The Role of Morphological Awareness in Vocabulary Acquisition in English of Saudi EFL Learners

This study aimed to assess the impact of explicit morphology instruction on Saudi EFL students’ morphological awareness and vocabulary knowledge. The experimental group received for six weeks in their English class morphological lessons that focused on the basic analytical and synthetic word formation rules to increase students’ morphological awareness and help in improving their vocabulary knowledge. On the other hand, the control group received the regular instruction in their English class. At the end of the instruction period, the pre- and post-test scores of the experimental group were compared. Then, the experimental group scores were compared to the control group. The results showed that explicit morphology instruction improved students’ morphological awareness and vocabulary knowledge. There was a statistically significant difference between the experimental group scores in the pre- and post-tests, and a statistically significant difference exists between the experimental group scores and the scores of the control group on the New Vocabulary level test and the Morphological Awareness test. As the results indicated that the intervention (morphology instruction) had a significant impact on the participants performance, this study suggests that teaching morphology plays a significant role in increasing students’ morphological awareness and vocabulary knowledge

Ensemble methods for instance-based Arabic language authorship attribution

The Authorship Attribution (AA) is considered as a subfield of authorship analysis and it is an important problem as the range of anonymous information increased with fast growing of internet usage worldwide. In other languages such as English, Spanish and Chinese, such issue is quite well studied. However, in Arabic language, the AA problem has received less attention from the research community due to complexity and nature of Arabic sentences. The paper presented an intensive review on previous studies for Arabic language. Based on that, this study has employed the Technique for Order Preferences by Similarity to Ideal Solution (TOPSIS) method to choose the base classifier of the ensemble methods. In terms of attribution features, hundreds of stylometric features and distinct words using several tools have been extracted. Then, Adaboost and Bagging ensemble methods have been applied on Arabic enquires (Fatwa) dataset. The findings showed an improvement of the effectiveness of the authorship attribution task in the Arabic language

Bringing Racial Justice to the Courtroom and Community: Race Matters for Juvenile Justice and the Charlotte Model

This article describes regional institutional organizing efforts to bring racial justice to the Charlotte courts and community through a collaborative called Race Matters for Juvenile Justice (RMJJ). The authors explain community and institutional organizing in-depth using the example of minority overrepresentation in the juvenile justice system, but recognize the pervasiveness of racial and ethnic disparities. Moreover, as the Race Matters for Juvenile Justice-Charlotte Model has gained national prominence, many jurisdictions seek to replicate the collaborative and the authors, therefore, provide RMJJ’s history as well as strategies for changing the narrative through communication and education, workforce development, data and research, community collaboration, practice change, and legislation reform

Ambient assisted living framework for elderly care using Internet of medical things, smart sensors, and GRU deep learning techniques

Due to the increase in the global aging population and its associated age-related challenges, various cognitive, physical, and social problems can arise in older adults, such as reduced walking speed, mobility, falls, fatigue, difficulties in performing daily activities, memory-related and social isolation issues. In turn, there is a need for continuous supervision, intervention, assistance, and care for elderly people for active and healthy aging. This research proposes an ambient assisted living system with the Internet of Medical Things that leverages deep learning techniques to monitor and evaluate the elderly activities and vital signs for clinical decision support. The novelty of the proposed approach is that bidirectional Gated Recurrent Unit, and Gated Recurrent Unit deep learning techniques with mutual information-based feature selection technique is applied to select robust features to identify the target activities and abnormalities. Experiments were conducted on two datasets (the recorded Ambient Assisted Living data and MHealth benchmark data) with bidirectional Gated Recurrent Unit, and Gated Recurrent Unit deep learning techniques and compared with other state of art techniques. Different evaluation metrics were used to assess the performance, findings reveal that bidirectional Gated Recurrent Unit deep learning techniques outperform other state of art approaches with an accuracy of 98.14% for Ambient Assisted Living data, and 99.26% for MHealth data using the proposed approach

Morphological and genetical changes of endothelial progenitor cells afterin-vitroconversion into photoreceptors

Background Retinal degeneration is a condition ensued by various ocular disorders such as artery occlusion, diabetic retinopathy, retrolental fibroplasia and retinitis pigmentosa which cause abnormal loss of photoreceptor cells and lead to eventual vision impairment. No efficient treatment has yet been found, however, the use of stem cell therapy such as bone marrow and embryonic stem cells has opened a new treatment modality for retinal degenerative diseases. The major goal of this study is to analyze the potential of endothelial progenitor cells derived from bone marrow to differentiate into retinal neural cells for regenerative medicine purposes. Methods In this study, endothelial progenitor cells were induced in-vitro with photoreceptor growth factor (taurine) for 21 days. Subsequently, the morphology and gene expression of CRX and RHO of the photoreceptors-induced EPCs were examined through immunostaining assay. Findings The results indicated that the induced endothelial progenitor cells demonstrated positive gene expression of CRX and RHO. Our findings suggested that EPC cells may have a high advantage in cell replacement therapy for treating eye disease, in addition to other neural diseases, and may be a suitable cell source in regenerative medicine for eye disorders

DNA-Binding Capabilities and Anticancer Activities of Ruthenium(II) Cymene Complexes with (Poly)cyclic Aromatic Diamine Ligands

Ruthenium(II) arene complexes of the general formula [RuCl(η6-p-cymene)(diamine)]PF6 (diamine = 1,2-diaminobenzene (1), 2,3-diaminonaphthalene (2), 9,10-diaminophenanthrene (3), 2,3-diaminophenazine (4), and 1,2-diaminoanthraquinone (5) were synthesized. Chloro/aqua exchange was evaluated experimentally for complexes 1 and 2. The exchange process was investigated theoretically for all complexes, revealing relatively fast exchange with no significant influence from the polycyclic aromatic diamines. The calf thymus DNA (CT-DNA) binding of the complexes increased dramatically upon extending the aromatic component of the diamines, as evaluated by changes in absorption spectra upon titration with different concentrations of CT-DNA. An intercalation binding mode was established for the complexes using the increase in the relative viscosity of the CT-DNA following addition of complexes 1 and 2. Theoretical studies showed strong preference for replacement of water by guanine for all the complexes, and relatively strong Ru-Nguanine bonds. The plane of the aromatic systems can assume angles that support non-classical interactions with the DNA and covalent binding, leading to higher binding affinities. The ruthenium arenes illustrated in this study have promising anticancer activities, with the half maximal inhibitory concentration (IC50) values comparable to or better than cisplatin against three cell lines.This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia under grant no. (KEP-60-130-38)

DNA-binding and anticancer activity of binuclear gold(I) alkynyl complexes with a phenanthrenyl bridging ligand

3,6-Diethynyl-9,10-diethoxyphenanthrene (4) was synthesized from phenanthrene and employed in the synthesis of the binuclear gold(I) alkynyl complexes (R3P)Au(C≡C-3-[C14H6-9,10-diethoxy]-6-C≡C)Au(PR3) (R = Ph (5a), Cy (5b)). The diyne 4 and complexes 5a and 5b were characterized by NMR spectroscopy, mass spectrometry, and elemental analysis. UV-Vis spectroscopy studies of the metal complexes and precursor diyne show strong π → π* transitions in the near UV region that red shift by ca. 50 nm upon coordination at the gold centers. The emission spectrum of 4 shows an intense fluorescence band centered at 420 nm which red shifts, slightly upon coordination of 4 to gold. Binding studies of 4, 5a, and 5b against calf thymus DNA were carried out, revealing that 4, 5a, and 5b have ≥40% stronger binding affinities than the commonly used intercalating agent ethidium bromide. The molecular docking scores of 4, 5a, and 5b with B-DNA suggest a similar trend in behavior to that observed in the DNA-binding study. Unlike the ligand 4, promising anticancer properties for 5a and 5b were observed against several cell lines; the DNA binding capability of the precursor alkyne was maintained, and its anticancer efficacy enhanced by the gold centers. Such phenanthrenyl complexes could be promising candidates in certain biological applications because the two components (phenanthrenyl bridge and metal centers) can be altered independently to improve the targeting of the complex, as well as the biological and physicochemical properties.This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia under grant no. (KEP-44-130-40). The authors, therefore, acknowledge with thanks DSR technical and financial support

Withdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: A multicenter cohort study

Background: Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against the use of this treatment. To date, the effect of iNO on the clinical outcomes of critically ill COVID-19 patients with moderate-to-severe ARDS remains arguable. Therefore, this study aimed to evaluate the use of iNO in critically ill COVID-19 patients with moderate-to-severe ARDS. Methods: This multicenter, retrospective cohort study included critically ill adult patients with confirmed COVID-19 treated from March 01, 2020, until July 31, 2021. Eligible patients with moderate-to-severe ARDS were subsequently categorized into two groups based on inhaled nitric oxide (iNO) use throughout their ICU stay. The primary endpoint was the improvement in oxygenation parameters 24 h after iNO use. Other outcomes were considered secondary. Propensity score matching (1:2) was used based on the predefined criteria. Results: A total of 1598 patients were screened, and 815 were included based on the eligibility criteria. Among them, 210 patients were matched based on predefined criteria. Oxygenation parameters (PaO2, FiO2 requirement, P/F ratio, oxygenation index) were significantly improved 24 h after iNO administration within a median of six days of ICU admission. However, the risk of 30-day and in-hospital mortality were found to be similar between the two groups (HR: 1.18; 95% CI: 0.77, 1.82; p = 0.45 and HR: 1.40; 95% CI: 0.94, 2.11; p= 0.10, respectively). On the other hand, ventilator-free days (VFDs) were significantly fewer, and ICU and hospital LOS were significantly longer in the iNO group. In addition, patients who received iNO had higher odds of acute kidney injury (AKI) (OR (95% CI): 2.35 (1.30, 4.26), p value = 0.005) and hospital/ventilator-acquired pneumonia (OR (95% CI): 3.2 (1.76, 5.83), p value = 0.001). Conclusion: In critically ill COVID-19 patients with moderate-to-severe ARDS, iNO rescue therapy is associated with improved oxygenation parameters but no mortality benefits. Moreover, iNO use is associated with higher odds of AKI, pneumonia, longer LOS, and fewer VFDs