Pelatihan dan Pendampingan Pengisian Konten Kelas Virtual Berbasis Web Blog

Perkembangan teknologi informasi telah diadopsi di berbagai bidang tidak terkecuali dunia pendidikan dalam bentuk e-learning. Universitas Halu Oleo (UHO) mendorong terlaksananya sistem pembelajaran berbasis online. Berbagai kegiatan pelatihan dan bimbingan teknis (bimtek) e-learning dilakukan namun tidak memberikan dampak yang signifikan. Kondisi ini terjadi dikarenakan keterbatasan waktu serta tidak adanya pendampingan pasca pelatihan dan bimtek. Dengan menggunakan metode pendekatan kemitraan melalui pelatihan dan pendampingan, kegiatan ini bermitra dengan perwakilan dosen dari setiap jurusan/program studi lingkup Fisip UHO. Kurangnya minat dan kemampuan dalam menggunakan kelas virtual baik dari segi pengelolaan dan desain tampilan kelas virtual hingga pengisian konten menjadi masalah prioritas yang dialami mitra. Hasil kegiatan menunjukkan perubahan pengetahuan dan keterampilan dalam menggunakan web blog yang terkoneksi dengan blog dosen UHO di lecture.uho.ac.id. Dosen yang mengikuti kegiatan pengabdian ini telah memanfaatkan kelas virtual blog dosen dalam beberapa mata kuliah baik sebagai sarana berbagi materi maupun tugas kuliah. Melalui pengabdian ini, telah ada sembilan web blog yang bisa menjadi blog dosen percontohan dari jurusan/Prodi lingkup Fisip dan bisa digunakan untuk menunjang akreditasi. Tidak hanya itu, tim pengabdian juga menyediakan ruang komunikasi bagi mitra dan tim untuk memastikan kelas virtual terus aktif dan produktif sebagai bentuk kegiatan pendampingan melalui grup WhatsApp

Histopathological and Biochemical evaluations of the antidotal efficacy of Nigella sativa oil on organophosphate induced hepato-toxicity

Objective: The study was designed to investigate the effects of continuous exposure of dichlorvos (DDVP) on hepatic function and hepatic histomorphology, with the possible antidotal efficacy of Nigella sativa oil (NSO).Methods: Twenty four Wistar rats were randomly divided into four groups, with each group comprising of six rats. The groups were labelled as Sunflower oil (SFO), DDVP, DDVP+NSO and NSO. After 14 days of treatments, blood samples were collected, centrifuged and levels of ALP (Alkaline phosphatase), ALT (Alanine aminotransferase), AST (Aspartate aminotransferase) and GGT (γ-glutamyl-transferase) concentrations were estimated in the serum. The livers were removed and prepared for histopathological examinations and evaluation.Results: The findings of the study shows significant increase in the serum concentration of ALT, ALP, AST and GGT with a marked distortion in the hepatic architecture in rats administered with DDVP. However, Nigella sativa oil (NSO) was observed to ameliorate the levels of impairment in the assessed hepatic function parameters and relatively restoration in the hepatic architecture in DDVP+NSO treated animals when compared to the control and group administered with DDVPonly.Conclusion: The study concludes that impaired liver functions and histomorphological tissue distortions observed in the experimental rats following DDVP exposure were ameliorated following theadministration of NSO.Keywords: Nigella sativa, dichlorvos, antidotal effect, hepatotoxicity, liver function tes

SUBJEK AGRARIA PADA LOKASI KONFLIK KAWASAN TRANSMIGRASI (STUDI KASUS: UNIT PEMUKIMAN TRANSMIGRASI ARONGO, KABUPATEN KONAWE SELATAN)

The presence of an agrarian reform program in the current administration provides new hope for the management of more prosperous agricultural land, not least on transmigration lands. Especially in the determination of the Land of Agrarian Reform Objects (TORA) transmigration land received a share of 0.6 million hectares from 9 million hectares of the government's target. Unfortunately, until now there are still many images of transmigration lands that are far from expectations. This means that there are still many transmigration lands involved in conflicts both vertically and horizontally. This paper aims to analyze conflicts on transmigration lands located in UPT. Arongo, South Konawe Regency, Southeast Sulawesi Province. Conflict analysis is directed at mapping agrarian subjects involved in a conflict. Qualitative descriptive methods are used to obtain in-depth information related to the agrarian subject. The results showed conflict in the UPT transmigration land. Arongo consists of 3 agrarian subjects namely elements of government, private and community. The government element is represented by the local government, transmigration service and National Land Agency. Community elements consist of local residents, migrants who are not directly affected and transmigrants whose land is directly affected. Community elements were also formed within the United Farmers Konawe Selatan and Konsorsium Pembaruan Agraria (KPA). While PT. Merbau Jaya Indah Raya Group is part of the agrarian subject of the private element

Pencegahan Luka Tekan Pada Pasien Hidrosefalus Di Ruang Pediatric Intensive Care Unit

Anak penderita hidrosefalus dengan penurunan kesadaran rentan mengalami gangguan integritas kulit, seperti luka tekan akibat tirah baring lama, imobilisasi dan terpasang alat medis. Studi kasus ini bertujuan mengevaluasi intervensi pencegahan luka tekan pada pasien hidrosefalus di ruang Pediatric Intensive Care Unit RSUP Dr. Wahidin Sudirohusodo Makassar. Metode yang digunakan adalah single case design dengan instrumen pedoman pencegahan luka tekan dari National Pressure Injury Advisory Panel pada subjek studi kasus. Pengumpulan data dilakukan dengan observasi dan intervensi serta dokumentasi mulai 19-22 Juni 2023. Hasil studi kasus menunjukkan skala Braden Q berada pada skor 15 di hari pertama dan kedua serta skor 14 di hari ketiga dan keempat (risiko luka tekan sedang). Intervensi pemeriksaan kulit didapatkan terjadi perubahan suhu menjadi normal, tidak ada ruam kulit, tidak ada indurasi, tidak edema dan tidak nyeri akibat tekanan serta tidak ada luka akibat peralatan medis. Selain itu, tidak ada luka pada area tonjolan tulang setelah pemberian posisi miring kanan dan kiri serta pemberian bantalan sebagai penyangga dapat mencegah risiko luka tekan. Penilaian dan standar dari manajemen nutrisi adalah tidak terjadi penurunan berat badan dan tidak ada tanda-tanda dehidrasi. Dapat disimpulkan skor skala Braden Q berada pada risiko sedang sehingga diberikan intervensi sesuai pedoman

Adoption of new health products in low and middle income settings: how product development partnerships can support country decision making

When a new health product becomes available, countries have a choice to adopt the product into their national health systems or to pursue an alternate strategy to address the public health problem. Here, we describe the role for product development partnerships (PDPs) in supporting this decision-making process. PDPs are focused on developing new products to respond to health problems prevalent in low and middle income settings. The impact of these products within public sector health systems can only be realized after a country policy process. PDPs may be the organizations most familiar with the evidence which assists decision making, and this generally translates into involvement in international policy development, but PDPs have limited reach into endemic countries. In a few individual countries, there may be more extensive involvement in tracking adoption activities and generating local evidence. This local PDP involvement begins with geographical prioritization based on disease burden, relationships established during clinical trials, PDP in-country resources, and other factors. Strategies adopted by PDPs to establish a presence in endemic countries vary from the opening of country offices to engagement of part-time consultants or with long-term or ad hoc committees. Once a PDP commits to support country decision making, the approaches vary, but include country consultations, regional meetings, formation of regional, product-specific committees, support of in-country advocates, development of decision-making frameworks, provision of technical assistance to aid therapeutic or diagnostic guideline revision, and conduct of stakeholder and Phase 4 studies. To reach large numbers of countries, the formation of partnerships, particularly with WHO, are essential. At this early stage, impact data are limited. But available evidence suggests PDPs can and do play an important catalytic role in their support of country decision making in a number of target countries

Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1

Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and demonstrate its role as an autocrine/paracrine pro-survival factor. This effect could only be removed using the CRF-R1 selective antagonist CP-154526, suggesting Ucn1 acts through CRF-R1 when promoting chondrocyte survival. This cell death was characterised by an increase in p53 expression, and cleavage of caspase 9 and 3. Antagonism of CRF-R1 with CP-154526 caused an accumulation of intracellular calcium (Ca2+) over time and cell death. These effects could be prevented with the non-selective cation channel blocker Gadolinium (Gd3+). Therefore, opening of a non-selective cation channel causes cell death and Ucn1 maintains this channel in a closed conformation. This channel was identified to be the mechanosensitive channel Piezo1. We go on to determine that this channel inhibition by Ucn1 is mediated initially by an increase in cyclic adenosine monophosphate (cAMP) and a subsequent inactivation of phospholipase A2 (PLA2), whose metabolites are known to modulate ion channels. Knowledge of these novel pathways may present opportunities for interventions that could abrogate the progression of OA

Too little but not too late: Results of a literature review to improve routine immunization programs in developing countries

<p>Abstract</p> <p>Background</p> <p>Globally, immunization services have been the center of renewed interest with increased funding to improve services, acceleration of the introduction of new vaccines, and the development of a health systems approach to improve vaccine delivery. Much of the credit for the increased attention is due to the work of the GAVI Alliance and to new funding streams. If routine immunization programs are to take full advantage of the newly available resources, managers need to understand the range of proven strategies and approaches to deliver vaccines to reduce the incidence of diseases. In this paper, we present strategies that may be used at the sub-national level to improve routine immunization programs.</p> <p>Methods</p> <p>We conducted a systematic review of studies and projects reported in the published and gray literature. Each paper that met our inclusion criteria was rated based on methodological rigor and data were systematically abstracted. Routine-immunization – specific papers with a methodological rigor rating of greater than 60% and with conclusive results were reported.</p> <p>Results</p> <p>Greater than 11,000 papers were identified, of which 60 met our inclusion criteria and 25 papers were reported. Papers were grouped into four strategy approaches: bringing immunizations closer to communities (n = 11), using information dissemination to increase demand for vaccination (n = 3), changing practices in fixed sites (n = 4), and using innovative management practices (n = 7).</p> <p>Conclusion</p> <p>Immunization programs are at a historical crossroads in terms of developing new funding streams, introducing new vaccines, and responding to the global interest in the health systems approach to improving immunization delivery. However, to complement this, actual service delivery needs to be strengthened and program managers must be aware of proven strategies. Much was learned from the 25 papers, such as the use of non-health workers to provide numerous services at the community level. However it was startling to see how few papers were identified and in particular how few were of strong scientific quality. Further well-designed and well-conducted scientific research is warranted. Proposed areas of additional research include integration of additional services with immunization delivery, collaboration of immunization programs with new partners, best approaches to new vaccine introduction, and how to improve service delivery.</p