Ideological narrative in modern American political discourse

The discourse of American politicians like any other political figures prominently features a narrative - a system of interconnected stories that transition from one into another from speech to speech. The ideological narrative in political discourse plays an important part in myth creation in supporting the concept of Exceptional Americ

Phosphodiesterase type 5 and high altitude pulmonary hypertension

Methods: 689 subjects (313 men) of mean (SD) age 44 (0.6) years living above 2500 m were screened for HAPH by medical examination and electrocardiography, and 188 (27%) met the criteria for right ventricular hypertrophy. 44 underwent cardiac catheterisation and 29 (66%) had a resting mean pulmonary artery pressure (PAP) above 25 mm Hg. 22 patients with a raised mean PAP were randomised to receive sildenafil (25 or 100 mg) or matching placebo taken 8 hourly for 12 weeks. Results: At 3 months, patients on sildenafil 25 mg 8 hourly (n = 9) had a significantly (p = 0.018) lower mean PAP (–6.9 mm Hg) at the end of the dosing interval than those on placebo (n = 8) (95% CI –12.4 to –1.3). The treatment effect for sildenafil 100 mg 8 hourly (n = 5) compared with placebo was –6.4 mm Hg (95% CI –12.9 to 0.1). Both doses improved 6 minute walk distance, the lower dose by 45.4 m (95% CI 11.5 to 79.4; p = 0.011) and the higher dose by 40.0 m (95% CI 0.2 to 79.8; p = 0.049). Sildenafil was well tolerated. Necroscopic lung specimens from three subjects with HAPH showed abundant PDE5 in the muscular coat of remodelled pulmonary arterioles. Conclusions: PDE5 is an attractive drug target for the treatment of HAPH and a larger study of the long term effects of PDE5 inhibition in HAPH is warranted

New national and regional bryophyte records, 67

Bulgaria. Samokov Region, Rila Mountains, Rila National Park, N slopes of peak Deno, on granite slabs and scree, collected with occasional sporophytes, 42.19709°N, 23.60322°E, 2780 m a.s.l, 17 September 2019, leg./det. R. Natcheva s.n. (SOM 9811-B). This arctic-alpine species has a north Holarctic circumpolar distribution and this is the first report of Andreaea blyttii for SE Europe. It is its southernmost locality and extends its range further south in Europe. The Rila Mountains are the highest in the Balkan peninsula and A. blyttii was found near the highest summit (Mussala, 2925 m a.s.l.). In Bulgaria the genus Andreaea is also represented by A. alpestris (Thed.) Schimp. and A. rupestris Hedw., both of which occur in the Rila Mountains