Torsion cycles as non-local magnetic sources in non-orientable spaces

Non-orientable spaces can appear to carry net magnetic charge, even in the absence of magnetic sources. It is shown that this effect can be understood as a physical manifestation of the existence of torsion cycles of codimension one in the homology of space.Comment: 17 pages, 4 figure

Obtención por vía SHS-AE de compuesto cerámico αSiC-αAl2O3-CaAl4O7

El presente trabajo muestra los resultados experimentales de la obtención del compuesto cerámico SiC-Al2O3-CaAl 4O7 mediante el proceso SHS-AE (síntesis auto-sostenida de alta temperatura combinada con arco eléctrico) a partir del sistema vidrio sódico-cálcico-Al-C. Se utilizó horno de arco eléctrico con atmósfera de argón para la reducción del contenido de sílice presente en el vidrio con aluminio.La combinación de la energía de la reacción de formación del Al2O3 con la del arco eléctrico provee suficiente energía térmica para superar las barreras cinéticas asociadas con la reacción de formación de los componentes cerámicos.A partir de las relaciones estequiométricas de las materias primas, (polvos que se compactan en forma de pastilla) se efectúa la síntesis alcanzando una temperatura superior a los 2500 K formándose el compuesto SiC-Al2O3-CaAl 4O7. Las muestras obtenidas se caracterizaron por DRX y MEB-EDX confirmando la obtención simultánea de αSiC-αAl2O3-CaAl4O7

Neumonía trombopenia y afectación hepática en un caso de fiebre Q aguda

PneumoniaFebr

Ahnak1 modulates L-type Ca(2+) channel inactivation of rodent cardiomyocytes

Ahnak1, a giant 700 kDa protein, has been implicated in Ca(2+) signalling in various cells. Previous work suggested that the interaction between ahnak1 and Cavbeta(2) subunit plays a role in L-type Ca(2+) current (I (CaL)) regulation. Here, we performed structure-function studies with the most C-terminal domain of ahnak1 (188 amino acids) containing a PxxP consensus motif (designated as 188-PSTP) using ventricular cardiomyocytes isolated from rats, wild-type (WT) mice and ahnak1-deficient mice. In vitro binding studies revealed that 188-PSTP conferred high-affinity binding to Cavbeta(2) (K (d) approximately 60 nM). Replacement of proline residues by alanines (188-ASTA) decreased Cavbeta(2) affinity about 20-fold. Both 188-PSTP and 188-ASTA were functional in ahnak1-expressing rat and mouse cardiomyocytes during whole-cell patch clamp. Upon intracellular application, they increased the net Ca(2+) influx by enhancing I (CaL) density and/or increasing I (CaL) inactivation time course without altering voltage dependency. Specifically, 188-ASTA, which failed to affect I (CaL) density, markedly slowed I (CaL) inactivation resulting in a 50-70% increase in transported Ca(2+) during a 0 mV depolarising pulse. Both ahnak1 fragments also slowed current inactivation with Ba(2+) as charge carrier. By contrast, neither 188-PSTP nor 188-ASTA affected any I (CaL) characteristics in ahnak1-deficient mouse cardiomyocytes. Our results indicate that the presence of endogenous ahnak1 is required for tuning the voltage-dependent component of I (CaL) inactivation by ahnak1 fragments. We suggest that ahnak1 modulates the accessibility of molecular determinants in Cavbeta(2) and/or scaffolds selectively different beta-subunit isoforms in the heart

Effects of type and level of fibre on digestive physiology and performance in reproducing and growing rabbits

The study aimed to evaluate the effect of level and type of fibre on performance and digestive traits of lactating does and growing rabbits. Two lactation diets were formulated to contain a similar level of NDF (29%): a mixture of alfalfa hay and wheat straw in diet L1 was substituted with apple pulp in diet L2. Three fattening diets were formulated: diet F1 was the same than diet L1 whereas F2 and F3 had higher level of NDF (33 and 36%, respectively) with a mixture of wheat straw and alfalfa hay in diet F2 substituted by apple pulp in diet F3. A total of 110 does and their litters were controlled during two consecutive lactations from 21 to 35 d. At weaning (35 days of age) 480 rabbits were housed collectively (four per cage) and 180 individually. Another 54 rabbits were slaughtered to determine digestive traits at 45 days of age. At 35 days of age, L1 rabbits showed 5.9 and 6.9% higher daily feed intake and body weight than L2 rabbits. In the fattening period (35 to 63 days), L1 rabbits showed a higher growth rate but a lower feed efficiency than L2 animals. In the fattening period, F1 rabbits showed a 5.9% higher weight gain and 8.8% lower feed conversion than F2 animals, whereas animals fed diet F2 had a higher weight gain (7.6%) and a worse feed conversion (6.5%) than animals fed diet F3. The highest apparent ileal digestibility of DM values was obtained for diets F1 and F3. Villi length tended to be longer (P<0.10) in animals fed the diet F1 and F3. No significant influence of treatments was detected on caecal pH, anaerobic bacteria counting or rabbit mortality (only 0.9% on average). In conclusion the substitution of a mixture of wheat straw and alfalfa hay by apple pulp in isofibrous diets increases feed efficiency but also impairs feed intake and growth rate. Furthermore, in a context of low mortality, diets with 29-30% NDF would lead to better performances in the fattening period than diets containing 33-36% NDF levels.This work was supported by a CDTI Project 04-0136.Alvarez, J.; Marguenda, I.; García-Rebollar, P.; Carabaño, R.; Blas, CD.; Corujo, A.; García-Ruiz, A. (2007). Effects of type and level of fibre on digestive physiology and performance in reproducing and growing rabbits. World Rabbit Science. 15(1):9-17. doi:10.4995/wrs.2007.61091715

Detecting Microscopic Black Holes with Neutrino Telescopes

If spacetime has more than four dimensions, ultra-high energy cosmic rays may create microscopic black holes. Black holes created by cosmic neutrinos in the Earth will evaporate, and the resulting hadronic showers, muons, and taus may be detected in neutrino telescopes below the Earth's surface. We simulate such events in detail and consider black hole cross sections with and without an exponential suppression factor. We find observable rates in both cases: for conservative cosmogenic neutrino fluxes, several black hole events per year are observable at the IceCube detector; for fluxes at the Waxman-Bahcall bound, tens of events per year are possible. We also present zenith angle and energy distributions for all three channels. The ability of neutrino telescopes to differentiate hadrons, muons, and possibly taus, and to measure these distributions provides a unique opportunity to identify black holes, to experimentally constrain the form of black hole production cross sections, and to study Hawking evaporation.Comment: 20 pages, 9 figure

Large time existence for 3D water-waves and asymptotics

We rigorously justify in 3D the main asymptotic models used in coastal oceanography, including: shallow-water equations, Boussinesq systems, Kadomtsev-Petviashvili (KP) approximation, Green-Naghdi equations, Serre approximation and full-dispersion model. We first introduce a ``variable'' nondimensionalized version of the water-waves equations which vary from shallow to deep water, and which involves four dimensionless parameters. Using a nonlocal energy adapted to the equations, we can prove a well-posedness theorem, uniformly with respect to all the parameters. Its validity ranges therefore from shallow to deep-water, from small to large surface and bottom variations, and from fully to weakly transverse waves. The physical regimes corresponding to the aforementioned models can therefore be studied as particular cases; it turns out that the existence time and the energy bounds given by the theorem are always those needed to justify the asymptotic models. We can therefore derive and justify them in a systematic way.Comment: Revised version of arXiv:math.AP/0702015 (notations simplified and remarks added) To appear in Inventione

The one-loop vacuum energy and RG flow induced by double-trace operators in AdS/CFT and dS/CFT correspondence

We calculate the difference of one-loop vacuum energies for massive scalar field in five-dimensional AdS black hole. (The same is done in five-dimensional deSitter space). In each case this difference is specified by the boundary conditions corresponding to the double-trace operator (massive term) and it describes RG flow in the manner discussed by Gubser-Mitra for pure AdS space. For AdS black hole there occurs instability which is the manifestation of the Hawking-Page phase transition. For stable phase of AdS black hole as well as for deSitter bulk, c-function found beyond the leading order approximation shows the monotonic behaviour consistent with c-theorem.Comment: LaTeX file, 3 eps files, 26 pages. The discussion is clarified, version to appear in PR

Large time wellposdness to the 3-D Capillary-Gravity Waves in the long wave regime

In the regime of weakly transverse long waves, given long-wave initial data, we prove that the nondimensionalized water wave system in an infinite strip under influence of gravity and surface tension on the upper free interface has a unique solution on [0,{T}/\eps] for some \eps independent of constant $T.$ We shall prove in the subsequent paper \cite{MZZ2} that on the same time interval, these solutions can be accurately approximated by sums of solutions of two decoupled Kadomtsev-Petviashvili (KP) equations.Comment: Split the original paper(The long wave approximation to the 3-D capillary-gravity waves) into two parts, this is the first on

Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations

AbstractThe deregulation of B cell differentiation has been shown to contribute to autoimmune disorders, hematological cancers, and aging. We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1+/CD19− and IgG1+/CD19+ B cell populations. Aldh1a1 regulated transcription factors during B cell differentiation in a sequential manner: 1) retinoic acid receptor alpha (Rara) in IgG1+/CD19− and 2) zinc finger protein Zfp423 and peroxisome proliferator-activated receptor gamma (Pparg) in IgG1+/CD19+ splenocytes. In Aldh1a1−/− mice, splenic IgG1+/CD19− and IgG1+/CD19+ B cells acquired expression of proto-oncogenic genes c-Fos, c-Jun, and Hoxa10 that resulted in splenomegaly. Human multiple myeloma B cell lines also lack Aldh1a1 expression; however, ectopic Aldh1a1 expression rescued Rara and Znf423 expressions in these cells. Our data highlight a mechanism by which an enzyme involved in vitamin A metabolism can improve B cell resistance to oncogenesis