Влияние новых синтетических аналогов пептидного препарата Семакс на АМРА-рецепторы в нейронах Пуркинье мозжечка крыс

New peptides analogues of Semax can potentiate AMPA receptors induced currents at lower concentrations (10–11–10–8 M) than those of Semax. This ability suggests that they may have cognitive-stimulating properties.Новые пептиды, аналоги препарата Семакс, способны потенцировать токи АМРА-рецепторов в более низких концентрациях (10–11–10–8 M), чем Семакс. Эта способность предполагает наличие у аналогов препарата когнитивно-стимулирующих свойств

The complex variability of blazars: time-scales and periodicity analysis in S4 0954+65

Among active galactic nuclei, blazars show extreme variability properties. We here investigate the case of the BL Lac object S4 0954+65 with data acquired in 2019–2020 by the Transiting Exoplanet Survey Satellite (TESS) and by the Whole Earth Blazar Telescope (WEBT) Collaboration. The 2-min cadence optical light curves provided by TESS during three observing sectors of nearly 1 month each allow us to study the fast variability in great detail. We identify several characteristic short-term time-scales, ranging from a few hours to a few days. However, these are not persistent, as they differ in the various TESS sectors. The long-term photometric and polarimetric optical and radio monitoring undertaken by the WEBT brings significant additional information, revealing that (i) in the optical, long-term flux changes are almost achromatic, while the short-term ones are strongly chromatic; (ii) the radio flux variations at 37 GHz follow those in the optical with a delay of about 3 weeks; (iii) the range of variation of the polarization degree and angle is much larger in the optical than in the radio band, but the mean polarization angles are similar; (iv) the optical long-term variability is characterized by a quasi-periodicity of about 1 month. We explain the source behaviour in terms of a rotating inhomogeneous helical jet, whose pitch angle can change in time.Accepted manuscrip

Multiwavelength behaviour of the blazar 3C 279: decade-long study from γ-ray to radio

We report the results of decade-long (2008–2018) γ-ray to 1 GHz radio monitoring of the blazar 3C 279, including GASP/WEBT, Fermi and Swift data, as well as polarimetric and spectroscopic data. The X-ray and γ-ray light curves correlate well, with no delay ≳ 3 h, implying general cospatiality of the emission regions. The γ-ray–optical flux–flux relation changes with activity state, ranging from a linear to a more complex dependence. The behaviour of the Stokes parameters at optical and radio wavelengths, including 43 GHz Very Long Baseline Array images, supports either a predominantly helical magnetic field or motion of the radiating plasma along a spiral path. Apparent speeds of emission knots range from 10 to 37c, with the highest values requiring bulk Lorentz factors close to those needed to explain γ-ray variability on very short time-scales. The Mg ii emission line flux in the ‘blue’ and ‘red’ wings correlates with the optical synchrotron continuum flux density, possibly providing a variable source of seed photons for inverse Compton scattering. In the radio bands, we find progressive delays of the most prominent light-curve maxima with decreasing frequency, as expected from the frequency dependence of the τ = 1 surface of synchrotron self-absorption. The global maximum in the 86 GHz light curve becomes less prominent at lower frequencies, while a local maximum, appearing in 2014, strengthens toward decreasing frequencies, becoming pronounced at ∼5 GHz. These tendencies suggest different Doppler boosting of stratified radio-emitting zones in the jet.First author draf

Features of the Internal Position of an Adult in Modern Students of Early Adolescence

The article presents the results of an empirical study dealing with the features of the adult internal position as a motivational basis for self-determination in modern high school and college students. The study aims to analyze the adult internal position in adolescent students, which is seen as a confluence of the social need for autonomy and the cognitive need for professional education. The hypothesis was tested that the peculiarity of the studied psychological phenomenon is due to the fact that the external conditions of development (environmental factors and institutional requirements for growing up) outpace the formation of internal conditions that ensure the modern young people&rsquo;s individual psychological readiness for self-determination. We tested the assumption that the institutional requirements for adulthood outpaced the modern young people&rsquo;s individual psychological readiness for self-determination. Standardized scale methods were used to diagnose the level of professional identity (A. Azbel), the level of ambition and self-esteem (the Dembo-Rubinshtein scale modified by A. Prikhozhan), the level of subjective control (modified by A. Gretsov), as well as to study the emotional attitude towards learning (modified by A. Andreeva-A. Prikhozhan). The sample of the study is 191 people, high school and colleges students from Moscow and Orsk. Correlative, cluster and factor analysis of the data obtained confirmed the assumptions made about the structure of the adult internal position in the early youth and the features of its formation in post-industrial societies. It is shown that the formation of the professional identity of modern high school and college students is more consistent with the objective requirements of the social situation, rather than the level of personal maturity necessary for making informed decisions.</p

THE IMPACT OF THE NASAL SPRAY FLUTIKAZON ON THE LOCAL IMMUNITY INDICES IN ALLERGIC RHINITIS PATIENTS

Medical library. medications – common over the counter medications the impact of a topical glucocorticoid flutikazon on the dynamics of the local immunity indices and microbiocenosis condition of the nasal mucosa was studied in the patients with the confirmed diagnosis of all the year round allergic rhinitis. In a year all patients demonstrated a sustained control of all the year round allergic rhinitis symptoms. A statistically significant increase of lysozyme, secretory and interferon γ concentration in the nasal and mouth mucous secretion as well as the decrease of tumor necrosis factor (TNF) α concentration and the frequency of yeast like fungi and gram negative bacteria growth were revealed. Thus, long term flutikazon therapy has brought about a sustained remission of all the year round allergic rhinitis clinical manifestations as well as a significant improvement of microbiocenosis indices of the upper respiratory mucous membranes and local immunity indices.Key words: allergic rhinitis, local immunity, mucous membranes microbiocenosis, topical glucocorticoids

THE IMPACT OF THE NASAL SPRAY FLUTIKAZON ON THE LOCAL IMMUNITY INDICES IN ALLERGIC RHINITIS PATIENTS

Medical library. medications – common over the counter medications the impact of a topical glucocorticoid flutikazon on the dynamics of the local immunity indices and microbiocenosis condition of the nasal mucosa was studied in the patients with the confirmed diagnosis of all the year round allergic rhinitis. In a year all patients demonstrated a sustained control of all the year round allergic rhinitis symptoms. A statistically significant increase of lysozyme, secretory and interferon γ concentration in the nasal and mouth mucous secretion as well as the decrease of tumor necrosis factor (TNF) α concentration and the frequency of yeast like fungi and gram negative bacteria growth were revealed. Thus, long term flutikazon therapy has brought about a sustained remission of all the year round allergic rhinitis clinical manifestations as well as a significant improvement of microbiocenosis indices of the upper respiratory mucous membranes and local immunity indices.Key words: allergic rhinitis, local immunity, mucous membranes microbiocenosis, topical glucocorticoids

Glyprolines exert protective and repair-promoting effects in the rat stomach: Potential role of the cytokine GRO/CINC-1

Glyprolines have been reported to exert protective effects in the stomach. In this study, we examined the potential effects of intranasal administration of Pro-Gly-Pro (PGP) and N-acetyl-Pro-Gly-Pro (AcPGP) on experimental gastric ulcer formation and healing. We also studied gastric release of the cytokine GRO/CINC-1, and its potential role in ulcer development and healing. Gastric ulcers were induced in rats by applying acetic acid to the serosa of the stomach. PGP and AcPGP were then administered at a dose of 3.7 µmol/kg once daily on either days 1 – 3 (ulcer formation) or days 4 – 6 (ulcer healing). Measurement of ulcer area and histological examination of gastric tissue were carried out on days 4 and 7 after application of acetic acid. In vitro studies involved addition of the glyprolines to cultured rat gastric epithelial cells with or without lipopolysaccharide. Reverse transcription PCR, real-time PCR and ELISAwere used for cytokine analysis. PGP and AcPGP significantly reduced ulcer areas on the 4th day and accelerated the healing on the 7th day compared with the control. After acetic acid-induced ulceration, the expression of GRO/CINC-1 mRNA in gastric tissue was increased 9-fold versus the sham-operated group. Treatment with PGP or AcPGP both significantly suppressed the expression of GRO/CINC-1 mRNA in gastric tissue. However, the glyprolines did not alter LPS-induced mRNA expression or release of GRO/CINC-1 from cultured rat gastric epithelial cells, even though those cells were harvested from rats subjected to the ulcer-induction procedure. The results of this study show that intranasal administration of PGP and AcPGP significantly increased resistance against acetic acid-induced ulceration and accelerated healing in the rats. These effects may be due, at least in part, to their ability to reduce the acetic acid-induced GRO/CINC-1 expression and production in gastric tissue. © 2016, Polish Physiological Society. All rights reserved