2,418 research outputs found
National Autism Indicators Report: Vocational Rehabilitation 2016
Employment is about more than simply earning a paycheck - it influences quality of life, independence, and wellness. Historically, employment outcomes for adults with autism are poor. The U.S. Vocational Rehabilitation system (VR) is designed to provide support to states for implementation of services to assist people with disabilities to prepare for, find, and keep employment. VR data allow us to examine some outcomes for those with autism compared to their peers.To make a difference, research must reach those who need it. The National Autism Indicators Report series presents our research findings in a clearly communicated, open-access, online format to speed the delivery of information to decision-makers while maintaining very high standards of scientific credibility
National Autism Indicators Report: Transition into Young Adulthood
There is very little research published concerning how people with autism do in the adult portion of their lifespans. We analyzed data from "The National Longitudinal Transition Study-2" and "The Survey of Pathways to Diagnosis and Services" to examine the service needs and life outcomes of adolescents and young adults on the autism spectrum. This report describes the prevalence of a wide variety of indicators related to transition planning, services access, unmet needs, employment, postsecondary education, living arrangements, social participation, and safety and risk
The Mitospecific Domain of Mrp7 (bL27) Supports Mitochondrial Translation during Fermentation and is Required for Effective Adaptation to Respiration
We demonstrate here that mitoribosomal protein synthesis, responsible for the synthesis of oxidative phosphorylation (OXPHOS) subunits encoded by the mitochondrial genome, occurs at high levels during glycolysis fermentation and in a manner uncoupled from OXPHOS complex assembly regulation. Furthermore, we provide evidence that the mitospecific domain of Mrp7 (bL27), a mitoribosomal component, is required to maintain mitochondrial protein synthesis during fermentation but is not required under respiration growth conditions. Maintaining mitotranslation under high-glucose-fermentation conditions also involves Mam33 (p32/gC1qR homologue), a binding partner of Mrp7’s mitospecific domain, and together they confer a competitive advantage for a cell’s ability to adapt to respiration-based metabolism when glucose becomes limiting. Furthermore, our findings support that the mitoribosome, and specifically the central protuberance region, may be differentially regulated and/or assembled, under the different metabolic conditions of fermentation and respiration. On the basis of our findings, we propose that the purpose of mitotranslation is not limited to the assembly of OXPHOS complexes, but also plays a role in mitochondrial signaling critical for switching cellular metabolism from a glycolysis- to a respiration-based state
The Arches Cluster: Extended Structure and Tidal Radius
At a projected distance of ~26 pc from Sgr A*, the Arches cluster provides
insight to star formation in the extreme Galactic Center (GC) environment.
Despite its importance, many key properties such as the cluster's internal
structure and orbital history are not well known. We present an astrometric and
photometric study of the outer region of the Arches cluster (R > 6.25") using
HST WFC3IR. Using proper motions we calculate membership probabilities for
stars down to F153M = 20 mag (~2.5 M_sun) over a 120" x 120" field of view, an
area 144 times larger than previous astrometric studies of the cluster. We
construct the radial profile of the Arches to a radius of 75" (~3 pc at 8 kpc),
which can be well described by a single power law. From this profile we place a
3-sigma lower limit of 2.8 pc on the observed tidal radius, which is larger
than the predicted tidal radius (1 - 2.5 pc). Evidence of mass segregation is
observed throughout the cluster and no tidal tail structures are apparent along
the orbital path. The absence of breaks in the profile suggests that the Arches
has not likely experienced its closest approach to the GC between ~0.2 - 1 Myr
ago. If accurate, this constraint indicates that the cluster is on a prograde
orbit and is located front of the sky plane that intersects Sgr A*. However,
further simulations of clusters in the GC potential are required to interpret
the observed profile with more confidence.Comment: 24 pages (17-page main text, 7-page appendix), 24 figures, accepted
to Ap
The Quintuplet Cluster: Extended Structure and Tidal Radius
The Quintuplet star cluster is one of only three known young ( Myr)
massive (M M) clusters within pc of the Galactic
Center. In order to explore star cluster formation and evolution in this
extreme environment, we analyze the Quintuplet's dynamical structure. Using the
HST WFC3-IR instrument, we take astrometric and photometric observations of the
Quintuplet covering a field-of-view, which is times
larger than those of previous proper motion studies of the Quintuplet. We
generate a catalog of the Quintuplet region with multi-band, near-infrared
photometry, proper motions, and cluster membership probabilities for
stars. We present the radial density profile of candidate Quintuplet
cluster members with M out to pc from the cluster
center. A lower limit of pc is placed on the tidal radius,
indicating the lack of a tidal truncation within this radius range. Only weak
evidence for mass segregation is found, in contrast to the strong mass
segregation found in the Arches cluster, a second and slightly younger massive
cluster near the Galactic Center. It is possible that tidal stripping hampers a
mass segregation signature, though we find no evidence of spatial asymmetry.
Assuming that the Arches and Quintuplet formed with comparable extent, our
measurement of the Quintuplet's comparatively large core radius of
pc provides strong empirical evidence that young massive
clusters in the Galactic Center dissolve on a several Myr timescale.Comment: 25 pages (21-page main text, 4-page appendix), 18 figures, submitted
to Ap
Circumstellar discs in Galactic centre clusters: Disc-bearing B-type stars in the Quintuplet and Arches clusters
We investigate the circumstellar disc fraction as determined from L-band
excess observations of the young, massive Arches and Quintuplet clusters
residing in the central molecular zone of the Milky Way. The Quintuplet cluster
was searched for L-band excess sources for the first time. We find a total of
26 excess sources in the Quintuplet cluster and 21 in the Arches cluster, of
which 13 are new detections. With the aid of proper motion membership samples,
the disc fraction of the Quintuplet cluster was derived for the first time to
be 4.0 +/- 0.7%. There is no evidence for a radially varying disc fraction in
this cluster. In the case of the Arches cluster, a disc fraction of 9.2 +/-
1.2% approximately out to the cluster's predicted tidal radius, r < 1.5 pc, is
observed. This excess fraction is consistent with our previously found disc
fraction in the cluster in the radial range 0.3 < r < 0.8 pc. In both clusters,
the host star mass range covers late A- to early B-type stars, 2 < M < 15 Msun,
as derived from J-band photospheric magnitudes. We discuss the unexpected
finding of dusty circumstellar discs in these UV intense environments in the
context of primordial disc survival and formation scenarios of secondary discs.
We consider the possibility that the L-band excess sources in the Arches and
Quintuplet clusters could be the high-mass counterparts to T Tauri
pre-transitional discs. As such a scenario requires a long pre-transitional
disc lifetime in a UV intense environment, we suggest that mass transfer discs
in binary systems are a likely formation mechanism for the B-star discs
observed in these starburst clusters.Comment: 47 pages, 22 figures, accepted by A&
Spatial disparities in the reported incidence and survival of myeloproliferative neoplasms in Australia
Acknowledgments:The authors wish to thank the MPN Alliance Australia for motivating this study and financial support. We would also like to thank the reviewers for their helpful comments. Funding: was provided by the MPN Alliance Australia. The MPN Alliance Australia did not play any role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.Peer reviewedPostprintPostprintPostprin
Toward Automation of the Supine Pressor Test for Preeclampsia
Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism. In this study, we first used a murine model to investigate the pathophysiology of left renal vein constriction. The results indicate that prolonged renal vein stenosis after 14 days can cause renal necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second part of this study aimed to automate a diagnostic tool, known as the supine pressor test (SPT), to enable pregnant women to assess their preeclampsia development risk. A positive SPT has been previously defined as an increase of at least 20 mmHg in diastolic BP when switching between left lateral recumbent and supine positions. The results from this study established a baseline BP increase between the two body positions in nonpregnant women and demonstrated the feasibility of an autonomous SPT in pregnant women. Our results demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and that pregnant women can autonomously perform the SPT. Overall, this work in both rodents and humans suggests that (1) stenosis of the left renal vein in mice leads to elevation in BP and acute renal failure, (2) nonpregnant women experience a baseline increase in BP when they shift from left lateral recumbent to supine position, and (3) the SPT can be automated and used autonomously
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