2,830 research outputs found

    Factorization for generic jet production

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    Factorization is the central ingredient in any theoretical prediction for collider experiments. We introduce a factorization formalism that can be applied to any desired observable, like event shapes or jet observables, for any number of jets and a wide range of jet algorithms in leptonic or hadronic collisions. This is achieved by using soft-collinear effective theory to prove the formal factorization of a generic fully-differential cross section in terms of a hard coefficient, and generic jet and soft functions. In this formalism, whether a given observable factorizes in the usual sense, depends on whether it is inclusive enough, so the jet functions can be calculated perturbatively. The factorization formula for any such observable immediately follows from our general result, including the precise definition of the jet and soft functions appropriate for the observable in question. As examples of our formalism, we work out several results in two-jet production for both e+e- and pp collisions. For the latter, we also comment on how our formalism allows one to treat underlying events and beam remnants.Comment: 33 pages, v2: minor typos corrected, journal versio

    Reducing Marginalization of Fishermen through Participatory Action Research in the Zambezi Valley, Zimbabwe

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    Equitable sharing of fishing resources has been the major source of tension between Zambezi Valley communities and the Zimbabwe government authorities since the 1950s following the Kariba Dam-induced resettlement. Using participatory action research, it was found that the fishing license system and criminalization of fishermen were the major sources of tension between fishermen and government authorities. Engaging with government authorities to address these tensions, fishermen were recognized as partners in the fishing industry. The conclusion was that enhancing community agencies through participatory action research would be fundamental towards creating socially just and equitable arrangements that could emancipate marginalized communities from abject poverty

    The Joint Program Dilemma: Analyzing the Pervasive Role That Social Dilemmas Play in Undermining Acquisition Success

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    Tenth Annual Acquisition Research Symposium Acquisition ManagementExcerpt from the Proceedings of the Tenth Annual Acquisition Research Symposium Acquisition ManagementNaval Postgraduate School Acquisition Research ProgramPrepared for the Naval Postgraduate School, Monterey, CANaval Postgraduate School Acquisition Research ProgramApproved for public release; distribution is unlimited

    Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation

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    Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce the tendency of rats to work for food, and alter effort-related decision making, but leave aspects of food motivation such as appetite intact. Recent evidence indicates that the purine neuromodulator adenosine, largely through actions on adenosine A2A receptors, also participates in regulating effort-related processes. Adenosine A2A antagonists can reverse the effects of dopamine D2 antagonists on effort-related choice, and intra- accumbens injections of adenosine A2A agonists produce effects that are similar to those induced by accumbens dopamine depletion or antagonism. These studies have implications for the understanding and treatment of energy-related disorders such as anergia and fatigue in psychiatry and neurology

    Lifelongα-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage

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    The effects of dietary antioxidant supplementation on oxidative stress and life span are confused. We maintained C57BL/6 mice at 7 ± 2°C and supplemented their diet with α-tocopherol from 4 months of age. Supplementation significantly increased (p = 0.042) median life span by 15% (785 days, n = 44) relative to unsupplemented controls (682 days, n = 43) and also increased maximum life span (oldest 10%, p = 0.028). No sex or sex by treatment interaction effects were observed on life span, with treatment having no effect on resting or daily metabolic rate. Lymphocyte and hepatocyte oxidative DNA damage and hepatic lipid peroxidation were unaffected by supplementation, but hepatic oxidative DNA damage increased with age. Using a cDNA macroarray, genes associated with xenobiotic metabolism were significantly upregulated in the livers of female mice at 6 months of age (2 months supplementation). At 22 months of age (18 months supplementation) this response had largely abated, but various genes linked to the p21 signaling pathway were upregulated at this time. We suggest that α-tocopherol may initially be metabolized as a xenobiotic, potentially explaining why previous studies observe a life span extension generally when lifelong supplementation is initiated early in life. The absence of any significant effect on oxidative damage suggests that the life span extension observed was not mediated via any antioxidant properties of α-tocopherol. We propose that the life span extension observed following α-tocopherol supplementation may be mediated via upregulation of cytochrome p450 genes after 2 months of supplementation and/or upregulation of p21 signaling genes after 18 months of supplementation. However, these signaling pathways now require further investigation to establish their exact role in life span extension following α-tocopherol supplementation

    Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007.

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    We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.9 cases/100,000 population per year (95% confidence interval [CI] 7.6-12.6). Rates were highest in those >65 years of age and in those <5 years, particularly in infants, for whom the incidence was 44.9/100,000 (95% CI 18.1-92.5). The case-fatality rate was 32% and was associated with increasing age and underlying coexisting disease, including diabetes and renal disease. Fifty-five of the GAS isolates underwent emm sequence typing; the types were highly diverse, with 38 different emm subtypes and no particular dominant type. Our data support the view that invasive GAS disease is common in developing countries and deserves increased public health attention

    Change management: The case of the elite sport performance team

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    The effective and efficient implementation of change is often required for both successful performance and management survival across a host of contemporary domains. However, although of major theoretical and practical significance, research to date has overlooked the application of change management (hereafter CM) knowledge to the elite sport performance team environment. Considering that the success of ‘off-field’ sports businesses are largely dependent on the performances of their ‘on-field’ team, this article explores the application of current CM theorizing to this specific setting and the challenges facing its utility. Accordingly, we identify the need and importance of developing theory specific to this area, with practical application in both sport and business, through examination of current knowledge and identification of the domain's unique, dynamic and contested properties. Markers of successful change are then suggested to guide initial enquiry before the article concludes with proposed lines of research which may act to provide a valid and comprehensive theoretical account of CM to optimize the research and practice of those working in the field

    Usefulness of disease surveillance data in enhanced early warning of the cholera outbreak in Southwest Cameroon, 2018.

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    Introduction: This study assesses the timeliness and completeness of disease surveillance data for early warning of the cholera outbreak during the socio-political crisis of Southwest Cameroon in 2018. It determines how routine integrated disease surveillance and response (IDSR) data was used for preventative actions and the challenges faced by key health staff in IDSR based decision-making. Methods: This was a mixed-methods study conducted from June 1st to September 2021. District Health Information System 2 (DHIS2) data from January 2018 to December 2020 for the Southwest region of Cameroon were analysed using simple linear regression on EPI Info 7.2 to determine a potential association of the sociopolitical crisis with timeliness andcompleteness of data. Qualitative data generated through in-depth interviews of key informants were coded and analyzed using NVivo 12. Results: Routine IDSR data was not a reliable way of providing early warning of the 2018 cholera outbreak due to incomplete and late reports. During high conflict intensity (2018 and 2019), average data timeliness and completeness were 16.3 percent and 67.2 percent, respectively, increasing to 40.7 percent and 80.2 percent, respectively, in 2020 when the conflict intensity had reduced. There was a statistically significant weak correlation between reduced conflict intensity and increased data timeliness (R2 =0.17, p=0.016) and there was also a weak correlation between reduced conflict intensity and data completeness but this was not statistically significant (R2=0.01, p=0.642). Possible reasons for the improvements in early warning included proximity to reporting sites and the presence of the performance based finance scheme. Areas to be maintained included the electronic report aspect of the DHIS2 and the supportive supervision conducted during the outbreak. Staff demotivation, the parallel multiplicity of data entry tools, poor communication, shortage of staff and the non-usability of data generated by the DHIS2 were systemic limitations to the early alert dimension of the IDSR system. Non–systemic limitations included high insecurity, far to reach outbreak sites and health personnel being targeted during the conflict. Conclusion: Reduced conflict intensity correlated with increased timeliness and completeness of data reporting. The IDSR was substantially challenged during the crisis, and erroneous data generated by the DHIS 2 significantly undermined the efforts and resources invested to control the outbreak. The Ministry of Public Health should reinforce efforts to build a reporting system that produces people-centered actionable data that engages health risk management during socio-political crises

    Kinematic constraints on the Rodinia to Gondwana transition

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    Earth's plate tectonic history during the breakup of the supercontinent Pangea is well constrained from the seafloor spreading record, but evolving plate configurations during older supercontinent cycles are much less well understood. A relative paucity of available palaeomagnetic and geological data for deep time reconstructions necessitates innovative approaches to help discriminate between competing plate configurations. More difficult is tracing the journeys of individual continents during the amalgamation and breakup of supercontinents. Typically, deep-time reconstructions are built using absolute motions defined by palaeomagnetic data, and do not consider the kinematics of relative motions between plates, even for occasions where they are thought to be ‘plate-pairs’, either rifting apart leading to the formation of conjugate passive margins separated by a new ocean basin, or brought together by collision and orogenesis. Here, we use open-source software tools (GPlates/pyGPlates) to assess quantitative plate kinematics inherent within alternative reconstructions, such as rates of relative plate motion. We analyse the Rodinia-Gondwana transition during the Neoproterozoic, investigating the proposed Australia-Laurentia configurations during Rodinia, and the motion of India colliding with Gondwana. We find that earlier rifting times provide more optimal kinematic results. The AUSWUS and AUSMEX configurations with rifting at 800 Ma are the most kinematically supported configurations for Australia and Laurentia (average rates of 57 and 64 mm/a respectively), and angular rotation of ∼1.4°/Ma, compared to a SWEAT configuration (average spreading rate ∼76 mm/a) and Missing-Link configuration (∼90 mm/a). Later rifting, at, or after, 725 Ma necessitates unreasonably high spreading rates of >130 mm/a for AUSWUS and AUSMEX and ∼150 mm/a for SWEAT and Missing-Link. Using motion paths and convergence rates, we create a kinematically reasonable (convergence below 70 mm/a) tectonic model that is built upon a front-on collision of India with Gondwana, while also incorporating sinistral strike-slip motion against Australia and East Antarctica. We use this simple tectonic model to refine a global model for the breakup of western Rodinia and the transition to eastern Gondwana. © 2017 Elsevier B.V.This manuscript is a contribution to IGCP projects 628 (Gondwana Map) and 648 (Supercontinent Cycles and Global Geodynamics). This research was supported by the Science Industry Endowment Fund (RP 04-174) Big Data Knowledge Discovery Project, Australian Research Council grant DP130101946 (RDM) and the AuScope NCRIS project. ASM is supported by a CSIRO-Data61 Postgraduate Scholarship. ASC's contribution forms TRaX Record #379 and was funded by an Australian Research Council Future Fellowship FT120100340
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