9 research outputs found
Crystal and Molecular Structure of (S)-a-(pCyanobenzenesulphonamido)-B- propiothiolactone, C10H8N203S2
Crystals of the title compound are monoclinic, space group
P21, with a = 1.0018(2), b = 0.9722(2), c = 0.6262(1) nm, fJ = 102.32(1)° and Z = 2. The structure was solved by direct methods using 1113 reflections with I 2\u27: 20 (I) and refined to a conventional R index
of 0.051. The heterocyclic four-membered ring is bent and has a
puckering angle of 18.7(7)°. The dihedral angle between the best
planes of the B-propiothiolactone and benzene ring is 70.2(3)°.
Discrete molecules are connected along the b axis by intermolecular
hydrogen bonds N--H ... O of 309.5(9) pm
Crystal and Molecular Structure of (S)-a-(p-Bromobenzenesulphonamido)-B-propiothiolactone
(S)-a-(p-Bromobenzenesulphonamido)-{J-propiothiolactone,
C9H8N03S2Br, crystallizes in the orthorhombic system with a =
= 1.0125(2), b = 1.2439(1) and c = 0.9304(3) nm, Z = 4 in space group
P212121• The compound is isostructural with the analogous chloro
derivative. The crystal structure has been refined from diffractometer
data to conventional R and Ra values of 0.045 and 0.048 for
2277 reflections with I ~ 2a (I). The heterocyclic four-membered
ring has a puckering angle of 8.9(4) 0
• The dihedral angle between
the best planes of the /)-propiothiolactone and benzene rings is
84.1(2) 0
• The structure consists of discrete molecules connected
along the a axis by intermolecular hydrogen bonds N-H ... O of
291.9(7) pm
Selective step-growth phenol-aldehyde polymerization. 4. Regio-, enantio-, and diastereo-controlled entry to chiral nonracemic all-ortho novolacs
Crystal and Molecular Structure of (S)-a-(pCyanobenzenesulphonamido)-B- propiothiolactone, C10H8N203S2
Crystals of the title compound are monoclinic, space group
P21, with a = 1.0018(2), b = 0.9722(2), c = 0.6262(1) nm, fJ = 102.32(1)° and Z = 2. The structure was solved by direct methods using 1113 reflections with I 2\u27: 20 (I) and refined to a conventional R index
of 0.051. The heterocyclic four-membered ring is bent and has a
puckering angle of 18.7(7)°. The dihedral angle between the best
planes of the B-propiothiolactone and benzene ring is 70.2(3)°.
Discrete molecules are connected along the b axis by intermolecular
hydrogen bonds N--H ... O of 309.5(9) pm
Crystal and molecular structure of (S)-a-(p-bromobenzenesulphonamido)-B-propiothiolactone
(S)-a-(p-Bromobenzenesulphonamido)-{J-propiothiolactone,
C9H8N03S2Br, crystallizes in the orthorhombic system with a =
= 1.0125(2), b = 1.2439(1) and c = 0.9304(3) nm, Z = 4 in space group
P212121• The compound is isostructural with the analogous chloro
derivative. The crystal structure has been refined from diffractometer
data to conventional R and Ra values of 0.045 and 0.048 for
2277 reflections with I ~ 2a (I). The heterocyclic four-membered
ring has a puckering angle of 8.9(4) 0
• The dihedral angle between
the best planes of the /)-propiothiolactone and benzene rings is
84.1(2) 0
• The structure consists of discrete molecules connected
along the a axis by intermolecular hydrogen bonds N-H ... O of
291.9(7) pm
Crystal and molecular structure of (S)-a-(pCyanobenzenesulphonamido)-B- propiothiolactone, C10H8N203S2
Crystals of the title compound are monoclinic, space group
P21, with a = 1.0018(2), b = 0.9722(2), c = 0.6262(1) nm, fJ = 102.32(1)° and Z = 2. The structure was solved by direct methods using 1113 reflections with I 2': 20 (I) and refined to a conventional R index
of 0.051. The heterocyclic four-membered ring is bent and has a
puckering angle of 18.7(7)°. The dihedral angle between the best
planes of the B-propiothiolactone and benzene ring is 70.2(3)°.
Discrete molecules are connected along the b axis by intermolecular
hydrogen bonds N--H ... O of 309.5(9) pm
Molecular inclusion in functionalized macrocycles part 10*: Crystal and molecular structure of ap-tert-butylcalix[6]arene hexapodand
Crystal and molecular structure of a 1:1 complex of a chiral α-d-glucosido-benzo-18-crown-6 and potassium thiocyanate
What counts more: The patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry
Inherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons' ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.OBJECTIVES: Inherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons' ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.METHODS: The registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline condition, tumour features, surgical techniques, devices, postoperative care, complications, conversions and the reasons thereof were detailed. Univariable and multivariable regressions were used to assess factors potentially linked to complications.RESULTS: Four thousand one hundred and ninety-one VATS lobectomies in 4156 patients (2480 men, 1676 women) were analysed. The median age-adjusted Charlson index of the patients was 4 (interquartile range 3-6). Grade 1 and 2 and Grade 3-5 complications were observed in 20.1% and in 5.8%, respectively. Ninety-day mortality was 0.55%. The overall conversion rate was 9.2% and significantly higher in low-volume centres (<100 cases, P < 0.001), but there was no significant difference between intermediate- and high-volume centres under this aspect. Low-volume centres were significantly more likely to convert due to issues with difficult local anatomy, but not significantly so for bleeding. Conversion, lower case-volume, comorbidity burden, male gender, adhesions, blood loss, operative time, sealants and epidural analgesia were significantly associated with increased postoperative morbidity.CONCLUSIONS: VATS lobectomy is a safe procedure even in medically compromised patients. An improved classification system for conversions is proposed and prevention strategies are suggested to reduce conversion rates and possibly complications in less-experienced centres