Impact of Asylum on Receiving Countries

Whereas asylum seekers and the systems for adjudicating their claims to refugee status in developed countries have garnished considerable attention and, often, have been at the centre of political controversy, there has been relatively little research on their actual impact on receiving countries. This article discusses the factors that determine the impact of asylum, as distinct from other forms of migration, concluding that the number of asylum seekers, government policies and socioeconomic characteristics all determine the impact of asylum. Hence, the impacts of asylum can differ significantly from country to country. Even within the same country, one could expect to see varied impacts depending on the age, education and skill level of individual asylum seekers. The paper then examines the fiscal, economic, and social impacts of asylum, as well as its impact on foreign policy and national security. It concludes with an examination of the impact of developed countries? asylum policies on the protection of refugees in developing countries. When refugee protection has been weakened in economically strong states and asylum restrictions are perceived as burden shifting, international protection in the developing world where most refugees try to survive has been undercut.asylum, fiscal impact, economic impact, national security

Indirect genetic effects clarify how traits can evolve even when fitness does not

Acknowledgmenets We thank Cortland Griswold, Loeske Kruuk, Alastair Wilson, Piter Bijma, Lucas Marie-Orleach, Joel McGlothlin, and an anonymous reviewer for comments and discussions that helped to improve this manuscript. The authors declare no conflicts of interest.Peer reviewedPublisher PD

Naturalism, normativity, and the 'open question' argument

The 'open question' argument, as it has come to be known, was popularized by G. E. Moore. However, it is universally recognized that his presentation of it is unconvincing, as it is based on dubious metaphysics, semantics and epistemology. Yet, philosophers have not confined the argument to the history books, and it continues to influence and shape modern meta-ethics. This thesis asks why this is the case, and whether such an influence is justified. It focuses on three main positions, analytic naturalism, non-analytic naturalism and supernaturalism. It concludes that the 'open question' argument challenges all three

Impact of asylum on receiving countries

Whereas asylum seekers and the systems for adjudicating their claims to refugee status in developed countries have garnished considerable attention and, often, have been at the centre of political controversy, there has been relatively little research on their actual impact on receiving countries. This article discusses the factors that determine the impact of asylum, as distinct from other forms of migration, concluding that the number of asylum seekers, government policies and socioeconomic characteristics all determine the impact of asylum. Hence, the impacts of asylum can differ significantly from country to country. Even within the same country, one could expect to see varied impacts depending on the age, education and skill level of individual asylum seekers. The paper then examines the fiscal, economic, and social impacts of asylum, as well as its impact on foreign policy and national security. It concludes with an examination of the impact of developed countries’ asylum policies on the protection of refugees in developing countries. When refugee protection has been weakened in economically strong states and asylum restrictions are perceived as burden shifting, international protection in the developing world where most refugees try to survive has been undercut

Natural Families of Triangles I: Parametrizing Triangle Space

We group triangles into families based on three parameters: the distance between the circumcenter O and the centroid G, the circumradius, and the measure of angle Ð GOAwhere A is one vertex. Using these parameters, we present triangle space, a subset of R3 in which every triangle is represented by exactly one point

Natural Families of Triangles II: A Locus of Symmedian Points

We group triangles into families based on three parameters: the distance between the circumcenter O and the centroid G, the circumradius, and the measure of angle Ð GOAwhere A is one vertex. We focus on the family of triangles which allows Ð GOA to vary and fixes the other two parameters. By construction, this grouping produces triangles which share the same Euler line. Perhaps unexpectedly, if we examine the family\u27s locus of a triangle center known as the symmedian point, we find that it always forms an arc of a circle centered at a specified point on the Euler line

Exact location of dopants below the Si(001):H surface from scanning tunnelling microscopy and density functional theory

Control of dopants in silicon remains the most important approach to tailoring the properties of electronic materials for integrated circuits, with Group V impurities the most important n-type dopants. At the same time, silicon is finding new applications in coherent quantum devices, thanks to the magnetically quiet environment it provides for the impurity orbitals. The ionization energies and the shape of the dopant orbitals depend on the surfaces and interfaces with which they interact. The location of the dopant and local environment effects will therefore determine the functionality of both future quantum information processors and next-generation semiconductor devices. Here we match observed dopant wavefunctions from low-temperature scanning tunnelling microscopy (STM) to images simulated from first-principles density functional theory (DFT) calculations. By this combination of experiment and theory we precisely determine the substitutional sites of neutral As dopants between 5 and 15A below the Si(001):H surface. In the process we gain a full understanding of the interaction of the donor-electron state with the surface, and hence of the transition between the bulk dopant (with its delocalised hydrogenic orbital) and the previously studied dopants in the surface layer.Comment: 12 pages; accepted for publication in Phys. Rev.

The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available for its treatment. Recent data suggest that drug resistance could soon be a problem. There is therefore the need to identify new drug targets and develop drugs for the treatment of schistosomiasis. Analysis of the Schistosoma mansoni genome sequence for proteins involved in detoxification processes found that it encodes a single cytochrome P450 (CYP450) gene. Here we report that the 1452 bp open reading frame has a characteristic heme-binding region in its catalytic domain with a conserved heme ligating cysteine, a hydrophobic leader sequence present as the membrane interacting region, and overall structural conservation. The highest sequence identity to human CYP450s is 22%. Double stranded RNA (dsRNA) silencing of S. mansoni (Sm)CYP450 in schistosomula results in worm death. Treating larval or adult worms with antifungal azole CYP450 inhibitors results in worm death at low micromolar concentrations. In addition, combinations of SmCYP450-specific dsRNA and miconazole show additive schistosomicidal effects supporting the hypothesis that SmCYP450 is the target of miconazole. Treatment of developing S. mansoni eggs with miconazole results in a dose dependent arrest in embryonic development. Our results indicate that SmCYP450 is essential for worm survival and egg development and validates it as a novel drug target. Preliminary structure-activity relationship suggests that the 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol moiety of miconazole is necessary for activity and that miconazole activity and selectivity could be improved by rational drug design

Immunocytologic Methods in the Diagnosis of Orbital Tumors

The pathologic diagnosis was supported or confirmed in three out of four cases that had an adequate cytologic specimen. The results demonstrate that adjunctive immunocytologic techniques can be used in combination with fine-needle aspiration for a variety of orbital tumors. The pathologic diagnosis was supported or confirmed in three out of four cases that had an adequate cytologic specimen. The results demonstrate that adjunctive immunocytologic techniques can be used in combination with fine-needle aspiration for a variety of orbital tumors