“Friends Are Thieves of Time": Heuristic Attention Sharing in Stable Friendship Networks

This paper studies a model of network formation in which agents create links following a simple heuristic -- they invest their limited resources proportionally more in neighbours who have fewer links. This decision rule captures the notion that when considering social value more connected agents are on average less beneficial as neighbours and node degree is a useful proxy when payoffs are difficult to compute. The decision rule illustrates an externalities effect whereby an agent's actions also influence his neighbours' neighbours. Besides complete networks and fragmented networks with complete components, the pairwise stable networks produced by this model include many non-standard ones with characteristics observed in real life networks like clustering and irregular components. Multiple stable states can develop from the same initial structure -- the stable networks could have cliques linked by intermediary agents while sometimes they have a core-periphery structure. The observed pairwise stable networks have close to optimal welfare. This limited loss of welfare is due to the fact that when a link is established, this is beneficial to the linking agents, but makes them less attractive as neighbours for others, thereby partially internalising the externalities the new connection has generated

Persuading communicating voters

This paper studies a multiple-receiver Bayesian persuasion model, where a sender communicates with receivers who have homogeneous beliefs and aligned preferences. The sender wants to implement a proposal and commits to a communication strategy which sends private (possibly) correlated messages to the receivers, who are in an exogenous and commonly known network. Receivers can observe their neighbors’ private messages and after updating their beliefs, vote sincerely on the proposal. We examine how networks of shared information affect the sender’s gain from persuasion and find that in many cases it is not restricted by the additional information provided by the receivers’ neighborhoods. Perhaps surprisingly, the sender’s gainfrom persuasion is not monotonically decreasing with the density of the network

Introduction of a simple experiment for the undergraduate organic chemistry laboratory demonstrating the Lewis acid and shape-selective properties of zeolite Na-Y

A simple, inexpensive, discovery-based experiment for undergraduate organic laboratories has been developed that demonstrates the Lewis acid and shape-selective properties of zeolites. Calcined zeolite Na-Y promotes the electrophilic aromatic bromination of toluene with a significantly higher para/ortho ratio than observed under conventional conditions. The experiment can be completed in one three-hour laboratory period. The zeolite can be recovered and regenerated for later reuse. A broad range of organic course topics from orientation in electrophilic aromatic substitution to photochemistry can be discussed

Directed Reciprocity Subverts Altruism in Highly Adaptive Populations

Directed reciprocity is generally considered to be a powerful driver for cooperation. Using extensive simulations within an established stylized framework, we test the strength of this relationship. We confirm that directed reciprocity boosts cooperation, but only in the case of relatively inert populations. For highly adaptive populations we find the opposite: directed reciprocity impedes cooperation

Directed Reciprocity Subverts Altruism in Highly Adaptive Populations

Directed reciprocity is generally considered to be a powerful driver for cooperation. Using extensive simulations within an established stylized framework, we test the strength of this relationship. We confirm that directed reciprocity boosts cooperation, but only in the case of relatively inert populations. For highly adaptive populations we find the opposite: directed reciprocity impedes cooperation

Enabling Technologies for the Future of Chemical Synthesis.

Technology is evolving at breakneck pace, changing the way we communicate, travel, find out information, and live our lives. Yet chemistry as a science has been slower to adapt to this rapidly shifting world. In this Outlook we use highlights from recent literature reports to describe how progresses in enabling technologies are altering this trend, permitting chemists to incorporate new advances into their work at all levels of the chemistry development cycle. We discuss the benefits and challenges that have arisen, impacts on academic-industry relationships, and future trends in the area of chemical synthesis.We are grateful to the Woolf Fisher Trust (D.E.F), Syngenta Crop Protection AG (C.B.) and EPSRC (S.V.L., grant codes EP/K009494/1, EP/M004120/1 and EP/K039520/1) for financial assistance.This is the final version of the article. It first appeared from the American Chemical Society via https://doi.org/10.1021/acscentsci.6b0001

Bridging Innate and Adaptive Antitumor Immunity Targeting Glycans

Effective immunotherapy for cancer depends on cellular responses to tumor antigens. The role of major histocompatibility complex (MHC) in T-cell recognition and T-cell receptor repertoire selection has become a central tenet in immunology. Structurally, this does not contradict earlier findings that T-cells can differentiate between small hapten structures like simple glycans. Understanding T-cell recognition of antigens as defined genetically by MHC and combinatorially by T cell receptors led to the “altered self” hypothesis. This notion reflects a more fundamental principle underlying immune surveillance and integrating evolutionarily and mechanistically diverse elements of the immune system. Danger associated molecular patterns, including those generated by glycan remodeling, represent an instance of altered self. A prominent example is the modification of the tumor-associated antigen MUC1. Similar examples emphasize glycan reactivity patterns of antigen receptors as a phenomenon bridging innate and adaptive but also humoral and cellular immunity and providing templates for immunotherapies

The dark side of biomass valorization: A laboratory experiment to understand humins formation, catalysis and green chemistry

This laboratory experiment introduces students to an important reaction in biomass valorization and allows them to gain a practical understanding of green chemistry. Acid-catalyzed dehydration reactions of fructose to 5-hydroxymethylfurfural and thus humins were performed both with and without aqueous solvent, along with two different catalysts (Amberlyst-15 and alumina). Students were able to compare and analyze the effects of these different conditions using thin-layer chromatography, while grasping concepts of catalysis and circular economy. By observing the formation of humins under some of the reactions tested, the students could evidence systems thinking in humin valorization

Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis