Quality of Life and Treatment Outcome Under Inhalation Sedation

Title: Quality of life and treatment outcome under inhalation sedation AIM: To assess the outcome of treatment and changes in quality of life (QoL) following comprehensive dental treatment using nitrous oxide inhalation sedation. METHODS Patients attending the Sedation Unit at the Leeds Dental Institute were asked to participate in the study. Baseline questionnaires included a quality of life (QoL) assessment (COHIP-SF19) and the p-IOSN tool (indication of sedation need). Participants were followed up to evaluate the outcome of their treatment. Those who completed treatment as planned completed a second QoL assessment at least 2 weeks following their last appointment. RESULTS: In total, 97 patients were recruited (44 males and 53 females), and of these 47 completed treatment as planned with 31 completing a 2nd QoL assessment, 18 are currently undergoing treatment, and 20 were referred to GA. There was a statistically significant improvement in QoL following treatment (p value= 0.000), with the largest effect size noted in the “oral health well-being” domain. When not controlling for other factors, a change from high to low anxiety was significantly associated with high baseline QoL (B= 6.632 p value = 0.023). Changing from high to low sedation need decreased the likely need for referring to GA and not completing treatment as planned (B -1.788 p value 0.05). CONCLUSION: Rendering the child dentally fit improved QoL. Using anxiety, gender, age group or sedation need as measures could not accurately predict the treatment outcome of the child or the baseline QoL scores, when controlling for sedation need and anxiety

Solar Energy

Solar energy schemes based on photovoltaic cells have attracted extensive interest in recent years due to their capabilities of clear and seemingly limitless generated energy. This chapter proposed a simple, cost effective and efficient system for solar photovoltaic applications. Solar energy is considered as an fastest growing renewable energy resource like wind energy for electricity generation. Solar energy is a free, clean abundant sun energy considered an inexhaustible source for electricity generation. The solar photovoltaic system is characterized by variable output power due to its operation dependency on solar irradiance and cell temperature. To maximize the energy generation potential of solar PV, a research effort is focused on solar cell manufacturing technology to increase its generation efficiency and explore advancements in power electronic devices for small and large scale deployment. The main aim is to find the unknown parameters of the nonlinear current–voltage (I-V) equations by adjusting the I-V curve at three remarkable points when the circuit is open (open circuit), when the circuit is delivering maximum power, and when it is short circuited. The data of these three studies are mentioned by all commercial PV module makers in their datasheets and with all these parameters of the adjusted I-V equation

Improvement of Newcastle disease virus vaccine by using gold nanoparticles and some natural food additives

       Newcastle is a disease consider is one of important poultry infectious diseases, it  cause highly significance economic loss for the poultry industry. 120 one day age chicks is divided into sexgroups (A,B,C,D,E,k) two first group injected with Newcastle vaccine mixed with gold nanoparticles in different  concentrations, third group vaccinated then fed Cinnamon powder mixed with bird feed, forth group Nigella stava seeds mixed with birds feed, fifth group Cinnamon oil mixed with vaccine and the last group injected with  vaccine only which consider as control group. Antibodies against Newcastle vaccine and interferon gamma titer are estimated in a different period after vaccination 14, 21, 28 and 35 days by ELISA method. Highly antibodies titer were found in third group after 35 days (0.6

Improvement of Newcastle disease virus vaccine by using gold nanoparticles and some natural food additives

       Newcastle is a disease consider is one of important poultry infectious diseases, it  cause highly significance economic loss for the poultry industry. 120 one day age chicks is divided into sexgroups (A,B,C,D,E,k) two first group injected with Newcastle vaccine mixed with gold nanoparticles in different  concentrations, third group vaccinated then fed Cinnamon powder mixed with bird feed, forth group Nigella stava seeds mixed with birds feed, fifth group Cinnamon oil mixed with vaccine and the last group injected with  vaccine only which consider as control group. Antibodies against Newcastle vaccine and interferon gamma titer are estimated in a different period after vaccination 14, 21, 28 and 35 days by ELISA method. Highly antibodies titer were found in third group after 35 days (0.60 ± 0.07) while the two first groups were given significant results elevated of antibodies during all periods of experiment compare to other groups (0.54).Results showed that there were a significance difference between the groups (A, B, C, D, and E) and control group (K).The study revealed that highest IFN level titer was in group (B) which was (1.91), followed by groups (E, A, K). At  5 weeks old chicks , the highest  level of IFN  was in group (A)(gold nanoparticles-vaccine group 50:50) (1.91) , followed in group (E , B, C) was ( 1.64 , 1.62 , 1.61).Significant differences(p< 0.05) were found between different groups during experiment tim

A prospective clinical study of regenerative endodontic treatment of traumatized immature teeth with necrotic pulps using bi-antibiotic paste

Aim: To evaluate the treatment outcomes of a revitalization endodontic technique (RET) for the management of traumatized immature teeth with necrotic pulps in children. Methodology: Fifteen healthy children (age range = 7–10 years) with traumatized immature maxillary incisors with necrotic pulps treated with bi-antibiotic revitalization endodontic technique were prospectively assessed over approximately two years (mean = 22 months). One operator undertook all treatments, clinical reviews and standardized radiographic exposures with radiographic analysis being carried out by two calibrated experienced clinicians. Crown colour change was assessed using an objective published methodology. Wilcoxon signed-rank test was used to compare root lengths, root dentinal widths and apical foramen widths over time. Results: Interoperator measurement reliability was consistently strong for all measurements. There was no significant difference in root lengths or root dentinal wall widths following RET. A significant difference in apical foramen widths was observed after 2 years (P = 0.013) with resolution of clinical signs of infection in all cases. Despite omitting minocycline and using Portland cement (nonbismuth containing cement), a noticeable crown colour change (yellower, redder and lighter), as measured by an objective colour measurement system with ΔE = 7.39, was recorded. Most patients, however, were satisfied with the aesthetic outcome. Conclusion: Traumatized immature teeth with necrotic pulps treated with revitalization endodontic technique did not demonstrate continuation of root development or dentine formation when assessed by periapical radiographs. However, apical closure and periodontal healing were observed. A measurable change in crown colour (yellower, redder and lighter), with mostly no aesthetic concern to the patients/parents, was also observed

FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation

SummaryTranslational control of mRNAs allows for rapid and selective changes in synaptic protein expression that are required for long-lasting plasticity and memory formation in the brain. Fragile X Related Protein 1 (FXR1P) is an RNA-binding protein that controls mRNA translation in nonneuronal cells and colocalizes with translational machinery in neurons. However, its neuronal mRNA targets and role in the brain are unknown. Here, we demonstrate that removal of FXR1P from the forebrain of postnatal mice selectively enhances long-term storage of spatial memories, hippocampal late-phase long-term potentiation (L-LTP), and de novo GluA2 synthesis. Furthermore, FXR1P binds specifically to the 5′ UTR of GluA2 mRNA to repress translation and limit the amount of GluA2 that is incorporated at potentiated synapses. This study uncovers a mechanism for regulating long-lasting synaptic plasticity and spatial memory formation and reveals an unexpected divergent role of FXR1P among Fragile X proteins in brain plasticity

The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response

Sensory perception requires accurate encoding of stimulus information by sensory receptor cells. We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Nckx4(-/-) (also known as Slc24a4) mouse OSNs displayed substantially prolonged responses and stronger adaptation. Single-cell electrophysiological analyses revealed that the majority of Na(+)-dependent Ca(2+) exchange in OSNs relevant to sensory transduction is a result of NCKX4 and that Nckx4(-/-) mouse OSNs are deficient in encoding action potentials on repeated stimulation. Olfactory-specific Nckx4(-/-) mice had lower body weights and a reduced ability to locate an odorous source. These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception

Constructed Wetlands: A Solution to Treating Milking Centre Washwaters

As of 2016, all dairy farmers are required to properly treat their milk house wastewater prior to disposal. Dairy farmers are interested in a low cost and effective treatment technology to apply. The objective of this presentation is to outline the design, construction and analysis of a Horizontal Subsurface Flow Constructed Wetland (HSSFCW) technology coupled with the use of a passive phosphorus (P) filter to treat milking centre wash waters and/or barnyard runoff in three different sites in Canada. A HSSFCW technology can enable farms to divert wash waters from liquid manure storages, with potential wastewater re-use. The passive P filter, can help remove the high levels of phosphate in the wash waters

Na+-affinity and relation to transport kinetics of Na+/Ca2+-K+ exchanger NCKX2

Bibliography: p. 83-92Some pages are in colou