Sensitivity of glacier volume change estimation to DEM void interpolation

Glacier mass balance has been estimated on individual glacier and regional scales using repeat digital elevation models (DEMs). DEMs often have gaps in coverage (“voids”), the properties of which depend on the nature of the sensor used and the surface being measured. The way that these voids are accounted for has a direct impact on the estimate of geodetic glacier mass balance, though a systematic comparison of different proposed methods has been heretofore lacking. In this study, we determine the impact and sensitivity of void interpolation methods on estimates of volume change. Using two spatially complete, high-resolution DEMs over southeast Alaska, USA, we artificially generate voids in one of the DEMs using correlation values derived from photogrammetric processing of Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) scenes. We then compare 11 different void interpolation methods on a glacier-by-glacier and regional basis. We find that a few methods introduce biases of up to 20&thinsp;% in the regional results, while other methods give results very close (&lt;1&thinsp;% difference) to the true, non-voided volume change estimates. By comparing results from a few of the best-performing methods, an estimate of the uncertainty introduced by interpolating voids can be obtained. Finally, by increasing the number of voids, we show that with these best-performing methods, reliable estimates of glacier-wide volume change can be obtained, even with sparse DEM coverage.</p

MMASTER: improved ASTER DEMs for elevation change monitoring

The Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) system on board the Terra (EOS AM-1) satellite has been a source of stereoscopic images covering the whole globe at 15-m resolution with consistent quality for over 16 years. The potential of these data in terms of geomorphological analysis and change detection in three dimensions is unrivaled and should be exploited more. Due to uncorrected errors in the image geometry due to sensor motion (“jitter”), however, the quality of the DEMs and orthoimages currently available is often insufficient for a number of applications, including surface change detection. We have therefore developed a series of algorithms packaged under the name MicMac ASTER (MMASTER). It is composed of a tool to compute Rational Polynomial Coefficient (RPC) models from the ASTER metadata, a method that improves the quality of the matching by identifying and correcting jitter-induced cross-track parallax errors and a correction for along-track jitter when computing differences between DEMs (either with another MMASTER DEM or with another data source). Our method outputs more precise DEMs with less unmatched areas and reduced overall noise compared to NASA’s standard AST14DMO product. The algorithms were implemented in the open source photogrammetric library and software suite MicMac. Here, we briefly examine the potential of MMASTER-produced DEMs to investigate a variety of geomorphological changes, including river erosion, seismic deformation, changes in biomass, volcanic deformation and glacier mass balance

Present Molecular Limitations of ON-Bipolar Cell Targeted Gene Therapy

Recent studies have demonstrated the safety and efficacy of ocular gene therapy based on adeno-associated viral vectors (AAVs). Accordingly, a surge in promising new gene therapies is entering clinical trials, including the first optogenetic therapy for vision restoration. To date, optogenetic therapies for vision restoration target either the retinal ganglion cells (GCs) or presynaptic ON-bipolar cells (OBCs). Initiating light responses at the level of the OBCs has significant advantages over optogenetic activation of GCs. For example, important neural circuitries in the inner retina, which shape the receptive fields of GCs, remain intact when activating the OBCs. Current drawbacks of AAV-mediated gene therapies targeting OBCs include (1) a low transduction efficiency, (2) off-target expression in unwanted cell populations, and (3) a poor performance in human tissue compared to the murine retina. Here, we examined side-by-side the performance of three state-of-the art AAV capsid variants, AAV7m8, AAVBP2, and AAV7m8(Y444F) in combination with the 4xGRM6-SV40 promoter construct in the healthy and degenerated mouse retina and in human post-mortem retinal explants. We find that (1) the 4xGRM6-SV40 promoter is not OBC specific, (2) that all AAV variants possess broad cellular transduction patterns, with differences between the transduction patterns of capsid variants AAVBP2 and AAV7m8 and, most importantly, (3) that all vectors target OBCs in healthy tissue but not in the degenerated rd1 mouse model, potentially limiting the possibilities for an OBC-targeted optogenetic therapy for vision restoration in the blind

How temperature determines formation of maghemite nanoparticles

a b s t r a c t We report on the formation of polymer-stabilized superparamagnetic single-core and multi-core maghemite nanoparticles. The particle formation was carried out by coprecipitation of Fe(II) and Fe(III) sulfate in a continuous aqueous process using a micromixer system. Aggregates containing 50 primary particles with sizes of 2 nm were formed at a reaction temperature of 30°C. These particles aggregated further with time and were not stable. In contrast, stable single-core particles with a diameter of 7 nm were formed at 80°C as revealed by small-angle X-ray scattering (SAXS) coupled in-line with the micromixer for particle characterization. X-ray diffraction and TEM confirmed the SAXS results. X-ray absorption near-edge structure spectroscopy (XANES) identified the iron oxide phase as maghemite

Three different glacier surges at a spot: what satellites observe and what not

In the Karakoram, dozens of glacier surges occurred in the past 2 decades, making the region a global hotspot. Detailed analyses of dense time series from optical and radar satellite images revealed a wide range of surge behaviour in this region: from slow advances longer than a decade at low flow velocities to short, pulse-like advances over 1 or 2 years with high velocities. In this study, we present an analysis of three currently surging glaciers in the central Karakoram: North and South Chongtar Glaciers and an unnamed glacier referred to as NN9. All three glaciers flow towards the same small region but differ strongly in surge behaviour. A full suite of satellites (e.g. Landsat, Sentinel-1 and 2, Planet, TerraSAR-X, ICESat-2) and digital elevation models (DEMs) from different sources (e.g. Shuttle Radar Topography Mission, SRTM; Satellite Pour l’Observation de la Terre, SPOT; High Mountain Asia DEM, HMA DEM) are used to (a) obtain comprehensive information about the evolution of the surges from 2000 to 2021 and (b) to compare and evaluate capabilities and limitations of the different satellite sensors for monitoring surges of relatively small glaciers in steep terrain. A strongly contrasting evolution of advance rates and flow velocities is found, though the elevation change pattern is more similar. For example, South Chongtar Glacier had short-lived advance rates above 10 km yr−1, velocities up to 30 m d−1, and surface elevations increasing by 170 m. In contrast, the neighbouring and 3-times-smaller North Chongtar Glacier had a slow and near-linear increase in advance rates (up to 500 m yr−1), flow velocities below 1 m d−1 and elevation increases up to 100 m. The even smaller glacier NN9 changed from a slow advance to a full surge within a year, reaching advance rates higher than 1 km yr−1. It seems that, despite a similar climatic setting, different surge mechanisms are at play, and a transition from one mechanism to another can occur during a single surge. The sensor inter-comparison revealed a high agreement across sensors for deriving flow velocities, but limitations are found on small and narrow glaciers in steep terrain, in particular for Sentinel-1. All investigated DEMs have the required accuracy to clearly show the volume changes during the surges, and elevations from ICESat-2 ATL03 data fit neatly to the other DEMs. We conclude that the available satellite data allow for a comprehensive observation of glacier surges from space when combining different sensors to determine the temporal evolution of length, elevation and velocity changes

Accelerated global glacier mass loss in the early twenty-first century

Glaciers distinct from the Greenland and Antarctic ice sheets are shrinking rapidly, altering regional hydrology1, raising global sea level2 and elevating natural hazards3. Yet, owing to the scarcity of constrained mass loss observations, glacier evolution during the satellite era is known only partially, as a geographic and temporal patchwork4,5. Here we reveal the accelerated, albeit contrasting, patterns of glacier mass loss during the early twenty-first century. Using largely untapped satellite archives, we chart surface elevation changes at a high spatiotemporal resolution over all of Earth’s glaciers. We extensively validate our estimates against independent, high-precision measurements and present a globally complete and consistent estimate of glacier mass change. We show that during 2000–2019, glaciers lost a mass of 267 ± 16 gigatonnes per year, equivalent to 21 ± 3 per cent of the observed sea-level rise6. We identify a mass loss acceleration of 48 ± 16 gigatonnes per year per decade, explaining 6 to 19 per cent of the observed acceleration of sea-level rise. Particularly, thinning rates of glaciers outside ice sheet peripheries doubled over the past two decades. Glaciers currently lose more mass, and at similar or larger acceleration rates, than the Greenland or Antarctic ice sheets taken separately7,8,9. By uncovering the patterns of mass change in many regions, we find contrasting glacier fluctuations that agree with the decadal variability in precipitation and temperature. These include a North Atlantic anomaly of decelerated mass loss, a strongly accelerated loss from northwestern American glaciers, and the apparent end of the Karakoram anomaly of mass gain10. We anticipate our highly resolved estimates to advance the understanding of drivers that govern the distribution of glacier change, and to extend our capabilities of predicting these changes at all scales. Predictions robustly benchmarked against observations are critically needed to design adaptive policies for the local- and regional-scale management of water resources and cryospheric risks, as well as for the global-scale mitigation of sea-level rise.ISSN:0028-0836ISSN:1476-468

Dynamic vulnerability revealed in the collapse of an Arctic tidewater glacier

Abstract Glacier flow instabilities can rapidly increase sea level through enhanced ice discharge. Surge-type glacier accelerations often occur with a decadal to centennial cyclicity suggesting internal mechanisms responsible. Recently, many surging tidewater glaciers around the Arctic Barents Sea region question whether external forces such as climate can trigger dynamic instabilities. Here, we identify a mechanism in which climate change can instigate surges of Arctic tidewater glaciers. Using satellite and seismic remote sensing observations combined with three-dimensional thermo-mechanical modeling of the January 2009 collapse of the Nathorst Glacier System (NGS) in Svalbard, we show that an underlying condition for instability was basal freezing and associated friction increase under the glacier tongue. In contrast, continued basal sliding further upstream increased driving stresses until eventual and sudden till failure under the tongue. The instability propagated rapidly up-glacier, mobilizing the entire 450 km2 glacier basin over a few days as the till entered an unstable friction regime. Enhanced mass loss during and after the collapse (5–7 fold compared to pre-collapse mass losses) combined with regionally rising equilibrium line altitudes strongly limit mass replenishment of the glacier, suggesting irreversible consequences. Climate plays a paradoxical role as cold glacier thinning and retreat promote basal freezing which increases friction at the tongue by stabilizing an efficient basal drainage system. However, with some of the most intense atmospheric warming on Earth occurring in the Arctic, increased melt water can reduce till strength under tidewater glacier tongues to orchestrate a temporal clustering of surges at decadal timescales, such as those observed in Svalbard at the end of the Little Ice Age. Consequently, basal terminus freezing promotes a dynamic vulnerability to climate change that may be present in many Arctic tidewater glaciers

Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. In particular, a therapeutic strategy under investigation for advanced forms of blindness involves using optogenetic molecules to render ON-bipolar cells light-sensitive. Currently, delivery of adequate levels of gene expression is a limiting step for this approach. The synthetic AAV capsid and promoter described here achieves high level of optogenetic transgene expression in ON-bipolar cells. This evokes high-frequency (∼100 Hz) spiking responses in ganglion cells of previously blind, rd1, mice. Our vector is a promising vehicle for further development toward potential clinical use