(2+1) Resonance Enhanced Ionization Spectroscopy of a State Selected Beam of OH Radicals

A state-selected beam of hydroxyl radicals is generated using a pulsed discharge source and hexapole field. The OH radicals are characterized by resonance-enhanced multiphoton ionization (REMPI) spectroscopy via the nested D  and 3  Rydberg states. Simplified spectra are observed from the selected ∣MJ∣ = 3/2 component of the upper Λ-doublet level of the lowest rotational state (J = 3/2) in ground (v″ = 0) and excited(v″ = 1–3) vibrational levels of the OH X  state. Two-photon transitions are observed to the D (v′ = 0–3) and 3 (v′ = 0,1) vibronic levels, extending previous studies to higher vibrational levels of the Rydberg states. Spectroscopic constants are derived for the Rydberg states and compared with prior experimental studies. Complementary first-principle theoretical studies of the D  and 3  Rydberg states [see M. P. J. van der Loo and G. C. Groenenboom, J. Chem. Phys. 123, 074310 (2005), following paper ] are used to interpret the experimental findings and examine the utility of the (2+1) REMPI scheme for sensitive detection of OH radicals

Occlusion-related lateral connections stabilize kinetic depth stimuli through perceptual coupling

Local sensory information is often ambiguous forcing the brain to integrate spatiotemporally separated information for stable conscious perception. Lateral connections between clusters of similarly tuned neurons in the visual cortex are a potential neural substrate for the coupling of spatially separated visual information. Ecological optics suggests that perceptual coupling of visual information is particularly beneficial in occlusion situations. Here we present a novel neural network model and a series of human psychophysical experiments that can together explain the perceptual coupling of kinetic depth stimuli with activity-driven lateral information sharing in the far depth plane. Our most striking finding is the perceptual coupling of an ambiguous kinetic depth cylinder with a coaxially presented and disparity defined cylinder backside, while a similar frontside fails to evoke coupling. Altogether, our findings are consistent with the idea that clusters of similarly tuned far depth neurons share spatially separated motion information in order to resolve local perceptual ambiguities. The classification of far depth in the facilitation mechanism results from a combination of absolute and relative depth that suggests a functional role of these lateral connections in the perception of partially occluded objects

Ammonia emission and nutrient load in outdoor runs of laying hens

Ammonia emission and nutrient load in outdoor runs of laying hens were measured at a commercial farm with an outdoor run for 3000 hens, and at an experimental farm with two outdoor runs, each for approximately 250 hens. Ammonia emission was recorded at 5, 10, 15 and 20 m from the hen house, using the ventilated chamber technique. Nutrient load was determined by analysing the fresh droppings. The results show ammonia emission to decrease with increasing distance from the hen house. The average emission per hen was 2.0 mg h-1 for the run of the commercial farm, and 0.95 and 0.86 mg h-1 for the two runs of the experimental farm. The nutrient load within 20 m from the hen house exceeded the threshold value for nutrient supply from manure (170 kg N and 44 kg P per ha) by a factor 15 on both the commercial farm and the experimental farm. The results show that the ammonia emission from the outdoor run of laying hens was relatively small compared with the emission from the hen house and that the nutrient load in the outdoor run near the house by far exceeded maximum acceptable levels

Photodissociation of the OD radical at 226 and 243 nm

The photodissociation dynamics of state selected OD radicals has been examined at 243 and 226 nm using velocity map imaging to probe the angle–speed distributions of theD(2S) and O(3P2) products. Both experiment and complementary first principle calculations demonstrate that photodissociation occurs by promotion of OD from high vibrational levels of the ground X 2Π state to the repulsive 1 2Σ− state

A Quantitative Comparison of Completely Visible Cadastral Parcels Using Satellite Images:A Step towards Automation

Estimates suggest that 70 percent of the world’s population has little or no access to formal land administration systems and hence their rights are often neither recognized nor secured by governments. A system of organized land rights information, embedded in a broader land administration system, is argued as a key pillar for underpinning any sustainable economy and equitable economic development. Cadastres are a core ingredient of any land administration system. Traditional methods for cadastral surveying and mapping are however, often lengthy and labor intensive. In response, remote sensing based techniques have great potential and are being increasingly employed for rapid creation and upgrading of cadastral maps: the Global Land Tool Network (GLTN)’s fit-for-purpose (FFP) land administration guidelines provide ample evidence in this regard. Furthermore, (semi)-automatic methods for detecting cadastral boundaries are currently under development. These methods seek to make use of very high resolution (VHR) satellite images or sensors capable of similar resolutions. Creating approaches that are both highly automated and transferable between contexts remain a challenge owing to diverse morphologies of parcel boundaries found across contexts. Anyhow, object-based image analysis methods appear highly promising as they mimic the human interpretation process to identify features from an image. A pre-step to utilizing any of these methods should be determining the quantity of the boundaries that are actually identifiable through visual interpretation. Therefore, in this paper, we assess the quantity of visible/non-visible boundaries in different contexts with the aim of determining the percentage of known cadastral parcels that are completely visible via VHR satellite images. For this purpose, we selected subsets from case locations in the contexts of Ethiopia, Ghana, Kenya, Mozambique, Rwanda, Guatemala and Nepal. To cover different landscapes, a combination of rural, peri-urban and urban areas were included. In each case, control cadastral data (i.e. vector files or existing cadastral maps) served as a reference for the assessment. Results show significant difference between visual identification for the samples from seven contexts. The percentage of completely visible cadastral parcels ranged from zero to 71 percent when compared to the reference cadastral map. These were parcels for which all boundaries were fully visible, i.e. a closed polygon. Considering the result of the study, it appears that (semi)-automated cadastral boundary extraction methods using VHR imagery will have high utility in specific contexts (e.g. smallholder and rural), whereas their use in complex urban environments may be challenging and require other methods or data. Nonetheless, an approach like this will greatly enhance the application of FFP approach in Land Administration for cadastral mapping in areas where no relaible data exists, for e.g. even if a small amount of boundaries could be automatically generated (e.g. 30 percent), potentially large cost reductions in cadastral surveying and mapping could be achieved

The runaway binary LP 400−22 is leaving the Galaxy

We present optical spectroscopy, astrometry, radio and X-ray observations of the runaway binary LP 400−22. We refine the orbital parameters of the system based on our new radial velocity observations. Our parallax data indicate that LP 400−22 is significantly more distant (3σ lower limit of 840 pc) than initially predicted. LP 400−22 has a tangential velocity in excess of 830 km s^−1; it is unbound to the Galaxy. Our radio and X-ray observations fail to detect a recycled millisecond pulsar companion, indicating that LP 400−22 is a double white dwarf system. This essentially rules out a supernova runaway ejection mechanism. Based on its orbit, a Galactic Centre origin is also unlikely. However, its orbit intersects the locations of several globular clusters; dynamical interactions between LP 400−22 and other binary stars or a central black hole in a dense cluster could explain the origin of this unusual binary

Nodal domains of Maass forms I

This paper deals with some questions that have received a lot of attention since they were raised by Hejhal and Rackner in their 1992 numerical computations of Maass forms. We establish sharp upper and lower bounds for the $L^2$-restrictions of these forms to certain curves on the modular surface. These results, together with the Lindelof Hypothesis and known subconvex $L^\infty$-bounds are applied to prove that locally the number of nodal domains of such a form goes to infinity with its eigenvalue.Comment: To appear in GAF

Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer

Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the cytosine base adjacent to guanine. Many tumor genes are inactivated by DNA methylation in gastric cancer. We evaluated the DNA methylation status of ANAPC1, CDKN2A and TP53 by methylation-specific PCR in 20 diffuse- and 26 intestinal-type gastric cancer samples and 20 normal gastric mucosa in individuals from Northern Brazil. All gastric cancer samples were advanced stage adenocarcinomas. Gastric samples were surgically obtained at the João de Barros Barreto University Hospital, State of Pará, and were stored at -80°C before DNA extraction. Patients had never been submitted to chemotherapy or radiotherapy, nor did they have any other diagnosed cancer. None of the gastric cancer samples presented methylated DNA sequences for ANAPC1 and TP53. CDKN2A methylation was not detected in any normal gastric mucosa; however, the CDKN2A promoter was methylated in 30.4% of gastric cancer samples, with 35% methylation in diffuse-type and 26.9% in intestinal-type cancers. CDKN2A methylation was associated with the carcinogenesis process for ~30% diffuse-type and intestinal-type compared to non-neoplastic samples. Thus, ANAPC1 and TP53 methylation was probably not implicated in gastric carcinogenesis in our samples. CDKN2A can be implicated in the carcinogenesis process of only a subset of gastric neoplasias.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FINEP/CT-INFRAFAEPAUniversidade Federal do Piauí Colegiado de BiomedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MorfologiaUniversidade Federal do Pará Instituto de Ciências Biológicas Laboratório de Citogenética HumanaHospital João de Barros Barreto Serviço de CirurgiaInstituto de Investigaciones BiomedicasUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de GenéticaUNIFESP, EPM, Depto. de MorfologiaFINEP/CT-INFRA: 0927-03SciEL

Symptomatic Skeletal Events and the Use of Bone Health Agents in a Real-World Treated Metastatic Castration Resistant Prostate Cancer Population:Results From the CAPRI-Study in the Netherlands

Background: Patients with metastatic castration resistant prostate cancer (mCRPC) are at risk of symptomatic skeletal events (SSE). Bone health agents (BHA, ie bisphosphonates and denosumab) and new life-prolonging drugs (LPDs) can delay SSEs. The aim of this study is to investigate the use of BHAs in relation to SSEs in treated real-world mCRPC population. Patients and Methods: We included patients from the CAPRI registry who were treated with at least one LPD and diagnosed with bone metastases prior to the start of first LPD (LPD1). Outcomes were SSEs (external beam radiation therapy (EBRT) to the bone, orthopedic surgery, pathologic fracture or spinal cord compression) and SSE-free survival (SSE-FS) since LPD1. Results: One-thousand nine hundred and twenty-three patients were included with a median follow-up from LPD1 of 16.7 months. Fifty-two percent (n = 996) started BHA prior or within 4 weeks after the start of LPD1 (early BHA). In total, 41% experienced at least one SSE. SSE incidence rate was 0.29 per patient year for patients without BHA and 0.27 for patients with early BHA. Median SSE-FS from LPD1 was 12.9 months. SSE-FS was longer in patients who started BHA early versus patients without BHA (13.2 vs. 11.0 months, P =.001). Conclusion: In a real-world population we observed an undertreatment with BHAs, although patients with early BHA use had lower incidence rates of SSEs and longer SSE-FS. This finding was irrespective of type of SSE and presence of risk factors. In addition to LPD treatment, timely initiation of BHAs is recommended in bone metastatic CRPC-patients with both pain and/or opioid use and prior SSE