Egocentric online social networks: Analysis of key features and prediction of tie strength in Facebook

The widespread use of online social networks, such as Facebook and Twitter, is generating a growing amount of accessible data concerning social relationships. The aim of this work is twofold. First, we present a detailed analysis of a real Facebook data set aimed at characterising the properties of human social relationships in online environments. We find that certain properties of online social networks appear to be similar to those found ?offline? (i.e., on human social networks maintained without the use of social networking sites). Our experimental results indicate that on Facebook there is a limited number of social relationships an individual can actively maintain and this number is close to the well-known Dunbar?s number (150) found in offline social networks. Second, we also present a number of linear models that predict tie strength (the key figure to quantitatively represent the importance of social relationships) from a reduced set of observable Facebook variables. Specifically, we are able to predict with good accuracy (i.e., higher than 80%) the strength of social ties by exploiting only four variables describing different aspects of users interaction on Facebook. We find that the recency of contact between individuals ? used in other studies as the unique estimator of tie strength ? has the highest relevance in the prediction of tie strength. Nevertheless, using it in combination with other observable quantities, such as indices about the social similarity between people, can lead to more accurate prediction

A very high performance stabilization system for large mass bolometerexperiments

Abstract CUORE is a large mass bolometric experiment, composed of 988 crystals, under construction in Hall A of the Gran Sasso Underground Laboratories (LNGS). Its main aim is the study of neutrinoless double beta decay of 130Te. Each bolometer is a 760 g crystal of Tellurium dioxide on which a Nuclear Transmutation Doped Ge thermistor, Ge NTD, is glued with proper thermal contact. The stability of the system is mandatory over many years of data taking. To accomplish this requirement a heating resistor is glued on each detector across which a voltage pulse can be injected at will, to develop a known calibrated heating power. We present the design solution for a pulse generator system to be used for the injection of such a small and short voltage pulse across the heaters. This system is composed by different custom PCB boards each of them having multi-channel independent outputs completely remotely programmable from the acquisition system, in pulse width and amplitude, through an on-board ARM7 microcontroller. Pulse amplitudes must be selectable, in order to handle each detector on its full dynamic range. The resolution of the output voltage is 12 bits over 10 V range. An additional 4 steps programmable voltage attenuator is added at every output. The width of any pulse can range from 100 μ s to 25.5 ms. The main features of the final system are: stability and precision in pulses generation (at the level of less than a ppm/°C), low cost (thanks to the use of commercial components) and compact implementation

An ultra fast, low power readout chain for single photon sensitivity with multi-anode photomultiplier tubes for the RICH upgrade at LHCb

Abstract An upgrade proposal for the LHCb RICH detectors at the Large Hadron Collider at CERN is being developed at the INFN section of Milano Bicocca, based on multi-anode photomultiplier tubes. The application requires the fast readout of Cherenkov rings of photons, with single photon sensitivity, at an event rate up to 40 MHz. The proposed readout chain is tailored for the R7600 multi-anode photomultiplier tubes from Hamamatsu, which proved to fit the single photon sensitivity requirement. The readout electronics for each pixel will be composed of an analog pulse shaper, a binary discriminator and additional digital circuitry to count the pulses. A prototype of the analog shaper was built with commercial discrete transistors in Silicon–Germanium (SiGe) Heterojunction technology. The tradeoff between response speed and power dissipation was investigated; and power as low as a few mW per channel could be achieved with response times of the order of one nanosecond. Furthermore, noise and jitter were evaluated, showing very good performances of the prototype

The Readout and Biasing System for the MARE Experiment in Milan

The complete readout and biasing system for the MARE experiment in Milan is presented. The experiment aims at a direct measurement of the neutrino mass, and is based on an array of microcalorimeters coupled to semiconductor thermistors. The readout is based on JFETs operated inside the cryostat at cold (130 K), to buffer the voltage signal from the thermistors. The sources of the JFETs are fed into second stage amplifiers with very low noise (less than $0.5~\mathrm{nV}/\sqrt{\mathrm{Hz}}$ white noise) and programmable high gain. The outputs are then processed by Bessel filters and acquired with a commercial DAQ system. Every 20 channels, an additional group of 4 is used to amplify the ground reference from inside the cryostat; this common ground signal is then subtracted from each channel. This approach allows to recover a fully differential readout with a smaller number of cables with respect to the standard differential configuration. The detector bias is programmable in voltage and sign with 8-bit resolution. A test signal can be superimposed on the bias voltage, in order to test each channel individually. All the readout system is remotely programmable from a PC, coupled through optical fibers

Very low noise AC/DC power supply systems for large detector arrays

In this work, we present the first part of the power supply system for the CUORE and LUCIFER arrays of bolometric detectors. For CUORE, it consists of AC/DC commercial power supplies (0–60 V output) followed by custom DC/DC modules (48 V input, ±5 V to ±13.5 V outputs). Each module has 3 floating and independently configurable output voltages. In LUCIFER, the AC/DC + DC/DC stages are combined into a commercial medium-power AC/DC source. At the outputs of both setups, we introduced filters with the aim of lowering the noise and to protect the following stages from high voltage spikes that can be generated by the energy stored in the cables after the release of accidental short circuits. Output noise is very low, as required: in the 100 MHz bandwidth the RMS level is about 37 μVRMS (CUORE setup) and 90 μVRMS (LUCIFER setup) at a load of 7 A, with a negligible dependence on the load current. Even more importantly, high frequency switching disturbances are almost completely suppressed. The efficiency of both systems is above 85%. Both systems are completely programmable and monitored via CAN bus (optically coupled)

Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion

Abstract Enteroendocrine cells are known primarily for their production of hormones that affect digestion, but they might also be implicated in sensing and neutralizing or expelling pathogens. We evaluate the expression of TLRs and the response to specific agonists in terms of cytokines, defensins, and hormones in enteroendocrine cells. The mouse enteroendocrine cell line STC-1 and C57BL/6 mice are used for in vitro and in vivo studies, respectively. The presence of TLR4, 5, and 9 is investigated by RT-PCR, Western blot, and immunofluorescence analyses. Activation of these receptors is studied evaluating keratinocyte-derived chemokine, defensins, and cholecystokinin production in response to their specific agonists. In this study, we show that the intestinal enteroendocrine cell line STC-1 expresses TLR4, 5, and 9 and releases cholecystokinin upon stimulation with the respective receptor agonists LPS, flagellin, and CpG-containing oligodeoxynucleotides. Release of keratinocyte-derived chemokine and β-defensin 2 was also observed after stimulation of STC-1 cells with the three TLR agonists, but not with fatty acids. Consistent with these in vitro data, mice showed increased serum cholecystokinin levels after oral challenge with LPS, flagellin, or CpG oligodeoxynucleotides. In addition to their response to food stimuli, enteroendocrine cells sense the presence of bacterial Ags through TLRs and are involved in neutralizing intestinal bacteria by releasing chemokines and defensins, and maybe in removing them by releasing hormones such as cholecystokinin, which induces contraction of the muscular tunica, favoring the emptying of the distal small intestine

MARE-1 in Milan: Status and Perspectives

The international project MARE (Microcalorimeter Array for a Rhenium Experiment) aims at the direct and calorimetric measurement of the electron neutrino mass with sub-eV sensitivity. Although the baseline of the MARE project consists in a large array of rhenium based thermal detectors, a different option for the isotope is also being considered. The different option is 163Ho. The potential of using 187Re for a calorimetric neutrino mass experiment has been already demonstrated. On the contrary, no calorimetric spectrum of 163Ho has been so far measured with the precision required to set a useful limit on the neutrino mass. The first phase of the project (MARE-1) is a collection of activities with the aim of sorting out both the best isotope and the most suited detector technology to be used for the final experiment. One of the MARE-1 activities is carried out in Milan by the group of Milano–Bicocca in collaboration with NASA/GSFC and Wisconsin groups. The Milan MARE-1 arrays are based on semiconductor thermistors, provided by the NASA/GSFC group, with dielectric silver perrhenate absorbers, AgReO4. The experiment, which is presently being assembled, is designed to host up to 8 arrays. With 288 detectors, a sensitivity of 3 eV at 90% CL on the neutrino mass can be reached within 3 years. This contribution gives an outlook for the MARE activities for the active isotope selection. In this contribution the status and the perspectives of the MARE-1 in Milan are also reported

Crosstalk between JNK and SUMO Signaling Pathways: deSUMOylation Is Protective against H2O2-Induced Cell Injury

Background: Oxidative stress is a key feature in the pathogenesis of several neurological disorders. Following oxidative stress stimuli a wide range of pathways are activated and contribute to cellular death. The mechanism that couples c-Jun N-terminal kinase (JNK) signaling, a key pathway in stress conditions, to the small ubiquitin-related modifier (SUMO), an emerging protein in the field, is largely unknown. Methodology/Principal Findings: With this study we investigated if SUMOylation participates in the regulation of JNK activation as well as cellular death in a model of H 2O 2 induced-oxidative stress. Our data show that H 2O 2 modulates JNK activation and induces cellular death in neuroblastoma SH-SY5Y cells. Inhibition of JNK’s action with the D-JNKI1 peptide rescued cells from death. Following H2O2, SUMO-1 over-expression increased phosphorylation of JNK and exacerbated cell death, although only in conditions of mild oxidative stress. Furthermore inhibition of SUMOylation, following transfection with SENP1, interfered with JNK activation and rescued cells from H 2O 2 induced death. Importantly, in our model, direct interaction between these proteins can occur. Conclusions/Significance: Taken together our results show that SUMOylation may significantly contribute to modulation o

Structure of Ego-alter relationships of Politicians in Twitter

We analyze the ego-alter Twitter networks of 300 Italian MPs and 18 European leaders, and of about 14,000 generic users. We find structural properties typical of social environments, meaning that Twitter activity is controlled by constraints that are similar to those shaping conventional social relationships. However, the evolution of ego-alter ties is very dynamic, which suggests that they are not entirely used for social interaction, but for public signaling and self-promotion. From this standpoint, the behavior of EU leaders is much more evident, while Italian MPs are in between them and generic users. We find that politicians, more than generic users, create relationships as a side effect of tweeting on discussion topics, rather than by contacting specific alters