Anti-proliferative, anti-inflammatory, anti-ulcerogenic and wound healing properties of chitosan

In this study, anti-inflammatory, wound healing and anti-ulcerogenic properties of chitosan were evaluated ‘in vivo’ using wistar rats and swiss adult mice and the anti-proliferative activity was tested ‘in vitro’. The tested chitosans displayed no anti-proliferative or anti-inflammatory properties. The cytotoxic activity of chitosan was found to be non-existent towards eight tumoral cell lines and no significant differences were found in the ear edema (anti-inflammatory model) induced by croton oil and chitosan groups. However, chitosan showed good anti-ulcerative and wound healing abilities. Low molecular weight (LMW) chitosan effectively reduced ulcerative wounds induced by ethanol, while high molecular weight (HMW) chitosan helped retain the stomachal folds rendering a gastro protective effect. These results suggest that chitosan can potentially be used in the treatment of peptic ulcers. HMW chitosan also potentiated the healing process both in normal and diabetic rats, probably without induction of fibroblast growth but via collagen synthesisN/

Pt(II) and Pd(II) complexes with ibuprofen hydrazide: characterization, theoretical calculations, antibacterial and antitumor assays and studies of interaction with CT-DNA

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOPalladium(II) and platinum(II) complexes with a hydrazide derivative of ibuprofen (named HIB) were synthesized and characterized by chemical and spectroscopic methods. Elemental and thermogravimetric analyses, as well as ESI-QTOF-MS studies for both compl1154469479FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO2015/25114-42013/22127-2sem informação442123/2014-0This study was supported by grants from Brazilian Agencies FAPESP (São Paulo State Research Council, grants #2015/25114-4 and #2013/22127-2), CAPES (Coordination for the Improvement of Higher Level Personnel) and CNPq (National Council for Scientific an