10 research outputs found
Emergence of competing magnetic interactions induced by Ge doping in the semiconductor FeGa3
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
ABSTRACT: FeGa3 is an unusual intermetallic semiconductor that presents intriguing magnetic responses to the tuning of its electronic properties. When doped with Ge, the system evolves from diamagnetic to paramagnetic to ferromagnetic ground states that are not well understood. In thiswork,we have performed a joint theoretical and experimental study of FeGa3−xGex using density functional theory and magnetic susceptibility measurements. For low Ge concentrations we observe the formation of localized moments on some Fe atoms and, as the dopant concentration increases, a more delocalized magnetic behavior emerges. The magnetic configuration strongly depends on the dopant distribution, leading even to the appearance of antiferromagnetic interactions in certain configurations
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
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- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
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- Akinyemi R.O.
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- Alarcón-Martín Emilio
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Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Tuning the p-type Schottky barrier in 2D metal/semiconductor interface:boron-sheet on MoSe 2
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
Recent progress of spintronics based on emerging 2D materials: CrI 3
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- Alvarez-Quiceno J C
- Bonanni A
- Chowdhury S
- Duan H
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- 'IOP Publishing'
- Publication date
- Field of study
Edge-Dependent Electronic and Magnetic Characteristics of Freestanding β 12-Borophene Nanoribbons
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- A Garcia-Fuente
- A Lherbier
- A Lopez-Bezanilla
- AD Zabolotskiy
- AJ Mannix
- B Feng
- B Feng
- B Feng
- B Mortazavi
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- G Liu
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- H Shu
- H Wang
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- J Carrete
- J Yuan
- JC Alvarez-Quiceno
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- JP Perdew
- M Ezawa
- M Gao
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- N Troullier
- Q Zhong
- Q Zhong
- RC Xiao
- S Izadi Vishkayi
- T Tsafack
- V Wang
- X Li
- X Wu
- Y Jiao
- Y Liu
- Y Zhao
- Y Zhao
- Y-W Son
- Z Zhang
- Z Zhang
- Z-Q Wang
- Z-Q Wang
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
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- Aaltonen V.
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- Veli-Matti Kosma
- Venkat Subramaniam Rathinakannan
- Verhey F.
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- Victor W Henderson
- Victoria Fernandez-Hernandez
- Victoria Perez
- Victoriana Martínez
- Vidal J. -S.
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- Vilas R. H.
- Vinay Mehta
- Vincent Deramecourt
- Vincent Deramerourt
- Vincent Llorens
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- Vonsattel J. -P.
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- Waring J.
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- Wayne C McCormick
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- Wei Gu
- Wei Zhou
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- Weintraub S.
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- Whitehead P. L.
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- Wilhelmsen K. C.
- Will S Bush
- William Kremen
- William Nash
- William W Seeley
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- Williams B.
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- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T. S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R. L.
- Wong R.
- Woods B.
- Woon M.
- Wright C. B.
- Wu C. -K.
- Wu Y.
- Xia T. -H.
- Xing Chen
- Xinli Hu
- Xiongwei Zhu
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- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
- Zompo M. D.
- Zulaica M.
- Zulma Sevillano
- Álvarez V.
- Åsa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)
Recommended from our members
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics Consortium
- Author
- Abner Erin
- Adams Perrie M.
- Aguirre Alyssa
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Lisa
- Apostolova Liana G.
- Arnold Steven E.
- Asthana Sanjay
- Atwood Craig S.
- Ayres Gayle
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bazemore Katrina
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Bertelson John
- Bird Thomas D.
- Blacker Deborah
- Boeve Bradley F.
- Bowen James D.
- Boxer Adam
- Brewer James
- Burke James R.
- Burns Jeffrey M.
- Bush William S.
- Buxbaum Joseph D.
- Cairns Nigel J.
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Chasse Scott
- Chesselet Marie-Francoise
- Chin Nathaniel A.
- Chui Helena C.
- Chung Jaeyoon
- Craft Suzanne
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cullum Munro
- Darby Eveleen
- Davis Barbara
- De Jager Philip L.
- DeCarli Charles
- DeToledo John
- Dick Malcolm
- Dickson Dennis W.
- Dombroski Beth A.
- Doody Rachelle S.
- Duara Ranjan
- Ertekin-Taner NIlüfer
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrell John J.
- Farrer Lindsay A.
- Fernandez-Hernandez Victoria
- Ferris Steven
- Foroud Tatiana M.
- Frosch Matthew P.
- Fulton-Howard Brian
- Galasko Douglas R.
- Gamboa Adriana
- Gearing Marla
- Geschwind Daniel H.
- Ghetti Bernardino
- Gilbert John R.
- Goate Alison M.
- Grabowski Thomas J.
- Graff-Radford Neill R.
- Green Robert C.
- Growdon John H.
- Grunin Michelle A.
- Haines Jonathan L.
- Hakonarson Hakon
- Hall James
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Harari Oscar
- Hardy John
- Harrell Lindy E.
- Haut Jacob
- Head Elizabeth
- Henderson Victor W.
- Hernandez Michelle
- Hohman Timothy
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hulette Christine M.
- Hyman Bradley T.
- Hynan Linda S.
- Ibanez Laura
- Iqbal Taha
- Jarvik Gail P.
- Jayadev Suman
- Jin Lee-Way
- Johnson Kim
- Johnson Leigh
- Jun Gyungah R.
- Kamboh M. Ilyas
- Karydas Anna M.
- Katz Mindy J.
- Kauwe John S.
- Kaye Jeffrey A.
- Keene C. Dirk
- Khaleeq Aisha
- Kim Ronald
- Knebl Janice
- Kowall Neil W.
- Kramer Joel H.
- Kuksa Pavel P.
- Kukull Walter A.
- Kunkle Brian W.
- Kushch Nicholas
- Kuzma Amanda B.
- LaFerla Frank M.
- Lah James J.
- Larson Eric B.
- Lee Wan-Ping
- Lerner Alan
- Leung Yuk Yee
- Leverenz James B.
- Levey Allan I.
- Li Donghe
- Lieberman Andrew P.
- Lipton Richard B.
- Logue Mark
- Lopez Oscar L.
- Lucio da Fonseca Eder
- Lunetta Kathryn L.
- Lyketsos Constantine G.
- Mains Douglas
- Margaret Flanagan E.
- Marson Daniel C.
- Martin Eden R R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Massman Paul
- Masurkar Arjun
- Mayeux Richard
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McDonough Stefan
- McKee Ann C.
- Mesulam Marsel
- Mez Jesse B.
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Montine Thomas J.
- Monuki Edwin S.
- Morris John C.
- Mukherjee Shubhabrata
- Myers Amanda J.
- Naj Adam C.
- Nguyen Trung
- Olichney John M.
- Ory Marcia
- O’Bryant Sid
- Palmer Ellen L.
- Palmer Raymond
- Parisi Joseph E.
- Pathak Omkar
- Paulson Henry L.
- Pavlik Valory
- Paydarfar David
- Perez Victoria
- Pericak-Vance Margaret A.
- Peskind Elaine
- Petersen Ronald C.
- Pierce Aimee
- Pillai Jagan
- Polk Marsha
- Poon Wayne W.
- Potter Huntington
- Qu Liming
- Quiceno Mary
- Quinn Joseph F.
- Raj Ashok
- Rajabli Farid
- Raskind Murray
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Ringman John M.
- Roberson Erik D.
- Rodriguear Monica
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Royall Donald R.
- Sager Mark A.
- Sano Mary
- Saykin Andrew J.
- Schellenberg Gerard D.
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Sha Jin
- Sherva Richard M.
- Slifer Susan H.
- Small Scott
- Smith Amanda G.
- Smith Janet P.
- Song Yeunjoo E.
- Sonnen Joshua A.
- Spina Salvatore
- St George-Hyslop Peter
- Stern Robert A.
- Stevens Alan B.
- Strittmatter Stephen M.
- Sultzer David
- Swerdlow Russell H.
- Tanzi Rudolph E.
- Tilson Jeffrey L.
- Tosto Giuseppe
- Trojanowski John Q.
- Troncoso Juan C.
- Tsuang Debby W.
- Valladares Otto
- Van Deerlin Vivianna M.
- van Eldik Linda J.
- Vance Jeffery M.
- Vardarajan Badri N.
- Vassar Robert
- Vinters Harry V.
- Vonsattel Jean-Paul
- Wang Li-San
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Wheeler Nicholas R.
- Whitehead Patrice L.
- Wijsman Ellen M.
- Wilhelmsen Kirk C.
- Williams Benjamin
- Williamson Jennifer
- Wilms Henrik
- Wingo Thomas S.
- Wisniewski Thomas
- Woltjer Randall L.
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zhu Xiongwei
- Publication venue
- Cold Spring Harbor Laboratory
- Publication date
- 08/07/2023
- Field of study
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer’s Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. We identified 13 loci with cross-ancestry associations including known loci at/near
CR1
,
BIN1
,
TREM2
,
CD2AP
,
PTK2B
,
CLU
,
SHARPIN
,
MS4A6A
,
PICALM
,
ABCA7
,
APOE
and two novel loci not previously reported at 11p12 (
LRRC4C
) and 12q24.13 (
LHX5-AS1
). Reflecting the power of diverse ancestry in GWAS, we observed the
SHARPIN
locus using 7.1% the sample size of the original discovering single-ancestry GWAS (n=788,989). We additionally identified three GWS ancestry-specific loci at/near (
PTPRK
(
P
=2.4×10
-8
) and
GRB14
(
P
=1.7×10
-8
) in HIS), and
KIAA0825
(
P
=2.9×10
-8
in NHW). Pathway analysis implicated multiple amyloid regulation pathways (strongest with
P
adjusted
=1.6×10
-4
) and the classical complement pathway (
P
adjusted
=1.3×10
-3
). Genes at/near our novel loci have known roles in neuronal development (
LRRC4C, LHX5-AS1
, and
PTPRK
) and insulin receptor activity regulation (
GRB14
). These findings provide compelling support for using traditionally-underrepresented populations for gene discovery, even with smaller sample sizes
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez Céline
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse Céline
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
- Brown Kristelle S.
- Brusco Luis Ignacio
- Bråthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido María J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
- Call Katherine
- Call Kathy
- campion Dominique
- Campos-Martin Rafael
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- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele