Stroke Survivors Who Score below Threshold on Standard Depression Measures May Still Have Negative Cognitions of Concern

Background and Purpose— There has been an increase in screening for depression in the physically ill. We explored whether important negative cognitions may be missed by conventional approaches to screening for depression in 2 independently conducted stroke studies with similar methods. Methods— The Auckland Regional Community Stroke (ARCOS) study was a prospective, population-based stroke incidence study conducted in Auckland, New Zealand, for 12 months in 2002 to 2003. The Stroke Outcomes Study was a prospective, hospital cohort study conducted in Leeds and Bradford, United Kingdom, for 33 months in 2002 to 2005. Symptoms of abnormal mood were assessed at 6 months in ARCOS with a single simple question, “Do you often feel sad and depressed?” and the 28-item General Health Questionnaire administered as part of a structured interview and in the Stroke Outcomes Study with the 28-item General Health Questionnaire and a single question about depressed mood taken from the Present State Examination. Results— Mood data were available at 6 months from 770 ARCOS and 492 Stroke Outcomes Study participants. A significant proportion (up to 28%) of people who did not meet study criteria for depression reported important negative cognitions such as hopelessness, worthlessness, or suicidality. People who were older, dependent in activities of daily living, or not partnered were more likely to report negative cognitions. Conclusions— Important negative cognitions, including suicidal thoughts, may be missed when people are screened for depression after stroke. Screening alone is not an adequate substitute for a sensitive exploration of the psychological impact of stroke on the survivor

Magnetization Relaxation via Quantum and Classical Vortex Motion in a Bose Glass Superconductor

I show that in Bose Glass superconductor with high $j_c$ and at low $T$ the magnetization relaxation (S), dominated by quantum tunneling, is $\propto{\sqrt j_c}$, which crosses over to the conventional classical rate $\propto T/j_c$ at higher $T$ and lower $j_c$, with the crossover $T^*\sim j_c^{3/2}$. I argue that due to interactions between flux lines there exist three relaxation regimes, depending on whether $BB_\phi$, corresponding to Strongly-pinned Bose Glass (SBG) with large $j_{c2}$, Mott Insulator (MI) with vanishing S, and Weakly-pinned Bose Glass (WBG) characterized by small $j_{c1}$. I discuss the effects of interactions on $j_c$ and focus attention on the recent experiment which is consistently described by the theory.Comment: 4 pages, self-unpacking uuencoded compressed postscript file with figures already inside text; to appear in Phys. Rev. Lett.(1995

Decay of Superflow Confined in Thin Torus: A Realization of Tunneling Quantum Fields

The quantum nucleation of phase slips in neutral superfluids confined in a thin torus is investigated by means of the collective coordinate method. We have devised, with numerical justification, a certain collective coordinate to describe the quantum nucleation process of a phase slip. Considering the quantum fluctuation around the local minimum of the action, we calculate the effective mass of the phase slip. Due to the coherence of the condensate throughout the torus, the effective mass is proportional to the circumference L of the torus, and the decay rate has a strong exponential L-dependence.Comment: 4 pages, 2 figures, REVTe

Quantum vortex creep :Hall and dissipative tunneling

Within the framework of the path-integral approach we study the quantum vortex creep for the situation where both the Hall and the dissipative dynamics are simultaneously present. We calculate the relaxation rate and the crossover temperature separating the thermal activation and the quantum tunneling processes for anisotropic or multilayer superconductors. The results are compared with the available experimental data.Comment: 16 pages, Latex, 2 figures, to appear in Physica

Boundary of two mixed Bose-Einstein condensates

The boundary of two mixed Bose-Einstein condensates interacting repulsively was considered in the case of spatial separation at zero temperature. Analytical expressions for density distribution of condensates were obtained by solving two coupled nonlinear Gross-Pitaevskii equations in cases corresponding weak and strong separation. These expressions allow to consider excitation spectrum of a particle confined in the vicinity of the boundary as well as surface waves associated with surface tension.Comment: 6 pages, 3 figures, submitted to Phys.Rev.

A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase

Background: Equine type 1 polysaccharide storage myopathy (PSSM1) is associated with a missense mutation (R309H) in the glycogen synthase (GYS1) gene, enhanced glycogen synthase (GS) activity and excessive glycogen and amylopectate inclusions in muscle. Methods: Equine muscle biochemical and recombinant enzyme kinetic assays in vitro and homology modelling in silico, were used to investigate the hypothesis that higher GS activity in affected horse muscle is caused by higher GS expression, dysregulation, or constitutive activation via a conformational change. Results: PSSM1-affected horse muscle had significantly higher glycogen content than control horse muscle despite no difference in GS expression. GS activity was significantly higher in muscle from homozygous mutants than from heterozygote and control horses, in the absence and presence of the allosteric regulator, glucose 6 phosphate (G6P). Muscle from homozygous mutant horses also had significantly increased GS phosphorylation at sites 2 + 2a and significantly higher AMPKα1 (an upstream kinase) expression than controls, likely reflecting a physiological attempt to reduce GS enzyme activity. Recombinant mutant GS was highly active with a considerably lower Km for UDP-glucose, in the presence and absence of G6P, when compared to wild type GS, and despite its phosphorylation. Conclusions: Elevated activity of the mutant enzyme is associated with ineffective regulation via phosphorylation rendering it constitutively active. Modelling suggested that the mutation disrupts a salt bridge that normally stabilises the basal state, shifting the equilibrium to the enzyme's active state. General significance: This study explains the gain of function pathogenesis in this highly prevalent polyglucosan myopathy

Microscopic Analysis of the Non-Dissipative Force on a Line Vortex in a Superconductor: Berry's Phase, Momentum Flows and the Magnus Force

A microscopic analysis of the non-dissipative force ${\bf F}_{nd}$ acting on a line vortex in a type-II superconductor at $T=0$ is given. We first examine the Berry phase induced in the true superconducting ground state by movement of the vortex and show how this induces a Wess-Zumino term in the hydrodynamic action $S_{hyd}$ of the superconducting condensate. Appropriate variation of $S_{hyd}$ gives ${\bf F}_{nd}$ and variation of the Wess-Zumino term is seen to contribute the Magnus (lift) force of classical hydrodynamics to ${\bf F}_ {nd}$. This first calculation confirms and strengthens earlier work by Ao and Thouless which was based on an ansatz for the many-body ground state. We also determine ${\bf F}_{nd}$ through a microscopic derivation of the continuity equation for the condensate linear momentum. This equation yields the acceleration equation for the superflow and shows that the vortex acts as a sink for the condensate linear momentum. The rate at which momentum is lost to the vortex determines ${\bf F}_{nd}$ and the result obtained agrees with the Berry phase calculation. The Magnus force contribution to ${\bf F}_{nd}$ is seen to be a consequence of the vortex topology. Preliminary remarks are made regarding finite temperature extensions, with emphasis on its relevance to the sign anomaly occurring in Hall effect experiments done in the flux flow regime.Comment: 40 pages, RevTex, UBCTP-94-00

Spin domain formation in spinor Bose-Einstein condensation

The spatial structure of the spinor Bose-Einstein condensates with the spin degrees of freedom is analyzed based on the generalized Gross-Pitaevskii equation (GP) in the light of the present spin domain experiment on m_F=\pm 1, and 0 of the hyperfine state F=1 of ^{23}Na atom gases. The GP solutions in three- and one-spatial dimensional cases reproduce the observed spin domain structures, revealing the length scale associated with the existence of the weak interaction of the spin-spin channel, other than the ordinary coherence length related to the density-density channel. The obtained domain structure in GP is compared with the result in Thomas-Fermi approximation. The former solution is found to better describe the observed features than the latter.Comment: 9 pages, 14 figure

Zero-temperature phase diagram of binary boson-fermion mixtures

We calculate the phase diagram for dilute mixtures of bosons and fermions at zero temperature. The linear stability conditions are derived and related to the effective boson-induced interaction between the fermions. We show that in equilibrium there are three possibilities: a) a single uniform phase, b) a purely fermionic phase coexisting with a purely bosonic one and c) a purely fermionic phase coexisting with a mixed phase.Comment: 8 pages, revtex, 3 postscript figures; NORDITA-1999/71 C