9 research outputs found
Risk categories in COVID-19 based on degrees of inflammation: data on more than 17,000 patients from the Spanish SEMI-COVID-19 registry
Background: the inflammation or cytokine storm that accompanies COVID-19 marks the prognosis. This study aimed to identify three risk categories based on inflammatory parameters on admission. Methods: retrospective cohort study of patients diagnosed with COVID-19, collected and followed-up from 1 March to 31 July 2020, from the nationwide Spanish SEMI-COVID-19 Registry. The three categories of low, intermediate, and high risk were determined by taking into consideration the terciles of the total lymphocyte count and the values of C-reactive protein, lactate dehydrogenase, ferritin, and D-dimer taken at the time of admission. Results: a total of 17,122 patients were included in the study. The high-risk group was older (57.9 vs. 64.2 vs. 70.4 years; p < 0.001) and predominantly male (37.5% vs. 46.9% vs. 60.1%; p < 0.001). They had a higher degree of dependence in daily tasks prior to admission (moderate-severe dependency in 10.8% vs. 14.1% vs. 17%; p < 0.001), arterial hypertension (36.9% vs. 45.2% vs. 52.8%; p < 0.001), dyslipidemia (28.4% vs. 37% vs. 40.6%; p < 0.001), diabetes mellitus (11.9% vs. 17.1% vs. 20.5%; p < 0.001), ischemic heart disease (3.7% vs. 6.5% vs. 8.4%; p < 0.001), heart failure (3.4% vs. 5.2% vs. 7.6%; p < 0.001), liver disease (1.1% vs. 3% vs. 3.9%; p = 0.002), chronic renal failure (2.3% vs. 3.6% vs. 6.7%; p < 0.001), cancer (6.5% vs. 7.2% vs. 11.1%; p < 0.001), and chronic obstructive pulmonary disease (5.7% vs. 5.4% vs. 7.1%; p < 0.001). They presented more frequently with fever, dyspnea, and vomiting. These patients more frequently required high flow nasal cannula (3.1% vs. 4.4% vs. 9.7%; p < 0.001), non-invasive mechanical ventilation (0.9% vs. 3% vs. 6.3%; p < 0.001), invasive mechanical ventilation (0.6% vs. 2.7% vs. 8.7%; p < 0.001), and ICU admission (0.9% vs. 3.6% vs. 10.6%; p < 0.001), and had a higher percentage of in-hospital mortality (2.3% vs. 6.2% vs. 23.9%; p < 0.001). The three risk categories proved to be an independent risk factor in multivariate analyses. Conclusion: the present study identifies three risk categories for the requirement of high flow nasal cannula, mechanical ventilation, ICU admission, and in-hospital mortality based on lymphopenia and inflammatory parameters
Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study)
Purpose: Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy in the DS pediatric population. We aimed to evaluate safety and tolerability of a dietary supplement containing EGCG and if EGCG improves cognitive and functional performance. Methods: A total of 73 children with DS (aged 6-12 years) were randomized. Participants received 0.5% EGCG (10 mg/kg daily dose) or placebo for 6 months with 3 months follow up after treatment discontinuation. Results: In total, 72 children were treated and 66 completed the study. A total of 38 participants were included in the EGCG group and 35 in the placebo group. Of 72 treated participants, 62 (86%) had 229 treatment-emergent adverse events (AEs). Of 37 participants in the EGCG group, 13 (35%) had 18 drug-related treatment-emergent AEs and 12 of 35 (34%) from the placebo group had 22 events. In the EGCG group, neither severe AEs nor increase in the incidence of AEs related to safety biomarkers were observed. Cognition and functionality were not improved compared with placebo. Secondary efficacy outcomes in girls point to a need for future work. Conclusion: The use of EGCG is safe and well-tolerated in children with DS, but efficacy results do not support its use in this population. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of American College of Medical Genetics and Genomics
Investigación joven con perspectiva de género II
Actas del II Congreso de jóvenes investigadorxs con perspectiva de género (Getafe, 26 y 27 de junio de 2017) organizado por el Instituto Universitario de Estudios de Género de la Universidad Carlos III de Madrid
IX Premio Nacional Educación para el Desarrollo "Vicente Ferrer" 2017 : buenas prácticas
La AECID junto con el Ministerio de Educación y Formación Profesional convoca anualmente los premios de educación para el desarrollo que están dirigidos a todos los centros docentes españoles sostenidos con fondos públicos que impartan educación infantil, educación primaria, educación secundaria obligatoria, bachillerato y formación profesional. Se recogen las buenas prácticas de los centros educativos premiados en la novena edición. Docentes que en el ejercicio de su función educadora han convertido el proceso educativo en un proceso dinámico e interactivo que permite al alumnado desarrollar un conocimiento crítico de nuestro mundo. Profesores y profesoras que han estimulado la participación del alumnado en la construcción de estructuras sociales más justas y solidarias, y han promovido actuaciones basadas en el principio de la corresponsabilidad de todos los actores implicados. El premio reconoce el esfuerzo realizado por centros educativos que establecen y creen en un modelo educativo que propone resaltar el papel de las personas y generar conciencias de carácter global que permitan al alumnado ser pieza clave de la ciudadanía del futuro, con un dinamismo que afronte las nuevas realidades desde una perspectiva más humana y responsable con el territorio en el que se ubican.ES
Long-term prognosis communication preferences in early-stage relapsing-remitting multiple sclerosis.
Multiple sclerosis is one of the most common causes of neurological disability in young adults with major consequences for their future lives. Improving communication strategies on prognosis may help patients deal with the disease and adjust their long-term life goals. However, there is limited information on patients' preferences of long-term prognosis (LTP) communication and associated factors. The aim of this study was to describe patients' preferences and assess the factors associated with LTP communication preferences in early-stage relapsing-remitting multiple sclerosis (RRMS) patients. A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration from first attack ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0-5.5 were included. The Prognosis in MS questionnaire was used to assess how much patients want to know about their LTP. Different patient-reported measures were administered to gather information on symptom severity, pain, fatigue, mood/anxiety, quality of life, stigma, illness perception, feeling of hopelessness, self-efficacy, information avoidance and coping strategies. Cognition was assessed using the Symbol Digit Modalities Test (SDMT). A multivariate logistic regression analysis was performed to assess the association between LTP information preference and demographic and clinical characteristics, as well as patients' perspectives. A total of 189 patients were included (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.2 ± 0.8 years). Median EDSS score was 1.0 (IQR = 0.0-2.0). A proportion of 68.5% (n = 126) of patients had never discussed LTP with their neurologists, whereas 69.2% (n = 126) reported interest in knowing it (73.5% at diagnosis). Bivariate analyses suggested that patients were significantly more likely to have higher LTP information preferences if they were male and had a lower SDMT score. Male gender and a lower SDMT score were predictors of LTP information preferences. Patients with early-stage RRMS want to discuss their LTP shortly after diagnosis. Understanding the factors involved may be useful to design individualized communication strategies
Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.4 ± 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making
#EllasSomosTodas
El trabajo obtuvo un premio de la Modalidad B de los Premios Tomás García Verdejo a las buenas prácticas educativas de la Comunidad Autónoma de Extremadura para el curso académico 2014/2015Se describe un proyecto llevado a cabo en el IES Al-Qazares (Cáceres), en concreto en el Ciclo Formativo de Grado Superior de Integración Social, orientado a la sensibilización contra la violencia de género en la sociedad y en el centro. Entre los objetivos de la experiencia destacan: animar al alumnado a ser partícipe de sus propios aprendizajes fomentando una metodología basada en la investigación-acción, utilizar las tecnologías de la información y comunicación, desarrollar habilidades de trabajo en equipo y gestión de conflictos, fomentar la igualdad entre hombres y mujeres y aplicar la perspectiva de género en el desarrollo del trabajo diarioExtremaduraES
Incidence and Prevalence of Children's Diffuse Lung Disease in Spain.
Children's diffuse lung disease, also known as children's Interstitial Lung Diseases (chILD), are a heterogeneous group of rare diseases with relevant morbidity and mortality, which diagnosis and classification are very complex. Epidemiological data are scarce. The aim of this study was to analyse incidence and prevalence of chILD in Spain. Multicentre observational prospective study in patients from 0 to 18 years of age with chILD to analyse its incidence and prevalence in Spain, based on data reported in 2018 and 2019. A total of 381 cases with chILD were notified from 51 paediatric pulmonology units all over Spain, covering the 91.7% of the paediatric population. The average incidence of chILD was 8.18 (CI 95% 6.28-10.48) new cases/million of children per year. The average prevalence of chILD was 46.53 (CI 95% 41.81-51.62) cases/million of children. The age group with the highest prevalence were children under 1 year of age. Different types of disorders were seen in children 2-18 years of age compared with children 0-2 years of age. Most frequent cases were: primary pulmonary interstitial glycogenosis in neonates (17/65), neuroendocrine cell hyperplasia of infancy in infants from 1 to 12 months (44/144), idiopathic pulmonary haemosiderosis in children from 1 to 5 years old (13/74), hypersensitivity pneumonitis in children from 5 to 10 years old (9/51), and scleroderma in older than 10 years old (8/47). We found a higher incidence and prevalence of chILD than previously described probably due to greater understanding and increased clinician awareness of these rare diseases
Políticas públicas
Amputación de extremidades superiores: caracterización epidemiológicaAnálisis comparado de las políticas de promoción de la salud entre Chile y CataluñaAnálisis de los Avisa para la toma de decisiones en políticas de saludAntecedentes de colelitiasis en pacientes que presentaron colecistitis aguda. ¿Se puede prevenir la urgencia?Asociación entre alcoholemia y traumatismos en Copiapó, 2009Automedicación en la población asistente al Cesfam de Puerto NatalesAutotoma vaginal para detección de VPH para la prevención de cáncer cervicouterino, ChileCalidad de atención programa Auge- cáncer cervicouterino: la perspectiva de los profesionalesCaracterización de los casos de traumatismo encéfalo craneano en la comuna de Til-TilConocimiento de conductores universitarios sobre la alcoholemia permitida para conducir y su equivalencia en bebidas alcohólicasDescripción de la consulta dermatológica pediátrica en el Hospital Roberto del Río (2007-2008)Elementos para un abordaje metodológico de la salud intercultural en la Región Metropolitana de SantiagoEstudio descriptivo de consultas Sapu Cesfam Angachilla, visión tras dos años de registro clínico-electrónicoEstudio descriptivo de ingresos a Conin Valdivia, una revisión de 10 años (1998-2008)Estudio descriptivo de pacientes hospitalizados por absceso y celulitis peritonsilar en el hospital de PurranqueEvaluación de la aceptabilidad y consumo de alimentos del Pacam inscritos en el Cesfam Dr. V.M.FEvaluación de la interacción de medicinas alternativas o complementarias (MAC) en dos centros APSExposición a humo de tabaco ambiental. Signos y síntomas respiratorios bajos: estudio de prevalenciaFactores relacionados con la rotación laboral de médicos en consultorios del Gran SantiagoFibrosis quística como patología GES: una mirada críticaHipersensibilidad dentinaria: comparación de diferentes alternativas terapéuticasImpacto del GES en cáncer mamario: seguimiento a 5 años en un hospital del SSMSImplementación de la política nacional de medicamentos: percepción del profesional químico farmacéuticoLa implementación de políticas públicas cambió mortalidad de los pacientes gran quemado en Chile¿La infertilidad debería ser considerada un problema de salud pública en el Perú?Modelo de monitoreo de una política de protección a la infanciaMortalidad materna en el Hospital Dr. Alfredo van Grieken Coro, Estado Falcón, Venezuela 2005-2009Objetivos de desarrollo del milenio. Modelación de la mortalidad infantil Nicaragua - Costa Rica 1978-2008Percepción de riesgo y beneficio respecto del cigarrillo y su relación con el tabaquismo adolescentePolíticas públicas y salud intercultural: la experiencia de la organización indígena Taiñ adkimnPrevalencia de atipias celulares del cuello uterino en mujeres entre 18 y 24 añosProceso de ser histerectomizada: relatos de experiencias de mujeres en un hospital público de SantiagoProceso de ser histerectomizada: relatos de experiencias de mujeres en un hospital público de SantiagoPrograma Auge y cáncer cervicouterino: calidad de atención percibida por las usuarias del programaResolución quirúrgica por patología adenoamigdalina: ¿Es la población mapuche un grupo de riesgo?Resultados de alcoholemias tanatológicas del Servicio Médico Legal de Copiapó 1999-2009Resultados de la evaluación de los objetivos sanitarios de la década 2000-2010Una mirada a los servicios de salud para adolescentes en Puente Alt