The changing relation between alcohol and life expectancy in Russia in 1965-2017.

INTRODUCTION AND AIMS: In the 1990s, a strong inverse relationship between life expectancy (LE) in Russia and mortality from alcohol poisoning was observed. This association is remarkable as this cause accounts for less than 2% of deaths each year. It can be explained by treating the alcohol poisoning mortality as the best available measure in Russia of the population prevalence of harmful drinking in any year which in turn associated with mortality from a wide range of causes. This study analyses the evolving relationship of LE with this mortality-based measure of harmful drinking since 1965, and places it in a policy context. DESIGN AND METHODS: We examine three periods: 1965-1984, a period of gradual LE decline; 1984-2003, a period of massive LE fluctuations; and 2003-2017, a period of LE improvement. Pearson's correlation coefficients and a linear relationship between annual changes in LE and alcohol poisoning were estimated for each period. RESULTS: The strongest negative correlation between changes in LE and alcohol poisonings was found in 1984-2003. Over the period 2003-2017 a consistent positive LE trend emerged that was statistically independent of alcohol poisoning. DISCUSSION AND CONCLUSIONS: These results suggest that in the period from the mid-2000s a growth of LE in Russia was to a large extent independent of changes in the population prevalence of harmful drinking. While there has been a reduction in mortality at ages 15-64, at older ages mortality reduction unrelated to alcohol has become an increasingly important driver of overall mortality improvements

Long-term trends in the longevity of scientific elites: evidence from the British and the Russian academies of science.

National science academies represent intellectual elites and vanguard groups in the achievement of longevity. We estimated life expectancy (LE) at age 50 of members of the British Royal Society (RS) for the years 1670-2007 and of members of the Russian Academy of Sciences (RAS) for the years 1750-2006. The longevity of academicians was higher than that of their corresponding national populations, with the gap widening from the 1950s. Since the 1980s, LE in the RS has been higher than the maximum LE among all high-income countries. In each period, LE in the RS was greater than in the RAS, although since the 1950s it has risen in parallel in the two academies. This steep increase shared by academicians in Britain and Russia suggests that general populations have the potential for a substantial increase in survival to high ages

Patterns in the relationship between life expectancy and gross domestic product in Russia in 2005-15: a cross-sectional analysis.

BACKGROUND: Since 2005, Russia has made substantial progress, experiencing an almost doubling of per-capita gross domestic product by purchasing power parity (GDP [PPP]) to US$24 800 and witnessing a 6-year increase in life expectancy, reaching 71·4 years by 2015. Even greater gains in GDP (PPP) were seen for Moscow, the Russian capital, reaching$43 000 in 2015 and with a life expectancy of 75·5 years. We aimed to investigate whether mortality levels now seen in Russia are consistent with what would be expected given this new level of per-capita wealth. METHODS: We used per-capita GDP (PPP) and life expectancy from 61 countries in 2014-15, plus those of Russia as a whole and its capital Moscow, to construct a Preston curve expressing the relationship between mortality and national wealth and to examine the positions of Russia and other populations relative to this curve. We adjusted life expectancy values for Moscow for underestimation of mortality at older ages. For comparison, we constructed another Preston curve based on the same set of countries for the year 2005. We used the stepwise replacement algorithm to decompose mortality differences between Russia or Moscow and comparator countries with similar incomes into age and cause-of-death components. FINDINGS: Life expectancy in 2015 for both Russia and Moscow lay below the Preston-curve-based expectations by 6·5 years and 4·9 years, respectively. In 2015, Russia had a lower per-capita income than 36 of the comparator countries but lower life expectancy than 60 comparator countries. However, the gaps between the observed and the Preston-expected life expectancy values for Russia have diminished by about 25% since 2005, when the life expectancy gap was 8·9 years for Russia and 6·6 years for Moscow. When compared with countries with similar level of income, the largest part of the life expectancy deficit was produced by working-age mortality from external causes for Russia and cardiovascular disease at older ages for Moscow. INTERPRETATION: Given the economic wealth of Russia, its life expectancy could be substantially higher. Sustaining the progress seen over the past decade depends on the ability of the Russian Government and society to devote adequate resources to people's health. FUNDING: This work was partly funded through the International Project on Cardiovascular Disease in Russia supported by a Wellcome Trust Strategic Award (100217) and was supported by the Russian Academic Excellence Project 5-100

Evidence of large systematic differences between countries in assigning ischaemic heart disease deaths to myocardial infarction: the contrasting examples of Russia and Norway

Background There is considerable variation in mortality rates from myocardial infarction (MI) across high-income countries, some of which may be artefactual. Methods Time trends in mortality rates from ischaemic heart disease (IHD) and MI were analysed for a set of high-income countries from the end of the 1970s. Using individual-level mortality data from Russia (2005-2017) and Norway (2005-2016), we investigated factors associated with the proportion of total IHD deaths certified as due to MI. Results In most countries, MI mortality rates have dramatically declined from the 1970s. However, the share of MI in total IHD deaths varies substantially across countries. In Russia, only 12% of IHD deaths had MI assigned as the underlying cause vs 63% in Norway. IHD deaths occurring outside of hospital without autopsy were far less likely to be assigned as MI in Russia (2%) than in Norway (59%). Conclusions Although established international criteria for MI require specific clinical or post-mortem evidence, it appears that certifying specialists in different countries may interpret these criteria differently. At one extreme, Russian doctors may only assign MI as a cause of death when there is specific pathophysiological evidence. At the other extreme, their counterparts in Norway may be willing to specify MI as the cause even when this evidence is not available. Internationally established criteria for MI diagnosis are challenging to apply for out-of-hospital deaths. Differences between countries in how certifiers interpret these criteria may account for at least some of the international variation in MI mortality rates

pH (Low) Insertion Peptide (pHLIP) Targets Ischemic Myocardium

The pH (low) insertion peptide (pHLIP) family enables targeting of cells in tissues with low extracellular pH. Here, we show that ischemic myocardium is targeted, potentially opening a new route to diagnosis and therapy. The experiments were performed using two murine ischemia models: regional ischemia induced by coronary artery occlusion and global low-flow ischemia in isolated hearts. In both models, pH-sensitive pHLIPs [wild type (WT) and Var7] or WT-pHLIP–coated liposomes bind ischemic but not normal regions of myocardium, whereas pH-insensitive, kVar7, and liposomes coated with PEG showed no preference. pHLIP did not influence either the mechanical or the electrical activity of ischemic myocardium. In contrast to other known targeting strategies, the pHLIP-based binding does not require severe myocardial damage. Thus, pHLIP could be used for delivery of pharmaceutical agents or imaging probes to the myocardial regions undergoing brief restrictions of blood supply that do not induce irreversible changes in myocytes

A tomographic approach to quantum nonlocality

We propose a tomographic approach to study quantum nonlocality in continuous variable quantum systems. On one hand we derive a Bell-like inequality for measured tomograms. On the other hand, we introduce pseudospin operators whose statistics can be inferred from the data characterizing the reconstructed state, thus giving the possibility to use standard Bell's inequalities. Illuminating examples are also discussed.Comment: 12 pages, 6 figures, IOP style, to appear in the Special Issue of J Opt.B connected with Wigner Centennial conference (references added and updated

Average age at death in infancy and infant mortality level: reconsidering the Coale-Demeny formulas at current levels of low mortality.

The longterm historical decline in infant mortality has been accompanied by increasing concentration of infant deaths at the earliest stages of infancy. The influence of prenatal and neonatal conditions has become increasingly dominant relative to postnatal conditions as external causes of death such as infectious disease have been diminished. In the mid-1960s Coale and Demeny developed formulas describing the dependency of the average age of death in infancy on the level of infant mortality from data obtained up to that time.Almost at the same time as Coale and Demeny’s analysis, as shown in this paper, in the more developed countries a steady rise in average age of infant death began. This paper demonstrates this phenomenon with several different data sources, including the linked individual birth and infant death datasets available from the US National Center for Health Statistics and the Human Mortality Database. A possible explanation for the increase in average age of death in infancy is proposed, and modifications of the Coale-Demeny formulas for practical application to contemporary low levels of mortality are offered

Average age at death in infancy and infant mortality level: Reconsidering the Coale-Demeny formulas at current levels of low mortality

Background: The long-term historical decline in infant mortality has been accompanied by increasing concentration of infant deaths at the earliest stages of infancy. In the mid-1960s Coale and Demeny developed formulas describing the dependency of the average age of death in infancy on the level of infant mortality, based on data obtained up to that time. Objective: In the more developed countries a steady rise in average age of infant death began in the mid-1960s. This paper documents this phenomenon and offers alternative formulas for calculation of the average age of death, taking into account the new mortality trends. Methods: Standard statistical methodologies and a specially developed method are applied to the linked individual birth and infant death datasets available from the US National Center for Health Statistics and the initial (raw) numbers of deaths from the Human Mortality Database. Results: It is demonstrated that the trend of decline in the average age of infant death becomes interrupted when the infant mortality rate attains a level around 10 per 1000, and modifications of the Coale-Demeny formulas for practical application to contemporary low levels of mortality are offered. Conclusions: The average age of death in infancy is an important characteristic of infant mortality, although it does not influence the magnitude of life expectancy. That the increase in average age of death in infancy is connected with medical advances is proposed as a possible explanation

Average age at death in infancy and infant mortality level: reconsidering the Coale-Demeny formulas at current levels of low mortality.

The longterm historical decline in infant mortality has been accompanied by increasing concentration of infant deaths at the earliest stages of infancy. The influence of prenatal and neonatal conditions has become increasingly dominant relative to postnatal conditions as external causes of death such as infectious disease have been diminished. In the mid-1960s Coale and Demeny developed formulas describing the dependency of the average age of death in infancy on the level of infant mortality from data obtained up to that time.Almost at the same time as Coale and Demeny’s analysis, as shown in this paper, in the more developed countries a steady rise in average age of infant death began. This paper demonstrates this phenomenon with several different data sources, including the linked individual birth and infant death datasets available from the US National Center for Health Statistics and the Human Mortality Database. A possible explanation for the increase in average age of death in infancy is proposed, and modifications of the Coale-Demeny formulas for practical application to contemporary low levels of mortality are offered