Spectrum of the S-wave fully-heavy tetraquark states

In present work, spectrum of the $S$-wave fully-heavy tetraquark states $QQ\bar{Q}\bar{Q}$ ($Q=c,b$), i.e., $cc\bar{c}\bar{c}$, $bb\bar{b}\bar{b}$, $cc\bar{b}\bar{b}$/$bb\bar{c}\bar{c}$, $bc\bar{c}\bar{c}$/ $cc\bar{b}\bar{c}$, $bb\bar{c}\bar{b}$/$cb\bar{b}\bar{b}$, and $bc\bar{b}\bar{c}$ are systematically investigated within an nonrelativistic constituent quark model, in which the Instanton-induced and one-gluon-exchange interactions are taken into account as the residual spin-dependent hyperfine interaction. Our results show that the states with $cc\bar{c}\bar{c}$ and $bb\bar{b}\bar{b}$ components could be located around $6500$ MeV and $19200$ MeV, respectively. Based on our calculations, the new $X(6900)$ state observed by LHCb may be not a ground $cc\bar{c}\bar{c}$ tetraquark state, while it could be an orbitally or radially excited state of $cc\bar{c}\bar{c}$ system. On the other hand, the recently reported $X(6600)$ state by CMS and ATLAS can be explained as a ground $cc\bar{c}\bar{c}$ tetraquark state with spin-parity $J^{PC} =0^{++}$.Comment: Version to appear in Eur. Phys. J.

Mesenchymal stem cells promote incision wound repair in a mouse model

Purpose: To investigate the wound healing process via the application of mesenchymal stem cells (MSCs) in a mouse model.Methods: MSCs were collected from the bone marrow of the femur and tibia of 6 – 12-week-old C57BL/6 mice. Full-thickness cutaneous wounds (4 × 2 cm) were made by incision on the dorsal side of the mice. The wound was then subjected to one of four random treatments: phosphate-buffered saline (PBS) solution, 3T3 fibroblasts, naive MSCs, or interferon gamma-activated MSCs. Chalkley method was used to determine vascular density. A score was given, for each field examined, for CD31-positive areas, and the results of blind analysis were confirmed by independent analysis of a second evaluator.Results: The tensile strength of the wound area was significantly lower in older versus younger mice (p ≤ 0.0007). Only one quarter of the mean force was required to disrupt wound integrity in older mice compared to young mice. Treatment with MSCs showed positive effects on wound healing. Activated MSCs showed the greatest efficacy at a dosage of 5 × 104 activated MSCs/8 cm2 of wound area or 6, 250 cells/cm2.Conclusion: The results suggest that MSC therapies enhance the tissue regeneration capacity in mice, especially in older populations, through effective transdifferentiation into the epithelium.Keywords: Mesenchymal stem cell, wound healing, mous

不同年龄和性别精神分裂症患者脑白质扩散张量成像的临床研究*

Objective: Diffusion tensor imaging (DTI) was used to analyze the changes of white matter fiber FA in patients with schizophrenia of different ages and genders, and to explore the reference of clinical imaging. Methods: Retrospective analysis of the clinical diagnosis of schizophrenia patients and healthy subjects in all 50 cases, were given routine examination of brain MRI parallel diffusion tensor imaging, comparison of different age and gender in different parts of the brain white matter changes of FA value. Results: (1) the FA values of white matter in different age groups were different between the patients and the normal group (P < 0.05). The normal group right superior frontal gyrus, left parietal lobe and left anterior cingulate gyrus of the cerebral white matter fiber FA value increased gradually before the age of 30, at the age of 30 and reached the peak gradually decreased after 30 years old. The left frontal gyrus and corpus callosum in patients with group pressure (after) of cerebral white matter fiber FA value increased gradually before the age of 30, at the age of 30 and reached the peak gradually decreased after 30 years old. (2) the FA values of white matter in different parts of male and female patients were different (P < 0.05). The white matter fiber FA in the left anterior capsule of the normal group was higher in males than in females. The FA value of bilateral occipital white matter in male patients was lower than that in female; the FA values of the central white matter in the left and right sides of the brain stem were higher in males than in females. Conclusion: the changes of FA value in the white matter of some parts of the brain in the normal group and the patient group are influenced by age and sex.  目的  运用扩散张量成像分析不同年龄和性别精神分裂症患者脑白质纤维FA值的变化，探讨临床影像学参考依据。方法  回顾性分析经临床确诊的精神分裂症患者和健康者各50例，均作颅脑MRI常规检查并行扩散张量成像，比较不同年龄和性别各部位脑白质FA值变化特点。结果  （1）患者组和正常组不同年龄各部位脑白质FA值有差异（P＜0.05）。正常组中右额上回、左顶叶及左扣带回前部脑白质纤维FA值在30岁前逐渐增高，30岁达高峰，在30岁后逐渐减少。患者组中左额上回及胼胝体压部（后）脑白质纤维FA值在30岁前逐渐增高，30岁达高峰，在30岁后逐渐减少。（2）患者组和正常组男女各部位脑白质FA值有差异（P＜0.05）。发现正常组中左侧内囊前肢脑白质纤维FA值男性较女性高。患者组中双侧枕叶脑白质纤维FA值男性较女性低；脑干左右侧中心脑白质FA值男性较女性高。结论  正常组和患者组大脑某些部位脑白质纤维FA值量的变化受年龄、性别的影响

Is tea consumption associated with the serum uric acid level, hyperuricemia or the risk of gout? A systematic review and meta-analysis

The methodological quality of cross-sectional studies in accordance with the Newcastle-Ottawa Scale (NOS). Table S2. The methodological quality of cohort studies in accordance with the Newcastle-Ottawa Scale (NOS). Table S3. The methodological quality of case–control studies in accordance with the Newcastle-Ottawa Scale (NOS). (DOCX 19 kb

A New Allele of the SPIKE1 Locus Reveals Distinct Regulation of Trichome and Pavement Cell Development and Plant Growth

The single-celled trichomes of Arabidopsis thaliana have long served as an elegant model for elucidating the mechanisms of cell differentiation and morphogenesis due to their unique growth patterns. To identify new components in the genetic network that governs trichome development, we carried out exhaustive screens for additional Arabidopsis mutants with altered trichome morphology. Here, we report one mutant, aberrantly branched trichome1-1 (abt1-1), with a reduced trichome branching phenotype. After positional cloning, a point mutation in the SPIKE1 (SPK1) gene was identified in abt1-1. Further genetic complementation experiments confirmed that abt1-1 is a new allele of SPK1, so abt1-1 was renamed as spk1-7 according to the literatures. spk1-7 and two other spk1 mutant alleles, covering a spectrum of phenotypic severity, highlighted the distinct responses of developmental programs to different SPK1 mutations. Although null spk1 mutants are lethal and show defects in plant stature, trichome and epidermal pavement cell development, only trichome branching is affected in spk1-7. Surprisingly, we found that SPK1 is involved in the positioning of nuclei in the trichome cells. Lastly, through double mutant analysis, we found the coordinated regulation of trichome branching between SPK1 and two other trichome branching regulators, ANGUSTIFOLIA (AN) and ZWICHEL (ZWI). SPK1 might serve for the precise positioning of trichome nuclei, while AN and ZWI contribute to the formation of branch points through governing the cMTs dynamics. In summary, this study presented a fully viable new mutant allele of SPK1 and shed new light on the regulation of trichome branching and other developmental processes by SPK1

TAO Conceptual Design Report: A Precision Measurement of the Reactor Antineutrino Spectrum with Sub-percent Energy Resolution

The Taishan Antineutrino Observatory (TAO, also known as JUNO-TAO) is a satellite experiment of the Jiangmen Underground Neutrino Observatory (JUNO). A ton-level liquid scintillator detector will be placed at about 30 m from a core of the Taishan Nuclear Power Plant. The reactor antineutrino spectrum will be measured with sub-percent energy resolution, to provide a reference spectrum for future reactor neutrino experiments, and to provide a benchmark measurement to test nuclear databases. A spherical acrylic vessel containing 2.8 ton gadolinium-doped liquid scintillator will be viewed by 10 m^2 Silicon Photomultipliers (SiPMs) of >50% photon detection efficiency with almost full coverage. The photoelectron yield is about 4500 per MeV, an order higher than any existing large-scale liquid scintillator detectors. The detector operates at -50 degree C to lower the dark noise of SiPMs to an acceptable level. The detector will measure about 2000 reactor antineutrinos per day, and is designed to be well shielded from cosmogenic backgrounds and ambient radioactivities to have about 10% background-to-signal ratio. The experiment is expected to start operation in 2022

Nonperturbative determination of the Collins-Soper kernel from quasitransverse-momentum-dependent wave functions

In the framework of large-momentum effective theory at one-loop matching accuracy, we perform a lattice calculation of the Collins-Soper kernel, which governs the rapidity evolution of transversemomentum-dependent (TMD) distributions. We first obtain the quasi-TMD wave functions at three different meson momenta, on a lattice with valence clover quarks on a dynamical highly improved staggered quark sea and lattice spacing a ¼ 0.12 fm from the MILC Collaboration, and renormalize the pertinent linear divergences using Wilson loops. Through one-loop matching to the light-cone wave functions, we determine the Collins-Soper kernel with transverse separation up to 0.6 fm. We study the systematic uncertainties from operator mixing and scale dependence, as well as the impact from higher power corrections. Our results potentially allow for a determination of the soft function and other transverse-momentum-dependent quantities at one-loop accuracy

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched in tumours from patients harbouring metastases. Genes regulating cytoskeleton remodelling processes are also frequently altered, especially in metastatic samples, of which the high expression level of IQGAP3 is identified as a marker for poor prognosis. Our study represents the first large-scale sequencing effort on lung adenocarcinoma in Asian patients and provides a comprehensive mutational landscape for both primary and metastatic tumours. This may thus form a basis for personalized medical care and shed light on the molecular pathogenesis of metastatic lung adenocarcinoma