Airway and Esophageal Stenting in Patients with Advanced Esophageal Cancer and Pulmonary Involvement

BACKGROUND: Most inoperable patients with esophageal-advanced cancer (EGC) have a poor prognosis. Esophageal stenting, as part of a palliative therapy management has dramatically improved the quality of live of EGC patients. Airway stenting is generally proposed in case of esophageal stent complication, with a high failure rate. The study was conducted to assess the efficacy and safety of scheduled and non-scheduled airway stenting in case of indicated esophageal stenting for EGC. METHODS AND FINDINGS: The study is an observational study conducted in pulmonary and gastroenterology endoscopy units. Consecutive patients with EGC were referred to endoscopy units. We analyzed the outcome of airway stenting in patients with esophageal stent indication admitted in emergency or with a scheduled intervention. Forty-four patients (58+/-\-8 years of age) with esophageal stenting indication were investigated. Seven patients (group 1) were admitted in emergency due to esophageal stent complication in the airway (4 fistulas, 3 cases with malignant infiltration and compression). Airway stenting failed for 5 patients. Thirty-seven remaining patients had a scheduled stenting procedure (group 2): stent was inserted for 13 patients with tracheal or bronchial malignant infiltration, 12 patients with fistulas, and 12 patients with airway extrinsic compression (preventive indication). Stenting the airway was well tolerated. Life-threatening complications were related to group 1. Overall mean survival was 26+/-10 weeks and was significantly shorter in group 1 (6+/-7.6 weeks) than in group 2 (28+/-11 weeks), p<0.001). Scheduled double stenting significantly improved symptoms (95% at day 7) with a low complication rate (13%), and achieved a specific cancer treatment (84%) in most cases. CONCLUSION: Stenting the airway should always be considered in case of esophageal stent indication. A multidisciplinary approach with initial airway evaluation improved prognosis and decreased airways complications related to esophageal stent. Emergency procedures were rarely efficient in our experience

Two new serovars of Salmonella: S. Natal and S. potengi, isolated from fluvial water in Natal, Rio Grande do Norte State, Brazil

Submitted by Sandra Infurna ([email protected]) on 2019-11-18T19:53:06Z No. of bitstreams: 1 ClaudeSolari_ErnestoHofer_etal_IOC_1984.pdf: 59069 bytes, checksum: e19d451d32bb8b6b25c7be3a8f4e6bb2 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-11-18T20:01:16Z (GMT) No. of bitstreams: 1 ClaudeSolari_ErnestoHofer_etal_IOC_1984.pdf: 59069 bytes, checksum: e19d451d32bb8b6b25c7be3a8f4e6bb2 (MD5)Made available in DSpace on 2019-11-18T20:01:17Z (GMT). No. of bitstreams: 1 ClaudeSolari_ErnestoHofer_etal_IOC_1984.pdf: 59069 bytes, checksum: e19d451d32bb8b6b25c7be3a8f4e6bb2 (MD5) Previous issue date: 1984Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Rio de Janeiro, RJ, Brasil.Instituto Adolfo Lutz. São Paulo, SP, Brasil.Descrevem-se dois novos sorotipos de Salmonella, isolados de águas do estuário do rio Potengi, Natal, RN, que receberam as denominações de S. natal (9,12:z4, z24:-) e S. potengi (18:z: -). Ambos pertencem ao subgênero I ou subespécie 1, embora tenham tido comportamento atípico (KCN +).Two new serovars of Salmonella from estuary waters of potengi river in Natal, Rio Grande do Norte, were isolated. They were named S. natal (9,12: z4, z24:-) and S. potengi (18;z: -). Both types belong to the subgenus I, or subspecies 1, thought they showed atypical behaviour (KCN +)