Hyposplenism in gastro-intestinal disease

The hazards of living without a spleen were recognised by the paediatricians in the early 1960’s when they focussed attention on the syndrome of fulminant sepsis, often due to pneumococcal infection, occurring in young children within the first two years of splenectomy. The danger of post-splenectomy sepsis (PSS) extends into adult life and splenectomised patients remain at risk 10, 20 and even 30 years after the operation. Problems following splenectomy may just be the tip of the iceberg. It is clear that many other diseases are associated with impaired splenic function in the presence of intact spleens.peer-reviewe

Comparing univariate and multivariate models to forecast portfolio value-at-risk

This article addresses the problem of forecasting portfolio value-at-risk (VaR) with multivariate GARCH models vis-à-vis univariate models. Existing literature has tried to answer this question by analyzing only small portfolios and using a testing framework not appropriate for ranking VaR models. In this work we provide a more comprehensive look at the problem of portfolio VaR forecasting by using more appropriate statistical tests of comparative predictive ability. Moreover, we compare univariate vs. multivariate VaR models in the context of diversified portfolios containing a large number of assets and also provide evidence based on Monte Carlo experiments. We conclude that, if the sample size is moderately large, multivariate models outperform univariate counterparts on an out-of-sample basis.Market risk, Backtesting, Conditional predictive ability, GARCH, Volatility, Capital requirements, Basel II

Structural anomalies, spin transitions and charge disproportionation in LnCoO3

The diamagnetic-paramagnetic and insulator-metal transitions in LnCoO3 perovskites (Ln = La, Y, rare earths) are reinterpreted and modeled as a two-level excitation process. In distinction to previous models, the present approach can be characterized as a LS-HS-IS (low-high-intermediate spin) scenario. The first level is the local excitation of HS Co3+ species in the LS ground state. The second excitation is based on the interatomic electron transfer between the LS/HS pairs, leading finally to a stabilization of the metallic phase based on IS Co3+. The model parameters have been quantified for Ln = La, Pr and Nd samples using the powder neutron diffraction on the thermal expansion of Co-O bonds, that is associated with the two successive spin transitions. The same model is applied to interpret the magnetic susceptibility of LaCoO3 and YCoO3.Comment: 52.Conference on Magnetism and Magnetic Materials, November 2007, Tamp

A Corona Australis cloud filament seen in NIR scattered light. III. Modelling and comparison with Herschel sub-millimetre data

With recent Herschel observations, the northern filament of the Corona Australis cloud has now been mapped in a number of bands from 1.2um to 870um. The data set provides a good starting point for the study of the cloud over several orders of magnitude in density. We wish to examine the differences of the column density distributions derived from dust extinction, scattering, and emission, and to determine to what extent the observations are consistent with the standard dust models. From Herschel data, we calculate the column density distribution that is compared to the corresponding data derived in the near-infrared regime from the reddening of the background stars, and from the surface brightness attributed to light scattering. We construct three-dimensional radiative transfer models to describe the emission and the scattering. The scattered light traces low column densities of A_V~1mag better than the dust emission, remaining useful to A_V ~ 10-15 mag. Based on the models, the extinction and the level of dust emission are surprisingly consistent with a sub-millimetre dust emissivity typical of diffuse medium. However, the intensity of the scattered light is very low at the centre of the densest clump and this cannot be explained without a very low grain albedo. Both the scattered light and dust emission indicate an anisotropic radiation field. The modelling of the dust emission suggests that the radiation field intensity is at least three times the value of the normal interstellar radiation field. The inter-comparison between the extinction, light scattering, and dust emission provides very stringent constraints on the cloud structure, the illuminating radiation field, and the grain properties.Comment: 13 pages, 16 figures, accepted to A&

Infall models of Class 0 protostars

We have carried out radiative transfer calculations of infalling, dusty envelopes surrounding embedded protostars to understand the observed properties of the recently identified ``Class 0'' sources. To match the far-infrared peaks in the spectral energy distributions of objects such as the prototype Class 0 source VLA 1623, pure collapse models require mass infall rates \sim10^{-4}\msunyr$^{-1}$. The radial intensity distributions predicted by such infall models are inconsistent with observations of VLA 1623 at sub-mm wavelengths, in agreement with the results of Andre et al. (1993) who found a density profile of $\rho \propto r^{-1/2}$ rather than the expected $\rho \propto r^{-3/2}$ gradient. To resolve this conflict, while still invoking infall to produce the outflow source at the center of VLA 1623, we suggest that the observed sub-mm intensity distribution is the sum of two components: an inner infall zone, plus an outer, more nearly constant-density region. This explanation of the observations requires that roughly half the total mass observed within 2000 AU radius of the source lies in a region external to the infall zone. The column densities for this external region are comparable to those found in the larger Oph A cloud within which VLA 1623 is embedded. The extreme environments of Class 0 sources lead us to suggest an alternative or additional interpretation of these objects: rather than simply concluding with Andre et al. that Class 0 objects only represent the earliest phases of protostellar collapse, and ultimately evolve into older ``Class I'' protostars, we suggest that many Class 0 sources could be the protostars of very dense regions. (Shortened)Comment: 22 pages, including 3 PostScript figures, accepted for publication in The Astrophysical Journa

Fabrication of free-standing ordered fluorescent polymer nanofibres by electrospinning

The authors are grateful to the Engineering and Physical Sciences Research Council for financial support.We demonstrate a static fabrication approach to make free-standing ordered arrays of fluorescent nanofibres through control of the transverse electrospinning field. The alignment and the density of the nanofibre arrays are optimised by careful design of both the source and collector electrode geometries which can control the transverse electric field over the full path of the jet. In doing so, we fabricate suspended fluorescent nanofibres with an aspect ratio of 10(4), and with a substantially increased density and order parameter (by a factor of similar to 10 compared to random deposition). Electrostatic modelling suggests that the field distribution of the component is the main contribution to the ordering between the plates. This method offers increased efficiency for the creation of ordered fibres collected over a small area and the characterisation of their photoluminescent properties.Publisher PDFPeer reviewe

Using Queer Knowledges to Build Inclusionary Pedagogy in Adult Education

This paper turns to queer history, theory, and studies to develop themes useful to adult educators who wish to build alternative pedagogies that explore issues of difference, inclusion, transgressive politics, knowledge production, and the inextricable link between culture and power

Occlusion-related lateral connections stabilize kinetic depth stimuli through perceptual coupling

Local sensory information is often ambiguous forcing the brain to integrate spatiotemporally separated information for stable conscious perception. Lateral connections between clusters of similarly tuned neurons in the visual cortex are a potential neural substrate for the coupling of spatially separated visual information. Ecological optics suggests that perceptual coupling of visual information is particularly beneficial in occlusion situations. Here we present a novel neural network model and a series of human psychophysical experiments that can together explain the perceptual coupling of kinetic depth stimuli with activity-driven lateral information sharing in the far depth plane. Our most striking finding is the perceptual coupling of an ambiguous kinetic depth cylinder with a coaxially presented and disparity defined cylinder backside, while a similar frontside fails to evoke coupling. Altogether, our findings are consistent with the idea that clusters of similarly tuned far depth neurons share spatially separated motion information in order to resolve local perceptual ambiguities. The classification of far depth in the facilitation mechanism results from a combination of absolute and relative depth that suggests a functional role of these lateral connections in the perception of partially occluded objects