A quasi-annual record of time-transgressive esker formation: implications for ice sheet reconstruction and subglacial hydrology

We identify and map chains of esker beads (series of aligned mounds) up to 15 m high and on average ~ 65 m wide across central Nunavut, Canada from the high-resolution (2 m) ArcticDEM. Based on the close one-to-one association with regularly spaced, sharp crested ridges interpreted as De Geer moraines, we interpret the esker beads to be quasi-annual ice-marginal deposits formed time-transgressively at the mouth of subglacial conduits during deglaciation. Esker beads therefore preserve a high-resolution record of ice-margin retreat and subglacial hydrology. The well-organised beaded esker network implies that subglacial channelised drainage was relatively fixed in space and through time. Downstream esker bead spacing constrains the typical pace of deglaciation in central Nunavut between 7.2 and 6 ka 14C BP to 165–370 m yr−1, although with short periods of more rapid retreat (> 400 m yr−1). Under our time-transgressive interpretation, the lateral spacing of the observed eskers provides a true measure of subglacial conduit spacing for testing mathematical models of subglacial hydrology. Esker beads also record the volume of sediment deposited in each melt season, thus providing a minimum bound on annual sediment fluxes, which is in the range of 103–104 m3 yr−1 in each 6–10 km wide subglacial conduit catchment. We suggest the prevalence of esker beads across this predominantly marine terminating sector of the former Laurentide Ice Sheet is a result of sediment fluxes that were unable to backfill conduits at a rate faster than ice-margin retreat. Esker ridges, conversely, are hypothesised to form when sediment backfilling of the subglacial conduit outpaced retreat resulting in headward esker growth close to but behind the margin. The implication, in accordance with recent modelling results, is that eskers in general record a composite signature of ice-marginal drainage rather than a temporal snapshot of ice-sheet wide subglacial drainage

Conceptual model for the formation of bedforms along subglacial meltwater corridors (SMCs) by variable ice‐water‐bed interactions

Subglacial meltwater landforms found on palaeo-ice sheet beds allow the properties of meltwater drainage to be reconstructed, informing our understanding of modern-day subglacial hydrological processes. In northern Canada and Fennoscandia, subglacial meltwater landforms are largely organized into continental-scale networks of subglacial meltwater corridors (SMCs), interpreted as the relics of subglacial drainage systems undergoing variations in meltwater input, effective pressure and drainage efficiency. We review the current state of knowledge of bedforms (hummocks, ridges, murtoos, ribbed bedforms) and associated landforms (channels, eskers) described along SMCs and use selected high-resolution DEMs in Canada and Fennoscandia to complete the bedform catalogue and categorize their characteristics, patterning and spatial distributions. We synthesize the diversity of bedform and formation processes occurring along subglacial drainage routes in a conceptual model invoking spatiotemporal changes in hydraulic connectivity, basal meltwater pressure and ice-bed coupling, which influences the evolution of subglacial processes (bed deformation, erosion, deposition) along subglacial drainage systems. When the hydraulic capacity of the subglacial drainage system is overwhelmed glaciofluvial erosion and deposition will dominate in the SMC, resulting in tracts of hummocks and ridges arising from both fragmentation of underlying pre-existing bedforms and downstream deposition of sediments in basal cavities and crevasses. Re-coupling of ice with the bed, when meltwater supply decreases, facilitates deformation, transforming existing and producing new bedforms concomitant with the wider subglacial bedform imprint. We finally establish a range of future research perspectives to improve understanding of subglacial hydrology, geomorphic processes and bedform diversity along SMCs. These perspectives include the new acquisition of remote-sensing and field-based sedimentological and geomorphological data, a better connection between the interpreted subglacial drainage configurations down corridors and the mathematical treatments studying their stability, and the quantification of the scaling, distribution and evolution of the hydraulically connected drainage system beneath present-day ice masses to test our bedform-related conceptual model

Theory Driven Hints in the Cheap Necklace Problem: A Preliminary Investigation

Three experiments investigated the effects of two hints derived from the Criterion for Satisfactory Progress theory (CSP) and Representational Change Theory (RCT) on the cheap necklace problem (insight problem). In Experiment 1, fewer participants given the CSP hint used an incorrect (maximizing) first move than participants given the RCT hint or control participants given no hint on a single attempt at the problem. Experiment 2 found the number of trials to solution was fewer in the CSP condition than in the control over ten trials, and there were fewer incorrect first moves in the CSP. The results appear to support the CSP theory. However, in Experiment 3, the CSP and RCT hints were combined yielding a 75% solution rate over 34.88% in the control. Perhaps aspects from both theories are employed during the problem solving process

Analysis of a hybrid TATA box binding protein originating from mesophilic and thermophilic donor organisms

CITATION: Barnard, D. A. et al. 2015. The utility of Xpert MTB/RIF performed on bronchial washings obtained in patients with suspected pulmonary tuberculosis in a high prevalence setting. BMC Pulmonary Medicine, 15:103, doi:10.1186/s12890-015-0086-z.The original publication is available at http://bmcpulmmed.biomedcentral.comBackground: Xpert MTB/RIF has been shown to have a superior sensitivity to microscopy for acid fast bacilli (AFB) in sputum and has been recommended as a standard first line investigation for pulmonary tuberculosis (PTB). Bronchoscopy is a valuable tool in diagnosing PTB in sputum negative patients. There is limited data on the utility of Xpert MTB/RIF performed on bronchial lavage specimens. Our aim was to evaluate the diagnostic efficiency of Xpert MTB/RIF performed on bronchial washings in sputum scarce/negative patients with suspected PTB. Methods: All patients with a clinical and radiological suspicion of PTB who underwent bronchoscopy between January 2013 and April 2014 were included. The diagnostic efficiencies of Xpert MTB/RIF and microscopy for AFB were compared to culture for Mycobacterium tuberculosis. Results: Thirty nine of 112 patients were diagnosed with culture-positive PTB. Xpert MTB/RIF was positive in 36/39 with a sensitivity of 92.3 % (95 % CI 78–98 %) for PTB, which was superior to that of smear microscopy (41 %; 95 % CI 26.0–57.8 %, p = 0.005). The specificities of Xpert MTB/RIF and smear microscopy were 87.7 % (95 % CI 77.4–93.9 %) and 98.6 % (95 % CI 91.6 %–99.9 %) respectively. Xpert MTB/RIF had a positive predictive value of 80 % (95 % CI; 65–89.9 %) and negative predictive value of 95.5 % (95 % CI 86.6–98.8 %). 3/9 patients with Xpert MTB/RIF positive culture negative results were treated for PTB based on clinical and radiological findings. Conclusion: Xpert MTB/RIF has a higher sensitivity than smear microscopy and similar specificity for the immediate confirmation of PTB in specimens obtained by bronchial washing, and should be utilised in patients with a high suspicion of pulmonary tuberculosis.http://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-015-0086-z#DeclarationsPublisher's versio

On the quadrupole collectivity in the yrast band of ¹⁶⁸Yb

The lifetimes of eight lower spin levels of the yrast band in Yb-168, populated via the Sm-154(O-18,4n) and Sn-124(Ca-48,4n) reactions, were measured, six of them for the first time, by means of the recoil-distance Doppler-shift method. Two versions of the differential decay-curve method have been applied for the data analysis resulting in a very good agreement. The reduced transition probabilities indicate some reduction of the collectivity for states just above the 6(1)(+) level, i.e. well below the band-crossing. The reasons of this effect are discussed in terms of an interaction between the ground-state band and yet unknown part of the two-quasiparticle (nu(13/2)) spin-aligned S-band by invoking the shell-structure or alternatively/additionally, as changes in the internal structure/shape induced by the rotation. (C) 2016 Elsevier B.V. All rights reserved

Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol

<p>Abstract</p> <p>Background</p> <p>A major barrier to accessing free government-provided antiretroviral treatment (ART) in South Africa is the shortage of suitably skilled health professionals. Current South African guidelines recommend that only doctors should prescribe ART, even though most primary care is provided by nurses. We have developed an effective method of educational outreach to primary care nurses in South Africa. Evidence is needed as to whether primary care nurses, with suitable training and managerial support, can initiate and continue to prescribe and monitor ART in the majority of ART-eligible adults.</p> <p>Methods/design</p> <p>This is a protocol for a pragmatic cluster randomised trial to evaluate the effectiveness of a complex intervention based on and supporting nurse-led antiretroviral treatment (ART) for South African patients with HIV/AIDS, compared to current practice in which doctors are responsible for initiating ART and continuing prescribing. We will randomly allocate 31 primary care clinics in the Free State province to nurse-led or doctor-led ART. Two groups of patients aged 16 years and over will be included: a) 7400 registering with the programme with CD4 counts of ≤ 350 cells/mL (mainly to evaluate treatment initiation) and b) 4900 already receiving ART (to evaluate ongoing treatment and monitoring). The primary outcomes will be time to death (in the first group) and viral suppression (in the second group). Patients' survival, viral load and health status indicators will be measured at least 6-monthly for at least one year and up to 2 years, using an existing province-wide clinical database linked to the national death register.</p> <p>Trial registration</p> <p>Controlled Clinical Trials ISRCTN46836853</p

Act first, think later: the presence and absence of inferential planning in problem solving

Planning is fundamental to successful problem solving, yet individuals sometimes fail to plan even one step ahead when it lies within their competence to do so. In this article, we report two experiments in which we explored variants of a ball-weighing puzzle, a problem that has only two steps, yet nonetheless yields performance consistent with a failure to plan. The results fit a computational model in which a solver's attempts are determined by two heuristics: maximization of the apparent progress made toward the problem goal and minimization of the problem space in which attempts are sought. The effectiveness of these heuristics was determined by lookahead, defined operationally as the number of steps evaluated in a planned move. Where move outcomes cannot be visualized but must be inferred, planning is constrained to the point where some individuals apply zero lookahead, which with n-ball problems yields seemingly irrational unequal weighs. Applying general-purpose heuristics with or without lookahead accounts for a range of rational and irrational phenomena found with insight and noninsight problems