Do the age profiles of health care expenditure really steepen over time? New evidence from Swiss cantons

The red herring hypothesis contends that the high health care expenditure in old age is caused by proximity to death rather than calendar age. Dissenters point to longitudinal data and claim that health care expenditure age profiles tend to steepen over time. The present paper tests the steepening claim for Swiss health insurance, covering the time period 1997 to 2006 and 25 cantons. It analyzes the cantonal health care expenditure profile of men and women, taking into account differences in the mortality rates. The study covers seven components of health care, including long-term care. By and large, no evidence is found for relevant steepening effects of age profiles for either total, or the components, of health care expenditure. --Ageing,health care expenditure,end-of-life expenditure

Do Red Herrings Swim in Circles? – Controlling for the Endogeneity of Time to Death

Studies on the effect of ageing on health care expenditures (HCE) have revealed the importance of controlling for time-to-death (TTD). These studies, however, are subject to possible endogeneity if HCE influences remaining life expectancy.This paper introduces a ten year observational period on monthly HCE, socioeconomic characteristics, and survivor status to first predict TTD and then uses predicted values of TTD as an instrument in the regression for HCE.While exogeneity of TTD has to be rejected, core results concerning the role of TTD rather than age as a determinant of HCE (the “red herring” hypothesis) are confirmed.Health care expenditure, proximity to death, ageing, “red herring” hypothesis

Einleitung zum Themenheft Authentizität zwischen Wahrhaftigkeit und Inszenierung?

The central question of this issue Authenticity between Truthfulness and Pretension? is directly related to the epistemologically explosive alternative of Reality or Construction?, which is the subject of an anthology published in 2018 under the same title (Felder/Gardt 2018). While the volume Reality or Construction dealt with interdisciplinary aspects with regard to the question of whether we actually have access to reality or whether we are merely caught up in our own constructions of reality, the present issue is concerned with a decidedly linguistic approach (more precisely: an approach based on the analysis of discourse and conversation, the history of concepts and relationships as well as social history), which also includes aspects of social symbolism and social semiotics. The articles focus on the phenomenon of authenticity, which opens up the speaker-centred perspective of truthfulness to complement the world-related issue of reality

EST analysis of the scaly green flagellate Mesostigma viride (Streptophyta): Implications for the evolution of green plants (Viridiplantae)

BACKGROUND: The Viridiplantae (land plants and green algae) consist of two monophyletic lineages, the Chlorophyta and the Streptophyta. The Streptophyta include all embryophytes and a small but diverse group of freshwater algae traditionally known as the Charophyceae (e.g. Charales, Coleochaete and the Zygnematales). The only flagellate currently included in the Streptophyta is Mesostigma viride Lauterborn. To gain insight into the genome evolution in streptophytes, we have sequenced 10,395 ESTs from Mesostigma representing 3,300 independent contigs and compared the ESTs of Mesostigma with available plant genomes (Arabidopsis, Oryza, Chlamydomonas), with ESTs from the bryophyte Physcomitrella, the genome of the rhodophyte Cyanidioschyzon, the ESTs from the rhodophyte Porphyra, and the genome of the diatom Thalassiosira. RESULTS: The number of expressed genes shared by Mesostigma with the embryophytes (90.3 % of the expressed genes showing similarity to known proteins) is higher than with Chlamydomonas (76.1 %). In general, cytosolic metabolic pathways, and proteins involved in vesicular transport, transcription, regulation, DNA-structure and replication, cell cycle control, and RNA-metabolism are more conserved between Mesostigma and the embryophytes than between Mesostigma and Chlamydomonas. However, plastidic and mitochondrial metabolic pathways, cytoskeletal proteins and proteins involved in protein folding are more conserved between Mesostigma and Chlamydomonas than between Mesostigma and the embryophytes. CONCLUSION: Our EST-analysis of Mesostigma supports the notion that this organism should be a suitable unicellular model for the last flagellate common ancestor of the streptophytes. Mesostigma shares more genes with the embryophytes than with the chlorophyte Chlamydomonas reinhardtii, although both organisms are flagellate unicells. Thus, it seems likely that several major physiological changes (e.g. in the regulation of photosynthesis and photorespiration) took place early during the evolution of streptophytes, i.e. before the transition to land

Construction of Gauge Theories on Curved Noncommutative Spacetime

We present a method where derivations of star-product algebras are used to build covariant derivatives for noncommutative gauge theory. We write down a noncommutative action by linking these derivations to a frame field induced by a nonconstant metric. An example is given where the action reduces in the classical limit to scalar electrodynamics on a curved background. We further use the Seiberg-Witten map to extend the formalism to arbitrary gauge groups. A proof of the existence of the Seiberg-Witten-map for an abelian gauge potential is given for the formality star-product. We also give explicit formulas for the Weyl ordered star-product and its Seiberg-Witten-maps up to second order.Comment: 35 pages, v2: references added, v3: PACS added, v4: final version, changes in the order of presentatio

De novo 454 sequencing of barcoded BAC pools for comprehensive gene survey and genome analysis in the complex genome of barley

<p>Abstract</p> <p>Background</p> <p><it>De novo </it>sequencing the entire genome of a large complex plant genome like the one of barley (<it>Hordeum vulgare </it>L.) is a major challenge both in terms of experimental feasibility and costs. The emergence and breathtaking progress of next generation sequencing technologies has put this goal into focus and a clone based strategy combined with the 454/Roche technology is conceivable.</p> <p>Results</p> <p>To test the feasibility, we sequenced 91 barcoded, pooled, gene containing barley BACs using the GS FLX platform and assembled the sequences under iterative change of parameters. The BAC assemblies were characterized by N50 of ~50 kb (N80 ~31 kb, N90 ~21 kb) and a Q40 of 94%. For ~80% of the clones, the best assemblies consisted of less than 10 contigs at 24-fold mean sequence coverage. Moreover we show that gene containing regions seem to assemble completely and uninterrupted thus making the approach suitable for detecting complete and positionally anchored genes.</p> <p>By comparing the assemblies of four clones to their complete reference sequences generated by the Sanger method, we evaluated the distribution, quality and representativeness of the 454 sequences as well as the consistency and reliability of the assemblies.</p> <p>Conclusion</p> <p>The described multiplex 454 sequencing of barcoded BACs leads to sequence consensi highly representative for the clones. Assemblies are correct for the majority of contigs. Though the resolution of complex repetitive structures requires additional experimental efforts, our approach paves the way for a clone based strategy of sequencing the barley genome.</p

Fundamental strings in Dp-Dq brane systems

We study conformal field theory correlation functions relevant for string diagrams with open strings that stretch between several parallel branes of different dimensions. In the framework of conformal field theory, they involve boundary condition changing twist fields which intertwine between Neumann and Dirichlet conditions. A Knizhnik-Zamolodchikov-like differential equation for correlators of such boundary twist fields and ordinary string vertex operators is derived, and explicit integral formulas for its solutions are provided.Comment: 30 pages, Plain TeX, 2 ps-figures; references adde

Out-of-equilibrium evolution of quantum fields in the hybrid model with quantum back reaction

The hybrid model with a scalar "inflaton" field coupled to a "Higgs" field with a broken symmetry potential is one of the promising models for inflation and (p)reheating after inflation. We consider the nonequilibrium evolution of the quantum fields of this model with quantum back reaction in the Hartree approximation, in particular the transition of the Higgs field from the metastable "false vacuum" to the broken symmetry phase. We have performed the renormalization of the equations of motion, of the gap equations and of the energy density, using dimensional regularization. We study the influence of the back reaction on the evolution of the classical fields and of the quantum fluctuations. We observe that back reaction plays an important role over a wide range of parameters. Some implications of our investigation for the preheating stage after cosmic inflation are presented.Comment: 35 pages, 16 eps figures, revtex4; v2: typos corrected and references added, accepted for publication in Physical Review

An optimal mix of conventional power systems in the presence of renewable energy: A new design for the German electricity market

In this paper we develop a new market design for the German electricity market. Our new market design simultaneously ensures security of energy supply and ongoing expansion of renewable energy (RE). The methodological approach applied considers the special challenges resulting from the intermittent nature of RE ‒ we simulate developments in the German electricity market between 2015 and 2034 and differentiate across various power plant technologies according to their ability to flexibly react to changes in the residual load. In theory, a composition of power plants that is optimally adapted to residual load always leads to the most cost efficient supply of electricity. However, our empirical analysis demonstrates that this does not necessarily lead to an improved market environment, both in terms of power plant profitability as well as uninterrupted power supply

Longitudinal Changes in Health-Related Quality of Life in Patients With Atrial Fibrillation.

Background Optimizing health-related quality of life (HRQoL) is an important aim of atrial fibrillation (AF) treatment. Little is known about patients' long-term HRQoL trajectories and the impact of patient and disease characteristics. The aim of this study was to describe HRQoL trajectories in an observational AF study population and in clusters of patients with similar patient and disease characteristics. Methods and Results We used 5-year follow-up data from the Swiss-Atrial Fibrillation prospective cohort, which enrolled 2415 patients with prevalent AF from 2014 to 2017. HRQoL data, collected yearly, comprised EuroQoL-5 dimension utilities and EuroQoL visual analog scale scores. Patient clusters with similar characteristics at enrollment were identified using hierarchical clustering. HRQoL trajectories were analyzed descriptively and with inverse probability-weighted regressions. Effects of postbaseline clinical events were additionally assessed using time-shifted event variables. Among 2412 (99.9%) patients with available baseline HRQoL, 3 clusters of patients with AF were identified, which we characterized as follows: "cardiovascular dominated," "isolated symptomatic," and "severely morbid without cardiovascular disease." Utilities and EuroQoL visual analog scale scores remained stable over time for the full population and the clusters; isolated symptomatic patients showed higher levels of HRQoL. Utilities were reduced after occurrences of stroke, hospitalization for heart failure, and bleeding, by -0.12 (95% CI, -0.18 to -0.06), -0.10 (95% CI, -0.13 to -0.08), and -0.06 (95% CI, -0.08 to -0.04), respectively, on a 0 to 1 utility scale. Utility of surviving patients returned to preevent levels 4 years after heart failure hospitalization; 3 years after bleeding; and 1 year after stroke. Conclusions In patients with prevalent AF, HRQoL was stable over time, irrespective of baseline patient characteristics. Clinical events of hospitalization for heart failure, stroke, and bleeding had only a temporary effect on HRQoL