7 research outputs found
Skin Cancer Detection and Classification
- Publication venue
- 'Vandana Publications'
- Publication date
- 30/04/2019
- Field of study
Skin cancer is a term given to the uncontrolled growth of strange skin cells. It occurs whenever unrepaired DNA damages to skin cells trigger mutations, or any other genetic defects, that lead the skin cells to multiply readily and form malignant tumors. Image processing is a commonly used method for skin cancer detection from the appearance of the affected area on the skin. The input to the system is that the skin lesion image so by applying novel image process techniques, it analyses it to conclude about the presence of skin cancer. The Lesion Image analysis tools checks for the various Melanoma parameters Like Asymmetry, Border, Colour, Diameter, (ABCD rule), etc. by texture, size and form analysis for image segmentation and have stages. The extracted feature parameters are accustomed classify the image as traditional skin and malignant melanoma cancerlesion. Artificial Neural Network (ANN) is one of the important branches of Artificial Intelligence, which has been accepted as a brand-new technology in computer science for image processing. Neural Networks is currently the area of interest in medicine, particularly in the fields of radiology, urology, cardiology, oncology, etc. Neural Network plays a vital role in an exceedingly call network. It has been used to analyze Melanoma parameters Like Asymmetry, Border, Colour, Diameter, etc. which are calculated using MATLAB from skin cancer images intending to developing diagnostic algorithms that might improve triage practices in the emergency department. Using the ABCD rules for melanoma skin cancer, we use ANN in the classification stage. Initially, we train the network with known target values. The network is well trained with 96.9% accuracy, and then the unknown values are tested for the cancer classification. This classification method proves to be more efficient for skin cancer classification
HOW SAFE ARE OUR BABIES? AN IN-SIGHT ON EFFECT OF BISPHENOL A (BPA) ON DEVELOPMENT
- Publication venue
- 'Society of Pharmaceutical Tecnocrats'
- Publication date
- 14/01/2014
- Field of study
Globally anthropogenic materials have replaced natural materials. These substances which were industrially useful have proved to be highly deleterious in recent decade. One of these compound is Bisphenol A (BPA), which is used in almost all food cans and containers. This paper focus on little known aspects of BPA which is an endocrine disruptor on oogenesis, gene implants, embryo development, mammary glands, prostate ,testis urethra. Exposure to even small concentrations of BPA have shown severe impact on different stages of embryo development. The behaviour modifications as well as carcinogenic effects are also discussed based on the studies on various animal models. Keywords: Bisphenol A, Leaching, Endocrine disruptor, Development, Carcinogenicity
INVESTIGATION ON THE EFFECTIVENESS OF PROBIOTIC MICROBIOTA ON CANCER
- Publication venue
- MB International Media and Publishing House
- Publication date
- 31/05/2021
- Field of study
Cancer is the one of the deadly menace diseases with high medical significance which remains one of the keys that causes ailments and death, the security and firmness of the typical chemotherapeutics drugs and artificial agents used to accomplish cancer are doubtful now a days. These mediators affect the quality of life or sometimes they causative for progress of drug resistance and are not judicious to the majority of the patients So the clinical management of the cancer with high efficiency can done with the probiotic microbiota. An imbalance in the gut microbiota promotes the progress of carcinogenesis through several mechanisms, including inflammation, initiation of carcinogens, and tumorigenic pathways as well. In vivo and molecular studies have exhibited the support to role of probiotics in cancer. Probiotic agents are live microbes or components of microbes that have a positive effect on the host. They exert their action through interaction with the immune system of the host. Some of this effect is localized and some is in improvement in total body system. The Probiotic bacteria are the live microorganisms that, when directed in acceptable amounts, deliberate a healthy benefit on the host, and they have been considered for their protective anti-tumour effects. This review emphases on the role of probiotic microbiota as substitute for the prevention and treatment of cancer in the relation between gut microbiota and the progress of cancer
Bacterial Pathogenesis in Various Fish Diseases: Recent Advances and Specific Challenges in Vaccine Development
- Publication venue
- MDPI AG
- Publication date
- 01/02/2023
- Field of study
Aquaculture is a fast-growing food sector but is plagued by a plethora of bacterial pathogens that infect fish. The rearing of fish at high population densities in aquaculture facilities makes them highly susceptible to disease outbreaks, which can cause significant economic loss. Thus, immunity development in fish through vaccination against various pathogens of economically important aquaculture species has been extensively studied and has been largely accepted as a reliable method for preventing infections. Vaccination studies in aquaculture systems are strategically associated with the economically and environmentally sustainable management of aquaculture production worldwide. Historically, most licensed fish vaccines have been developed as inactivated pathogens combined with adjuvants and provided via immersion or injection. In comparison, live vaccines can simulate a whole pathogenic illness and elicit a strong immune response, making them better suited for oral or immersion-based therapy methods to control diseases. Advanced approaches in vaccine development involve targeting specific pathogenic components, including the use of recombinant genes and proteins. Vaccines produced using these techniques, some of which are currently commercially available, appear to elicit and promote higher levels of immunity than conventional fish vaccines. These technological advancements are promising for developing sustainable production processes for commercially important aquatic species. In this review, we explore the multitude of studies on fish bacterial pathogens undertaken in the last decade as well as the recent advances in vaccine development for aquaculture
Students' participation in collaborative research should be recognised
- Author
- Aashay Vaidya
- Abbas Palkhi
- Abdul Badran
- Abdulmajid Ali
- Abdurrahman Islim
- Abhi Sharma
- Abhishek Chitnis
- Abiola Adeogun
- Abraham Francis
- Ace Mcdermott
- Adam Gwozdz
- Adam Williams
- Adeeb Naasan
- Aditya Borakati
- Aditya Kale
- Adnan Ali
- Adreana Zulkifli
- Ahmad Chaudhry
- Ahmed Daoub
- Ahmed Hassane
- Ahmed Kerwan
- Ahmed Soualhi
- Aidan Mellan
- Ailin Rogers
- Aishah Azri Yahaya
- Ajay Mohite
- Ajit Kishore
- Akashdeep Dhillon
- Alec Engledow
- Alejandro Marcos Rodrigo
- Alethea Tang
- Alex Boddy
- Alex Fowler
- Alex Rogers
- Alex von Roon
- Alex Ward
- Alex Wilkins
- Alexa Lazarou
- Alexander Baldwin
- Alexander Light
- Alexander Mehta
- Alexander Smith
- Alexandra Thatcher
- Alexandra Urquhart
- Alexandros Charalabopoulos
- Ali Ghaffar
- Alia Al-Mousawi
- Alice Castle
- Alice Mortimer
- Alice Ormrod
- Alisha Burman
- Alison Downey
- Aliya Mackenzie
- Amanda Gilbert
- Ameer Mustafa
- Ameerah Mohd Azmilssss
- Amina Bhatti
- Amir Afzul
- Amirul Adlan
- Amogh Patil
- Amy Burrows
- Amy Campbell
- Amy Hough
- Amy Pendrill
- Ana Catarina Pinho-Gomes
- Anand Alagappan
- Anand Radhakrishnan
- Anant Sinha
- Andrea Gonzalez-Ciscar
- Andreas Luhmann
- Andrew Ang
- Andrew Atayi
- Andrew Beamish
- Andrew Gaukroger
- Andrew Logan
- Andrew Simon
- Andrew Williamson
- Andrew Wilson
- Aneel Bhangu
- Angela Yan
- Angelos G. Kolias
- Angus McNair
- Angus Radford
- Angus Watson
- Aniket Sonsale
- Aniruddh Shenoy
- Anita Bolina
- Anna Betts
- Anna Craig-Mcquaide
- Anna Kinsella
- Anna Kolodziejczyk
- Anna Parry
- Anne Karunatilleke
- Ansh Radotra
- Anusha Prem Kumar
- Apar Shah
- Aparnah Sureshkumar
- Apoorva Khajuria
- Arachchige Ponweera
- Arathi Menon
- Ardit Begaj
- Areej Abdel-Fattah
- Arham Qureshi
- Aria Rahem
- Arin Saha
- Arpan Doshi
- Arun Nair
- Aseem Mishra
- Ashleigh Draper
- Ashni Kheterpal
- Ashveen Gill
- Ashwin Suri
- Awad Shamali
- Ayushah Khan
- Azelea Rushd
- Behrad Barmayehvar
- Belinda Hughes
- Ben Cresswell
- Ben Murphy
- Ben Murphy
- Ben Roberts
- Ben Stubbs
- Beniamino Forte
- Benjamin France
- Benjamin Ng
- Beth Taylor
- Bhangu
- Bharpoor Singh
- Bhavi Patel
- Bhavi Patel
- Bhavik Patel
- Bilal Alkhaffaf
- Bilal Ibrahim
- Bill Campbell
- Bill Campbell
- Bradley Storey
- Brendan Skelly
- Brooke Powell
- Bryony Peiris
- Byron Lu Morrell
- Caitlin Billyard
- Caoimhe Murray
- Carey Girling
- Carla White
- Caroline Baillie
- Caroline Osborne
- Cathal McCarthy
- Cathleen Grossart
- Chaamanti Sivakumar
- Chandan Sanghera
- Chantal Patel
- Chapman
- Charlotte Grieco
- Charlotte Horseman
- Charlotte Phillips
- Charlotte Roberts
- Charlotte Smith
- Chern Choy
- Chetan Khatri
- Chia Yew Kong
- Chinomso Ogbuokiri
- Chloe Roy
- Chloe Searle
- Chris Laing
- Chris Manson
- Chris Thompson
- Christianne Guillotte
- Christopher Blore
- Christopher Graham
- Christos Episkopos
- Chuanyu Gao
- Ciaran Doehrty
- Ciaran Murphy
- Cissy Yong
- Claire Guy
- Claire Joyner
- Claudia Ciurleo
- Clementina Calabria
- Colin Peirce
- Cong Luo
- Connor Barker
- Connor Bruce
- Conor Jones
- Conor Magee
- Conor Mccann
- Constantine Halkias
- Courtney Johnson
- Damien Brown
- Damien Salekin
- Daniah Thomas
- Daniel Cave
- Daniel Fletcher
- Daniel George
- Daniel Guerero
- Daniel Weinberg
- Danielle Banfield
- David Bartlett
- David Bosanquet
- David Gold
- David Golding
- David Henshall
- David Holroyd
- David Messenger
- Dee Varma
- Denise Kelly
- Denisha Ramjas
- Dermot Burke
- Diana Lim
- Dilan Joshi
- Dimitri Pournaras
- Dimitrios Karponis
- Dinisha Patel
- Divya Ramakrishnan
- Dmitri Nepogodiev
- Dominic Waugh
- Donald Menzies
- Donald Nyanhongo
- Doug Bowley
- Doug McKechnie
- Duncan Rutherford
- E. Mclean
- E. Tian Tan
- Eda Yardimci
- Edemanwan Andah
- Edward Balai
- Edward Cope
- Edward Karam
- Edward Leung
- Eleanor Cartwright
- Elisabeth Hall
- Elizabeth Hester
- Elizabeth McLennan
- Elizabeth Sharkey
- Ellen James
- Elliot Brown
- Ellis Rea
- Elspeth Cumber
- Emezie Okorocha
- Emily Birkin
- Emily Briggs
- Emily Budd
- Emily Davies
- Emily Heywood
- Emily Heywood
- Emma Das
- Emma Griffiths
- Emma Hamilton
- Emma Sanders
- Emma-Jane Jones
- Emmet Mccann
- Esha Arora
- Esha Prakash
- Eshen Ang
- Esther Wright
- Ethan Toner
- Eve Lancaster
- Evelina Woin
- Evelyn Fennelly
- Ewen Griffiths
- Ewen M. Harrison
- Ezgi Ozcan
- Faisal Mahmood
- Fatima Mansour
- Fiyin Babatunde
- Fiza Ahmed
- Frances Hill
- Francesco Giovinazzo
- Francesco Palazzo
- Frank McDermott
- Gabriel Lee
- Gabriella Morley
- Gabrielle Vernet
- Gagira Mudalige
- Gareth Davies
- Gargi Pandey
- Gary Nicholson
- Gayathri Bhaskaran
- Geeta Kaur
- Geev Kumaran
- Gemma Nixon
- George Hourston
- George Miller
- George Ninkovic-Hall
- George Petrov
- George Ramsay
- Georgia Irene Neophytou
- Georgia Mclachlan
- Georgina Laing
- Gethin Williams
- Gijs van Boxel
- Gillian Mccoll
- Ginimol Mathew
- Godwin Tong
- Gordon McFarlane
- Grace Carr
- Grace Pike
- Grace Pike
- Grace Roberts
- Graham Branagan
- Greg Mcconaghie
- Guat Ng
- Gurpreet Beghal
- Gurvinder Singh Harbhajan Singh
- Hadyn Kankam
- Hamdi Ebdewi
- Hamzah Khan
- Hannah Marsden
- Hannah Mownah
- Hannah Murray
- Hannah Turley
- Hansen Li
- Hanzla Naeem
- Harkiran Sagoo
- Harkiran Seehra
- Haroon Khan
- Harpreet Kaur Sekhon Inderjit Singh
- Harry Blege
- Harry Fitzpatrick
- Harry Heath
- Harry King
- Harry Robinson
- Harry Spiers
- Hasseb Hamid
- Haweya Abdikadir
- Helen Cui
- Helen Hawkins
- Helen Puddy
- Helena Adjei
- Henal Desai
- Henry Claireaux
- Hiral Jhala
- Holly Joyce
- Holly Wilson
- Hosam Aglan
- Howard Stringer
- Huai Ling Tan
- Hugh Furness
- Hugh O'Sullivan
- Hui Lim
- Huma Hosamuddin
- Hussamuddin Adwan
- Hyder Tahir
- Ian Daniels
- Ibrahim Yasin
- Imogen Hutchings
- Imran Siddiqui
- Inioluwa Adelaja
- Iona Lyell
- Isabel FitzGerald
- Isabel Huppatz
- Ishani Seth
- Ismael Yasin
- J. Edward Fitzgerald
- J. Singh
- Jacinthe Willson
- Jack Lowe-Zinola
- Jacob Edwards
- Jacob Matthews
- Jalal Moradzadeh
- Jamal Ghaddar
- Jameel Mushtaq
- James Archer
- James Daniels
- James Glasbey
- James Haddow
- James Hill
- James Lloyd
- James Nicholas
- James O'Brien
- James Olivier
- James Park
- James Parsonage
- James Rammell
- James Turner
- James Wilson
- Jane Barnfield
- Jane Blazeby
- Jared Torkington
- Jasmesh Sandhu
- Jasmine Latter
- Jason Smith
- Jazleen Dada
- Jeffrey Dalli
- Jenna Godfrey
- Jennifer Parker
- Jenny Isherwood
- Jenny Thomas
- Jenny Wright
- Jessica Belchos
- Jessica Brayley
- Jessica Court
- Jessica Harvey
- Jessica Kennett
- Jessica Pearce
- Jeyoung Lee
- Jih Dar Yau
- Jillian McKenna
- Jing Qi Ng
- Jingjie Cheng
- Joanna Brecher
- Joanna Osmanska
- Joanne Wylie
- Joel Lambert
- John Hardman
- John Hayes
- John Mason
- John Spearman
- John Trotter
- Jon Lund
- Jonathan Bannard-Smith
- Jonathan C.M. Wan
- Jonathan Epstein
- Jonathan Macdonald
- Jonathan Mayes
- Jonathan Neville
- Jordan Ashwood
- Joseph Doyle
- Joseph Duncumb
- Joseph Home
- Joseph Lim
- Joseph Yates
- Josephine Saramunda
- Joshua Burke
- Joshua Lucas de Carvalho
- Joshua Luck
- Joshua Yip
- Juan Jose Segura-Sampedro
- Julia Diamond
- Julian Camilleri-Brennan
- Justin Alberts
- Justine Durno
- Jyothis Manalayil
- Kajal Gohil
- Kamal Mahawar
- Kapil Sahnan
- Karishma Desai
- Kassem Alubaidi
- Katarzyna Bera
- Katharine Whitehurst
- Katherine Deasy
- Kathryn Boyce
- Kathryn Lee
- Kathryn Waite
- Katie De Jong
- Katie Hughes
- Katy Concannon
- Kaushik Sadanand
- Kaustuv Das
- Kaywaan Khan
- Keaton Jones
- Kellie Bateman
- Kenneth McLean
- Kenneth Mealy
- Kenny Lau
- Keshav K. Nambiar
- Kiran Nadeem
- Kirstine Andrew
- Kirsty Cattle
- Kirsty Davies
- Kirsty Hill
- Kirtan Patel
- Krishna Moorthy
- Kristen Davies
- Kristina Bresges
- Kulvinder Lal
- Kwaku Baryeh
- Kwong Tsang
- Kyriacos Gregoriou
- Laura Burney
- Laura Cunliffe
- Laura Horne
- Laura Jayne Watson
- Laura Martin
- Laura Myers
- Laura Sandland-Taylor
- Laura Tan
- Lauren Crozier
- Lauren Mecia
- Lauren Passby
- Lauren Satterthwaite
- Lema Imam
- Leo Brown
- Lewis Walker
- Liandra Ramachenderam
- Lin Chew
- Lina Kanapeckaite
- Liyang Wang
- Lizzie Wilson
- Lloyd Warren
- Lolade Giwa
- Lorna Luo
- Lorna Sandison
- Lothaire Garard
- Louisa Chenciner
- Louise Cox
- Lucie Ferguson
- Lucy Cuckow
- Lucy Elliott
- Lucy Simmonds
- Luisa Lopez Rojas
- Luke Carr
- Luke Mason
- Luke Williams
- Lydia Lilis
- Lydia Longstaff
- Lydon Eccles
- Lydon Eccles
- Lyndsay Pearce
- M. Long
- Maaz Khan
- Madeline Leadon
- Madhusoodhana Hebbar
- Mag Ting
- Mahrukh Hussain
- Maire Ni Bhoirne
- Maithem Al-Attar
- Malaz Elsaddig
- Malcolm West
- Maleasha Shergill
- Maniragav Manimaran
- Manuk Wijeyaratne
- Maria Khan
- Maria Marks
- Mariam Choudhry
- Mariam Masood
- Marianne Hollyman
- Mariasoosai Pathmarajah
- Mario Shaid
- Mark McDowell
- Mark Vipond
- Martinique Vella-Baldacchino
- Mary Catherine Gribbon
- Mary Goble
- Maryam Alfa-Wali
- Massimo Varcada
- Matt Archer
- Matthew Arnold
- Matthew Boissaud-Cooke
- Matthew Cant
- Matthew Doe
- Matthew Lee
- Maxine Feldman
- May Ho
- Medha Agrawal
- Megan Harty
- Megan Wilson
- Mehnoor Khaliq
- Mehreen Mahfooz
- Melina Rejayee
- Melissa Cunha
- Melissa Gough
- Michael Bath
- Michael Gallagher
- Michael Murray
- Michael Perry
- Michael Pullinger
- Michael Saat
- Michael Stoddart
- Michael Thomaa
- Michael Wilson
- Michal Dzieweczynski
- Michelle Latter
- Midhun Mohan
- Mihai Bica
- Mike Norwood
- Miles Triniman
- Mimi Li
- Minaam Abbas
- Miraen Kiandee
- Mohamed Elbuzidi
- Mohamed Rabie
- Mohammed Bux
- Mohammed Ibrar Murtaza
- Mohammed Salik Sait
- Molly Kerr
- Molly Traish
- Moritz Schramm
- Mostafa Khalil
- Mostafa Salem
- Mubasher Qamar
- Muhammad Abdalkoddus
- Muhammad Naqi
- Muhammed Al-Ausi
- N. Sandhu
- Nabila Rehnnuma
- Nadeem Ashraf
- Nadeem Jamal
- Nadia Salloum
- Nahim Rahman
- Naina Verma
- Narisu Yang
- Nasir Rafiq
- Natalie Blencowe
- Natalie Cheng
- Natarajan Manimaran
- Nathan Griffiths
- Nathan Hudson-Peacock
- Nathan Jeffreys
- Nathan Walker
- Neil Cruickshank
- Neil Sharma
- Neil Smart
- Nicholas Markham
- Nicholas Wroe
- Nick Heywood
- Nick Rajan
- Nicola Eardley
- Nicola Fearnhead
- Nicolò Favero
- Nienke Warnaar
- Nigel Keelty
- Nikhil Math
- Nikita Punjabi
- Nikitha Rajaraman
- Nimai Vadgama
- Nirmitha Jayaratne
- Niroshan Francis
- Niroshan Francis
- Nisha Mohamed Mushaini
- Nishat Dewan
- Niv Sukir
- Nivian Sukirthan
- Noor Yasin
- Oliver Charles Putt
- Oliver Warren
- Olivia Corbridge
- Olivia Cundy
- Oluwafunto Ogunleye
- Omar Ismail
- Omar Kouli
- Omar Qadir
- Onyinye Akpenyi
- Padma Eedarapalli
- Panagiotis A. Dimitriadis
- Panagis Lykoudis
- Panna Patel
- Panna Patel
- Paresh Chauhan
- Parhana Polly
- Parisa Khonsari
- Patrick Elder
- Patrick Green
- Patrick Quinn
- Paul Choi
- Paul Glen
- Paul Marriott
- Paul Moxey
- Paul Thomas
- Pedro Cunha
- Penelope Hurst
- Pepa Bruce
- Peter Coe
- Peter Dib
- Peter Lalor
- Peter Sodde
- Petros Fessas
- Petya Popova
- Petya Popova
- Philip Herrod
- Philip Stather
- Phoebe Hazenberg
- Pooja Mahankali-Rao
- Pradeep Patil
- Praminthra Chitsabesan
- Prashant Jain
- Prashant Naik
- Prashant Singh
- Pratiksha Patel
- Praveena Deekonda
- Praveena Prabakaran
- Prita Daliya
- Priya Dhillon
- Priya Loganathan
- Priyal Taribagil
- Priyesh Chauhan
- Qasim Wadood
- R. Heer
- Rachael Allen
- Rachel Davies
- Rachel Khaw
- Rachel Mcdougall
- Rachel Thavayogan
- Raees Ashraf
- Rahim Esmail
- Rahima Hashemi
- Raisah Owasil
- Raiyyan Aftab
- Rajiv Sethi
- Ralph Austin
- Ramesh Rajagopal
- Ratan Randhawa
- Raunak Poonawala
- Raykal Sim
- Rebecca Carr
- Rebecca Sagar
- Rebecca Smith
- Rebecca Varley
- Rebekah Wilson
- Reem Abdelgalil
- Rele Ologunde
- Rhiannon Gribbell
- Rhiannon Harries
- Rhydian Harris
- Richard Anderson
- Richard Bartlett
- Richard Buka
- Richard Carr
- Richard Lovegrove
- Richard McGregor
- Richard Morgan
- Richard Novell
- Richard Slater
- Richard Wilkin
- Rishi Agrawal
- Rishi Gupta
- Ritika Rampal
- Rizwan Iqbal
- Robert Sinnerton
- Robert Spencer
- Robert Whitham
- Robert Williams
- Robin Brown
- Roisin Hegarty O'Dowd
- Romman Nourzaie
- Ron Sangal
- Ronan Cahill
- Rory Brown
- Rory Buckle
- Rory Ingham
- Rory O'Kane
- Rose Ingleton
- Roshan Joseph
- Ross Goodson
- Ross Mcallister
- Roudi Bachar
- Rupert Scott
- Ryad Chebbout
- Ryan Adams
- Ryan Broll
- Ryan Devlin
- Saad Rehman
- Sabeera Dar
- Sabine Jamal
- Sachin Sharma
- Sagar Kanabar
- Sahil Deepak
- Sai Geethan Lambotharan
- Saif Sait
- Salomone Di Saverio
- Salwah Rehman
- Sam Easdon
- Sam Freeman
- Sam Gray
- Sam Myers
- Sam Waters
- Sameera Auckburally
- Samina Kauser
- Samir Makwana
- Samuel Greenhalgh
- Samuel Kim
- Samuel Lee
- Samuel Munday
- Samuel Small
- Sanchit Turaga
- Sandra Mcallister
- Sanjay Chaudhri
- Sara Aeyad
- Sara Griffiths
- Sara Venturini
- Sarah Adams
- Sarah Choi
- Sarah Cumming
- Sarah Duff
- Sarah Easby
- Sarantos Kaptanis
- Satheesh Yalamarthi
- Saurabh Verma
- Scott Mccain
- Scott McKinstry
- Scott Smith
- Sebastian Owczarek
- Sebi Kukran
- Sevi Kukran
- Shafaque Shaikh
- Shahab Khan
- Shahram Shirazi
- Shaikh Sanjid Seraj
- Shamira Ghouse
- Shams Mustafa
- Sharif Omara
- Shashank Iyer
- Shazia Hafiz
- Shiva Dindyal
- Shoaib Fahad Hussain
- Shona Gardner
- Shreya Goel
- Shubhangi Govil
- Shyam Gokani
- Siddharth Basetti
- Sidhartha Sinha
- Simi George
- Simon Bach
- Simon Beecroft
- Simon Cole
- Sivesh K. Kamarajah
- Siyin Liu
- Sobia Akhtar
- Sohaib Mallick
- Sona Mistry
- Sophie Carlson
- Sophie Dupre
- Sophie Emesih
- Sreelata Periketi
- Sri Palaniappan
- Stefan Klimach
- Stephanie Rees
- Stephen Chapman
- Stephen Fenwick
- Stephen O'Neill
- Stephen Robinson
- Steve Hornby
- Steven Arnell
- Stuart Fergusson
- Stuart Gallagher
- Su Oh
- Sudhakar Mangam
- Sufyan Mansoor
- Suji Kim
- Sultana Azam
- Sumetha Rajendran
- Sung-Hee Kim
- Sunil Francis
- Surabhika Lunawat
- Suzanne Harrogate
- Swati Vara
- Syed Rahman
- Syeda Hussain
- Taher Fatayer
- Tahira Mohamed
- Talisa Ross
- Tamara Ali
- Tanya Dhir
- Tapani Pratumsuwan
- Tara Bergara
- Tara Dogra
- Tatiana Zhelezniakova
- Teresa Fung
- Tharindri Wijekoon
- Theophilus Anyomih
- Thomas Gower
- Thomas Hawthorne
- Thomas Lewis
- Thomas M. Drake
- Thomas Oakley
- Thomas Pinkney
- Thomas Stringfellow
- Thomas Ward
- Tiago Martins
- Tim White
- Tim Wilson
- Timen Swartbol
- Tinaye Mandishona
- Toby Jackman
- Toby Noton
- Tom Malik
- Tom Newman
- Tomas Urbonas
- Tonia Forjoe
- Tricia Yeoh
- Trupesh Patel
- Tseun Han James Kong
- Umarah Muhammad
- Ursula Mc Gee
- Usama Asif
- Vani Agarwal
- Vartan Balian
- Vasudev Zaver
- Veeru Kasivisvanathan
- Vicky Fretwell
- Victor Jones
- Victoria Dawe
- Vincent Ng
- Vladislav Kutuzov
- Waleed Al-Khyatt
- Wan Jane Liew
- Wenn Goh
- William Beasley
- William Bolton
- William English
- William Rook
- William Simpson
- Xue Wang
- Yan Ning Neo
- Yanish Poolovadoo
- Yao Ren Liew
- Yao Zong Tay
- Yasir Suleman
- Yat Wing Smart
- Yiwang Xu
- Ysabelle Embury-Young
- Yun Cao
- Yunzi Chen
- Yusuf Patrick
- Zainab Al-Nasser
- Zakaria Rob
- Zara Taylor
- Zehra Naqvi
- Zenab China
- Zhan Herr Ng
- Zhi Lim
- Zhi Min Soh
- Zhubene Mesbah
- Zoe Johnston
- Zong Lee
- Publication venue
- 'Elsevier BV'
- Publication date
- 04/02/2017
- Field of study
Letter to the editor
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
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- de Andrés-Asenjo Beatriz
- de Deken Julie
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- en Siew Bei
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- Yemez Kursat
- Yew Chor Kuan
- Yılmaz Gülseren
- Yilmazlar Tuncay
- Yiğit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- ÓSullivan Sara Nuñez
- Özçelik Mehmet Faik
- Ćoza Ivo
- Şanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
- Author
- A Nizarudeen
- Aalem Hajer Abd Alhamed
- Ababneh Hazim
- Abbas Ahmed
- Abbas Aram
- Abbas Hussain
- Abbasi Arezou
- Abbassi Fariba
- Abbasy Jibran
- Abbood Ali H
- Abboud Kirellos
- Abdallah Ahmed
- Abdalsalam Sabriya Juma Ali
- Abdelaal Abdelrahman
- Abdelalemm Mohamed
- Abdelhafez Mohammed Hisham Zayan
- Abdelhalim Karim
- Abdeljalil Mahmoud
- Abdelkarem Mohamed
- Abdelmageed Abdelfatah
- Abdelmageed Abdelfatah
- Abdelmaksoud Mohamed
- Abdelmawgoud Sherif
- Abdelmawla Mohamed
- Abdelmawla Mohamed Osama Mohammed Kamel
- Abdelmoneim Noha
- Abdelnoor Ahmad
- Abdelrahman Fatma
- Abdelrazek Hussein A
- Abdelrhman Reham
- Abdelzaher Abdurrahman
- Abdelzaher Abdurrahman Taha
- Abdou Khaled
- Abdoun Meriem
- Abdualqader Mahmmoud
- Abdualqader Mahmmoud Yehia Mohammed
- Abdulhaq Aram
- Abduljawad Heba
- Abdullaev Abakar
- Abdullah Nik Azim Nik
- Abdulmonem Aya
- Abdulwahed Eman
- Abebrese John
- Abiyere Henry
- Abobakr Abobakr Mahfoz
- Aboelfath Shiamaa
- Abosamak Nour Eldin
- Abu-Elfatth Ahmed Mohammed
- Abu-Ghazal Sara
- Abu-Ghazal Sara Yassir
- Abuali Ahmed S A M E
- Abuelazm Mohamed
- Abuelnaga Yasmeen
- Abuelnaga Yasmeen
- Abughazal Sara Yasser
- Abuleil Amro
- Abusannuga Malek
- Abuzaina Khalil
- Adam Islam
- Aday Ulaş
- Adeyeye Ademola
- Adeyeye Nigeria Ademola
- Adham Mustapha
- Adhikari Krishna Mohan
- Affary Anter Al
- Afzal Ameer
- Afzal Iqraa
- Aghdassi Ali
- Ahmed Emad Ali
- Ahmed Mohamed Bahaa Eldin
- Ahmed Randa
- Ahmeed Sultan
- Ajayi Peter
- Akahoshi Keiichi
- Akbar Ali
- Akhtar Naseem
- Al-Abdi Radfan
- Al-Abed Omar
- Al-Ameri Saba
- Al-Ameri Saba Ahmed Ahmed Saleh
- Al-Asadi Mohammed Abdulkhaleq Mohammed Mohsen
- Al-Dowsh Nagra Are
- Al-Eryani Fatima
- Al-Faiq Siham
- Al-Haj Ahmad
- Al-Hyari Abdelkareem
- Al-Isawi Ali
- Al-juaifari Maytham Aqeel
- Al-Khawlani Qaeid
- Al-Kubati Waheeb
- Al-Maadani Basma
- Al-Mallah Rozana
- Al-Markiz Eman
- Al-Mekhlafi Ayat
- Al-Melhani Watheeq
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Ogaili Mustafa
- Al-Qasrawi Shahd
- Al-Saban Rafat
- Al-saban Rafat Ameen Mohammed
- Al-Sader Maytham Al-Juaifari
- Al-Samawi Abdulaziz
- Al-Samawi Hytham
- Al-Sarireh Bilal
- Al-Shami Khayry
- Al-shami Manar
- Al-sharabi Ebrahim Ahmed Esmail
- Al-Shehari Mohammed
- Al-Tekreeti Sarah
- Alahmed Farouq
- Alahmed Hoor
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- Alali Mahmoud Bilal
- Alannaz Omar
- Alansary Marwa Nasrelden
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- Alazab Emad
- Albaba Safa'
- Albakry Rudaina
- Albar Aisha
- Albaraesi Mohammed N
- Albarouni Sofian
- Albishti Ahmed
- Alboridy Muneera
- Aldoescu Sorin
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- Alfatah Maryam Abd
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- Emar Mohammad Farid Mohammad
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- Emral Ahmet Cihangir
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- Fareed Ahmed M
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- Hardgrave Hailey
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- Konstantinidis Michael K
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- Mahafdah Mahmoud R
- Mahfoodh Zainab
- Mahli Nihad
- Mahmoud Abdelrahman
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- Mahmoud Samir Hosney
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- Marques Narimã
- Marshod Mohamed Ali
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- Martins Ruben
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- Martinsone Katrina Deja
- Martí-Cruchaga Pablo
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- Masetti M
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- Mcnally Stephen
- Meerdink M
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- Melchor-Ruan Javier
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- Oliver Tiffany
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- Papadopoulos Vasileios N
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- Yadav Kaushal
- Yadev Induprabha
- Yadev Induprabha
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- Yassin Raya
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- Yoong Boon Koon
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- Younes Eman
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- Yousef Amal
- Youssef Amal
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- Zacharakis Emmanouil
- Zacharoulis Dimitrios
- Zachiotis Marinos
- Zagainov Vladimir
- Zaharie Florin
- Zahed Mohamed
- Zahed Mohamed Samir Mohamed
- Zakaria Andee Dzulkarnaen
- Zamri Fatimah Mardhiyyah Binti
- Zanatta Michela
- Zanello Matteo
- Zanini Nicola
- Zanus Giacomo
- Zanus Giacomo
- Zaruba Pavel
- Zawia Ali
- Zayed Ahmed
- Zdujic Predrag
- Zedelj Jurica
- Zeh Herbert J
- Zentar Aziz
- Zerbi Alessandro
- Zidan Taha
- Zidan Taha
- Zironda Andrea
- Zitawi Abdullah
- Zivanovic Marko
- Zogopoulos George
- Zonta Sandro
- Zonta Sandro
- Zorrilla Carlos Florez
- Zozaya Gabriel
- Zreqat Qusai
- Zuhdi Zamri
- Zuhdy Mohammad
- Zygomalas Apollon
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide.Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters.Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries.Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)