Supersymmetric Dark Matter Detection at Post-LEP Benchmark Points

We review the prospects for discovering supersymmetric dark matter in a recently proposed set of post-LEP supersymmetric benchmark scenarios. We consider direct detection through spin-independent nuclear scattering, as well as indirect detection through relic annihilations to neutrinos, photons, and positrons. We find that several of the benchmark scenarios offer good prospects for direct detection through spin-independent nuclear scattering, as well as indirect detection through muons produced by neutrinos from relic annihilations in the Sun, and photons from annihilations in the galactic center.Comment: 4 pages, 3 figures, uses RevTeX4, contribution to Snowmass 200

Prospects for Detecting Supersymmetric Dark Matter at Post-LEP Benchmark Points

A new set of supersymmetric benchmark scenarios has recently been proposed in the context of the constrained MSSM (CMSSM) with universal soft supersymmetry-breaking masses, taking into account the constraints from LEP, $b \to s \gamma$ and $g_\mu - 2$. These points have previously been used to discuss the physics reaches of different accelerators. In this paper, we discuss the prospects for discovering supersymmetric dark matter in these scenarios. We consider direct detection through spin-independent and spin-dependent nuclear scattering, as well as indirect detection through relic annihilations to neutrinos, photons, and positrons. We find that several of the benchmark scenarios offer good prospects for direct detection via spin-independent nuclear scattering and indirect detection via muons produced by neutrinos from relic annihilations inside the Sun, and some models offer good prospects for detecting photons from relic annihilations in the galactic centre.Comment: 24 pages, 14 figure

Re-Evaluation of the Elastic Scattering of Supersymmetric Dark Matter

We examine the cross sections for the elastic scattering of neutralinos $\chi$ on nucleons $p,n$, as functions of $m_\chi$ in the constrained minimal supersymmetric standard model. We find narrow bands of possible values of the cross section, that are considerably lower than some previous estimates. The constrained model is based on the minimal supergravity-inspired framework for the MSSM, with universal scalar and gaugino masses $m_0, m_{1/2}$, and $\mu$ and the MSSM Higgs masses treated as dependent parameters. We explore systematically the region of the $(m_{1/2}, m_0)$ plane where LEP and other accelerator constraints are respected, and the relic neutralino density lies in the range $0.1 \le \Omega_{\chi} h^2 \le 0.3$ preferred by cosmology. We update previous discussions of both the spin-independent and -dependent scattering matrix elements on protons and neutrons, using recent analyses of low-energy hadron experiments.Comment: 16 pages, latex, 14 eps figure

Gravitating Instantons In 3 Dimensions

We study the Einstein-Chern-Simons gravity coupled to Yang-Mills-Higgs theory in three dimensional Euclidean space with cosmological constant. The classical equations reduce to Bogomol'nyi type first order equations in curved space. There are BPS type gauge theory instanton (monopole) solutions of finite action in a gravitational instanton which itself has a finite action. We also discuss gauge theory instantons in the vacuum (zero action) AdS space. In addition we point out to some exact solutions which are singular.Comment: 17 pages, 4 figures, title has changed, gravitational instanton actions are adde

Power Diagrams and Sparse Paged Grids for High Resolution Adaptive Liquids

© ACM, 2017. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published in Aanjaneya, M., Gao, M., Liu, H., Batty, C., & Sifakis, E. (2017). Power Diagrams and Sparse Paged Grids for High Resolution Adaptive Liquids. ACM Trans. Graph., 36(4), 140:1–140:12. https://doi.org/10.1145/3072959.3073625We present an efficient and scalable octree-inspired fluid simulation framework with the flexibility to leverage adaptivity in any part of the computational domain, even when resolution transitions reach the free surface. Our methodology ensures symmetry, definiteness and second order accuracy of the discrete Poisson operator, and eliminates numerical and visual artifacts of prior octree schemes. This is achieved by adapting the operators acting on the octree's simulation variables to reflect the structure and connectivity of a power diagram, which recovers primal-dual mesh orthogonality and eliminates problematic T-junction configurations. We show how such operators can be efficiently implemented using a pyramid of sparsely populated uniform grids, enhancing the regularity of operations and facilitating parallelization. A novel scheme is proposed for encoding the topology of the power diagram in the neighborhood of each octree cell, allowing us to locally reconstruct it on the fly via a lookup table, rather than resorting to costly explicit meshing. The pressure Poisson equation is solved via a highly efficient, matrix-free multigrid preconditioner for Conjugate Gradient, adapted to the power diagram discretization. We use another sparsely populated uniform grid for high resolution interface tracking with a narrow band level set representation. Using the recently introduced SPGrid data structure, sparse uniform grids in both the power diagram discretization and our narrow band level set can be compactly stored and efficiently updated via streaming operations. Additionally, we present enhancements to adaptive level set advection, velocity extrapolation, and the fast marching method for redistancing. Our overall framework gracefully accommodates the task of dynamically adapting the octree topology during simulation. We demonstrate end-to-end simulations of complex adaptive flows in irregularly shaped domains, with tens of millions of degrees of freedom.National Science FoundationNational Sciences and Engineering Research Council of Canad

CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors:the phase 1 BNT211-01 trial

The oncofetal antigen Claudin 6 (CLDN6) is highly and specifically expressed in many solid tumors, and could be a promising treatment target. We report dose escalation results from the ongoing phase 1/2 BNT211-01 trial evaluating the safety and feasibility of chimeric antigen receptor (CAR) T cells targeting the CLDN6 with or without a CAR-T cell-amplifying RNA vaccine (CARVac) at two dose levels (DLs) in relapsed/refractory CLDN6-positive solid tumors. The primary endpoints were safety and tolerability, maximum tolerated dose and recommended phase 2 dose (RP2D). Secondary endpoints included objective response rate (ORR) and disease control rate. We observed manageable toxicity, with 10 out of 22 patients (46%) experiencing cytokine release syndrome including one grade 3 event and 1 out of 22 (5%) with grade 1 immune effector cell-associated neurotoxicity syndrome. Dose-limiting toxicities occurred in two patients at the higher DL, resolving without sequelae. CAR-T cell engraftment was robust, and the addition of CARVac was well tolerated. The unconfirmed ORR in 21 evaluable patients was 33% (7 of 21), including one complete response. The disease control rate was 67% (14 of 21), with stable disease in seven patients. Patients with germ cell tumors treated at the higher DL exhibited the highest response rate (ORR 57% (4 of 7)). The maximum tolerated dose and RP2D were not established as the trial has been amended to utilize an automated manufacturing process. A repeat of the dose escalation is ongoing and will identify a RP2D for pivotal trials. ClinicalTrials.gov Identifier: NCT04503278 .</p