Demographic and socioeconomic inequalities in the risk of emergency hospital admission for violence: cross-sectional analysis of a national database in Wales

Objectives To investigate the risk of emergency hospital admissions for violence (EHAV) associated with demographic and socioeconomic factors in Wales between 2007/2008 and 2013/2014, and to describe the site of injury causing admission. Design Database analysis of 7 years’ hospital admissions using the Patient Episode Database for Wales (PEDW). Setting and participants Wales, UK, successive annual populations ∼2.8 million aged 0–74 years. Primary outcome The first emergency admission for violence in each year of the study, defined by the International Classification of Diseases V.10 (ICD-10) codes for assaults (X85-X99, Y00-Y09) in any coding position. Results A total of 11 033 admissions for assault. The majority of admissions resulted from head injuries. The overall crude admission rate declined over the study period, from 69.9 per 100 000 to 43.2 per 100 000, with the largest decrease in the most deprived quintile of deprivation. A generalised linear count model with a negative binomial log link, adjusted for year, age group, gender, deprivation quintile and settlement type, showed the relative risk was highest in age group 18–19 years (RR=6.75, 95% CI 5.88 to 7.75) compared with the reference category aged 10–14 years. The risk decreased with age after 25 years. Risk of admission was substantially higher in males (RR=4.55, 95% CI 4.31 to 4.81), for residents of the most deprived areas of Wales (RR=3.60, 95% CI 3.32 to 3.90) compared with the least deprived, and higher in cities (RR=1.37, 95% CI 1.27 to 1.49) and towns (RR=1.32, 95% CI 1.21 to 1.45) compared with villages. Conclusions Despite identifying a narrowing in the gap between prevalence of violence in richer and poorer communities, violence remains strongly associated with young men living in areas of socioeconomic deprivation. There is potential for a greater reduction, given that violence is mostly preventable. Recommendations for reducing inequalities in the risk of admission for violence are discussed

EuroCarto 2022

From the 19th to the 21st of September 2022, the Vienna University of Technology (TU Wien) hosted the 3rd European Cartographic Conference, EuroCarto 2022. The conference was endorsed by the International Cartographic Association (ICA) and jointly organized by the Research Unit Cartography at TU Wien, the German (DGfK), Austrian (ÖKK), Swiss (SGK) and British (BCS) Cartographic Societies. Sponsors were the Environmental Systems Research Institute (Esri), the Federal Office of Metrology and Surveying (BEV) and the University of Toronto Press Journals Division (UTP). The conference provided a forum for discussion, exchange, and research collaboration for cartographers and professionals in related disciplines.Od 19. do 21. rujna 2022. Tehničko sveučilište u Beču (TU Wien) bilo je domaćin 3. europske kartografske konferencije, EuroCarto 2022. Konferenciju je podržalo Međunarodno kartografsko društvo (ICA), a zajednički su je organizirali Istraživačka jedinica za kartografiju na TU Wien te njemačko (DGfK), austrijsko (ÖKK), švicarsko (SGK) i britansko (BCS) kartografsko društvo. Sponzori su bili Istraživački institut za sustave okoliša (Esri), Savezni ured za mjeriteljstvo i mjerenje (BEV) i University of Toronto Press Journals Division (UTP). Konferencija je omogućila forum za raspravu, razmjenu i istraživačku suradnju kartografima i stručnjacima iz srodnih disciplina

C-level managers and born-digitals' scaling: The case of Initial Coin Offerings (ICOs)

This research contributes to the Management of Technology (MOT) literature by scrutinizing the interrelation between education, experience, and the scaling aptitudes of high-tech companies. The study hinges on a comprehensive analysis of data collected from 1987 C-level executives and 3644 born-digital firms that pursued funding via blockchain-based Initial Coin Offerings (ICOs). Employing structural equation modeling, we systematically tested our hypotheses, contrasting the scaling trajectories of companies that successfully procured funding against those that fell short. Our findings reveal that amongst the diverse managerial competencies, only the leadership acumen of CEOs plays an important role in fostering the scaling of tech-companies across the spectrum, leaving the proficiencies of CFOs and CTOs with negligible impact. More crucially, the competencies of a CEO magnify in importance in relation to a tech-company's scaling potential post the securing of funds. The insights gained from this study not only enrich the existing body of knowledge on scaling and ICOs within the MOT literature but also hold considerable practical value for crafting effective scaling strategies in the high-tech industry

Demographic and socioeconomic patterns in the risk of alcohol-related hospital admission in children and young adults with childhood onset type-1 diabetes from a record-linked longitudinal population cohort study in Wales

Acknowledgements AG was funded by the National Centre for Population Health and Wellbeing Research Wales (WCPHWR), and SP, DF, and JG are members of the NCPHWR team in Cardiff University. We would like to thank the Brecon Group (which comprises all paediatricians and paediatric diabetes healthcare staff in Wales with an interest in Diabetes and endocrinology). The Brecon Group was supported initially by grants from NovoNordisk and subsequently the Welsh Government. Funds from the Economic and Social Research Council, the Medical Research Council, and Alcohol Research UK supported the establishment of the ELASTiC data platform.This study used anonymised data held in the Secure Anonymised Information Linkage (SAIL) Databank. We would like to acknowledge all the data providers who enable SAIL to make anonymised data available for research. Data sharing The datasets used in this study are available in the SAIL Databank at Swansea University, Swansea, UK, but as restrictions apply, they are not publicly available. All proposals to use SAIL data are subject to review by an independent Information Governance Review Panel (IGRP). Before any data can be accessed, approval must be given by the IGRP. The IGRP gives careful consideration to each project to ensure proper and appropriate use of SAIL data. When access has been granted, it is gained through a privacy-protecting safe haven and remote access system referred to as the SAIL Gateway. SAIL has established an application process to be followed by anyone who would like to access data via SAIL at https://www.saildatabank.com/application-process. Funding information: Alcohol Research UK; Medical Research Council; Economic and Social Research Council; Welsh Government; Novo Nordisk; Brecon Group; National Centre for Population Health and Wellbeing Research WalesPeer reviewedPostprintPublisher PD

Does selective migration alter socioeconomic inequalities in mortality in Wales? : a record-linked total population e-cohort study

Funding for this work was received from Public Health Wales NHS Trust as part of a report on migration and health. Support for the report was also received from the National Centre for Population Health and Wellbeing Research (NCPHWR). Andrea Gartner is funded through the NCPHWR and David Fone, Shantini Paranjothy and Daniel Farewell are members of the NCPHWR team in Cardiff University, School of Medicine. Neither funder bears any responsibility for the analysis or interpretation of the data presented here. We used data from the CHALICE project, which was originally funded by the National Institute for Health Research Public Health Research (NIHR PHR) Programme (project number 09/3007/02). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR PHR Programme or the Department of Health. We would like to thank Jenny Morgan for her work on data cleaning and validation of the original dataset.Peer reviewedPublisher PD

Epidemiology of alcohol-related emergency hospital admissions in children and adolescents: an e-cohort analysis in Wales in 2006-2011

Funding: This work was supported by funds from the Economic and Social Research Council, the Medical Research Council and Alcohol Research UK to the ELAStiC Project (ES/L015471/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data Availability: The data used in this study are available in the SAIL databank at Swansea University, Swansea, UK. All proposals to use SAIL data are subject to review by an independent Information Governance Review Panel (IGRP). Before any data can be accessed, approval must be given by the IGRP. The IGRP gives careful consideration to each project to ensure proper and appropriate use of SAIL data. When access has been granted, it is gained through a privacy-protecting safe haven and remote access system referred to as the SAIL Gateway. SAIL has established an application process to be followed by anyone who would like to access data via SAIL https://www.saildatabank.com/application-process.Peer reviewedPublisher PD

Mental health selection : common mental disorder and migration between multiple states of deprivation in a UK cohort

Funding Funding for this work was received from Public Health Wales NHS Trust as part of a report on migration and health. Support for the report was also received from the National Centre for Population Health and Wellbeing Research (NCPHWR). The eCATALYsT multiagency dataset and the baseline survey was supported by the Wales Office of Research and Development (SCC99/1/105 and R00/1/017). The follow-up survey was supported by a Welsh Assembly Government/Medical Research Council Health Research Partnership Award (H07-3-030), and the electronic cohort is supported by a National Institute for Social Care and Health Research Welsh Assembly Government Translational Health Research Platform Award (TPR08-020). Data availability statement Data may be obtained from a third party and are not publicly available. The electronic cohort is securely stored and maintained on the Secure Anonymised Information Linkage (SAIL) databank at Swansea University Medical School. The authors welcome general enquiries and ideas for new collaborations. Readers with an interest in further details should contact Professor Shantini Paranjothy, Principal Investigator.Peer reviewedPublisher PD

Finding of a novel fungal immunomodulatory protein coding sequence in ganoderma australe

Título en ingles: Finding of a novel fungal immunomodulatory protein coding sequence in Ganoderma australeTítulo en español: Hallazgo de una nueva secuencia codificadora para una proteína inmunomoduladora de origen fúngico en Ganoderma australeSHORT TITLE: A novel hypothetical immunomodulatory protein in Ganoderma australeAbstract:  Among the most common human diseases with immune system compromise are autoimmune diseases, cancer, and the acquired immunodeficiency syndrome (AIDS). Many of these diseases still have no treatment or their therapies have undesirable side effects. This has aroused a great interest in the search for new natural products with therapeutic potential and scientifically proven effects, showing minimal side effects. Formal clinical and pharmacological investigation in various medicinal fungi of the genus Ganoderma (Ganodermataceae) has shown immunomodulatory effects and tumor growth inhibition in mammals, attributable to the presence of immunomodulatory proteins and other secondary metabolites. To date, six fungal immunomodulatory proteins (FIPs) have been reported in Ganoderma. This paper seeks to advance in the discovery of immunomodulatory proteins present in Ganoderma australe, through mycelium transcriptome 454 Roche® pyrosequencing (RNA-seq) and bioinformatics analyses. The results suggest the presence of gene sequences related to an immunomodulatory protein which has been reported only once in other fungal species Taiwanofungus camphoratus. The candidate gene sequences found in G. australe exhibit high identity values in their amino acid composition and predicted protein secondary structure with the protein reported for Tai. camphoratus. According to present knowledge about the action mechanisms of these proteins, it is possible to suggest that this is a promising molecule for the treatment and prevention of diseases associated with certain immune deficiencies, cancer, and other diseases with compromised immune systems. Future studies are proposed in order to determine its immunomodulatory potential using in vitro and in vivo assays. Keywords: Ganoderma, fungal immunomodulatory protein, immunomodulation, transcriptome, therapeuticResumen: Enfermedades comunes como las autoinmunes, el cáncer y el síndrome de inmunodeficiencia adquirida aún no tienen tratamiento o sus terapias tienen efectos secundarios indeseables. Ello ha suscitado el interés en la investigación de bioproductos con potencial terapéutico, que no impliquen efectos secundarios. Investigaciones farmacológicas y clínicas en algunos hongos medicinales del género Ganoderma (Ganodermataceae) han comprobado efectos inmunomoduladores e inhibidores de crecimiento tumoral en mamíferos, atribuibles a la presencia de proteínas fúngicas inmunomoduladoras (FIPs) y otros metabolitos secundarios. Este trabajo busca avanzar en el descubrimiento de proteínas inmunomoduladoras presentes en Ganoderma australe, mediante la secuenciación del transcriptoma de micelio por tecnología de pirosecuenciación 454 Roche® (RNA-seq) y análisis bioinformáticos. Los resultados sugieren la presencia de secuencias génicas relacionadas con una proteína inmunomoduladora que se ha reportado en la especie de hongos Taiwanofungus camphoratus. Las secuencias génicas candidatas halladas en G. australe exhiben una altos valores de similitud en sus predicciones de composición aminoacídica y estructura secundaria proteica con la proteína reportada para Tai. camphoratus. Los mecanismos de acción de este tipo de proteínas inmunomoduladoras sugieren que se trata de una molécula con potencial promisorio para el tratamiento y prevención de enfermedades con compromiso del sistema inmunológico y el cáncer. Se proponen nuevos estudios que permitan determinar el potencial inmunomodulador de la proteína hipotética hallada mediante estudios in vivo e in vitro.Palabras clave: Ganoderma, proteína fúngica inmunomoduladora, inmunomodulación, transcriptoma, terapéuticaRecibido: Febrero 18 de 2014  Aprobado: octubre 10 de 201

Electronic longitudinal alcohol study in communities (ELAStiC) Wales - protocol for platform development

Introduction: Excessive alcohol consumption has adverse effects on health and there is a recognised need for the longitudinal analysis of population data to improve our understanding of the patterns of alcohol use, harms to consumers and those in their immediate environment. The UK has a number of linkable, longitudinal databases that if assembled properly could support valuable research on this topic. Aims and Objectives This paper describes the development of a broad set of cross-linked cohorts, e-cohorts, surveys and linked electronic healthcare records (EHRs) to construct an alcohol-specific analytical platform in the United Kingdom using datasets on the population of Wales. The objective of this paper is to provide a description of existing key datasets integrated with existing, routinely collected electronic health data on a secure platform, and relevant derived variables to enable population-based research on alcohol-related harm in Wales. We illustrate our use of these data with some exemplar research questions that are currently under investigation. Methods: Record-linkage of routine and observational datasets. Routine data includes hospital admissions, general practice, and cohorts specific to children. Two observational studies were included. Routine socioeconomic descriptors and mortality data were also linked. Conclusion: We described a record-linked, population-based research protocol for alcohol related harm on a secure platform. As the datasets used here are available in many countries, ELAStiC provides a template for setting up similar initiatives in other countries. We have also defined a number of alcohol specific variables using routinely-collected available data that can be used in other epidemiological studies into alcohol related outcomes. With over 10 years of longitudinal data, it will help to understand alcohol-related disease and health trajectories across the lifespan