A Simple Angle of Arrival Estimation System

We propose a practical, simple and hardware friendly, yet novel and very efficient, angle of arrival (AoA) estimation system. Our intuitive, two-phases cross-correlation based system requires a switched beam antenna array with a single radio frequency chain. Our system cross correlates a reference omni-directional signal with a set of received directed signals to determine the AoA. Practicality and high efficiency of our system are demonstrated through performance and complexity comparisons with multiple signal classification algorithm.Scopu

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

A first update on mapping the human genetic architecture of COVID-19

peer reviewe

Selective determination of tolterodine tartrate in presence of its oxi- dative degradation product

Four stability-indicating methods were developed for determination of tolterodine tartrate in the presence of its oxidative degradation product (the metabolite). The degradation product was prepared via oxidation with hydrogen peroxide. The degradation product was characterized and struc- turally elucidated. The first method was the first derivative 1D by measur- ing the peak amplitude at 292nm. The second method was a second de- rivative by measuring the peak amplitude at 236, 287, 296 nm. The third method was a high performance liquid chromatographic using a reversed phase column and a mobile phase of phosphate buffer: methanol: triethyl amine (60: 40; 0.2 by volume). The forth method was a thin layer chroma- tography coupled with densitometric detection.Selective quantification of tolterodine in pure form, pharmaceutical formu- lation and/or in the presence of its degradant was demonstrated. The indi- cation of stability was done under condition likely to be expected at normal storage condition.  2016 Trade Science Inc. - INDI