Barreiras enfrentadas pela população transgênero no atendimento odontológico: uma revisão narrativa

In Brazil, despite the implementation of affirmative policies in the SUS that expand accessibility to the transgender population in public health, the challenges for universal access still persist. In addition, there are gaps in training in health and its professionals. The objective of this study was to analyze the barriers that transsexuals face in the Unified Health System (SUS) and reinforce the importance of professionals from the multidisciplinary team, including the dental surgeon, to adopt an empathetic and inclusive approach towards these people. A narrative review of the literature on the subject was carried out, including publications produced between 2013 and 2023. It is necessary to emphasize the prejudice and gender stigmas that the transsexual population suffers in accessing health services, including dentistry offered by the SUS. The lack of training, combined with the structure of rooted prejudices, makes empathetic and inclusive care difficult, facilitating the removal and embarrassment of these people. It is evident that there is a need for social reform to give visibility to the transgender public, integrating them in a universal, equitable and integral way, bringing them closer to the services offered by the SUS, guaranteeing health and quality of life.No Brasil, apesar da implementação de políticas afirmativas no SUS que ampliam a acessibilidade à população transgênero na saúde coletiva, os desafios para o acesso universal ainda persistem. Além disso, observa-se lacunas na formação em saúde e de seus profissionais. O objetivo deste trabalho foi analisar as barreiras que transexuais enfrentam no Sistema Único de Saúde (SUS) e reforçar a importância dos profissionais da equipe multiprofissional, incluindo o cirurgião-dentista, adotarem uma abordagem empática e inclusiva para com essas pessoas. Foi realizada uma revisão narrativa da literatura acerca da temática, incluindo as publicações produzidas entre 2013 a 2023. É necessário ressaltar o preconceito e os estigmas de gênero que a população transexual sofre no acesso aos serviços de saúde, incluindo a odontologia oferecida pelo SUS. A falta de capacitação, aliada à estrutura de preconceitos enraizados, dificulta o atendimento empático e inclusivo, facilitando o afastamento e constrangimento dessas pessoas. É evidente que há necessidades de uma reforma social para dar visibilidade ao público transgênero, integrando-os de forma universal, equânime e integral desse público, aproximando-os dos serviços ofertados no SUS garantindo saúde e qualidade de vida

Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection Revisão de modelos experimentais de cirrose hepática induzida por ligadura do ducto biliar e por injeção de tetracloreto de carbono

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.<br>OBJETIVO: Apresentar revisão sobre estudo comparativo da indução de cirrose hepática (CH) experimental com a injeção de tetra-cloreto de carbono (CCl4) comparado à ligadura do ducto biliar (BDL). MÉTODOS: A pesquisa foi realizada nas bases de dados do Medline/PubMed e SciELO procurando trabalhos com as palavras indução de CH e ratos. Foram encontrados 107 artigos, mas somente 30 foram selecionados no período de 2004 à 2011. RESULTADOS: Os procedimentos mais comum para indução de CH em ratos foram a injeção de CCl4 e a BDL. O CCl4 induzia CH no período de 36 horas após a injeção e a DBL de sete dias à quatro semanas após a cirurgia. CONCLUSÃO: A BDL é o método mais seguro para indução de CH quando comparado a injeção de CCl4 pela ausência de toxicidade para os pesquisadores e o menor tempo para se obter a lesão hepática

PortoLivingLab: an IoT-based Sensing Platform for Smart Cities

Smart cities aim to improve the citizens' quality of life by leveraging information about urban scale processes extracted from heterogeneous data sources collected on city-wide deployments. The Internet-of-Things (IoT) is, thus, the enabler of smart city technologies at urban scale. In this paper, we present PortoLivingLab, a multisource sensing infrastructure that leverages IoT technology to achieve city-scale sensing of four phenomena: weather, environment, public transport, and people flows. To sense these processes on a city scale, we deployed a vehicular network with over 600 vehicles and 19 static environmental sensors. We also developed an easily reconfigurable crowdsensing platform and carried out several crowdsensing campaigns with more than 600 participants. The data is collected in a common backend and stored using similar spatio-temporal data models to simplify sharing and joint analysis for the characterization of urban dynamics. We describe the architecture and composing elements of PortoLivingLab, highlighting the IoT technologies, and challenges faced. We present several pro-of-ofconcept use cases(e.g., passenger flows from WiFi connections) that provide new insights into different components of an evolving and moving city. Finally, we lay out the future lines of work that will strive for finding hidden phenomena by leveraging data from the three complementary platforms

Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype

Familial hypercholesterolemia (FH) is a common genetic disorder of lipid metabolism caused by pathogenic/likely pathogenic variants in LDLR, APOB, and PCSK9 genes. Variants in FH-phenocopy genes (LDLRAP1, APOE, LIPA, ABCG5, and ABCG8), polygenic hypercholesterolemia, and hyperlipoprotein (a) [Lp(a)] can also mimic a clinical FH phenotype. We aim to present a new diagnostic tool to unravel the genetic background of clinical FH phenotype. Biochemical and genetic study was performed in 1,005 individuals with clinical diagnosis of FH, referred to the Portuguese FH Study. A next-generation sequencing panel, covering eight genes and eight SNPs to determine LDL-C polygenic risk score and LPA genetic score, was validated, and used in this study. FH was genetically confirmed in 417 index cases: 408 heterozygotes and 9 homozygotes. Cascade screening increased the identification to 1,000 FH individuals, including 11 homozygotes. FH-negative individuals (phenotype positive and genotype negative) have Lp(a) >50 mg/dl (30%), high polygenic risk score (16%), other monogenic lipid metabolism disorders (1%), and heterozygous pathogenic variants in FH-phenocopy genes (2%). Heterozygous variants of uncertain significance were identified in primary genes (12%) and phenocopy genes (7%). Overall, 42% of our cohort was genetically confirmed with FH. In the remaining individuals, other causes for high LDL-C were identified in 68%. Hyper-Lp(a) or polygenic hypercholesterolemia may be the cause of the clinical FH phenotype in almost half of FH-negative individuals. A small part has pathogenic variants in ABCG5/ABCG8 in heterozygosity that can cause hypercholesterolemia and should be further investigated. This extended next-generation sequencing panel identifies individuals with FH and FH-phenocopies, allowing to personalize each person’s treatment according to the affected pathway

Relações entre profissionais de saúde e usuários durante as práticas em saúde Relationships between health professionals and users throughout health care practices

Apresenta-se uma revisão integrativa sobre estudos que abordam as relações entre profissionais de saúde e usuários durante as práticas em saúde. Objetivou-se identificar os aspectos pesquisados no cotidiano dos serviços acerca dessas relações. A coleta foi realizada nas bases Lilacs e Pubmed segundo os descritores: acolhimento; relações profissional-família; relações profissional-paciente; humanização da assistência; e a palavra 'vínculo' associada ao descritor Sistema Único de Saúde. Selecionaram-se 290 estudos publicados entre 1990 e 2010. Por meio da análise temática, foram criados cinco núcleos de sentido: a relevância da confiança na relação profissional-usuário; sentimentos e sentidos na prática do cuidado; a importância da comunicação nos serviços de saúde; modo de organização das práticas em saúde; e (des)colonialismo. Identificou-se que as relações estabelecidas nas práticas de saúde têm uma dimensão transformadora. No entanto, permanece o desafio de humanizar os serviços de saúde. A enfermagem se destaca na produção do conhecimento nessa temática.<br>This article presents an integrative review about studies that address the relationships between health professionals and users in health care practices. It aimed to identify aspects that were researched on the daily life of the services concerning such relationships. Data were collected from the Lilacs and Pubmed databases based on these descriptors: user embracement; professionalfamily relations; professionalpatient relations; humanization of the care; and the bonding word associated to the Single Health System descriptor. Two hundred and ninety studies, published from 1990 to 2010, were selected. Through thematic analyses, five meaning cores were created: the relevance of the confidence in the professionaluser relationship; feelings and senses in the health care practice; the importance of communications in health care services; ways to organize health care practices and (de)colonialism. It was found that relationships established in health care practices have a transformative dimension. However, the challenge to humanize health care services remains. Nursing stands out in the production of knowledge on such theme

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora

ATLANTIC ANTS: a data set of ants in Atlantic Forests of South America

International audienc