Botulinum Toxin for the Face

Botulinum toxin is a corner stone in the facial esthetics. It has been used for decades for various medical and esthetic indications. Botulinum toxin is a neurotoxin that interferes with the transmission at the neuromuscular/neurosecretory junctions by inhibiting the release of acetylcholine. An in depth knowledge of the functional anatomy of facial muscles is required to obtain the best results of the botulinum toxin injections. In this book chapter, a detailed practical guide for the FDA approved and the off label uses of botulinum toxin in the face is presented. The recently developed new indications are listed. The lengthy experience with botulinum toxin injections has proved safety and tolerability of the procedure; however, the probable complications, and steps for their prevention and management are highlighted

Correlation between Metabolic Syndrome and Psoriasis

Background: Psoriasis is a chronic inflammatory disease that is mediated by the immune system. It was thought to be a specific skin condition, but numerous studies have shown that it is a systemic disorder, as well as psychological difficulties like shyness, low self-esteem, and anxiety are related with it. Resistin is considered to be an important modulator of chronic inflammation.Objective: To determine serum level of resistin and C-reactive protien (CRP) in psoriasis vulgaris patients with metabolic syndrome (MetS).Patients and Methods: Clinical examinations were performed on 40 patients ranging in age from 28 to 53, and venous blood samples were collected. Tests were performed on the blood samples to identify levels of, resistin, and C-reactive protein (CRP). Results: levels of resistin were elevated with increased severity of psoriasis as measured by Psoriasis Area/Severity Index (PASI) score with statistically significant relation; p value (0.04), PASI score also was positively associated with elevated CRP levels; p value (0.001) .Conclusion: We conclude that resistin levels provide important value to optimize medical treatment and improve clinical outcomes in patients with psoriasis

GGTase I 阻害活性置換クエン酸天然物シトラフンジンAの合成に関する研究

長崎大学学位論文 学位記番号:博（医歯薬）甲第106号 学位授与年月日:平成19年3月20

Modelling and Control of seven DOF Ride Model Using Hybrid Controller Optimized By Particle Swarm Optimization

In this study, a seven degree of freedom (DOF) ride model of armored vehicle is employed in control system to control the vehicle ride performance especially in body acceleration, body pitch acceleration and body roll acceleration due to extreme road profile and disturbance using Hybrid control structure optimized by Particle Swarm Optimization (PSO) algorithm. The seven DOF ride model parameters are obtained from CARSIM software by selecting heavy vehicle High Mobility Multipurpose Wheeled Vehicle (HMMWV) as benchmark. The performance of the Hybrid control structure without optimization were compared to the performance of a simple PID control structure and passive 7 DOF vehicle ride model. Lastly, the performance of Hybrid control structure without optimization were compared to the performance of Hybrid control structure optimized by PSO algorithm

The Arabic Version of the Impact of Event Scale-Revised : psychometric evaluation among psychiatric patients and the general public within the context of COVID-19 outbreak and quarantine as collective traumatic events

The Coronavirus Disease-19 (COVID-19) pandemic has provoked the development of negative emotions in almost all societies since it first broke out in late 2019. The Impact of Event Scale-Revised (IES-R) is widely used to capture emotions, thoughts, and behaviors evoked by traumatic events, including COVID-19 as a collective and persistent traumatic event. However, there is less agreement on the structure of the IES-R, signifying a need for further investigation. This study aimed to evaluate the psychometric properties of the Arabic version of the IES-R among individuals in Saudi quarantine settings, psychiatric patients, and the general public during the COVID-19 outbreak. Exploratory factor analysis revealed that the items of the IES-R present five factors with eigenvalues > 1. Examination of several competing models through confirmatory factor analysis resulted in a best fit for a six-factor structure, which comprises avoidance, intrusion, numbing, hyperarousal, sleep problems, and irritability/dysphoria. Multigroup analysis supported the configural, metric, and scalar invariance of this model across groups of gender, age, and marital status. The IES-R significantly correlated with the Depression Anxiety Stress Scale-8, perceived health status, and perceived vulnerability to COVID-19, denoting good criterion validity. HTMT ratios of all the subscales were below 0.85, denoting good discriminant validity. The values of coefficient alpha in the three samples ranged between 0.90 and 0.93. In path analysis, correlated intrusion and hyperarousal had direct positive effects on avoidance, numbing, sleep, and irritability. Numbing and irritability mediated the indirect effects of intrusion and hyperarousal on sleep and avoidance. This result signifies that cognitive activation is the main factor driving the dynamics underlying the behavioral, emotional, and sleep symptoms of collective COVID-19 trauma. The findings support the robust validity of the Arabic IES-R, indicating it as a sound measure that can be applied to a wide range of traumatic experiences

The Effect of System Quality and User Quality of Information Technology on Internal Audit Effectiveness in Jordan, And the Moderating Effect of Management Support

The goal of this study is to ascertain the moderating role that management support has in internal audit effectiveness in Jordan, as well as the impact of system quality and user quality of information technology. There were 172 responders in all, and they were split across Jordanian auditors. In the data analysis process, the quantitative analysis test— which consists of the validity test, reliability test, test of conventional assumptions, and hypothesis test—is applied. Information technology system and user quality are independent variables in this study. The dependent variable in this study is internal audit effectiveness, and the moderating variable is management support. The results of this study show that the effectiveness of internal audits is significantly impacted by the system quality and user quality of information technology. Additionally, with Management support acting as a moderating factor, the link between System quality and Audit effectiveness improves. The findings also indicate that when moderating variables are present, the connection between User quality and Audit effectiveness changes from positive to negative. Future research might look at risk management

Serological and molecular characterization of Syrian Tomato spotted wilt virus isolates

Thirty four Syrian isolates of Tomato spotted wilt virus (TSWV) collected from tomato and pepper were tested against five specific monoclonal antibodies using TAS-ELISA. The isolates were in two serogroups. Fourteen tomato and sixteen pepper isolates were similar in their reaction with MAb-2, MAb-4, MAb-5 and MAb-6, but did not react with MAb-7 (Serogroup 1). Meanwhile, four isolates collected from pepper reacted with all the MAbs used (Serogroup 2). The expected 620 bp DNA fragment was obtained by RT-PCR from six samples using a specific primer pair designed to amplify the nucleocapsid protein (NP) gene of TSWV. The PCR products were sequenced and a phylogenetic tree was constructed. Sequence analysis revealed that the Syrian TSWV isolates were very similar at the nucleotide (97.74 to 99.84% identity) and amino acid (96.17 to 99.03% identity) sequences levels. The phylogenetic tree showed high similarity of Syrian TSWV isolates with many other representative isolates from different countries

Comparison of survival in patients with T cell lymphoma after autologous and allogeneic stem cell transplantation as a frontline strategy or in relapsed disease.

We studied the roles of autologous (A) and allogeneic (allo) stem cell transplantation (SCT) in the treatment of 134 patients with T cell lymphoma (TCL) at our center. For frontline SCT, 58 patients were studied. The 4-year overall survival (OS) rates for ASCT (n = 47; median age, 49 years) and alloSCT (n = 11; median age, 55 years) groups were 76% and 54%, respectively (P \u3e .05). The 4-year OS rates for first complete remission (CR1) patients were 84% and 83%, respectively. For SCT for relapsed disease, 76 patients were studied (41 with ASCT and 35 with alloSCT). The 4-year OS rates were 50% and 36% for ASCT and alloSCT patients with chemosensitive disease, respectively (P \u3e .05). Those who were in CR2 and CR3 had 4-year OS rates of 59% and 53%, respectively. Similar results were also observed in patients with refractory disease (29% and 35%, respectively). These data suggest that a pre-SCT CR is associated with improved outcomes in TCL patients after SCT. Considering the 84% 4-year OS rates in CR1 patients and the unpredictable responses in patients with relapsed disease, we favor the use of ASCT as consolidation therapy after CR1. AlloSCT did not result in a superior outcome compared with ASCT

Ameliorative effect of heat-killed lactobacillus plantarum L.137 and/or Aloe vera against colitis in mice

Inflammatory bowel disease (IBD) is one of the predominant intestinal diseases associated with chronic inflammation and ulceration of the colon. This study explored the ameliorative effect of Aloe vera extract (Aloe) and/or heat-killed Lactobacillus plantarum L.137 (HK L.137) on dextran sodium sulfate (DSS)-induced colitis in mice. Aloe and/or HK L.137 were supplied for 9 days and the mice were challenged with DSS for 7 days. The DSS group demonstrated bloody diarrhea, colitis of high histologic grade, increased nuclear factor-kappa B (NF-κB) p65, inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO), interleukin (IL)-6, and tumor necrosis factor (TNF)-α, and decreased IL-10 expression. These alterations were dwindled in DSS-induced mice treated with Aloe and HK L.137 separately. Aloe and HK L.137 together have augmented the therapeutic e_ect of each other. In conclusion, our findings demonstrated that Aloe and/or HK L.137 ameliorated DSS-induced colitis by promoting the secretion of anti-inflammatory cytokines and suppressing pro-inflammatory mediators. This study indicated that A. vera may function synergistically with HK L.137 to confer an e_ective strategy to prevent colitis