Libras no atendimento a pessoa surda no serviço de odontologia: uma revisão de literatura / Freedonms in service to the deaf person in the dentistry service: a literature review

Introdução: A surdez compreende a perda total ou parcial da percepção normal dos sons. Na antiguidade era considerada algo discriminador, pessoas surdas eram vistas como doentes merecedoras de pena e vítimas da incompreensão da sociedade. Objetivo: discutir a importância da língua brasileira de sinais (LIBRAS) no atendimento a pessoas surdas nos serviços de odontologia. Metodologia: este trabalho é uma revisão integrativa da literatura. Procurou explorar a língua brasileira de sinais no atendimento a pessoas surdas por profissionais da Odontologia. A pesquisa foi baseada no levantamento de artigos científicos publicados entre os anos 2009 e 2019 nas bases dados on line Literatura Latino Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO) e Periódicos Capes. Resultados e Discussão: Os resultados dessa pesquisa demonstraram uma deficiência na literatura a respeito do assunto abordado, tendo em vista a existência de poucas publicações sobre esta temática, Conclusão: A partir dessa revisão de literatura foi possível observar a necessidade do conhecimento da linguagem de sinais pelos profissionais da Odontologia, permitindo que este público tenha acesso a um atendimento mais completo e eficaz, garantindo assim, a manutenção da saúde bucal desses pacientes. 

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Risco de cheia e inundação: exposição e adaptação na área ribeirinha de Ponte de Lima

A modelação hidrológica, a avaliação do risco de inundação e a cartografia de áreas inundáveis tornam-se essenciais no planeamento local e regional associada à decisão-ação técnico-politica. Este trabalho pretende analisar o funcionamento hidrológico da bacia hidrográfica do rio Lima, a incidência histórica de inundações no centro histórico da vila de Ponte de Lima e os potenciais impactes, exposição e vulnerabilidade sobre o meio natural e humano bem como, a adaptação humana através do planeamento aos padrões das inundações.La modelización del riesgo de la crescida y la inundación: la exposición, la vulnerabilidad y la adaptación en la zona ribereña de Ponte de Lima - La modelización del régimen hidrológico, la evaluación de los riesgos de inundación y cartografía de las zonas inundables convertido en algo esencial en la planificación local y regional, así como la política técnico-decisión-acción. Este estudio tiene como objetivo examinar el funcionamiento de la cuenca hidrológica del río Lima, la incidencia histórica de las inundaciones en la histórica ciudad de Ponte de Lima y los posibles impactos, la vulnerabilidad y la exposición en el medio ambiente humano y natural, así como la adaptación humana a los padrones de inundaciones.La modélisation des risques de crues et inondation: l'exposition, la vulnérabilité et l'adaptation dans la zone riveraine de Ponte de Lima - La modélisation du régime hydrologique, l'évaluation des risques d'inondation et la cartographie des zones inondées devenues essentielles dans la planification locale et régionale, ainsi que á la décision-action technique and politique. Cette étude vise à examiner le fonctionnement du bassin hydrologique de la rivière Lima, l'incidence historique d'inondation dans la ville historique de Ponte de Lima et les impacts potentiels, la vulnérabilité et l'exposition sur l'environnement humain et naturel, ainsi que l'adaptation humaine aux inondations.Modelling of flood risk: exposure, vulnerability and adaptation in the riverside area of Ponte de Lima - The hydrological regime modeling, flood risk assessment and flooded areas mapping become essential in local and regional planning, as well as in technical and political action-decision making. This study aims to examine the functioning of the river Lima basin, the historical incidence of flooding in the historic town of Ponte de Lima and the potential impacts, vulnerability and exposure on the human and natural environment as well as human adaptation to floods patterns

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection Mycobacterium massiliense clone BRA100 associado a infecções pós-cirúrgicas: resistência a altas concentrações de glutaraldeído e produtos alternativos para desinfecção de alto nível

PURPOSE: To evaluate the minimum inhibitory concentration (MIC) of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD). METHODS: Reference mycobacteria and clinical M. massiliense strains were included in this study. Active cultures were submitted to susceptibility qualitative tests with GTA dilutions (ranging from 1.5% to 8%), and commercial orthophthaldehyde (OPA) and peracetic acid (PA) - based solutions, during the period of exposure as recommended by National Agency of Sanitary Surveillance for HLD. RESULTS: All reference and M. massiliense non-BRA100 strains, recovered from sputum, were susceptible to any GTA concentration, OPA and PA solutions. M. massiliense BRA100 strains presented MIC of 8% GTA and were susceptible to OPA and PA. CONCLUSION: M. massiliense BRA100 strain is resistant to high GTA concentrations (up to 7%), which proves that this product is non-effective against specific rapidly growing mycobacteria and should be substituted by OPA or PA - based solutions for HLD.<br>OBJETIVO: Avaliar a concentração mínima inibitória (CMI) de GTA frente a M. massiliense e a susceptibilidade a produtos alternativos para desinfecção de alto nível (DAN). MÉTODOS: Cepas de M. massiliense de origem clínica e de referência foram incluídas no estudo. As culturas ativadas foram submetidas a testes qualitativos com diluições de GTA (de 1,5% a 8%) e com soluções comerciais de ortoftaldeído (OPA) ou ácido peracético (PA), utilizando os tempos de exposição recomendados pela Agência Nacional de Vigilância Sanitária para DAN. RESULTADOS: Todas as cepas de referência e M. massiliense não-BRA100, obtida de escarro, foram susceptíveis às concentrações de GTA, e soluções de OPA e PA. As cepas de M. massiliense BRA100 apresentaram CMI de 8% para GTA e foram susceptíveis a OPA e PA. CONCLUSÃO: M. massiliense BRA100 é resistente a altas concentrações de GTA (até 7%), o que demonstra que esse composto não é eficaz, e deve ser substituído por OPA ou PA nos processos de DAN

Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A

The yellow fever vaccine (YF17DD) is highly effective with a single injection conferring protection for at least 10 years. The YF17DD induces polyvalent responses, with a TH1/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-&gamma;), culminating in high titers of neutralizing antibodies. Furthermore, C-type lectin domain containing 5A (CLEC5A) has been implicated in innate outcomes in other flaviviral infections. Here, we conducted a follow-up study in volunteers immunized with YF17DD, investigating the humoral response, cellular phenotypes, gene expression, and single nucleotide polymorphisms (SNPs) of IFNG and CLEC5A, to clarify the role of these factors in early response after vaccination. Activation of CLEC5A+ monocytes occurred five days after vaccination (DAV). Following, seven DAV data showed activation of CD4+ and CD8+T cells together with early positive correlations between type II IFN and genes of innate antiviral response (STAT1, STAT2, IRF7, IRF9, OAS1, and RNASEL) as well as antibody levels. Furthermore, individuals with genotypes rs2430561 AT/AA, rs2069718 AG/AA (IFNG), and rs13237944 AC/AA (CLEC5A), exhibited higher expression of IFNG and CLEC5A, respectively. Together, we demonstrated that early IFN-&gamma; and CLEC5A responses, associated with rs2430561, rs2069718, and rs13237944 genotypes, may be key mechanisms in the long-lasting immunity elicited by YF17DD

Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A

The yellow fever vaccine (YF17DD) is highly effective with a single injection conferring protection for at least 10 years. The YF17DD induces polyvalent responses, with a TH1/TH2 CD4+ profile, robust T CD8+ responses, and synthesis of interferon-gamma (IFN-γ), culminating in high titers of neutralizing antibodies. Furthermore, C-type lectin domain containing 5A (CLEC5A) has been implicated in innate outcomes in other flaviviral infections. Here, we conducted a follow-up study in volunteers immunized with YF17DD, investigating the humoral response, cellular phenotypes, gene expression, and single nucleotide polymorphisms (SNPs) of IFNG and CLEC5A, to clarify the role of these factors in early response after vaccination. Activation of CLEC5A+ monocytes occurred five days after vaccination (DAV). Following, seven DAV data showed activation of CD4+ and CD8+T cells together with early positive correlations between type II IFN and genes of innate antiviral response (STAT1, STAT2, IRF7, IRF9, OAS1, and RNASEL) as well as antibody levels. Furthermore, individuals with genotypes rs2430561 AT/AA, rs2069718 AG/AA (IFNG), and rs13237944 AC/AA (CLEC5A), exhibited higher expression of IFNG and CLEC5A, respectively. Together, we demonstrated that early IFN-γ and CLEC5A responses, associated with rs2430561, rs2069718, and rs13237944 genotypes, may be key mechanisms in the long-lasting immunity elicited by YF17DD

DIAGNÓSTICO MOLECULAR DA LEUCEMIA MIELOIDE AGUDA: UMA REVISÃO INTEGRATIVA

A medula óssea é um órgão de grande importância na vida do ser humano. Possui como uma de suas funções a regulação da produção de células sanguíneas, a qual orienta a formação, o desenvolvimento, a distinção e a maturação das células. Este processo ocorre a partir das células-tronco que, por serem indistintas, dispõem da competência de formar diversos tipos celulares e linhagens específicas, como: linfoide e mieloide. O presente trabalho consiste em uma revisão integrativa, no qual tem como objetivo discorrer acerca do diagnóstico molecular da leucemia mieloide aguda, mediante considerações acerca da Reação em Cadeia da Polimerase, do Cariótipo e da Imunofenotipagem, com o intuito de esclarecer a finalidade destes para estudantes e profissionais da área. Trata-se de uma revisão de literatura do tipo integrativa, na qual foi realizada uma pesquisa bibliográfica. O diagnóstico da Leucemia Mieloide Aguda fundamenta-se a partir da anamnese, definindo os sinais e sintomas, associado ao hemograma, o qual deve representar, um número de blastos superior a 20% a cada 200 células, na contagem diferencial no sangue periférico. Para a análise citomorfológica das células blásticas, a classificação Franco-Américo-Britânico era a mais aceita para melhor determinar os subtipos que caracterizam a doença, sendo eles de M0-M7. Todavia, esse procedimento está em desuso e, hoje, outros exames de origem bio molecular, citogenética e imunofenotipagem são mais específicos e estão sendo usados como predileção. Em suma, é possível concluir que os exames empregados para o diagnóstico de leucemia mieloide aguda são fundamentais para sua descoberta

Reply: Genetic polymorphisms and cerebrovascular disease in children with sickle cell anemia from Rio de Janeiro, Brazil

The aim of the present work was to examine possible genetic risk factors related to the occurrence of cerebrovascular disease (CVD) in Brazilian population, the frequency of βS-globin gene haplotypes and co-inheritance with α-thalassemia (-α3.7kb) and single nucleotide polymorphism of methylenetetrahydrofolate reductase (MTHFR-C677T), Factor V Leiden (FV-G1691A) and prothrombin (PT-G20210A) genes in children from Rio de Janeiro. Ninety four children with sickle cell anemia (SCA) were included, 24 patients with cerebrovascular involvement and 70 patients without CVD as control group. The mean age of children at the time of the cerebrovascular event was similar to the control group. The frequency of -α3.7kb thalassemia was similar in both groups (p=0.751). Children with Bantu/Atypical βS-globin gene haplotype presented 15 times more chance (OR=15.4 CI 95% 2.9-81.6) of CVD than the other βS-globin gene haplotypes. The C677T polymorphism of MTHFR gene was similar in both groups (p=0.085). No mutation in the FV Leiden or PT genes was found. A large study seems necessary to establish the role of these genetic polymorphisms in Brazilian miscegenated population