How to Create Entrepreneurial and Innovative Culture and Sustain it in a Large Organization?

Research on entrepreneurial culture in large and established organizations is a field that has been growing more and more recently. With foundational research dating as far back as 1970, there was a significant acceleration in corporate entrepreneurship research in the 1990s. We have entered a new era in the years 2000-2012 with explorations of topics such as corporate venturing and efficient opportunity recognition (Zahra, Randerson, and Fayolle, 2013). We will present here results that are relevant to our question, starting by defining the characteristics and advantages of a strong entrepreneurial culture, then we will present research on the process of implementing such a culture

What are the Characteristics that Separate High Potential Executives From the Rest?

One of the most active field in business oriented psychology has been concerning the matter of the identification of personality and behavioral traits that separate high performers from the rest of the pack. Which characteristics seem to be the most effective in predicting an executive’s performance? How can we precisely define them? Which ways allow us to detect them easily? The effective identification of the predominant traits that are common to high performance executives allow for an easier way to detect potential for talent and promotion, and thus improves greatly the company’s competitiveness

From a Global Perspective, Based on Cost­‐Benefit Analysis, Which Social Media Tool(s) is/are the Most Effective for Attracting Talent?

Social media usage has been growing quite impressively in the last few years, and it has penetrated the recruiting market almost entirely: the number of companies using social media to support their recruitment efforts has gone from 78% in 2008 to 92% in 2013 (Rawson). As such, the efficient use of social media is at the center of the recruiting field, and even is considered one of the biggest competitive advantages: in 2013, when it came to talent acquisition strategy, the difference between the best-­‐in-­‐class companies and the rest was more than twice higher in the areas of sourcing strategy development and company branding than in any other area (Laurano). Both of those areas are the ones where social media has the most impact, and thus the effective use of social media can provide companies with a very potent competitive advantage when it comes to attracting talent

Blur Quantification of Medical Images: Dicom Media, Whole Slide Images, Generic Images and Videos

Introduction/ Background We have designed a quality assurance tool to quantify blur by quantifying the sharpness of custom-sized tiles composing an image, generating global results, detailed exchangeable logs and sharpness-maps regardless of their dimensions, quantity or acquisition rate [1]. We have now integrated the programming libraries and the standalone program we built to existing workflows and software, in order to improve quality assurance procedures. Aims When integrated in an acquisition workflow, the ability to map the quality of local areas inside an image allows to re-acquire parts of the image that were not scanned properly, or discard and re-acquire images when the global results fall under the thresholds set by the users. When integrated in an image analysis software, the regions of interest can be automatically chosen or suggested to the user according to the quality-map of the image to analyze, reducing the amount of incoherent analysis results. When integrated as a library in an image management platform, or as a standalone program in a storage server, a systematic quality check can detect de-calibration of the acquisition software, failed acquisitions that may be automatically deleted and users can be notified to re-acquire the images when below their quality-thresholds profiles. A quantified quality score can be inserted in each image’s metadata for traceability purposes. When integrated as a library in a local or remote image viewer, the best quality tiles can be sent first to the viewer, and magnification levels can be dynamically resampled for a better render. Methods One notable implementation, using our Java library, is inside the FlexMIm project [2], which includes 27 pathology laboratories in the Paris area (coordinated by APHP), research laboratories from University Paris 6 Paris 7, as well as 3 companies: TRIBVN, PERTIMM and Orange. All Whole Slide Images are systematically analyzed and mapped as they enter the platform. The focus map may be displayed on the web interface next to the thumbnail link to the WSI, or in the viewer as a semi-transparent layer over the WSI, or over the WSI map. During the test phase and first integrations in laboratories and hospitals as well as in the FlexMIm project, more than 5000 whole slide images of multiple formats (Hamamatsu NDPI, Aperio SVS, Mirax MRXS, JPEG2000 …) as well as hundreds of thousands of images of various formats (DICOM, TIFF, PNG, JPEG ...) and videos (H264) have been analyzed using our standalone software or our C, C++, Java and Python libraries. Using default or customizable thresholds’ profiles, WSI are sorted as “accepted”, “to review”, “to rescan”. In order to target the samples contained inside each WSI, special attention was paid to detecting blank tiles. Dynamic blank tile detection based on statistical analysis of each WSI was built and successfully validated for all our samples. Results More than 20 trillion pixels have been analyzed at a 3.5 billion pixels per quad-core processor per minute speed rate. Quantified results can be stored in JSON formatted logs or inside a MySQL or MongoDB database) or converted to any chosen data structure to be interoperable with existing software, each tile’s result being accessible in addition to the quality map and the global quality results. This solution is easily scalable as images can be stored at different locations, analysis can be distributed amongst local or remote servers, and quantified results can be stored in remote databases

Whole slide image registration for the study of tumor heterogeneity

Consecutive thin sections of tissue samples make it possible to study local variation in e.g. protein expression and tumor heterogeneity by staining for a new protein in each section. In order to compare and correlate patterns of different proteins, the images have to be registered with high accuracy. The problem we want to solve is registration of gigapixel whole slide images (WSI). This presents 3 challenges: (i) Images are very large; (ii) Thin sections result in artifacts that make global affine registration prone to very large local errors; (iii) Local affine registration is required to preserve correct tissue morphology (local size, shape and texture). In our approach we compare WSI registration based on automatic and manual feature selection on either the full image or natural sub-regions (as opposed to square tiles). Working with natural sub-regions, in an interactive tool makes it possible to exclude regions containing scientifically irrelevant information. We also present a new way to visualize local registration quality by a Registration Confidence Map (RCM). With this method, intra-tumor heterogeneity and charateristics of the tumor microenvironment can be observed and quantified.Comment: MICCAI2018 - Computational Pathology and Ophthalmic Medical Image Analysis - COMPA

Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

Mitochondrial outer membrane permeabilization by proapoptotic Bcl-2 family proteins, such as Bax, plays a crucial role in apoptosis induction. However, whether this only causes the intracytosolic release of inducers of caspase-dependent death, such as cytochrome c, or also of caspase-independent death, such as apoptosis-inducing factor (AIF) remains unknown. Here, we show that on isolated mitochondria, Bax causes the release of cytochrome c, but not of AIF, and the association of AIF with the mitochondrial inner membrane provides a simple explanation for its lack of release upon Bax-mediated outer membrane permeabilization. In cells overexpressing Bax or treated either with the Bax- or Bak-dependent proapoptotic drugs staurosporine or actinomycin D, or with hydrogen peroxide, caspase inhibitors did not affect the intracytosolic translocation of cytochrome c, but prevented that of AIF. These results provide a paradigm for mitochondria-dependent death pathways in which AIF cannot substitute for caspase executioners because its intracytosolic release occurs downstream of that of cytochrome c

Stack or trash? Quality assessment of virtual slides

International audienc

Best Practice Recommendations for the Implementation of a Digital Pathology Workflow in the Anatomic Pathology Laboratory by the European Society of Digital and Integrative Pathology (ESDIP)

The interest in implementing digital pathology (DP) workflows to obtain whole slide image (WSI) files for diagnostic purposes has increased in the last few years. The increasing performance of technical components and the Food and Drug Administration (FDA) approval of systems for primary diagnosis led to increased interest in applying DP workflows. However, despite this revolutionary transition, real world data suggest that a fully digital approach to the histological workflow has been implemented in only a minority of pathology laboratories. The objective of this study is to facilitate the implementation of DP workflows in pathology laboratories, helping those involved in this process of transformation to identify: (a) the scope and the boundaries of the DP transformation; (b) how to introduce automation to reduce errors; (c) how to introduce appropriate quality control to guarantee the safety of the process and (d) the hardware and software needed to implement DP systems inside the pathology laboratory. The European Society of Digital and Integrative Pathology (ESDIP) provided consensus-based recommendations developed through discussion among members of the Scientific Committee. The recommendations are thus based on the expertise of the panel members and on the agreement obtained after virtual meetings. Prior to publication, the recommendations were reviewed by members of the ESDIP Board. The recommendations comprehensively cover every step of the implementation of the digital workflow in the anatomic pathology department, emphasizing the importance of interoperability, automation and tracking of the entire process before the introduction of a scanning facility. Compared to the available national and international guidelines, the present document represents a practical, handy reference for the correct implementation of the digital workflow in Europe.publishedVersio