Environmental indicators applied to reality of Eco-Industrial Park (EIP)

Part of: Seliger, Günther (Ed.): Innovative solutions : proceedings / 11th Global Conference on Sustainable Manufacturing, Berlin, Germany, 23rd - 25th September, 2013. - Berlin: Universitätsverlag der TU Berlin, 2013. - ISBN 978-3-7983-2609-5 (online). - http://nbn-resolving.de/urn:nbn:de:kobv:83-opus4-40276. - pp. 84-89.The Eco-Industrial Parks (EIP - Eco-Industrial Park) emerged as a new model of spatial organization for industrial arrangements. An important feature for an EIP is the adoption of the concept of industrial symbiosis (IS), in which companies reuse waste to reach a closed system, reducing environmental impact. The article describes an analysis of the environmental indicators used in EIPs through a systematic literature review (RBS). Results indicated that there are proposals to evaluate the waste stream and the symbiosis of an EIP through detailed indicators, which capture the need in a particular moment of time. The paper describes, compares and analyzes these proposals. As a result, it was shown that they have limitations described and exemplified in the text

Blended diets for gastrostomy fed children: A scoping review

Objective: The objective of the review was to identify what is known about the use of blended diets with gastrostomy fed children and young people and to identify gaps in the literature on this topic in order to inform future research and policy. Method: A scoping review methodology was used; searching online databases PUBMED, PsychINFO, CINAHL, SCOPUS and AMED, EMBASE for articles that addressed issues pertaining to blended diets. The review identified a broad range of literature regardless of study design and described and evaluated the quality, range and nature of research activity related to the use of blenderised diets. Results: Forty-three studies were included in the review. The studies focused on nutrition, equipment, views of carers and patients and views of professionals. Several studies described the lack of evidence regarding pros and cons of blended diets and highlighted the need for further research into the field. Conclusions: There were gaps in the evidence base regarding the impact of blended diets on health and well-being of the children who are given them and upon the carers who feed them. The nutritional impact of blended diets is not fully understood, and the knowledge and views of professionals involved in the care of those receiving blended diets varies

EMERGÊNCIA E DESENVOLVIMENTO INICIAL DE PLÂNTULAS DE SOJA EM FUNÇÃO DO VIGOR E DIFERENTES PROFUNDIDADES DE SEMEADURA

Diversos fatores podem afetar o crescimento e a produção de soja, dos quais pode-se destacar o usode sementes de baixa qualidade e a profundidade de deposição da semente no solo. Este trabalhoteve como objetivo avaliar a influência do vigor e da profundidade de semeadura no estabelecimento inicialde plantas de soja. Um experimento a campo foi conduzido em delineamento inteiramente casualizadosob arranjo fatorial 2 x 4, com quatro repetições. O primeiro fator foi constituído por dois níveis de vigor desoja (Alto e baixo) e o segundo por quatro profundidades de semeadura (4, 8, 10 e 12 cm), totalizando 32parcelas experimentais. Cada unidade experimental foi constituída por uma linha de semeadura contendo50 sementes. Foram avaliados a emergência, o índice de velocidade de emergência de plântulas, matéria fresca eseca das plantas, comprimento das raízes e parte aérea das plantas. Os resultados demonstram que aprofundidade de semeadura estudadas não afeta a emergência e matéria seca de plantas de soja,independentemente do nível de vigor das sementes utilizadas. Porém o comprimento de planta foi alterado, sendoque sementes de alto vigor foram maiores que as de baixo vigor, quando depositadas na maior profundidade(12cm). Também foi evidente o efeito isolado do vigor das sementes na emergência de plântulas em campo,sendo superior quando oriundas das sementes de alto vigor. Assim, o vigor e a profundidade desemeadura afeta a emergência e o crescimento inicial de plantas de soja

The effect of PTC mutations on CFTR messenger RNA abundance

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A INFECÇÃO DO TRATO URINÁRIO RELACIONADA AO USO DE SONDA VESICAL DE DEMORA EM PACIENTES CRÍTICOS: O IMPACTO DA ASSISTÊNCIA DE ENFERMAGEM

Introduction: Intensive care units (ICUs) are intended for patients known as critical, requiring care that requires greater health care complexities, in a specialized and continuous manner. UTIs are characterized by several clinical conditions that occur due to the presence of microorganisms in the urinary tract, which colonize the region after attaching themselves to the epithelium. The use of an indwelling urinary catheter (SVD) is linked to a high rate of UTI, corresponding to approximately 70% to 98% of asymptomatic bacteriuria and 10% to 35% of symptomatic infections. Methodology: The research was developed through an integrative review of the literature, using a synopsis of results found through previously published research, with the aim of carrying out a discussion on the data obtained. Results and Discussion: According to the results of this study, it was found that, despite bringing great benefits to many patients, the use of urethral catheters presented consequences and risks due to manipulation of the urinary tract. A scoping review that evaluated infection factors related to nursing procedures in the ICU showed that, seeking to prevent or reduce the incidence of Healthcare-Associated Infections (HAIs), nursing has resources to improve the execution of SVD (survey bladder delay) (PAIVA et al., 2021). Conclusion: It can be seen that evidence-based interventions can facilitate the assessment of the need for urinary catheterization and promote the removal of the catheter when it is no longer necessary, resulting in a reduction in urinary tract infection (UTI) rates.Introdução: As unidades de terapia intensiva (UTIs), destinam-se a pacientes denominados como críticos, necessitando de cuidados que requerem maiores complexidades assistenciais a saúde, de maneira especializada e contínua. As ITUs são caracterizadas por diversas condições clínicas que acorrem devido a presença de microrganismos nas vias urinárias estes colonizam a região após se fixarem no epitélio. O uso de Sonda Vesical de Demora (SVD) está atrelado a um grande índice de ITU, correspondendo cerca de 70% a 98% referente a bacteriúria assintomática e 10% a 35% de infecções sintomáticas. Metodologia: A elaboração da pesquisa decorreu por meio de uma revisão integrativa da literatura, foram utilizados uma sinopse de resultados encontrados através de pesquisas publicadas anteriormente, com intuito de realizar discussão alusivo aos dados obtidos. Resultados e Discussão: De acordo com os resultados deste estudo, verificou-se que, apesar de trazer grandes benefícios para muitos pacientes, o uso de cateteres uretrais apresentou consequências e riscos devido à manipulação do trato urinário. Uma revisão de escopo que avaliou os fatores de infecções relacionados aos procedimentos de enfermagem na UTI evidenciou que, buscando prevenir ou reduzir a incidência de Infecções Relacionadas à Assistência à Saúde (IRAS), a enfermagem dispõe de recursos para melhorar a execução da SVD (sondagem vesical de demora) (PAIVA et al., 2021). Conclusão: Pode-se perceber que as intervenções embasadas em evidências podem facilitar a avaliação da necessidade de cateterismo urinário e promover a remoção do cateter quando não é mais necessário, resultando na redução das taxas de infecção do trato urinário (ITU)

Bloodstream infections in early postsurgery liver transplant: an analysis of 401 patients over 10 years

Bloodstream infections are a major factor contributing to morbidity and mortality following liver transplantation. The increasing occurrence of multidrug-resistant bloodstream infections represents a challenge for the prevention and treatment of those infections. The aim of this study was to evaluate the occurrence and microbiological profile of bloodstream infections during the early postoperative period (from day 0 to day 60) in patients undergoing liver transplantation from January 2005 to June 2016 at the State University of Campinas General Hospital. A total of 401 patients who underwent liver transplantation during this period were included in the study. The most common cause of liver disease was hepatitis C virus cirrhosis (34.01%), followed by alcoholic disease (16.24%). A total of 103 patients had 139 microbiologically proven bloodstream infections. Gram-negative bacteria were isolated in 63.31% of the cases, gram-positive bacteria in 28.78%, and fungi in 7.91%. Fifty-six infections (43.75%) were multidrug-resistant bacteria, and 72 (56.25%) were not. There was no linear trend concerning the occurrence of multidrug-resistant organisms throughout the study period. Patients with multidrug-resistant bloodstream infections had a significantly lower survival rate than those with no bloodstream infections and those with non multidrug-resistant bloodstream infections. In conclusion, the occurrence of bloodstream infections during the early postoperative period was still high compared with other profile patients, as well as the rates of multidrug-resistant organisms. Even though the occurrence of multidrug resistance has been stable for the past decade, the lower survival rates associated with that condition and the challenge related to its treatment are of major concern.5161972197

The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read-through therapies in cystic fibrosis

A major challenge in cystic fibrosis (CF) research is applying mutation-specific therapy to individual patients with diverse and rare CF transmembrane conductance regulator (CFTR) genotypes. Read-through agents are currently the most promising approach for Class I mutations that introduce premature termination codons (PTCs) into CFTR mRNA. However, variations in degradation of PTC containing transcripts by nonsense mediated decay (NMD) might lower read-through efficacy. Allele specific quantitative real time (qRT)-PCR was used to measure variations in CFTR mRNA abundance for several PTC mutations in respiratory cells and intestinal organoids. The majority of PTC mutations were associated with reduced levels of relative mRNA transcript abundance (similar to 33% and 26% of total CFTR mRNA in respiratory cells and intestinal organoids, respectively, compared to >50% for non-PTC causing mutations). These levels were generally not affected by PTC mutation type or position, but there could be twofold variations between individuals bearing the same genotype. Most PTC mutations in CFTR are subject to similar levels of NMD, which reduce but do not abolish PTC bearing mRNAs. Measurement of individual NMD levels in intestinal organoids and HNE cells might, therefore, be useful in predicting efficacy of PTC read-through in the context of personalized CFTR modulator therapy.40332633

Measurements of CFTR-Mediated Cl- Secretion in Human Rectal Biopsies Constitute a Robust Biomarker for Cystic Fibrosis Diagnosis and Prognosis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Background: Cystic Fibrosis (CF) is caused by similar to 1,900 mutations in the CF transmembrane conductance regulator (CFTR) gene encoding for a cAMP-regulated chloride (Cl-) channel expressed in several epithelia. Clinical features are dominated by respiratory symptoms, but there is variable organ involvement thus causing diagnostic dilemmas, especially for non-classic cases. Methodology/Principal Findings: To further establish measurement of CFTR function as a sensitive and robust biomarker for diagnosis and prognosis of CF, we herein assessed cholinergic and cAMP-CFTR-mediated Cl- secretion in 524 freshly excised rectal biopsies from 118 individuals, including patients with confirmed CF clinical diagnosis (n = 51), individuals with clinical CF suspicion (n = 49) and age-matched non-CF controls (n = 18). Conclusive measurements were obtained for 96% of cases. Patients with "Classic CF'', presenting earlier onset of symptoms, pancreatic insufficiency, severe lung disease and low Shwachman-Kulczycki scores were found to lack CFTR-mediated Cl- secretion (= 30-35% and data evidenced good correlations with various clinical parameters. Finally, comparison of these values with those in "CF suspicion'' individuals allowed to confirm CF in 16/49 individuals (33%) and exclude it in 28/49 (57%). Statistical discriminant analyses showed that colonic measurements of CFTR-mediated Cl- secretion are the best discriminator among Classic/Non-Classic CF and non-CF groups. Conclusions/Significance: Determination of CFTR-mediated Cl- secretion in rectal biopsies is demonstrated here to be a sensitive, reproducible and robust predictive biomarker for the diagnosis and prognosis of CF. The method also has very high potential for (pre-) clinical trials of CFTR-modulator therapies.710TargetScreen2 [EU/FP6/LSH/2005/037365, PIC/IC/83103/2007]FCT (Portugal) [PEstOE/BIA/UI4046/2011, PEstOE/MAT/UI0006/2011, SFRH/BD/35936/2007, SFRH/BD/69180/2010]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Mukoviszidose e.V. (Germany) [S02/10][PTDC/MAT/118335/2010]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)TargetScreen2 [EU/FP6/LSH/2005/037365, PIC/IC/83103/2007]FCT (Portugal) [PEstOE/BIA/UI4046/2011, PEstOE/MAT/UI0006/2011, SFRH/BD/35936/2007, SFRH/BD/69180/2010]CNPq [40.8924/2006/3]Mukoviszidose e.V. (Germany) [S02/10][PTDC/MAT/118335/2010