I Am Error

I Am Error is a platform study of the Nintendo Family Computer (or Famicom), a videogame console first released in Japan in July 1983 and later exported to the rest of the world as the Nintendo Entertainment System (or NES). The book investigates the underlying computational architecture of the console and its effects on the creative works (e.g. videogames) produced for the platform. I Am Error advances the concept of platform as a shifting configuration of hardware and software that extends even beyond its ‘native’ material construction. The book provides a deep technical understanding of how the platform was programmed and engineered, from code to silicon, including the design decisions that shaped both the expressive capabilities of the machine and the perception of videogames in general. The book also considers the platform beyond the console proper, including cartridges, controllers, peripherals, packaging, marketing, licensing, and play environments. Likewise, it analyzes the NES’s extension and afterlife in emulation and hacking, birthing new genres of creative expression such as ROM hacks and tool-assisted speed runs. I Am Error considers videogames and their platforms to be important objects of cultural expression, alongside cinema, dance, painting, theater and other media. It joins the discussion taking place in similar burgeoning disciplines—code studies, game studies, computational theory—that engage digital media with critical rigor and descriptive depth. But platform studies is not simply a technical discussion—it also keeps a keen eye on the cultural, social, and economic forces that influence videogames. No platform exists in a vacuum: circuits, code, and console alike are shaped by the currents of history, politics, economics, and culture—just as those currents are shaped in kind

Fast Timing Bi-Directional Charge Coupled Devices for Use in Gamma -Ray Astronomy.

A Charge Coupled Device (CCD) coupled with a pixellated inorganic scintillator (such as segmented CsI) can provide high position resolution (∼300 mum). However, standard CCDs are integrating devices typically operating no faster than video rates. For a balloon-borne gamma-ray telescope capable of measuring the energy of individual photons, the CCD must have a time resolution better than the average time interval between cosmic ray events on the veto shield (∼10 kHz). A Fast Timing Bi-Directional CCD has better than 10 mus time resolution and 50 mum position resolution. We describe the CCD readout architecture, the ASIC readout design, the present status of the development, and the application to a gamma-ray astronomy telescope suitable for a 100-day Ultra Long Duration Balloon mission

Integrated Models of Care for Individuals with Opioid Use Disorder: How Do We Prevent HIV and HCV?

Purpose of Review To describe models of integrated and co-located care for opioid use disorder (OUD), hepatitis C (HCV), and HIV. Recent Findings The design and scale-up of multidisciplinary care models that engage, retain, and treat individuals with HIV, HCV, and OUD are critical to preventing continued spread of HIV and HCV. We identified 17 models within primary care (N = 3), HIV specialty care (N = 5), opioid treatment programs (N = 6), transitional clinics (N = 2), and community-based harm reduction programs (N = 1), as well as two emerging models. Summary Key components of such models are the provision of (1) medication-assisted treatment for OUD, (2) HIV and HCV treatment, (3) HIV pre-exposure prophylaxis, and (4) behavioral health services. Research is needed to understand differences in effectiveness between co-located and fully integrated care, combat the deleterious racial and ethnic legacies of the “War on Drugs,” and inform the delivery of psychiatric care. Increased access to harm reduction services is crucial

A qualitative assessment of an abstinence-oriented therapeutic community for prisoners with substance use disorders in Kyrgyzstan.

BACKGROUND: Kyrgyzstan, where HIV is concentrated in prisons and driven by injection drug use, provides a prison-based methadone maintenance therapy program as well as abstinence-oriented therapeutic community based on the 12-step model called the "Clean Zone." We aimed to qualitatively assess how prisoners navigate between these treatment options to understand the persistence of the Clean Zone despite a lack of evidence to support its effectiveness in treating opioid use disorders. METHODS: We conducted an analysis of policy documents and over 60 h of participant observation in February 2016, which included focus groups with a convenience sample of 20 therapeutic community staff members, 110 prisoners across three male and one female prisons, and qualitative interviews with two former Clean Zone participants. Field notes containing verbatim quotes from participants were analyzed through iterative reading and discussion to understand how participants generally perceive the program, barriers to entry and retention, and implications for future treatment within prisons. RESULTS: Our analyses discerned three themes: pride in the mission of the Clean Zone, idealism regarding addiction treatment outcomes against all odds, and the demonization of methadone. CONCLUSION: Despite low enrollment and lack of an evidence base, the therapeutic community is buttressed by the strong support of the prison administration and its clients as an "ordered" alternative to what is seen as chaotic life outside of the Clean Zone. The lack of services for Clean Zone patients after release likely contributes to high rates of relapse to drug use. The Clean Zone would benefit from integration of stabilized methadone patients combined with a post-release program

Charge-coupled devices with fast timing for astrophysics and space physics research

A charge coupled device is under development with fast timing capability (15 millisecond full frame readout, 30 microsecond resolution for measuring the time of individual pixel hits). The fast timing CCD will be used in conjunction with a CsI microfiber array or segmented scintillator matrix detector to detect x rays and gamma rays with submillimeter position resolution. The initial application will be in conjunction with a coded aperture hard x ray/gamma ray astronomy instrument. We describe the concept and the readout architecture of the device

Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research

To date, HIV prevention efforts have largely relied on singular strategies (e.g., behavioral or biomedical approaches alone) with modest HIV risk-reduction outcomes for people who use drugs (PWUD), many of whom experience a wide range of neurocognitive impairments (NCI). We report on the process and outcome of our formative research aimed at developing an integrated biobehavioral approach that incorporates innovative strategies to address the HIV prevention and cognitive needs of high-risk PWUD in drug treatment. Our formative work involved first adapting an evidence-based behavioral intervention—guided by the Assessment–Decision–Administration–Production–Topical experts–Integration–Training–Testing model—and then combining the behavioral intervention with an evidence-based biomedical intervention for implementation among the target population. This process involved eliciting data through structured focus groups (FGs) with key stakeholders—members of the target population (n = 20) and treatment providers (n = 10). Analysis of FG data followed a thematic analysis approach utilizing several qualitative data analysis techniques, including inductive analysis and cross-case analysis. Based on all information, we integrated the adapted community-friendly health recovery program—a brief evidence-based HIV prevention behavioral intervention—with the evidence-based biomedical component [i.e., preexposure prophylaxis (PrEP)], an approach that incorporates innovative strategies to accommodate individuals with NCI. This combination approach—now called the biobehavioral community-friendly health recovery program—is designed to address HIV-related risk behaviors and PrEP uptake and adherence as experienced by many PWUD in treatment. This study provides a complete example of the process of selecting, adapting, and integrating the evidence-based interventions—taking into account both empirical evidence and input from target population members and target organization stakeholders. The resultant brief evidence-based biobehavioral approach could significantly advance primary prevention science by cost-effectively optimizing PrEP adherence and HIV risk reduction within common drug treatment settings

Anomaly Detection on Small Wind Turbine Blades Using Deep Learning Algorithms

Wind turbine blade maintenance is expensive, dangerous, time-consuming, and prone to misdiagnosis. A potential solution to aid preventative maintenance is using deep learning and drones for inspection and early fault detection. In this research, five base deep learning architectures are investigated for anomaly detection on wind turbine blades, including Xception, Resnet-50, AlexNet, and VGG-19, along with a custom convolutional neural network. For further analysis, transfer learning approaches were also proposed and developed, utilizing these architectures as the feature extraction layers. In order to investigate model performance, a new dataset containing 6000 RGB images was created, making use of indoor and outdoor images of a small wind turbine with healthy and damaged blades. Each model was tuned using different layers, image augmentations, and hyperparameter tuning to achieve optimal performance. The results showed that the proposed Transfer Xception outperformed other architectures by attaining 99.92% accuracy on the test data of this dataset. Furthermore, the performance of the investigated models was compared on a dataset containing faulty and healthy images of large-scale wind turbine blades. In this case, our results indicated that the best-performing model was also the proposed Transfer Xception, which achieved 100% accuracy on the test data. These accuracies show promising results in the adoption of machine learning for wind turbine blade fault identification

Measurements of Compton Scattered Transition Radiation at High Lorentz Factors

X-ray transition radiation can be used to measure the Lorentz factor of relativistic particles. Standard transition radiation detectors (TRDs) typically incorporate thin plastic foil radiators and gas-filled x-ray detectors, and are sensitive up to \gamma ~ 10^4. To reach higher Lorentz factors (up to \gamma ~ 10^5), thicker, denser radiators can be used, which consequently produce x-rays of harder energies (>100 keV). At these energies, scintillator detectors are more efficient in detecting the hard x-rays, and Compton scattering of the x-rays out of the path of the particle becomes an important effect. The Compton scattering can be utilized to separate the transition radiation from the ionization background spatially. The use of conducting metal foils is predicted to yield enhanced signals compared to standard nonconducting plastic foils of the same dimensions. We have designed and built a Compton Scatter TRD optimized for high Lorentz factors and exposed it to high energy electrons at the CERN SPS. We present the results of the accelerator tests and comparisons to simulations, demonstrating 1) the effectiveness of the Compton Scatter TRD approach; 2) the performance of conducting aluminum foils; and 3) the ability of a TRD to measure energies approximately an order of magnitude higher than previously used in very high energy cosmic ray studies.X-ray transition radiation can be used to measure the Lorentz factor of relativistic particles. Standard transition radiation detectors (TRDs) typically incorporate thin plastic foil radiators and gas-filled x-ray detectors, and are sensitive up to \gamma ~ 10^4. To reach higher Lorentz factors (up to \gamma ~ 10^5), thicker, denser radiators can be used, which consequently produce x-rays of harder energies (>100 keV). At these energies, scintillator detectors are more efficient in detecting the hard x-rays, and Compton scattering of the x-rays out of the path of the particle becomes an important effect. The Compton scattering can be utilized to separate the transition radiation from the ionization background spatially. The use of conducting metal foils is predicted to yield enhanced signals compared to standard nonconducting plastic foils of the same dimensions. We have designed and built a Compton Scatter TRD optimized for high Lorentz factors and exposed it to high energy electrons at the CERN SPS. We present the results of the accelerator tests and comparisons to simulations, demonstrating 1) the effectiveness of the Compton Scatter TRD approach: 2) the performance of conducting aluminum foils: and 3) the ability of a TRD to measure energies approximately an order of magnitude higher than previously used in very high energy cosmic ray studies

Absence of antiretroviral therapy and other risk factors for morbidity and mortality in Malaysian compulsory drug detention and rehabilitation centers

Background: Throughout Asia, people who use drugs are confined in facilities referred to as compulsory drug detention and rehabilitation centers. The limited transparency and accessibility of these centers has posed a significant challenge to evaluating detainees and detention conditions directly.Despite HIV being highly prevalent in this type of confined setting, direct evaluation of detainees with HIV and their access to medical care has yet to be reported in the literature. Methods: We evaluated the health status of 100 adult male detainees with HIV and their access to medical care in the two largest Malaysian compulsory drug detention and rehabilitation centers holding HIV-infected individuals.Results: Approximately 80% of all detainees with HIV were surveyed in each detention center. Most participants reported multiple untreated medical conditions. None reported being able to access antiretroviral therapy during detention and only 9% reported receiving any HIV-related clinical assessment or care. Nearly a quarter screened positive for symptoms indicative of active tuberculosis, yet none reported having been evaluated for tuberculosis.Although 95% of participants met criteria for opioid dependence prior to detention, none reported being able to access opioid substitution therapy during detention, with 86% reporting current cravings for opioids and 87% anticipating relapsing to drug use after release.Fourteen percent of participants reported suicidal ideation over the previous two weeks.Conclusion: We identified a lack of access to antiretroviral therapy in two of the six compulsory drug detention and rehabilitation centers in Malaysia designated to hold HIV-infected individuals and found significant, unmet health needs among detainees with HIV. Individuals confined under such conditions are placed at considerably high risk for morbidity and mortality.Our findings underscore the urgent need for evidence-based drug policies that respect the rights of people who use drugs and seek to improve, rather than undermine, their health