Human Orf: An Under-recognized Entity

Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Professionals rarely seek medical attention as they are aware of its benign nature (4)

Um modelo multifásico para estruturas em concreto armado considerando a fissuração do concreto

Assessing the global behavior of reinforced materials from the individual properties of their components has been the subject of a considerable amount of experimental and theoretical works in the last years. The so-called multiphase model is an alternative generalization of the homogenization method and it relies upon the idea that, at the macroscopic scale, the reinforced concrete is a geometrical superposition of the matrix phase (concrete) and the reinforcing phase (steel bars). This technique was already successfully employed in several geotechnical structures. Considering the particular case of concrete structures, Figueiredo et al [1] analyzed the mechanical behavior of reinforced concrete flat slabs under prescribed loading using the multiphase model in elastoplasticity. The present contribution extents a previously numerical code to account for concrete cracking based on a smeared crack approach. Comparison with direct simulation results emphasizes the advantage of such multiphase model in terms of reduced computational cost.Determinar o comportamento global de materiais reforçados a partir das propriedades individuais de seus componentes vem sendo tema de um considerável número de trabalhos experimentais e teóricos nos últimos anos. A modelagem multifásica é uma generalização alternativa do método de homogeneização cujo princípio básico consiste em descrever o concreto armado como a superposição geométrica da fase matriz (concreto) e da fase reforço (barras de aço). Esta técnica foi empregada com sucesso em uma série de trabalhos envolvendo estruturas geotécnicas. No caso da estruturas de concreto, Figueiredo et al (2009) estuda o comportamento mecânico de placas de concreto armado sob a ação de carregamento prescrito com o uso da modelagem multifásica em elastoplasticidade. No presente trabalho é acrescentado ao modelo previamente desenvolvido o algoritmo que leva em conta a fissuração do concreto baseado no modelo de fissuras distribuídas apresentado por Hinton (1988). São realizadas comparações com simulações diretas clássicas visando salientar as vantagens do modelo como a redução significativa do custo computacional

Sildenafil improves right ventricular function in a cardiac transplant recipient

We report the case of a male patient who underwent orthotopic cardiac transplantation. A marginal donor was used, because the recipient's clinical condition was critical. He experienced cardiogenic shock due to right ventricular dysfunction secondary to pulmonary hypertension associated with vasoplegia. After the introduction of sildenafil, the patient recovered hemodynamically, his pulmonary vascular resistance decreased, the vasoactive drugs were withdrawn, and his right ventricular function improved.Relatamos caso de um paciente submetido a transplante cardíaco ortotópico, onde se utilizou um doador marginal pela piora clínica do receptor, que apresentava choque cardiogênico por disfunção de ventrículo direito secundária a hipertensão pulmonar associado à vasoplegia. Obtivemos recuperação hemodinâmica do paciente, com redução da resistência vascular pulmonar, retirada de drogas vasoativas e recuperação da função do ventrículo direito após a introdução de sildenafil.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciEL

Human Orf: An Under-recognized Entity

Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Professionals rarely seek medical attention as they are aware of its benign nature (4)

Unilateral punctate porokeratosis - Case report

This case report involves a 20-year-old man with unilateral punctate porokeratosis. The patient presented an 8-year history of numerous asymptomatic keratotic papules and pits with linear distribution on his left pal-mar surface and fifth finger of the left hand. Histopathological examination of the keratotic plug revealed findings of distinct epidermal depressions containing cornoid lamellae. This report review draws attention to differential diagnoses of punctate porokeratosis