Taş yapıların cephelerindeki malzeme bozulmalarının yersel lazer tarama yöntemiyle araştırılması: Mardin Konağı örneği

Mardin Mansion is located in the protected area of the Mardin urban site. The building is a valuable building that reflects the architectural features of the traditional houses of Mardin. The aim of the study is to investigate the stone material problems of the historical Mardin mansion, which reflects the traditional housing characteristics of the province of Mardin. For this purpose, the data obtained from observational and laser scanning were combined and interpreted. As a result of the study, the most common types of material deterioration in buildings; It has been seen that there are dıscolouratıon and plants. It is thought that the intense discolouration occurring on the facades is due to the effect of increasing air pollution in the region. As a result, it is recommended to take precautions against the damages caused by air pollution on the facades of the buildings in the region.Mardin Köşkü, Mardin kentsel sit alanındaki koruma altına alınmış bölgede yer almaktadır. Yapı Mardingeleneksel evlerinin yöreye mimari özelliklerini yansıtan değerli bir yapıdır. Geleneksel konakta, çeşitlietkenlerden dolayı oluşan bozulmalar açıkça görülmektedir. Çalışmanın amacı, Mardin ili gelenekselkonut özelliklerini yansıtan tarihi Mardin konağının taş malzeme sorunlarının araştırılmasıdır. Bu amaçlagözlemsel ve lazer taramadan elde edilen veriler birleştirilerek yorumlanmıştır. Çalışma sonucundayapılarda en sık görülen malzeme bozulması türlerinin; yüzey kirliliği ve bitkilenme olduğu görülmüştür.Cephelerde meydana gelen yoğun yüzey kirliliğinin, yörede artan hava kirliliğinin etkisindenkaynaklandığı düşünülmektedir. Sonuçta, bölgedeki yapıların cephelerinde hava kirliliğinin nedenolduğu hasarlara karşı önlem alınması önerilmektedir

Remission of a Pregnant Woman with Persistent Hyperemesis Gravidarum with Corticosteroid Treatment

Nausea and vomiting affect more than 50% of pregnancies. It presents a broad spectrum of symptoms ranging from mild symptoms to severe weight loss and that may affect daily activities. Hyperemesis gravidarum is a severe pathologic form of nausea and vomiting of pregnancy characterized by a greater than 5% loss of weight and unexplained ketonuria. Hyperemesis gravidarum affects approximately 0.5% of pregnancies. The pathogenesis of hyperemesis gravidarum is not exactly known but multifactorial. Previous pregnancy history, low body mass index, maternal inheritance, maternal mood disorders are thought to be associated with. Other causes of nausea and vomiting, such as gastrointestinal tract, genitourinary system, central nervous system, toxic metabolism, must be ruled out. The risk factors include family history, obstetric history, molar pregnancy, multiple pregnancy, nulliparity, female fetus, hyperthyroidism, diabetes, asthma, depression, peptic ulcer or other gastrointestinal disorders. Severe symptoms affect daily activities, cause anxiety, and sometimes may even lead to the termination of pregnancy and cancellation of future pregnancy plans. The symptoms that started in the first trimester of pregnancy decrease and recover to starting of the second trimester. In our case, we will discuss the successful treatment of severe form of hyperemesis gravidarum with parenteral and oral corticosteroids atypically in the second trimester

Distribution of RET mutations and evaluation of treatment approaches in hereditary medullary thyroid carcinoma in Turkey

Objective: This retrospective multicenter study, centrally conducted and supported by the Society of Endocrinology and Metabolism of Turkey, aimed to evaluate the impact of free RET proto-oncogene testing in medullary thyroid carcinoma (MTC) patients. Surgical timing, adequacy of the treatment, and frequency of prophylactic thyroidectomy (PTx) in mutation carriers were also assessed. Methods: Genetic testing for MTC and pheochromocytoma was conducted between July 2008 and January 2012 in 512 patients. Application forms and RET mutation analyses of these patients whose blood samples were sent from various centers around Turkey were assessed retrospectively. An evaluation form was sent to the physicians of the eligible 319 patients who had confirmed sporadic MTC, familial MTC (FMTC), multiple endocrine neoplasia type 2 (MEN2), or who were mutation carriers. Physicians were asked to give information about the surgical history, latest calcitonin levels, morbidity, mortality, genetic screening, and PTx among family members. Twenty-five centers responded by filling in the forms of 192 patients. Results: Among the 319 patients, RET mutation was detected in 71 (22.3%). Cys634Arg mutation was the most prevalent mutation (43.7%), followed by Val804Met in 18 patients (25.4%), and Cys634Tyr in 6 patients (8.5%). Among 192 MTC patients, the diagnosis was sporadic MTC in 146 (76.4%), FMTC in 14 (7.3%), MEN2A in 15 patients (7.9%), and MEN2B in one patient. The number of mutation carriers among 154 apparently sporadic MTC patients was 8 (5.2%). Ten patients were submitted to PTx out of twenty-four mutation carriers at a mean age of 35 +/- 19 years. Conclusion: Turkish people have a similar RET proto-oncogene mutation distribution when compared to other Mediterranean countries. Despite free RET gene testing, the number of the PTx in Turkey is limited and relatively late in the life span of the carriers. This is mainly due to patient and family incompliance and incomplete family counselling.SEM

Material analysis for restoration application: a case study of the world’s first university Mor Yakup Church in Nusaybin, Mardin

Abstract The Mor Yakup Church, located in the Nusaybin District of Mardin, is known as the world’s first educational university in history and represents one of the oldest Christian medieval monuments. In this study, it is aimed to determine the factors of the strength problems of the structure by investigating the characterization of building materials and what kind of factors affect the material behavior with various observational and experimental methods. It was determined that the main deterioration types in the materials of the building were erosion, fractures, loss of parts and the dissolve of the joint mortars between the masonry work on the facades. Since the materials used in the construction of the building are unable in terms of physico-mechanics, it has been determined that the severe continental climate conditions prevailing in the region easily cause such physical deterioration on the construction materials. In addition, the presence of clays in the conventional mortar used in the building has been defined as an internal problem that causes the material to get tired with the osmotic pressure it creates by absorbing water. A very high rate of salinization was detected in the building materials of the building and it was observed that this salting was caused by the acid effect caused by air pollution and the portland cement used in the previous repairs in the building. Finally, this study presents restoration recommendations to repair the material deterioration in the building and to prevent its occurrence in the future

Investigating the limestone quarries as geoheritage sites: Case of Mardin ancient quarry

Abandoned quarries are valuable as a tourism element, as they exhibit the building material of the buildings built in the geographical area they are located in as historical objects. However, in order to determine how the quarries can be used for tourism purposes, it is necessary to determine the constraints on the choice of solution in spatial arrangements. The aim of this study is to investigate how the ancient limestone quarry of Mardin, which is a natural and cultural geological heritage, can be used for tourism and to develop suggestions. Within the scope of the study, in order to examine the possibilities of how an idle quarry located in Mardin province in Turkey can be used for tourism, the constraints in the selection of the post-use solution will be determined. In order to determine whether the Mardin quarry is accessible and safe to visit, various field studies were carried out in the study area, laboratory experiments and analyses. The caves were scanned with a 3D laser scanner, and its plans and sections were obtained. The findings were evaluated and suggestions were developed for the use of the ancient limestone quarry for tourism

The efficacy of vestibular electrical stimulation on patients with unilateral vestibular pathologies

WOS: 000422785900006Objectives: This study aims to investigate the efficacy of vestibular electrical stimulation (VES) in unilateral vestibular lesions including benign paroxysmal positional vertigo (BPPV). Patients and methods: Between June 2007 and August 2007, a total of 19 patients diagnosed with BPPV were included in this study and they were randomized into two groups using the 1: 1 method. Ten patients were administered medical treatment plus VES (treatment group; 1 male, 9 females; mean age 55.8 years; range 27 to 74 years), whereas nine patients were only administered medicine (control group; 2 males, 6 females; mean age 54.9 years; range 34 to 73 years). Both groups received the same medical treatment throughout the study. Vestibular electrical stimulation was performed for 30 min long twice a day, three times a week; 12 sessions in total with 80 Hz high-frequency Transcutaneous Electrical Nerve Stimulation (TENS). Before and after the treatment, patients' severity of dizziness was assessed with Visual Analog Scale (VAS) and daily life activities with Dizziness Handicap Inventory (DHI), and their duration (sec) of single leg stance with eyes open and closed was recorded. Results: Compared to prior to the treatment, VAS-dizziness and DHI scores, and the duration of single leg stance on one foot with eyes open and closed at the end of the treatment showed statistically significant improvement in both groups; however, although VES provided a positive contribution, we did not find a statistically significant difference between the two groups. Conclusion: It can be concluded that VES has positive contribution to medical treatment of patients with dizziness due to unilateral vestibular lesions; however the results of this study should be further investigated with larger groups of patients