Architects need environmental feedback

The role of environmental feedback within architects' offices is examined as a fundamental ingredient of sustainability. Three case study buildings are examined using a feedback exercise encompassing the whole building process from early key design decisions to occupation. Results show that sometimes design decisions are taken for aesthetic reasons without certainty on their environmental impact. Improvements are possible especially in energy consumption, glare, the usability of controls, the communication of strategies and comfort conditions. The architects report the feedback lessons relevant for their work. A systematic approach to project feedback is proposed with emphasis in feeding forward to new projects and recording decision-making. To close the information loop, briefs need explicitly to mention performance targets for energy use, management expectations, control requirements and to promote feedback itself

Molecular Imaging in TB: From the Bench to the Clinic

Despite all efforts, tuberculosis (TB) still constitutes a serious global health threat with 9.4 million new cases and 1.7 million deaths worldwide in 2009 (World Health Organisation,2010). Furthermore, an estimated one third of the worlds’ population is infected with the bacterium responsible, Mycobacterium tuberculosis. The main handicaps in fighting TB include a vaccine which works poorly in the most affected populations, and an arduous treatment regimen, involving a combination of several drugs taken over many months. This is further complicated by the emergence of multi-drug resistant (MDR) and extensively drug-resistant (XDR) M. tuberculosis strains, which require even longer treatment times with less well-tolerated drugs. Eradication of TB will require the development of new drugs and vaccines, alongside improved methods for diagnosis and monitoring treatment efficacy. With the vast burden of disease falling in resource poor settings, the challenge will also be to develop methodologies that can be deployed with minimal investment in infrastructure, maintenance and staff expertise. Recent decades have seen the emergence of the new discipline of molecular imaging. In essence, molecular imaging enables the non-invasive visualisation, characterisation, and quantification of biological processes taking place within intact living subjects, be it a mouse or man (Filippi & Rocca, 2011; Horky & Treves, 2011; Pysz et al., 2010; Sandhu et al., 2010). Imaging has long been applied to managing TB; simple chest x-rays have allowed clinicians to visualise TB in people for over a century (Singh & Nath, 1994). However, the new molecular imaging techniques are revolutionising medical research, with the potential to translate into significant changes in clinical practice. In this chapter we describe the new generation of imaging modalities and how these are being applied to eradicating TB, from the laboratory bench and in to the clinic

A caricature of a singular curvature flow in the plane

We study a singular parabolic equation of the total variation type in one dimension. The problem is a simplification of the singular curvature flow. We show existence and uniqueness of weak solutions. We also prove existence of weak solutions to the semi-discretization of the problem as well as convergence of the approximating sequences. The semi-discretization shows that facets must form. For a class of initial data we are able to study in details the facet formation and interactions and their asymptotic behavior. We notice that our qualitative results may be interpreted with the help of a special composition of multivalued operators

Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system

Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice

Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal muscular atrophy. GARS is ubiquitously expressed and may have functions in addition to its canonical role in protein synthesis through catalyzing the addition of glycine to cognate tRNAs. Methodology/Principal findings: We have recently described a new mouse model with a point mutation in the Gars gene resulting in a cysteine to arginine change at residue 201. Heterozygous Gars^{C201R/+} mice have locomotor and sensory deficits. In an investigation of genetic mutations that lead to death of motor and sensory neurons, we have crossed the Gars^{C201R/+} mice to two other mutants: the TgSOD1^{G93A} model of human amyotrophic lateral sclerosis and the Legs at odd angles mouse (Dync1h1^{Loa}) which has a defect in the heavy chain of the dynein complex. We found the Dync1h1^{Loa/+}; Gars^{C201R/+} double heterozygous mice are more impaired than either parent, and this is may be an additive effect of both mutations. Surprisingly, the Gars^{C201R} mutation significantly delayed disease onset in the SOD1^{G93A}; Gars^{C201R/+} double heterozygous mutant mice and increased lifespan by 29% on the genetic background investigated. Conclusions/Significance: These findings raise intriguing possibilities for the study of pathogenetic mechanisms in all three mouse mutant strains

Dealing with inaccurate face detection for automatic gender recognition with partially occluded faces

Gender recognition problem has not been extensively studied in situations where the face cannot be accurately detected and it also can be partially occluded. In this contribution, a comparison of several characterisation methods of the face is presented and they are evaluated in four different experiments that simulate the previous scenario. Two of the characterization techniques are based on histograms, LBP and local contrast values, and the other one is a new kind of features, called Ranking Labels, that provide spatial information. Experiments have proved Ranking Labels description is the most reliable in inaccurate situation

Manejo del riego y la fertilización para la mitigación de gases de efecto invernadero y adaptación de un cultivo de maíz en clima mediterráneo

Los inhibidores de la nitrificación y ureasa han demostrado en numerosos ensayos su potencial para mitigar las emisiones de óxido nitroso (N2O) y aumentar los rendimientos bajo condiciones determinadas. Del mismo modo, otras prácticas basadas en un manejo eficiente del riego y la fertilización pueden ser incluso más efectivas a la hora de reducir las pérdidas de N del agrosistema, tal y como se confirmó en un reciente meta-análisis

Acoustic effects at prehistoric landscapes: an archaeoacoustics analysis of rock art sites from Western Mediterranean

Many pre-state societies around the world give special importance to places where distinctive acoustic effects are generated. These places often receive special treatment including the production of rock paintings in them. In the Western Mediterranean, it seems that outstanding acoustic effects such as directional echoes, augmented audibility and long reverberation time are present in some rock art areas with Neolithic depictions made between the 7th and 4th millennia BC. These have been painted in different styles that have been given the name of Macroschematic, Levantine and Schematic rock art styles. On the basis of the results of our acoustic tests, we argue that there is a strong probability of acoustics having been used as a method by Neolithic artists to select the shelters in which to produce rock art. This paper presents the results of the ongoing ARTSOUNDSCAPES ERC Project on archaeoacoustics. This project seeks to explore the role of sound in the creation and use of rock art sites. he authors discuss the results of previous fieldwork in three countries (Spain, France and Italy) and the development of an innovative set of research methods that include 3D Ambisonic recordings, GIS soundshed analysis, and Transmission Loss measurements

Greenhouse gas emissions and crop yields under different organic fertilizers and irrigation treatments in a Mediterranean maize field

In this experiment, we aimed to assess the effect of different organic amendments (pig urine (PU); pig urine with the nitrification inhibitor 3,4 dimethylpyrazolephosphate (DMPP, PUI); compost from the solid phase of pig slurry (PC)) compared to urea (U); and two different irrigation systems (sprinkler and drip) on greenhouse gas (GHG) emissions, crop yield and Nitrogen Use Efficiency (NUE) in a maize (Zea mays L.) crop