From Lab-on-chip to Lab-in-App: Challenges towards silicon photonic biosensors product developments

This work presents and evaluates different approaches of integrated optical sensors based on photonic integrated circuit (PIC) technologies for refractive index sensing. Bottlenecks in the fabrication flow towards an applicable system are discussed that hinder a cost-effective mass-production for disposable sensor chips. As sensor device, a waveguide coupled micro-ring based approach is chosen which is manufactured in an 8” wafer level process. We will show that the co-integration with a reproducible, scalable and low-cost microfluidic interface is the main challenge which needs to be overcome for future application of silicon technology based PIC sensor chips

Direct observation and simultaneous use of linear and quadratic electro-optical effects

We report on the direct observation and simultaneous use of the linear and quadratic electro-optical effect and propose a method by which higher-order susceptibilities of electro-optical materials can be determined. The evaluation is based on the separation of the second- and third-order susceptibilities and the experimental technique uses a slot waveguide ring resonator fabricated in integrated photonic circuit technology, which is embedded by a guest-host polymer system consisting of the azobenzene dye Disperse Red 1 in a poly(methyl methacrylate) matrix as an active electro-optical material. The contribution of both effects on the electro-optical response under the influence of static and time-varying electrical fields is investigated. We show that the quadratic electro-optical effect has a significant influence on the overall electro-optical response even with acentric molecular orientated molecules. Our findings have important implications for developing electro-optical devices based on polymer-filled slot waveguides and give rise to advanced photonic circuits. © 2020 IOP Publishing Ltd

Oxidative stress and epigenetic regulation in ageing and age-related diseases

Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments for age-associated diseases, such as cancer, diabetes, Alzheimer and cardiovascular accidents. Mechanistically, it is well accepted that the accumulation of intracellular damage determined by reactive oxygen species (ROS) might orchestrate the progressive loss of control over biological homeostasis and the functional impairment typical of aged tissues. Here, we review how epigenetics takes part in the control of stress stimuli and the mechanisms of ageing physiology and physiopathology. Alteration of epigenetic enzyme activity, histone modifications and DNA-methylation is, in fact, typically associated with the ageing process. Specifically, ageing presents peculiar epigenetic markers that, taken altogether, form the still ill-defined “ageing epigenome”. The comprehension of mechanisms and pathways leading to epigenetic modifications associated with ageing may help the development of anti-ageing therapies

Ultrafilters on words for a fragment of logic

International audienceWe give a method for specifying ultrafilter equations and identify their projections on the set of profinite words. Let B be the set of languages captured by first-order sentences using unary predicates for each letter, arbitrary uniform unary numerical predicates and a predicate for the length of a word. We illustrate our methods by giving ultrafilter equations characterising B and then projecting these to obtain profinite equations characterising B ∩ Reg. This suffices to establish the decidability of the membership problem for B ∩ Reg.Nous donnons une méthode pour spécifier des équations en ultrafiltres et identifier leurs projections sur l'ensemble des mots profinis. Soit B l'ensemble des langages décrits par des énoncés du premier ordre utilisant des prédicats unaires pour chaque lettre, des prédicats numériques uniformes unaires arbitraires et un prédicat pour la longueur d'un mot. Nous illustrons notre méthode en donnant des équations profinies caractérisant B à l'aide d'équations en ultrafiltres puis en projetant ces équations pour obtenir des équations profinies caractérisant B ∩ Reg. Cela suffit à établir la décidabilité de l'appartenance à B ∩ Re