Chapter I disegni della chiesa della SS. Annunziata dei Catalani a Messina. Tra rilievo e ricostruzione grafica

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

Logica di Hoare applicata su un linguaggio procedurale: implementazione Matita

Nell’ambito dello sviluppo del software, garantire la correttezza dei programmi scritti ´e cruciale per fornire affidabilit´a e sicurezza. La logica di Hoare[2], introdotta da Tony Hoare nel 1969, fornisce un approccio formale per la specifica e la verifica della correttezza dei programmi. Tale approccio si basa sull’idea di specificare le precondizioni e le postcondizioni per ciascun frammento di programma, definendo la nozione di tripla di Hoare, la quale consente di dimostrare logicamente che un determinato programma soddisfa determinate propriet´a. Lo scopo del progetto presentato nel documento ´e quello di utilizzare il software Matita[1], per definire la sintassi e la semantica di un linguaggio imperativo con memoria statica (stack), memoria dinamica (heap) e parallelismo. Dopo aver creato il linguaggio, implementare, dimostrandone la validit´a attraverso la funzionalit´a di Proof Assistant di Matita, le regole di inferenza sulle triple di Hoare, per consentire in ultimo di effettuare dimostrazioni rigorose su programmi scritti nello stesso linguaggio. Il presente documento riepiloga in primis i concetti fondamentali riguardanti la teoria che sta alla base del sistema di inferenze di Hoare e di come quest’ultimo dipenda dal linguaggio di programmazione su cui si adopera. In seguito viene invece relazionato il processo di lavoro svolto su Matita per la relativa implementazione pratica

The Honor Capital and Save-A-Lot Partnership

Franchising and licensing represent a form of business proprietorship in which an individual or group of individuals are given the right to use a business format, brand, and identifying marks to sell a product or provide a service under specified terms and conditions. In the United States, roughly one out of every 12 business is a franchise, and hiring within this business sector has outpaced the national average in recent years. The number of workers employed now exceeds the workforce of many major industries. It’s estimated that franchising provides nearly 18 million jobs and contributes over 2.1 trillion dollars to the economy. Franchising in the grocery industry is a well-tested model for independent grocers serving cities, small towns and rural communities. This panel examines the advantages and challenges of the franchising and licensing models for rural grocers and explore the success and innovative partnership between Honor Capital, a veterans-owned business and Save-A-Lot, a hard discount, limited assortment grocery store format with over 1300 locations nationwide. Honor Capital was founded in 2014 by a group of post-9/11 veterans with a dual mission to promote veteran entrepreneurship and improve access to healthy food in underserved communities. While working for a grocery wholesaler in the mid-1970s, Save-a-Lot founder Bill Moran identified an opportunity for small grocers to compete against emerging superstore and created the limited assortment business model. Today, Save-a-Lot is one of the fastest-growing brands in the retail grocery industry

Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions

We report on a 46-year-old athletic patient, previously treated with anterior cruciate ligament reconstruction, with large degenerative chondral lesions of the medial femoral condyle, trochlea and patella, which was successfully treated with a closing-wedge high tibial osteotomy and the implant of a newly developed biomimetic nanostructured osteochondral bioactive scaffold. After 1 year of follow-up the patient was pain-free, had full knee range of motion, and had returned to his pre-operation level of athletic activity. MRI evaluation at 6 months showed that the implant gave a hyaline-like signal as well as a good restoration of the articular surface, with minimal subchondral bone oedema. Subchondral oedema was almost non-visible at 12 months

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament disorganization, and progressive death of cerebellar Purkinje neurons. It is unclear why the loss of sacsin causes these deficits or why they manifest as cerebellar ataxia. Here, we perform multi-omic profiling in sacsin knockout (KO) cells and identify alterations in microtubule dynamics and mislocalization of focal adhesion (FA) proteins, including multiple integrins. Deficits in FA structure, signaling, and function can be rescued by targeting PTEN, a negative regulator of FA signaling. ARSACS mice possess mislocalization of ITGA1 in Purkinje neurons and synaptic disorganization in the deep cerebellar nucleus (DCN). The sacsin interactome reveals that sacsin regulates interactions between cytoskeletal and synaptic adhesion proteins. Our findings suggest that disrupted trafficking of synaptic adhesion proteins is a causal molecular deficit in ARSACS

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament disorganization, and progressive death of cerebellar Purkinje neurons. It is unclear why the loss of sacsin causes these deficits or why they manifest as cerebellar ataxia. Here, we perform multi-omic profiling in sacsin knockout (KO) cells and identify alterations in microtubule dynamics and mislocalization of focal adhesion (FA) proteins, including multiple integrins. Deficits in FA structure, signaling, and function can be rescued by targeting PTEN, a negative regulator of FA signaling. ARSACS mice possess mislocalization of ITGA1 in Purkinje neurons and synaptic disorganization in the deep cerebellar nucleus (DCN). The sacsin interactome reveals that sacsin regulates interactions between cytoskeletal and synaptic adhesion proteins. Our findings suggest that disrupted trafficking of synaptic adhesion proteins is a causal molecular deficit in ARSACS

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a childhood-onset cerebellar ataxia caused by mutations in SACS, which encodes the protein sacsin. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament disorganization, and progressive death of cerebellar Purkinje neurons. It is unclear why the loss of sacsin causes these deficits or why they manifest as cerebellar ataxia. Here, we perform multi-omic profiling in sacsin knockout (KO) cells and identify alterations in microtubule dynamics and mislocalization of focal adhesion (FA) proteins, including multiple integrins. Deficits in FA structure, signaling, and function can be rescued by targeting PTEN, a negative regulator of FA signaling. ARSACS mice possess mislocalization of ITGA1 in Purkinje neurons and synaptic disorganization in the deep cerebellar nucleus (DCN). The sacsin interactome reveals that sacsin regulates interactions between cytoskeletal and synaptic adhesion proteins. Our findings suggest that disrupted trafficking of synaptic adhesion proteins is a causal molecular deficit in ARSACS

Equal pay, comparable worth and the wage gap : from Rosie the Riveter to the presen

The major question that I will attempt to answer is: Equal Pay and Comparable Worth, what does it all mean for women and the wage gap? I want to take the legalese and distill down to its fundamental basics and then convey what it means for women. How do these laws affect women, and what led to the laws being enacted? How did the Rosies\u27 play a part in the equal pay laws? How did women organize themselves to ensure a positive change for all women? Also I want to take the whole process one step further and make it personal; I will do this by incorporating narratives from Rosies\u27, as well women whose lives have been affected by equal pay, comparable worth, and the wage gap. My working thesis is that women have historically been discriminated against in the work force, in terms of pay, and that the major movements to change this began to gain strong footing after the WWII, when women lost their high paying war jobs to the men returning from war. After proving my thesis I will go on to discuss the elements of equal pay, comparable worth, and the wage gap. The focus for my project will begin with Rosie, but it will expand to a much broader topic and the timeline will end with the present

The crosstalk between the tumour microenvironment (TME) and cancer cells: the role of ion channels.

The tumour microenvironment (TME) is a dynamic and intricate network of cells and molecules that evolves in response to cancer invasion, influencing tumour biology and treatment responses. This study investigates the role of ion channels, particularly hERG1, in the communication between cancer cells and the TME. We elucidate a mechanistic pathway involving hERG1 interaction with the β1 integrin receptor, unveiling its profound impact on cell migration, response to mechanical stimuli, and stroma interaction. Our findings reveal that integrin engagement triggers a biphasic response in hERG1 ion channels. Initial stimulation leads to the translocation of hERG1 channels to the plasma membrane, resulting in increased current amplitude and membrane hyperpolarization. Subsequently, hERG1 forms a complex with integrin, maintaining a closed conformation on the plasma membrane, which gradually restores the initial state. This hERG1/β1 integrin complex, modulated by the Gαi3 signalling pathway, significantly influences cancer cell migration and response to mechanical cues, in part due to its impact on cytoskeletal elements like cortical f-actin. In addition, we demonstrate the role of hERG1 in mediating the response of cancer cells to changes in extracellular matrix stiffness, implicating YAP mechanotransduction. This connection adds to the growing understanding of the role of mechanotransduction in cancer progression and supports the potential for targeted therapies in this context. Overall, this research provides crucial insights into the complex interplay between ion channels, the TME, and cancer cells, offering new avenues for anti-metastatic strategies and personalized treatment approaches in the field of oncology. The mechanistic insights provided by our findings, indeed, suggest the potential for targeting hERG1 and β1 integrin interaction during the initial phases of cancer cell migration as an anti-metastatic strategy. This approach may offer therapeutic benefits without affecting hERG1 function in non-cancerous tissues, thus circumventing cardiotoxic side effects associated with hERG1 blockers. Our results also highlight the potential use of Ectica plates for conducting preclinical research and personalized treatment in patient-derived primary culture