The Seismicity of Ischia Island, Italy: An Integrated Earthquake Catalogue From 8th Century BC to 2019 and Its Statistical Properties

Ischia is a densely inhabited and touristic volcanic island located in the northern sector of the Gulf of Naples (Italy). In 2017, the Mw 3.9 Casamicciola earthquake occurred after more than one century of seismic quiescence characterized only by minor seismicity, which followed a century with three destructive earthquakes (in 1828, 1881, and 1883). These events, despite their moderate magnitude (Mw < 5.5), lead to dreadful effects on buildings and population. However, an integrated catalogue systematically covering historical and instrumental seismicity of Ischia has been still lacking since many years. Here, we review and systematically re-analyse all the available data on the historical and instrumental seismicity, to build an integrated earthquake catalogue for Ischia with a robust characterization of existing uncertainties. Supported by new or updated macroseismic datasets, we significantly enriched existing catalogues, as the Italian Parametric Earthquake Catalogue (CPTI15) that, with this analysis, passed from 12 to 57 earthquakes with macroseismic parametrization. We also extended back by 6 years the coverage of the instrumental catalogue, homogenizing the estimated seismic parameters. The obtained catalogue will not only represent a solid base for future local hazard quantifications, but also it provides the unique opportunity of characterizing the evolution of the Ischia seismicity over centuries. To this end, we analyse the spatial, temporal, and magnitude distributions of Ischia seismicity, revealing for example that, also in the present long-lasting period of volcanic quiescence, is significantly non-stationary and characterized by a b-value larger than 1

Dataset of the manuscript “4D Imaging of the Volcano Feeding System beneath the Urban Area of the Campi Flegrei Caldera”

This work has been supported by Spanish Agencia Estatal de Investigación (10.13039/501100011033) grant RTI2018-093874-B-I00 (DEEP-MAPS), and grants G2HOTSPOTS (PID2021-122142OB-I00) and Defsour-PLUS (PDC2022-133304-I00) from the AEI/10.13039/501100011033/Union Europea NextGeneration. We thank ASI (Italian Space Agency) Project “DInSAR - 3M” (ASI Contract n. 2021-8-U.0 “DInSAR Multi-frequency/Multi-platform for Multi-scale analysis of ground movements” to partially support the activities. We also thank the Italian DPC and DInSAR-3M projects for partially funding this research activity and ASI and ESA for providing the SAR images. The efforts of KFT was supported in part by NOAA cooperative agreements NA17OAR4320101 and NA22OAR4320151 and NSF Award OAC 1835566. This work represents a contribution to CSIC PTI TELEDETEC.Peer reviewe

Scenari di ricostruzione delle interazioni uomo-ambiente-clima in Lombardia (N-Italia) dal Paleolitico medio all’età del Ferro

This contribution aims to provide an updated and concise overview of the main events and developments characterising the interaction between human communities and their environment in Lombardy (Northern Italy) between the Middle Paleolithic and the Late Iron Age (60,000 to 2,100 years cal BP). Within the above defined geographic and chronological context, our main goal is to highlight and summarise the role of natural factors in the development of human history, both over the long durée and within defined periods. We provide a short history of the ecosystems and socio-ecological systems in Lombardy, for which – thanks to the contribution of several research groups and scholars active in the region – we analyse specific key issues. These analyses are facilitated by chronostratigraphic tables and GIS-based cartography, and introduced by an overview of the climatic changes that affected Alpine and Po Plain landscapes across the Last Glaciation and subsequent Late Glacial times, up to the shortlasting events which influenced the development of Holocene civilisations. The structure and significance of the issues introduced in the overview will be discussed by individual research groups working within this study are

Characterising key issues in human–environment interactions in Lombardy (N-Italy) from the Middle Paleolithic to the Iron Age

This contribution aims to provide an updated and concise overview of the main events and developments characterising the interaction between human communities and their environment in Lombardy (Northern Italy) between the Middle Paleolithic and the Late Iron Age (60,000 to 2,100 years cal BP). Within the above defined geographic and chronological context, our main goal is to highlight and summarise the role of natural factors in the development of human history, both over the long durée and within defined periods. We provide a short history of the ecosystems and socio-ecological systems in Lombardy, for which – thanks to the contribution of several research groups and scholars active in the region – we analyse specific key issues. These analyses are facilitated by chronostratigraphic tables and GIS-based cartography, and introduced by an overview of the climatic changes that affected Alpine and Po Plain landscapes across the Last Glaciation and subsequent Late Glacial times, up to the shortlasting events which influenced the development of Holocene civilisations. The structure and significance of the issues introduced in the overview will be discussed by individual research groups working within this study are

GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery:early analysis on 977 patients

Objective: Older patients with cancer value functional outcomes as much as survival, but surgical studies lack functional recovery (FR) data. The value of a standardized frailty assessment has been confirmed, yet it's infrequently utilized due to time restrictions into everyday practice. The multicenter GOSAFE study was designed to (1) evaluate the trajectory of patients' quality of life (QoL) after cancer surgery (2) assess baseline frailty indicators in unselected patients (3) clarify the most relevant tools in predicting FR and clinical outcomes. This is a report of the study design and baseline patient evaluations. Materials & Methods: GOSAFE prospectively collected a baseline multidimensional evaluation before major elective surgery in patients (≥70 years) from 26 international units. Short−/mid−/long-term surgical outcomes were recorded with QoL and FR data. Results: 1003 patients were enrolled in a 26-month span. Complete baseline data were available for 977(97.4%). Median age was 78 years (range 70–94); 52.8% males. 968(99%) lived at home, 51.6% without caregiver. 54.4% had ≥ 3 medications, 5.9% none. Patients were dependent (ADL 20 s (5.2%) or ASAIII-IV (48.8%). Major comorbidities (CACI > 6) were detected in 36%; 20.9% of patients had cognitive impairment according to Mini-Cog. Conclusion: The GOSAFE showed that frailty is frequent in older patients undergoing cancer surgery. QoL and FR, for the first time, are going to be primary outcomes of a real-life observational study. The crucial role of frailty assessment is going to be addressed in the ability to predict postoperative outcomes and to correlate with QoL and FR

Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study

PURPOSE The GOSAFE study evaluates risk factors for failing to achieve good quality of life (QoL) and functional recovery (FR) in older patients undergoing surgery for colon and rectal cancer.METHODS Patients age 70 years and older undergoing major elective colorectal surgery were prospectively enrolled. Frailty assessment was performed and outcomes, including QoL (EQ-5D-3L) recorded (3/6 months postoperatively). Postoperative FR was defined as a combination of Activity of Daily Living &gt;= 5 + Timed Up &amp; Go test &lt;20 seconds + MiniCog &gt;2.RESULTS Prospective complete data were available for 625/646 consecutive patients (96.9%; 435 colon and 190 rectal cancer), 52.6% men, and median age was 79.0 years (IQR, 74.6-82.9 years). Surgery was minimally invasive in 73% of patients (321/435 colon; 135/190 rectum). At 3-6 months, 68.9%-70.3% patients experienced equal/better QoL (72.8%-72.9% colon, 60.1%-63.9% rectal cancer). At logistic regression analysis, preoperative Flemish Triage Risk Screening Tool &gt;= 2 (3-month odds ratio [OR], 1.68; 95% CI, 1.04 to 2.73; P = .034, 6-month OR, 1.71; 95% CI, 1.06 to 2.75; P = .027) and postoperative complications (3-month OR, 2.03; 95% CI, 1.20 to 3.42; P = .008, 6-month OR, 2.56; 95% CI, 1.15 to 5.68; P = .02) are associated with decreased QoL after colectomy. Eastern Collaborative Oncology Group performance status (ECOG PS) &gt;= 2 is a strong predictor of postoperative QoL decline in the rectal cancer subgroup (OR, 3.81; 95% CI, 1.45 to 9.92; P = .006). FR was reported by 254/323 (78.6%) patients with colon and 94/133 (70.6%) with rectal cancer. Charlson Age Comorbidity Index &gt;= 7 (OR, 2.59; 95% CI, 1.26 to 5.32; P = .009), ECOG &gt;= 2 (OR, 3.12; 95% CI, 1.36 to 7.20; P = .007 colon; OR, 4.61; 95% CI, 1.45 to 14.63; P = .009 rectal surgery), severe complications (OR, 17.33; 95% CI, 7.30 to 40.8; P &lt; .001), fTRST &gt;= 2 (OR, 2.71; 95% CI, 1.40 to 5.25; P = .003), and palliative surgery (OR, 4.11; 95% CI, 1.29 to 13.07; P = .017) are risk factors for not achieving FR.CONCLUSION The majority of older patients experience good QoL and stay independent after colorectal cancer surgery. Predictors for failing to achieve these essential outcomes are now defined to guide patients' and families' preoperative counseling

Quality of life in older adults after major cancer surgery: the GOSAFE international study

Abstract Background Accurate quality of life (QoL) data and functional results after cancer surgery are lacking for older patients. The international, multicenter Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery (GOSAFE) Study compares QoL before and after surgery and identifies predictors of decline in QoL. Methods GOSAFE prospectively collected data before and after major elective cancer surgery on older adults (≥70 years). Frailty assessment was performed and postoperative outcomes recorded (30, 90, and 180 days postoperatively) together with QoL data by means of the three-level version of the EuroQol five-dimensional questionnaire (EQ-5D-3L), including 2 components: an index (range = 0-1) generated by 5 domains (mobility, self-care, ability to perform the usual activities, pain or discomfort, anxiety or depression) and a visual analog scale. Results Data from 26 centers were collected (February 2017-March 2019). Complete data were available for 942/1005 consecutive patients (94.0%): 492 male (52.2%), median age 78 years (range = 70-95 years), and primary tumor was colorectal in 67.8%. A total 61.2% of all surgeries were via a minimally invasive approach. The 30-, 90-, and 180-day mortality was 3.7%, 6.3%, and 9%, respectively. At 30 and 180 days, postoperative morbidity was 39.2% and 52.4%, respectively, and Clavien-Dindo III-IV complications were 13.5% and 18.7%, respectively. The mean EQ-5D-3L index was similar before vs 3 months but improved at 6 months (0.79 vs 0.82; P &lt; .001). Domains showing improvement were pain and anxiety or depression. A Flemish Triage Risk Screening Tool score greater than or equal to 2 (odds ratio [OR] = 1.58, 95% confidence interval [CI] = 1.13 to 2.21, P = .007), palliative surgery (OR = 2.14, 95% CI = 1.01 to 4.52, P = .046), postoperative complications (OR = 1.95, 95% CI = 1.19 to 3.18, P = .007) correlated with worsening QoL. Conclusions GOSAFE shows that older adults’ preoperative QoL is preserved 3 months after cancer surgery, independent of their age. Frailty screening tools, patient-reported outcomes, and goals-of-care discussions can guide decisions to pursue surgery and direct patients’ expectations

The management of complicated colorectal cancer in older patients in a global perspective after COVID-19: the CO-OLDER WSES project

BACKGROUND: Colorectal (CRC) cancer is becoming a disease of the elderly. Ageing is the most significant risk factor for presenting CRC. Early diagnosis of CRC and management is the best way in achieving good outcomes and longer survival but patients aged ≥75 years are usually not screened for CRC. This group of patients is often required to be managed when they are symptomatic in the emergency setting with high morbidity and mortality rates. Our main aim is to provide clinical data about the management of elderly patients presenting complicated colorectal cancer who required emergency surgical management to improve their care. METHODS: The management of complicated COlorectal cancer in OLDER patients (CO-OLDER; ClinicalTrials.gov ID: NCT05788224; evaluated by the local ethical committee CPP EST III-France with the national number 2023-A01094-41) in the emergency setting project provides carrying out an observational multicenter international cohort study aimed to collect data about patients aged ≥75 years to assess modifiable risk factors for negative outcomes and mortality correlated to the emergency surgical management of this group of patients at risk admitted with a complicated (obstructed and perforated) CRC. The CO-OLDER protocol was approved by Institutional Review Board and released. Each CO-OLDER collaborator is asked to enroll ≥25 patients over a study period from 1st January 2018 to 30th October 2023. Data will be analyzed comparing two periods of study: before and after the COVID-19 pandemic. A sample size of 240 prospectively enrolled patients with obstructed colorectal cancer in a 5-month period was calculated. The secured database for entering anonymized data will be available for the period necessary to achieve the highest possible participation. RESULTS: One hundred eighty hospitals asked to be a CO-OLDER collaborator, with 36 potentially involved countries over the world. CONCLUSIONS: The CO-OLDER project aims to improve the management of elderly people presenting with a complicated colorectal cancer in the emergency setting. Our observational global study can provide valuable data on the effectiveness of different management strategies in improving primary assessment, management and outcomes for elderly patients with obstructed or perforated colorectal cancer in the emergency setting, guiding clinical decision-making. This information can help healthcare providers make informed decisions about the best course of action for these patients