSD and ASRM relative to baseline. Results: Decrements in various ASRM were observed in response to both tournaments (ES = −0.80 ± 0.91 to −1.73 ± 1.03, p < 0.05) and international travel (ES = −1.03 ± 0.93 to −1.70 ± 1.02, p < 0.05) whereas decrements in LnRMSSD were only observed in response to the international tournament (ES = −0.89 ± 0.92 to −1.21 ± 0.96, p = 0.02–0.07). No clear differences in internal or external match-load parameters were observed between tournaments (ES = −0.35 ± 0.88 to 0.13 ± 0.88, p > 0.05). Conclusions: Greater decrements in cardiac-autonomic activity were observed in response to an international tournament relative to a domestic tournament, despite no difference in match-physical demands. Thus, factors separate from competition alone may impact players’ cardiac-autonomic response to an international tournament
Pharmacological potential of novel agonists for FFAR4 on islet and enteroendocrine cell function and glucose homeostasis
Benefits of Sustained Upregulated Unimolecular GLP-1 and CCK Receptor Signalling in Obesity-Diabetes
Heart Rate Variability, Neuromuscular and Perceptual Recovery Following Resistance Training
We quantified associations between changes in heart rate variability (HRV), neuromuscular and perceptual recovery following intense resistance training (RT). Adult males (n = 10) with \u3e1 year RT experience performed six sets to failure with 90% of 10 repetition maximum in the squat, bench press, and pull-down. Changes (∆) from pre- to immediately (IP), 24 and 48 h post-RT were calculated for neuromuscular performance markers (counter-movement jump peak power and mean concentric bench press and squat velocity with load corresponding to 1.0 m∙s−1) and perceived recovery and soreness scales. Post-waking natural logarithm of the root-mean square of successive differences (LnRMSSD) in supine and standing positions were recorded pre-RT (5 day baseline), IP and two mornings post-RT. All parameters worsened at IP (p \u3c 0.05). LnRMSSD measures were not different from baseline by 24 h. Neuromuscular markers were not different from pre-RT by 48 h. Perceptual measures remained suppressed at 48 h. No significant associations among ∆ variables were observed (p = 0.052–0.978). These data show varying timeframes of recovery for HRV, neuromuscular and perceptual markers at the group and individual level. Thus, post-RT recovery testing should be specific and the status of one metric should not be used to infer that of another
Effects of consecutive domestic and international tournaments on heart rate variability in an elite rugby sevens team
Objectives The purpose of this study was to evaluate heart rate variability and athlete self-report measures of recovery status (ASRM) in response to consecutive domestic and international tournaments among an elite rugby sevens team. Design Retrospective. Methods Olympic-level rugby sevens players (n = 10) recorded post-waking natural logarithm of the root mean square of successive differences (LnRMSSD) and ASRM (sleep quality, energy, soreness, recovery and mood) throughout a 1-week baseline period and daily thereafter throughout a domestic and subsequent international tournament, separated by five days. Linear mixed models and Hedge’s effect sizes ± 95% confidence interval (ES ± 95% CI) were used to evaluate variation in LnRMSSD and ASRM relative to baseline. Results Decrements in various ASRM were observed in response to both tournaments (ES = −0.80 ± 0.91 to −1.73 ± 1.03, p \u3c 0.05) and international travel (ES = −1.03 ± 0.93 to −1.70 ± 1.02, p \u3c 0.05) whereas decrements in LnRMSSD were only observed in response to the international tournament (ES = −0.89 ± 0.92 to −1.21 ± 0.96, p = 0.02–0.07). No clear differences in internal or external match-load parameters were observed between tournaments (ES = −0.35 ± 0.88 to 0.13 ± 0.88, p \u3e 0.05). Conclusions Greater decrements in cardiac-autonomic activity were observed in response to an international tournament relative to a domestic tournament, despite no difference in match-physical demands. Thus, factors separate from competition alone may impact players’ cardiac-autonomic response to an international tournament
Warm beach, warmer turtles: Using drone-mounted thermal infrared sensors to monitor sea turtle nesting activity
For decades sea turtle projects around the world have monitored nesting females using labor-intensive human patrolling techniques. Here we describe the first empirical testing of a drone-mounted thermal infrared sensor for nocturnal sea turtle monitoring; on the Osa peninsula in Costa Rica. Preliminary flights verified that the drone could detect similar sea turtle activities as identified by on-the-ground human patrollers – such as turtles, nests and tracks. Drone observers could even differentiate tracks of different sea turtle species, detect sea turtle hatchlings, other wildlife, and potential poachers. We carried out pilot flights to determine optimal parameters for detection by testing different thermal visualization modes, drone heights, and gimbal angles. Then, over seven nights, we set up a trial to compare the thermal drone and operators’ detections with those observed by traditional patrollers. Our trials showed that thermal drones can record more information than traditional sea turtle monitoring methods. The drone and observer detected 20% more sea turtles or tracks than traditional ground-based patrolling (flights and patrols carried out across the same nights at the same time and beach). In addition, the drone operator detected 39 other animals/predators and three potential poachers that patrollers failed to detect. Although the technology holds great promise in being able to enhance detection rates of nesting turtles and other beach activity, and in helping to keep observers safer, we detail challenges and limiting factors; in drone imagery, current cost barriers, and technological advances that need to be assessed and developed before standardized methodologies can be adopted. We suggest potential ways to overcome these challenges and recommend how further studies can help to optimize thermal drones to enhance sea turtle monitoring efforts worldwide
Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice
Daily Heart Rate Variability before and after Concussion in an American College Football Player
This case report demonstrates the effects of sport-related concussion (SRC) on heart rate variability (HRV) in an American college football player. Daily measures of resting, ultra-short natural logarithm of the root mean square of successive differences (LnRMSSD), subjective wellbeing, and Player Load were obtained each training day throughout a 4-week spring camp and 4 weeks of preseason training. SRC occurred within the first 2 weeks of the preseason. During spring camp and preseason pre-SRC, the athlete demonstrated minimal day-to-day fluctuations in LnRMSSD, which increased post-SRC (LnRMSSD coefficient of variation pre-SRC ≤ 3.1%, post-SRC = 5.8%). Moderate decrements in daily-averaged LnRMSSD were observed post-SRC relative to pre-SRC (Effect Size ± 90% Confidence Interval = −1.12 ± 0.80), and the 7-day rolling average fell below the smallest worthwhile change for the remainder of the preseason. LnRMSSD responses to SRC appeared similar to trends associated with stress and training fatigue. Therefore, performance and sports medicine staff should maintain regular communication regarding player injury and fatigue status so that HRV can be interpreted in the appropriate context. Detection and monitoring of autonomic dysregulation post-SRC may require near-daily assessment, as LnRMSSD showed greater daily fluctuations rather than chronic suppression following the head injury
Peptide YY (1–36) peptides from phylogenetically ancient fish targeting mammalian neuropeptide Y1 receptors demonstrate potent effects on pancreatic β-cell function, growth and survival
Aim: To investigate the antidiabetic efficacy of enzymatically stable Peptide YY (PYY) peptides from phylogenetically ancient fish. Materials and methods: N-terminally stabilized, PYY (1–36) sequences from Amia calva (bowfin), Oncorhynchus mykiss (trout), Petromyzon marinus (sea lamprey) and Scaphirhynchus albus (sturgeon), were synthesized, and both biological actions and antidiabetic therapeutic efficacy were assessed. Results: All fish PYY (1–36) peptides were resistant to dipeptidyl peptidase-4 (DPP-4) degradation and inhibited glucose- and alanine-induced (P < 0.05 to P < 0.001) insulin secretion. In addition, PYY (1–36) peptides imparted significant (P < 0.05 to P < 0.001) β-cell proliferative and anti-apoptotic benefits. Proliferative effects were almost entirely absent in β cells with CRISPR-Cas9-induced knockout of Npyr1. In contrast to human PYY (1–36), the piscine-derived peptides lacked appetite-suppressive actions. Twice-daily administration of sea lamprey PYY (1–36), the superior bioactive peptide, for 21 days significantly (P < 0.05 to P < 0.001) decreased fluid intake, non-fasting glucose and glucagon in streptozotocin (STZ)-induced diabetic mice. In addition, glucose tolerance, insulin sensitivity, pancreatic insulin and glucagon content were significantly improved. Metabolic benefits were linked to positive changes in pancreatic islet morphology as a result of augmented (P < 0.001) proliferation and decreased apoptosis of β cells. Sturgeon PYY (1–36) exerted similar but less impressive effects in STZ mice. Conclusion: These observations reveal, for the first time, that PYY (1–36) peptide sequences from phylogenetically ancient fish replicate the pancreatic β-cell benefits of human PYY (1–36) and have clear potential for the treatment of type 2 diabetes
Cardiac Rehabilitation Improves Endothelial Function in Coronary Artery Disease Patients
Exercise-based cardiac rehabilitation may be an effective nonpharmacological
intervention for improving endothelial function
in coronary artery disease patients. Therefore, this systematic
review with meta-analysis aimed to (a) estimate the
training-induced effect on endothelial and vascular smooth
muscle function, assessed by flow-mediated dilation and nitroglycerin-
mediated dilation, respectively, in coronary artery
disease patients; and to (b) study the influence of potential
trial-level variables (i. e. study and intervention characteristics)
on the training-induced effect on endothelial and vascular
smooth muscle function. Electronic searches were performed
in Pubmed, Scopus, and Embase up to February 2021. Randomeffects
models of standardised mean change were estimated.
Heterogeneity analyses were performed by using the Chi2 test
and I2 index. Our results showed that exercise-based cardiac
rehabilitation significantly enhanced flow-mediated dilation
(1.04 [95 % confidence interval = 0.76 to 1.31]) but did not significantly
change nitroglycerin-mediated dilation (0.05 [95 %
confidence interval = –0.03 to 0.13]). Heterogeneity testing
reached statistical significance (p < .001) with high inconsistency
for flow-mediated dilation (I2 = 92 %). Nevertheless, none
of the analysed variables influenced the training-induced effect
on flow-mediated dilation. Exercise-based cardiac rehabilitation
seems to be an effective therapeutic strategy for improving
endothelial-dependent dilation in coronary artery disease patients,
which may aid in the prevention of cardiovascular
events
- …