Civil aircraft advanced avionics architectures - an insight into saras avionics, present and future perspective

Traditionally, the avionics architectures being implemented are of federated nature, which means that each avionics function has its own independent, dedicated fault-tolerant computing resources. Federated architecture has great advantage of inherent fault containment and at the same time envelops a potential risk of massive use of resources resulting in increase in weight, looming, cost and maintenance as well. With the drastic advancement in the computer and software technologies, the aviation industry is gradually moving towards the use of Integrated Modular Avionics (IMA) for civil transport aircraft, potentially leading to multiple avionics functions housed in each hardware platform. Integrated Modular Avionics is the most important concept of avionics architecture for next generation aircrafts. SARAS avionics suite is purely federated with almost glass cockpit architecture complying to FAR25. The Avionics activities from the inception to execution are governed by the regulations and procedures under the review of Directorate General of Civil Aviation (DGCA). Every phase of avionics activity has got its own technically involvement to make the system perfect. In addition the flight data handling, monitoring and analysis is again a thrust area in the civil aviation industry leading to safety and reliability of the machine and the personnel involved. NAL has been in this area for more than two decades and continues to excel in these technologies

Report of Acoustic Test on PSLV IS.1/2L Structure

The results of acoustic conducted on PSLV IS.1/2L at Acoustic Test Facility are briefly given. It contains test set up, Instrumentation details and tables of spectral response

Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study

<p>Abstract</p> <p>Background</p> <p>Despite being the most commonly used herbal for sleep disorders, chamomile's (<it>Matricaria recutita</it>) efficacy and safety for treating chronic primary insomnia is unknown. We examined the preliminary efficacy and safety of chamomile for improving subjective sleep and daytime symptoms in patients with chronic insomnia.</p> <p>Methods</p> <p>We performed a randomized, double-blind, placebo-controlled pilot trial in 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months. Patients were randomized to 270 mg of chamomile twice daily or placebo for 28-days. The primary outcomes were sleep diary measures. Secondary outcomes included daytime symptoms, safety assessments, and effect size of these measures.</p> <p>Results</p> <p>There were no significant differences between groups in changes in sleep diary measures, including total sleep time (TST), sleep efficiency, sleep latency, wake after sleep onset (WASO), sleep quality, and number of awakenings. Chamomile did show modest advantage on daytime functioning, although these did not reach statistical significance. Effect sizes were generally small to moderate (Cohen's <it>d </it>≤ 0.20 to < 0.60) with sleep latency, night time awakenings, and Fatigue Severity Scale (FSS), having moderate effect sizes in favor of chamomile. However, TST demonstrated a moderate effect size in favor of placebo. There were no differences in adverse events reported by the chamomile group compared to placebo.</p> <p>Conclusion</p> <p>Chamomile could provide modest benefits of daytime functioning and mixed benefits on sleep diary measures relative to placebo in adults with chronic primary insomnia. However, further studies in select insomnia patients would be needed to investigate these conclusions.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov Identifier <a href="http://www.clinicaltrials.gov/ct2/show/NCT01286324">NCT01286324</a></p

Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study

In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out. Copeptin improves risk stratification in several acute diseases. Herein, we investigated the value of copeptin to discriminate between serious secondary headache and benign headache forms in the emergency setting.; Patients presenting with acute non-traumatic headache were prospectively enrolled into an observational cohort study. Copeptin was measured upon presentation to the emergency department. Primary endpoint was serious secondary headache defined by a neurologic cause requiring immediate treatment of the underlying disease. Secondary endpoint was the combination of mortality and hospitalization within 3 months. Two board-certified neurologist blinded to copeptin levels verified the endpoints after a structured 3-month-telephone interview.; Of the 391 patients included, 75 (19%) had a serious secondary headache. Copeptin was associated with serious secondary headache (OR 2.03, 95%CI 1.52-2.70, p &lt; 0.0001). Area under the curve (AUC) for copeptin to identify the primary endpoint was 0.70 (0.63-0.76). After adjusting for age &gt; 50, focal-neurological abnormalities, and thunderclap onset of symptoms, copeptin remained an independent predictive factor for serious secondary headache (OR 1.74, 95%CI 1.26-2.39, p = 0.001). Moreover, copeptin improved the AUC of the multivariate logistic clinical model (p-LR-test &lt; 0.001). Even though copeptin values were higher in patients reaching the secondary endpoint, this association was not significant in multivariate logistic regression.; Copeptin was independently associated with serious secondary headache as compared to benign headaches forms. Copeptin may be a promising novel blood biomarker that should be further validated to rule out serious secondary headache in the emergency department.; Study Registration on 08/02/2010 as NCT01174901 at clinicaltrials.gov

Association between Selected Oral Pathogens and Gastric Precancerous Lesions

We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87–2.12), P. gingivalis (OR = 1.12, 0.67–1.88) and T. denticola (OR = 1.34, 0.83–2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13–5.56) among those with ≥ median of percent tooth sites with PD≥3 mm, compared with no association among those below the median (OR = 0.86, 0.43–1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03–0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2-oxoglutarate-dependent dioxygenases. Both metabolite enantiomers, R- and S-2-hydroxyglutarate, are detectible in healthy individuals, yet their physiological function remains elusive. Here we show that 2-hydroxyglutarate accumulates in mouse CD8+ T cells in response to T-cell receptor triggering, and accumulates to millimolar levels in physiological oxygen conditions through a hypoxia-inducible factor 1-alpha (HIF-1α)-dependent mechanism. S-2-hydroxyglutarate predominates over R-2-hydroxyglutarate in activated T cells, and we demonstrate alterations in markers of CD8+ T-cell differentiation in response to this metabolite. Modulation of histone and DNA demethylation, as well as HIF-1α stability, mediate these effects. S-2-hydroxyglutarate treatment greatly enhances the in vivo proliferation, persistence and anti-tumour capacity of adoptively transferred CD8+ T cells. Thus, S-2-hydroxyglutarate acts as an immunometabolite that links environmental context, through a metabolic-epigenetic axis, to immune fate and function

Re-configurable avionics architecture algorithm for embedded applications

The paper presents a new method for re-configuration of tasks or a process in an embedded avionics application. The13; proposed algorithm works based on four control parameters: re-configurability Information factor, Schedulability13; Test/TL/UF, Context Adaptability/suitability and Context Flight Safety. The algorithm is data centric and interfaces13; system health as control input and initiation of the re-configuration is only after successful evaluation of the parameter metrics. It enhances the availability and reliability of the system under failed conditions by efficient selection and procedural re-configuration with safe state exit. The advantage of the new approach over the non-configurable systems is the increased availability of flight critical applications under failed conditions. It also preserves the advantages of non-Reconfigurable systems over federated architecture. Invalid failure of control parameter brings the system to safe state. The scheme, algorithm and the control parameters metrics and their validation approach are described. The algorithm is13; novel in terms of dynamic re-configuration compared to existing static avionics architectur

Civil Aircraft Advanced Avionics Architecutres - An Insight Into Saras Avionics, Present and Future Perspective13;

Traditionally, the avionics architectures being implemented are of federated nature, which means that each avionics function has its own independent, dedicated fault-tolerant computing resources. Federated architecture has great advantage of inherent fault containment and at the same time envelops a potential risk of massive use of resources resulting in increase in weight, looming,13; cost and maintenance as well.13; With the drastic advancement in the computer and software13; technologies, the aviation industry is gradually moving towards the use of Integrated Modular Avionics(IMA) for civil transport aircraft, potentially leading to multiple avionics functions housed in each hardware platform. Integrated Modular Avionics is the most important13; concept of avionics architecture for next generation aircrafts. SARAS avionics suite is purely federated with almost glass cockpit architecture complying to FAR25. The Avionics activities from the inception to execution are governed by the regulations and procedures under the review of Directorate General of Civil Aviation(DGCA). Every phase of avionics activity has got its own technically involvement to make the system perfect.13; In addition the flight data handling, monitoring and analysis is again a thrust area in the civil aviation industry leading to safety and reliability of the machine and the personnel involved. NAL has been in this area for more than two decades and continues to excel in13; these technologies

Validation of control parameters for a re-configurable algorithm in a flight critical avionics application

Earlier generation avionics, federated architecture (FA) is used where each function has its own independent, dedicated fault-tolerant computing resources. To overcome few disadvantages of federated architecture, NAL had developed and proposed a re-configurable algorithm for avionics flight13; critical software applications under integrated time and memory partitioned applications. The algorithm13; uses four control parameters, which define the re-configurable state of the system in real time. It also13; preserves the advantages of non-Reconfigurable systems over federated architecture. The availability of13; the avionics applications increases substantially with the use of this new algorithm13; The paper presents a detailed validation process, methodology and data dictionary for control parameters13; namely: re-configurability Information factor, Schedulability Test/TL/UF, Context13; Adaptability/suitability and Context Flight Safety. The algorithm is data centric and interfaces system13; health as control input and initiation of the re-configuration is only after successful evaluation of the13; parameter metrics. The control parameters are validated against the statistical data generated based on the13; system design analysis like FMEA, FHA, SSA and the basic architecture of the system. Since the control13; parameters define the re-configuration state, it is very critical to verify and validate the correctness of the13; control. Parameter characteristic data as it leads to critical action in flight. This enhances the availability13; and reliability of the system under failed conditions by efficient selection and procedural re-configuration13; with safe state exit. Invalid failure of control parameter validation brings the system to safe state. The13; scheme, algorithm and the control parameters validation metrics and their validation approach are13; described with experimentation using VxWorks environment